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Search Results: 1 - 10 of 422 matches for " Malgorzata Przygodzka "
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Immune system as a new therapeutic target for antibiotics  [PDF]
Brygida Kwiatkowska, Maria Maslinska, Malgorzata Przygodzka, Joanna Dmowska-Chalaba, Justyna Dabrowska, Katarzyna Sikorska-Siudek
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.44A013

Since the discovery of penicillin by Fleming in 1928, the knowledge of the antibiotics’ spectrum and mechanism of action has been steadily increasing. Antibiotics became an effective tool in the fight against many pathogens, changing the prognosis of outcome for many serious diseases. It is already known that antibiotics not only have the antibacterial activity, but many of theme.g. macrolides, sulphonamides and tetracyclineshave immunomodulating effect, affecting functions of lymphocytes, macrophages and costimulatory molecules, macrophage migration and phagocytosis, as well as proinflammatory cytokine secretion. The expanding knowledge of the effects of antibiotics on the immune system has brought with it new applications of antibiotics in organ transplantation, invasive cardiology and treatment of autoimmune diseases such as rheumatoid arthritis or asthma.

Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment
Patrycja Przygodzka, Bj?rn Ramstedt, Tobias Tengel, G?ran Larsson, Malgorzata Wilczynska
BMC Cell Biology , 2010, DOI: 10.1186/1471-2121-11-30
Abstract: We found that the majority of naturally expressed bomapin was located in the nucleus. Both the natural and recombinant bomapin had a disulfide bond which linked the only two bomapin cysteines: one located in the CD-loop and the other near the C-terminus. Computer modelling showed that the cysteines are distant in the reduced bomapin, but can easily be disulfide-linked without distortion of the overall bomapin structure. Low-level ectopic expression of bomapin in bomapin-deficient K562 cells resulted in about 90% increased cell proliferation under normal growth conditions. On the other hand, antisense-downregulation of natural bomapin in U937 cells resulted in a decreased cell proliferation. Bomapin C395S mutant, representing the reduced form of the serpin, had no effect on cell proliferation, suggesting that the disulfide bond-linked conformation of bomapin is biologically important. The bomapin-dependent effect was specific for myeloid cells, since ectopic expression of the serpin in HT1080 cells did not change cell proliferation. In contrast to the survival-promoting activity of bomapin in cells cultured under optimal growth conditions, bomapin enhanced cell apoptosis following growth factor withdrawal.We propose that bomapin is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability.Mature blood cells arise in bone marrow from a small population of haematopoietic stem cells during the haematopoietic process. Haematopoietic stem cells give rise to erythroid/myeloid and lymphoid precursors which then continuously proliferate and differentiate to adult blood cells [1]. Biological functions of haematopoietic cells are tightly regulated with multiple growth factors and cytokines, and by interactions with other cells in bone marrow compartment. These factors determine the rate of haematopoietic cells renewal, proliferation, differentiation, and apoptosis. A failure to respond to external sti
New Method for Measurement of Plant Roots Specific Surface  [PDF]
Grzegorz , Jozefaciuk, Malgorzata Lukowska
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.45135

To provide enough space to carry all surface charges responsible for high cation exchange capacity of plant roots, large area of the root specific surface is necessary, however all experimental methods used up to date give too small surface area values. In this paper, we propose to measure the plant roots surface area using water vapor adsorption isotherm. This method gives roots specific surface areas compatible to CEC. Methodical aspects of the measurements are described along with theoretical background for calculating specific surface area on the example of roots of barley grown in nutrient solution.

