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Search Results: 1 - 10 of 2165 matches for " Makoto Kittaka "
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Clinical Analysis of Pulmonary Nontuberculous Mycobacterial Disease Complicated by Lung Cancer during the Follow-Up Periods  [PDF]
Yoshihiro Kobashi, Makoto Kittaka, Keiji Mouri, Shigeki Kato, Mikio Oka
Open Journal of Respiratory Diseases (OJRD) , 2016, DOI: 10.4236/ojrd.2016.64009
Abstract: Introduction: The objective of this study was the estimation of the clinical characteristics of patients with pulmonary nontuberculous mycobacterial (NTM) disease complicated by lung cancer during the follow-up periods. Methods: We analyzed the clinical findings of four patients (2.0%) complicated by lung cancer during the follow-up periods of over six months at least after the definite diagnosis of pulmonary NTM disease of 202 patients with pulmonary NTM disease experienced in our hospital in the last decade. Results: There were four patients with pulmonary NTM disease complicated by lung cancer and all of them were caused by Mycobacterium avium complex (MAC). They were all elderly male patients and had underlying diseases. Three patients were diagnosed with primary lung cancer and one diagnosed with metastatic lung cancer from colon cancer within 3 years after the diagnosis of pulmonary NTM disease. The treatments for lung cancer were surgical resection for all patients with localized lesions. One patient died due to the worsening of underlying disease and the remaining three survived except for the recurrence of one patient. Conclusion: Although the complication rate of pulmonary NTM disease and lung cancer was a lower percentage (2.0%) than in previous reports, the careful follow-up for patients with pulmonary NTM disease without forgetting the possible complication of lung cancer is necessary.
Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone
Toru Sugiyama,Atsushi Kittaka
Molecules , 2013, DOI: 10.3390/molecules18010287
Abstract: A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA. PNAs are resistant to nucleases and proteases and have a low affinity for proteins. These properties make PNAs an attractive agent for biological and medical applications. To improve the antisense and antigene properties of PNAs, many backbone modifications of PNAs have been explored under the concept of preorganization. This review focuses on chiral PNAs bearing a substituent in the N-(2-aminoethyl)glycine backbone. Syntheses, properties, and applications of chiral PNAs are described.
A Peptide Nucleic Acid to Reduce Type I Collagen Production by Fibroblast Cells  [PDF]
Yasutada Imamura, Suzuka Tsuboi, Toru Sugiyama, Atsushi Kittaka, Yonchol Shin
Open Journal of Medicinal Chemistry (OJMC) , 2015, DOI: 10.4236/ojmc.2015.51001
Abstract: In this study, we prepared a peptide nucleic acid (PNA) against the gene coding for the human alpha 1 chain of type I collagen. This PNA was incorporated into normal human fibroblast cells by electroporation, leading to a decrease in the mRNA level of the gene. Furthermore, mRNA for the alpha 2 chain of type I collagen was also reduced. The production of collagen protein exhibited a similar profile to the changes in mRNA. These results indicate that PNA targeting COL1A1 is effective as an antigene reagent, and opens the possibility of future clinical applications in fibroproliferative disorders.
Novel Vitamin D Analogs for Prostate Cancer Therapy
Tai C. Chen,Atsushi Kittaka
ISRN Urology , 2011, DOI: 10.5402/2011/301490
On Canard Homoclinic of a Liénard Perturbation System  [PDF]
Makoto Hayashi
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.210170
Abstract: The classification on the orbits of some Liénard perturbation system with several parameters, which is relation to the example in [1] or [2], is discussed. The conditions for the parameters in order that the system has a unique limit cycle, homoclinic orbits, canards or the unique equilibrium point is globally asymptotic stable are given. The methods in our previous papers are used for the proofs.
Traffic Dynamics and Congested Phases Derived from an Extended Optimal-Velocity Model  [PDF]
Makoto Watanabe
Engineering (ENG) , 2014, DOI: 10.4236/eng.2014.68048

Dynamics is studied for one-dimensional single-lane traffic flow by means of an extended optimal-velocity model with continuously varied bottleneck strength for nonlinear roads. Two phases exist in this model such as free flow and wide moving jam states in the systems having relatively small values of the bottleneck strength parameter. In addition to the two phases, locally congested phaseappears as the strength becomes prominent. Jam formation occurs with the similar mechanism to the boomerang effect as well as the pinch one in it. Wide scattering of the flow-density relation in fundamental diagram is found in the congested phase.

Employment Protection, Employers’ Hiring Strategies and the Screening Role of Temporary Contracts  [PDF]
Makoto Masui
Modern Economy (ME) , 2016, DOI: 10.4236/me.2016.77080
Abstract: In this paper, we develop a matching model with both permanent and temporary contracts to address situations in which the quality of a match formed by a worker-firm pair is not observable to both workers and firms. The screening and cost-saving aspects of temporary employment contracts are two primary reasons that firms use them, but screening has received little attention in the study of employment protection. We show that increasing dismissal costs decreases job creation and that higher dismissal costs are likely to reduce the hiring threshold for temporary jobs and raise the threshold for permanent jobs. We also examine how changes in dismissal costs affect the average productivity of permanent jobs and discuss the effectiveness of the policy of increasing labour market flexibility by weakening firing restrictions for permanent employment.
