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Search Results: 1 - 10 of 2696 matches for " Makoto Tomita "
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Fourier Analysis of Slow and Fast Image Propagation through Single and Coupled Image Resonators
Parvin Sultana,Takahiro Matsumoto,Makoto Tomita
International Journal of Optics , 2012, DOI: 10.1155/2012/960985
Abstract: We applied Fourier space analysis to a comprehensive study of the propagation of pulsed two-dimensional images through single and coupled image resonators. The Fourier method shows that the image can propagate through the resonator successfully as long as the spatial and temporal Fourier components of the image are within the bandwidth of the amplitude and phase transfer functions. The relevant steep dispersion of the cavity can yield delayed or advanced images. The Fourier method reproduces characteristic aspects of the experimental observations of the image propagation, and also predicts new aspects, such as the spatial image profile dependence on the observation time and the coupling strength. To demonstrate the time evolution of the experiment, space- and time-resolved image propagations were performed using a streak camera. 1. Introduction When propagating through media, the velocity of an optical wave packet depends on the variation of the refractive index. In recent years, there has been increasing interest in media in which the refractive index changes drastically with respect to changes in frequency, resulting in significant modification in the corresponding group velocities of the optical pulses. We refer to this phenomenon as “slow light” or “fast light.” Experimental demonstrations of slow and fast light have been realized based on stimulated Brillouin scattering in optical fibers [1], electromagnetically induced absorption (EIA) and transparency (EIT) in atomic vapors [2–5], structural dispersion in microsphere-optical fiber systems [6], coupled-resonator-induced transparency (CRIT) with classical light [7], and squeezed vacuum studies [8]. Recently, various groups have reported stopping light altogether, which leads to new methods of storing information [9, 10]. It is challenging to apply slow and fast light techniques to two-dimensional (2D) image propagation. All-optical methods for delaying images have great potential in many applications, including holography and optical pattern correlation measurements or futuristic all-optical image routers for large capacity image information. The first experimental demonstration of an all-optical image delay was reported in Cs atoms [11]. The storage and retrieval of a transverse image in an atomic vapor was demonstrated using a technique based on EIT [12, 13]. Recently, researchers succeeded in eliminating arbitrary paraxial image diffraction by manipulating the susceptibility in momentum space [14]. This work opens up new possibilities for utilizing EIT to realize high-resolution imaging and
Chemotherapy (Gemcitabine plus Carboplatin versus Paclitaxel plus Carboplatin) in Elderly Patients with Non-Small Cell Lung Cancer  [PDF]
Takanori Ayabe, Masaki Tomita, Eiichi Chosa, Makoto Ikenoue, Yukie Shirasaki, Kunihide Nakamura
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.53035

Background: This retrospective study was to evaluate the efficacy and toxicity of gemcitabine plus carboplatin (GC regimen) and paclitaxel plus carboplatin (PC regimen) combination chemotherapy in elderly patients with non-small cell lung cancer. Methods: Seventy-four patients (GC regimen, n = 44; PC regimen, n= 30) received gemcitabine at a dose of 1000 mg/m2 on days 1 and 8, and carboplatin with the target dose of area under the curve (AUC) of 4 on day 8 every 28 days and paclitaxel at a dose of 70 mg/m2 on days 1, 8 and 15, and carboplatin with the target dose of AUC of 5 on day 1 every 28 days. Patients were divided in two groups (younger one: n = 42, <70 years old; elderly one: n= 32, ≥70 years old). Results: A total of 222 cycles of the treatment wasadministered. Seventy-one patients (95.9%) completed the scheduled cycles. Two patients in the elderly group were discontinued (6.3%) due to hematological toxicity and melena in

Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis
Chieko Mitaka, Toshifumi Kudo, Go Haraguchi, Makoto Tomita
Critical Care , 2011, DOI: 10.1186/cc10519