National frameworks' survey on standardization of e-Government documents and processes for interoperability
Journal of theoretical and applied electronic commerce research , 2008, DOI: 10.4067/S0718-18762008000200006
Abstract: e-government can be defined as internet applications for public administration processes and decisión making on local, regional, national as well as cross-national level. therefore, the strong necessity to ensure vertical and horizontal interoperation of administrative units is arrived. the main goal of the paper is to reveal how interoperability is built into the public administration engineering process. the paper covers explanations how interoperability is important for e-governmental processes covering documents flows and what activities have been realized with eu agencies to ensure interoperability development. the first part of the paper comprises explanation of e-government document engineering and administrative process development. the second part covers consideration on interoperability for e-business and public administration. the third part includes analysis of what standardization is demanded for interoperability of e-government agencies and how different countries' governments are prepared to ensure such interoperability in public administration in the light of documents, institutional norms and open standards.
Differential top pair cross section and top anti-top plus jets Physics
Worek, Malgorzata
High Energy Physics - Phenomenology , 2013,
Abstract: A brief summary of the current status of the next-to-leading order QCD corrections to top quark pair production and the associated production of top anti-top with jet(s) in different configurations, i.e. with one jet, two jets and another top anti-top pair, is presented.
Monte Carlo Generators for the LHC
Worek, Malgorzata
High Energy Physics - Phenomenology , 2007,
Abstract: The status of two Monte Carlo generators, HELAC-PHEGAS, a program for multi-jet processes and VBFNLO, a parton level program for vector boson fusion processes at NLO QCD, is briefly presented. The aim of these tools is the simulation of events within the Standard Model at current and future high energy experiments, in particular the LHC. Some results related to the production of multi-jet final states at the LHC are also shown.
Sensibiliser les enfants à une langue étrangère par le biais d'une activité musicale
Malgorzata Pamula
Synergies Espagne , 2008,
Abstract: Face à la séparation en compartiments étanches des divers enseignementsque re oivent les jeunes apprenants, l’enseignement intégral éveille chez euxl’activité cognitive, développe leur créativité et l’envie d’entreprendre. L’auteuranalyse l’impact de cette méthode nouvellement appliquée dans l’enseignementdes écoles élémentaires polonaises. L’apprentissage du fran ais dans ce cadred’enseignement intégral (musique, arts plastiques) peut parfaitement être menédès les premières étapes de l’éducation musicale. L’on met surtout l’accent surla formation de la perception des phénomènes acoustiques relevant d’une oeuvremusicale, de la musique. Mais en même temps on prend en considération uneaptitude perceptive importante: la sensibilité phonétique. à travers des exercicesqui préparent les jeunes apprenants à la découverte de l’écrit en langue étrangèrese développe ainsi la sensiblilsation à cette langue et la conscience phonologiquede l’enfant.
An Evaluation of the American Models of Public Library Service for Disabled Users for Poland An Evaluation of the American Models of Public Library Service for Disabled Users for Poland
Malgorzata Fedorowicz
Türk Kütüphanecili?i , 2007,
Abstract: The service of disabled people is an extremely important segment of public libraries activity. In the United States, Canada and Scandinavian countries a great importance is attached to expanding library offer by adding services aimed to this category of users. In this work three American models of library service in public libraries are discussed. The models are: delivering library services outside a library, in other words, an outreach program, rendering services in special needs centers and integrated service, which is provided in the same place and in the same way as for the remaining members of the community (it is also called mainstreaming). Next, the models are compared with actions taken in this field in Polish libraries, which after many years of isolation from the latest trends currently are trying to overtake backlogs.
Autopoiesis in Virtual Organizations
Malgorzata PAMKOWSKA
Informatica Economica Journal , 2008,
Abstract: Virtual organizations continuously gain popularity because of the benefits created by them. Generally, they are defined as temporal adhocracies, project oriented, knowledge-based network organizations. The goal of this paper is to present the hypothesis that knowledge system developed by virtual organization is an autopoietic system. The term ¢ € autopoiesis ¢ € was introduced by Maturana for self-productive systems. In this paper, Wikipedia is described as an example of an autopoietic system. The first part of the paper covers discussion on virtual organizations. Next, autopoiesis ¢ € interpretations are delivered and the value of autopoiesis for governance of virtual organizations is presented. The last parts of the work comprise short presentation of Wikipedia, its principles and conclusions of Wikipedia as an autopoietic system.
The theoretical link between Capital Account liberalization and Currency Crisis Episodes
Malgorzata Sulimierska
International Journal of Business and Management , 2009, DOI: 10.5539/ijbm.v3n4p75
Abstract: The paper investigates theoretical background if countries with unregulated capital flows are more vulnerable to currency crises. In order to solve this question properly the paper considers sequence, precondition of the Capital Account Liberalization process and different generation of currency crisis models. Furthermore, theoretical studies pointed that the speed and sequence of the CAL process needs to be adequate for the country financial development and financial liberalization.
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