On Utilization of K-Means for Determination of q-Parameter for Tsallis-Entropy-Maximized-FCM  [PDF]
Makoto Yasuda
Journal of Software Engineering and Applications (JSEA) , 2017, DOI: 10.4236/jsea.2017.107033
Abstract: In this paper, we consider a fuzzy c-means (FCM) clustering algorithm combined with the deterministic annealing method and the Tsallis entropy maximization. The Tsallis entropy is a q-parameter extension of the Shannon entropy. By maximizing the Tsallis entropy within the framework of FCM, membership functions similar to statistical mechanical distribution functions can be derived. One of the major considerations when using this method is how to determine appropriate q values and the highest annealing temperature, Thigh?, for a given data set. Accordingly, in this paper, a method for determining these values simultaneously without introducing any additional parameters is presented. In our approach, the membership function is approximated by a series of expansion methods and the K-means clustering algorithm is utilized as a preprocessing step to estimate a radius of each data distribution. The results of experiments indicate that the proposed method is effective and both q and Thigh can be determined automatically and algebraically from a given data set.
A Case Report of Spontaneous Closure of a Posttraumatic Arterioportal Fistula
Hirotada Kittaka,Hiroshi Akimoto,Keitaro Tashiro
Case Reports in Emergency Medicine , 2013, DOI: 10.1155/2013/623704
Abstract: As the indications for the nonoperative management (NOM) of hepatic injury have expanded, the incidence of complications of NOM has increased. Among such complications, arterioportal fistula (APF) formation is rare, although dangerous, due to the potential for portal hypertension. Embolization is performed in APF patients with clinical signs suggestive of portal hypertension. Meanwhile, no indications for treatment have been established in APF patients without symptoms, as the natural history of posttraumatic APF is not well understood. We herein report the case of a 35-year-old female with severe hepatic injury (Grade IV on the Organ Injury Scale of the American Association for the Surgery of Trauma) due to a traffic accident. Her hemodynamic state remained stable, and an enhanced CT scan obtained on admission showed no extravasation of contrast medium, pseudoaneurysm formation, or APF; therefore, NOM was selected. Although the patient’s physical condition was stable, an enhanced CT scan obtained 13 days after the injury showed APF in segment 8 of the liver. Although embolization was considered, the APF was not accompanied by portal dilatation suggestive of portal hypertension; hence, strict observation was selected. Consequently, follow-up CT performed on day 58 after the injury revealed spontaneous closure of the APF. 1. Introduction The most common cause of arterioportal fistula (APF) has been reported to be hepatic trauma (28%), followed by iatrogenic procedures (16%), congenital vascular malformation (15%), malignancy (15%), and rupture of splanchnic artery aneurysms (14%) [1]. As the indications for the nonoperative management (NOM) of hepatic trauma injury have expanded, with high reported success rates ranging from 83% to 100% [2–4], the incidence of complications, including APF, posttraumatic pseudoaneurysms, bile leakage, and hepatic abscesses, has increased [3, 5, 6]. APF is rare; however, it is considered to be clinically dangerous due to the possibility of portal hypertension and ultimate rupture of esophageal varices. Therefore, transarterial embolization is usually performed in APF patients with clinical signs, such as splenomegaly or ascites, that are suggestive of portal hypertension [7–9]. On the other hand, no indications for treatment have been established in APF patients without symptoms, as the natural history of posttraumatic APF is not well understood. We encountered a rare case of spontaneous closure of posttraumatic APF detected on follow-up enhanced computed tomography (CT) for blunt liver trauma. 2. Case Report A 35-year-old
Large Enhancement of 3-K Phase Superconductivity in the Sr2RuO4-Ru Eutectic System by Uniaxial Pressure
Shunichiro Kittaka,Hiroshi Yaguchi,Yoshiteru Maeno
Physics , 2009, DOI: 10.1143/JPSJ.78.103705
Abstract: While the superconducting transition temperature Tc of Sr2RuO4 is 1.5 K, its onset Tc is enhanced as high as 3 K in the Sr2RuO4-Ru eutectic system, which is often referred to as the 3-K phase. We have investigated effects of uniaxial pressure on the non-bulk superconductivity in the 3-K phase. While Tc of pure Sr2RuO4 is known to be suppressed by hydrostatic pressure, a large enhancement of the superconducting volume fraction of the 3-K phase was observed for both out-of-plane and in-plane uniaxial pressures. Especially, under the in-plane pressure, the shielding fraction at 1.8 K of only less than 0.5% at 0 GPa exceeds 40% at 0.4 GPa. Such a large shielding fraction suggests that under the uniaxial pressure interfacial 3-K phase superconductivity penetrates deep into the bulk of Sr2RuO4. The present finding provides a significant implication to the unresolved origin of the enhancement of Tc to 3 K in the Sr2RuO4-Ru eutectic system.
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