Abstract: Electronic databases, including PubMed, EMBASE and references from identified articles were used for a literature search.Data on the infusion of ANP or BNP in cardiovascular surgery patients was collected from fifteen randomized controlled trials and combined. The infusion of ANP or BNP increased the urine output and creatinine clearance or glomerular filtration rate, and reduced the use of diuretics and the serum creatinine levels. A meta-analysis showed that ANP infusion significantly decreased peak serum creatinine levels, incidence of arrhythmia and renal replacement therapy. The meta-analysis also showed that ANP or BNP infusion significantly decreased the length of ICU stay and hospital stay compared with controls. However, the combined data were insufficient to determine how ANP or BNP infusion during the perioperative period influences long-term outcome in cardiovascular surgery patients.The infusion of ANP or BNP may preserve postoperative renal function in cardiovascular surgery patients. A large, multicenter, prospective, randomized controlled trial will have to be performed to assess the therapeutic potential of ANP or BNP in preventing and treating AKI in the cardiovascular surgical setting.Even with the latest advances in surgical and anesthetic techniques and postoperative intensive care, patients undergoing cardiovascular surgery for left ventricular dysfunction still have a fairly high mortality [1,2]. The mortality for severe left ventricular dysfunction in patients undergoing coronary artery bypass grafting is 4.6% to 5.6% and 22.3% to 31% at 30-days and 5 years, respectively, whereas the mortality for normal left ventricular function is 1.1% to 1.9% and 5.5% to 7% at 30 days and 5 years, respectively[1,2]. These cardiovascular surgery patients spend prolonged periods in the ICU and hospital, and their survival is strongly dependent on their pre-operative left ventricular ejection fraction [1]. Cardiorenal syndrome is another serious concern, as p
Visualization of three-way comparisons of omics data
Richard Baran, Martin Robert, Makoto Suematsu, Tomoyoshi Soga, Masaru Tomita
BMC Bioinformatics , 2007, DOI: 10.1186/1471-2105-8-72
Abstract: We propose a color-coding approach for the representation of three-way comparisons. The approach is based on the HSB (hue, saturation, brightness) color model. The three compared values are assigned specific hue values from the circular hue range (e.g. red, green, and blue). The hue value representing the three-way comparison is calculated according to the distribution of three compared values. If two of the values are identical and one is different, the resulting hue is set to the characteristic hue of the differing value. If all three compared values are different, the resulting hue is selected from a color gradient running between the hues of the two most distant values (as measured by the absolute value of their difference) according to the relative position of the third value between the two. The saturation of the color representing the three-way comparison reflects the amplitude (or extent) of the numerical difference between the two most distant values according to a scale of interest. The brightness is set to a maximum value by default but can be used to encode additional information about the three-way comparison.We propose a novel color-coding approach for intuitive visualization of three-way comparisons of omics data.Color-coded representations of differences between omics datasets provide an intuitive and global comparative view of the data [1]. Such visualizations further facilitate the use of human pattern recognition abilities to complement the automated approaches to pinpoint subtle differences [2]. Currently, most visualizations are limited to pairwise comparisons where differences of interest between two corresponding datapoints are mapped onto color gradients for positive or negative ranges. In addition, results of statistical tests (F ratio, z-score, quartile analysis, etc.) performed across multiple datasets can be visualized to highlight sets of corresponding datapoints containing a difference [3]. These results, however, do not provide informa
Effects of rock wool on the lungs evaluated by magnetometry and biopersistence test
Yuichiro Kudo, Makoto Kotani, Masayuki Tomita, Yoshiharu Aizawa
Journal of Occupational Medicine and Toxicology , 2009, DOI: 10.1186/1745-6673-4-5
Abstract: Using the nose-only inhalation exposure system, 6 male Fischer 344 rats (6 to 10 weeks old) were exposed to RW fibers at a target fiber concentration of 100 fibers/cm3 (length [L] > 20 μm) for 6 hours daily, for 5 consecutive days. As a magnetometric indicator, 3 mg of triiron tetraoxide suspended in 0.2 mL of physiological saline was intratracheally administered after RW exposure to these rats and 6 unexposed rats (controls). During one second magnetization in 50 mT external magnetic field, all magnetic particles were aligned, and immediately afterwards the strength of their remanent magnetic field in the rat lungs was measured in both groups. Magnetization and measurement of the decay (relaxation) of this remanent magnetic field was performed over 40 minutes on 1, 3, 14, and 28 days after RW exposure, and reflected cytoskeleton dependent intracellular transport within macrophages in the lung. Similarly, 24 and 12 male Fisher 344-rats were used for biopersistence test and pathologic evaluation, respectively.In the lung magnetometric evaluation, biopersistence test and pathological evaluation, the arithmetic mean value of the total fiber concentration was 650.2, 344.7 and 390.7 fibers/cm3, respectively, and 156.6, 93.1 and 95.0 fibers/cm3 for fibers with L > 20 μm, respectively. The lung magnetometric evaluation revealed that impaired relaxation indicating cytoskeletal toxicity did not occur in the RW exposure group. In addition, clearance of the magnetic tracer particles was not significantly affected by the RW exposure. No effects on lung pathology were noted after RW exposure.These findings indicate that RW exposure is unlikely to cause pulmonary toxicity within four weeks period. Lung magnetometry studies involving long-term exposure and observation will be necessary to ensure the safety of RW.Rock wool (RW) is a kind of asbestos substitute and is widely used in the construction industry, in particular for fire-resisting insulation, thermal insulation, and acous
Immunoadsorption therapy reduces oxidative stress in patients with dilated cardiomyopathy  [PDF]
Hiroki Kasai, Yuichiro Kashima, Atsushi Izawa, Takeshi Tomita, Yusuke Miyashita, Jun Koyama, Masafumi Takahashi, Taku Yoshio, Yoshikazu Yazaki, Makoto Higuchi, Uichi Ikeda
World Journal of Cardiovascular Diseases (WJCD) , 2012, DOI: 10.4236/wjcd.2012.24048
Abstract: Several literatures have reported that the elimination of autoantibodies by immunoadsorption (IA) therapy induced short- and long-term improvements in cardiac function of patients with dilated cardiomyopathy (DCM). We assessed whether reduction in oxidative stress was related to the mechanism underlying left ventricular functional benefit from IA. We studied 7 patients with DCM (New York Heart Association (NYHA) functional class III/IV). Autoantibodies were removed with IA by passing patients’ plasma over tryptophan columns. The level of anti-β1-adrenoreceptor (AR) autoantibodies was measured by enzyme- linked immunosorbent assay. The level of diacron- reactive oxygen metabolite (d-ROM) was determined as a marker of oxidative stress. During IA, the anti- β1-AR autoantibodies titers of all the patients decreased significantly from 27.8 ± 5.0 to 18.7 ± 5.5 U/ml (p < 0.01). IA induced the following hemodynamic improvements: cardiac index increased from 1.71 ± 0.40 to 1.97 ± 0.41 l/min/m2 and left ventricular ejection fraction (LVEF) increased from 22.8 ± 6.1 to 29.1±9.1% (p < 0.05). d-ROM level decreased significantly from 392.7 ±17.0 to 314.1 ± 22.0 Carratelli units (p < 0.05), and was negatively correlated with LVEF before and after IA therapy (r = -0.601, p < 0.05). The anti-β1-AR autoantibodies, LVEF and d- ROM returned to the baseline levels at 12 months after IA. In conclusion, oxidative stress reduction may be responsible for the beneficial effect of IA therapy in patients with DCM.
Reattachment of the Osteotomized Greater Trochanter in Hip Surgery Using an Ultrahigh Molecular Weight Polyethylene Fiber Cable: A Multi-Institutional Study  [PDF]
Seiya Jingushi, Tsutomu Kawano, Hirokazu Iida, Kenichi Oe, Kenji Ohzono, Yoshihide Nakamura, Makoto Osaki, Hidetsugu Ohara, Seung Bak Lee, Toshihiko Hara, Naohide Tomita
Open Journal of Orthopedics (OJO) , 2013, DOI: 10.4236/ojo.2013.36052

The purpose of this multicenter study was to evaluate the clinical performance of an ultrahigh molecular weight polyethylene (UHMWPE) fiber cable for re-attachment of the osteotomized greater trochanter in hip surgery. Included in the study were 85 hips that had undergone surgery with greater trochanter osteotomy, including 50 hip arthroplasty procedures and 35 hip osteotomies. The osteotomized greater trochanter was reattached using one or more UHMWPE fiber cables. The bone union and displacement of the greater trochanter were assessed in radiographs for up to 12 months after surgery. Non-union of the osteotomy site occurred in 4.7% of the cases. In approximately 90% of the cases, displacement was less than 2 mm at up to 12 months after surgery. The UHMWPE fiber cable was a good biomaterial for reattaching the osteotomized greater trochanter and may also be an option for osteosynthesis procedures.

Cancer-Associated Lymphatic and Venous Vessels in Colonic Carcinomas  [PDF]
Tatsuo Tomita
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.43016

Objective: Colonic carcinomas spread to regional lymph nodes and liver. There are cancer-associated lymphatic and venous vessels at the margin of colonic carcinomas, which facilitate spreading carcinoma through lymphatic and venous vessels. This study aimed to examine cancer-associated lymphatic and venous vessels in TNM T1 to T3 carcinomas using lymphatic vessel hyaluronan receptor for lymphatic vessels and von Willebrand factor for venous vessels by immunocytochemical staining. Materials and Methods: A total of 40 cases of moderately differentiated colonic carcinoma were studied using routinely formalin-fixed and paraffin-embedded sections. The cases consisted of 10 cases of TNM T1, 15 cases each of T2 and T3 cases. Immunocytochemical staining was performed using goat antihuman LYVE-1for lymphatic vessels and rabbit antihuman von Willebrand factor for venous vessels. Results: In TNM T1 carcinoma, increased, irregular and narrow lymphatic and venous vessels were present in the adjacent normal mucosa to the carcinoma, some of which penetrated cancerous lesion. There were no tumor emboli in lymphatic and venous vessels. In TNM T2 carcinoma, there were few lymphatic and venous vessels in midst of the carcinoma whereas numerous small lymphatic and venous vessels were present within muscle layers adjacent to the invading carcinoma. Extramural tumor embolus

Tumor-Associated Lymphatic and Venous Vessels in Medullary Thyroid Carcinomas  [PDF]
Tatsuo Tomita
Open Journal of Pathology (OJPathology) , 2015, DOI: 10.4236/ojpathology.2015.52008
Abstract: Objective: Medullary thyroid carcinomas (MTCs) invade local lymph node through lymphatic vessels and metastasize to distant organs hematogenously and account for a significant mortality. There are possibly increased lymphatic and venous vessels, through which the tumor spreads to lymph nodes and distant organs. Materials and Methods: By immunocytochemical staining for lymphatic and venous vessels, MTC lesions with adjacent normal thyroid and both normal and metastatic lymph nodes were studied for the peritumoral lymphatic and venous vessels, which were morphometrically compared with those of normal thyroid and lymph nodes. Sixteen cases of MTC cases with adjacent thyroid tissues and attached lymph nodes were immunocytochemically stained for lymphatic vessels using lymphatic vessel hyaluronan receptor (LYVE-1) and venous vessels for factor VIII (F-8). The immunostained sections of MTC lesions and metastatic lymph nodes were morphometrically compared for the number and sizes of the vessels with those of normal thyroid tissues and lymph nodes. Results: Significantly increased lymphatic vessels and markedly increased blood vessels were identified in many MTC cases at the peritumoral tissues and metastatic lymph nodes whereas a few lymphatic vessels and no venous vessels were identified in midst of MTCs. The irregular peritumoral lymphatic vessels resembled that of immature lymphatic vessels observed in papillary thyroid carcinomas and increased irregularly, entrapped venous vessels in peritumoral tissues resembled those observed in follicular thyroid carcinomas. Conclusion: The significantly increased lymphatic vessels and markedly increased venous vessels in the peritumoral thyroid tissue support a propensity of MTCs for providing an easy access of tumor cells to both lymphatic spread to the regional lymph nodes and venous spread to distant organs with further tumor spread through metastatic lymph nodes by moderately increased lymphatic and venous vessels.
A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment
Ayako Yachie-Kinoshita,Taiko Nishino,Hanae Shimo,Makoto Suematsu,Masaru Tomita
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/642420
Abstract: The human red blood cell (RBC) has long been used for modeling of complex biological networks, for elucidation of a wide variety of dynamic phenomena, and for understanding the fundamental topology of metabolic pathways. Here, we introduce our recent work on an RBC metabolic model using the E-Cell Simulation Environment. The model is sufficiently detailed to predict the temporal hypoxic response of each metabolite and, at the same time, successfully integrates modulation of metabolism and of the oxygen transporting capacity of hemoglobin. The model includes the mechanisms of RBC maintenance as a single cell system and the functioning of RBCs as components of a higher order system. Modeling of RBC metabolism is now approaching a fully mature stage of realistic predictions at the molecular level and will be useful for predicting conditions in biotechnological applications such as long-term cold storage of RBCs.
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