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Search Results: 1 - 10 of 461797 matches for " Maimoona A. Zariwala "
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Histo-Blood Group Gene Polymorphisms as Potential Genetic Modifiers of Infection and Cystic Fibrosis Lung Disease Severity
Jennifer L. Taylor-Cousar, Maimoona A. Zariwala, Lauranell H. Burch, Rhonda G. Pace, Mitchell L. Drumm, Hollin Calloway, Haiying Fan, Brent W. Weston, Fred A. Wright, Michael R. Knowles, for the Gene Modifier Study Group
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004270
Abstract: Background The pulmonary phenotype in cystic fibrosis (CF) is variable; thus, environmental and genetic factors likely contribute to clinical heterogeneity. We hypothesized that genetically determined ABO histo-blood group antigen (ABH) differences in glycosylation may lead to differences in microbial binding by airway mucus, and thus predispose to early lung infection and more severe lung disease in a subset of patients with CF. Methods and Principal Findings Clinical information and DNA was collected on >800 patients with the ΔF508/ΔF508 genotype. Patients in the most severe and mildest quartiles for lung phenotype were enrolled. Blood samples underwent lymphocyte transformation and DNA extraction using standard methods. PCR and sequencing were performed using standard techniques to identify the 9 SNPs required to determine ABO blood type, and to identify the four SNPs that account for 90–95% of Lewis status in Caucasians. Allele identification of the one nonsynonymous SNP in FUT2 that accounts for >95% of the incidence of nonsecretor phenotype in Caucasians was completed using an ABI Taqman assay. The overall prevalence of ABO types, and of FUT2 (secretor) and FUT 3 (Lewis) alleles was consistent with that found in the Caucasian population. There was no difference in distribution of ABH type in the severe versus mild patients, or the age of onset of Pseudomonas aeruginosa infection in the severe or mild groups. Multivariate analyses of other clinical phenotypes, including gender, asthma, and meconium ileus demonstrated no differences between groups based on ABH type. Conclusions and Significance Polymorphisms in the genes encoding ABO blood type, secretor or Lewis genotypes were not shown to associate with severity of CF lung disease, or age of onset of P. aeruginosa infection, nor was there any association with other clinical phenotypes in a group of 808 patients homozygous for the ΔF508 mutation.
Clinical Presentation and Outcome of Bacterial Meningitis in University Hospital  [PDF]
Maimoona Mushtaq Ahmed
Advances in Infectious Diseases (AID) , 2014, DOI: 10.4236/aid.2014.43019
Abstract:

Purpose: To determine the clinical characteristics and outcome of bacterial meningitis in adult patients using CT, MRI and CSF culture. Methods: Patients admitted to the university hospital with clinical diagnosis of meningitis were included in the present study. All patients were subjected to clinical examination as well as CT, MRI scanning and CSF-bacteriological culture. Results: The age distribution of the patients shows that there is high frequency of symptoms found in the age group between ages 40 - 45. CSF in the present study included WBS, RBC, glucose and protein, which is associated with the adverse outcome. Meningitis can be confirmed by many methods, in the present study three different methods were used, which included CT scan, MRI and CSF analysis and bacterial culture. In CT scan, among the predictors of meningitis, persons with TB (P = 0.037), patients with HIV (P = 0.036) and stroke (P = 0.036) showed significant association. Whereas MRI findings were significantly associated with TB meningitis (P = 0.015). Meningitis was prevalent in the age group of <45. Conclusion: This study highlights the importance of several modalities for diagnosing and predicting the outcome of meningitis in adults.

Visual Tuning Properties of Genetically Identified Layer 2/3 Neuronal Types in the Primary Visual Cortex of Cre-Transgenic Mice
Hatim A. Zariwala,Linda Madisen,Kurt F. Ahrens,Amy Bernard,Edward S. Lein,Allan R. Jones,Hongkui Zeng
Frontiers in Systems Neuroscience , 2011, DOI: 10.3389/fnsys.2010.00162
Abstract: The putative excitatory and inhibitory cell classes within the mouse primary visual cortex V1 have different functional properties as studied using recording microelectrode. Excitatory neurons show high selectivity for the orientation angle of moving gratings while the putative inhibitory neurons show poor selectivity. However, the study of selectivity of the genetically identified interneurons and their subtypes remain controversial. Here we use novel Cre-driver and reporter mice to identify genetic subpopulations in vivo for two-photon calcium dye imaging: Wfs1(+)/Gad1(?) mice that labels layer 2/3 excitatory cell population and Pvalb(+)/Gad1(+) mice that labels a genetic subpopulation of inhibitory neurons. The cells in both mice were identically labeled with a tdTomato protein, visible in vivo, using a Cre-reporter line. We found that the Wfs1(+) cells exhibited visual tuning properties comparable to the excitatory population, i.e., high selectivity and tuning to the angle, direction, and spatial frequency of oriented moving gratings. The functional tuning of Pvalb(+) neurons was consistent with previously reported narrow-spiking interneurons in microelectrode studies, exhibiting poorer selectivity than the excitatory neurons. This study demonstrates the utility of Cre-transgenic mouse technology in selective targeting of subpopulations of neurons and makes them amenable to structural, functional, and connectivity studies.
Thermodynamical Study of Alcoholic Solutions of Poly (ethylene glycol) Diacrylate and Poly (ethylene glycol) Dimethacrylate
Maimoona Yasmin,Manisha Gupta
International Journal of Thermodynamics , 2012, DOI: 10.5541/ijot.371
Abstract: With the aim to study the behaviour of polymer solutions, density and ultrasonic velocity of binary mixtures of pentanol with polyethylene glycol diacrylate and polyethylene glycol dimethacrylate have been investigated at 293.15 K, 303.15 K and 313.15 K, under atmospheric pressure. Thermophysical parameters viz. intermolecular free length, internal pressure and pseudo-Grüneisen parameter have been calculated which infer about the interactions and structural changes on mixing pentanol with these polymers. Enthalpy, entropy and Gibbs free energy of activation for viscous flow at different concentrations of polymer solution have been reported. Excess molar volume, deviation in isentropic compressibility, deviation in ultrasonic velocity, excess acoustic impedance and excess molar enthalpy have been calculated and results have been correlated with Redlich-Kister polynomial equation. Density and ultrasonic velocity data have been fitted by third order polynomial equation.
Dimethyl (1,1′-binaphthyl-2,2′-dioxy)diacetate
Asra Mustafa,Muhammad Raza Shah,Maimoona Khatoon,Seik Weng Ng
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809010824
Abstract: The two naphthyl fused-ring systems in the title compound, C22H26O6, are aligned at 86.7 (1)°. Weak intermolecular C—H...O hydrogen bonding is present in the crystal structure.
Di-tert-butyl (1,1′-binaphthyl-2,2′-dioxy)diacetate
Asra Mustafa,Muhammad Raza Shah,Maimoona Khatoon,Seik Weng Ng
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809010836
Abstract: In the crystal structure of the title compound, C32H34O6, the molecule is located on a twofold rotation axis. The two naphthyl fused-ring systems are aligned at 72.6 (1)°. Weak intermolecular C—H...O hydrogen bonding is present in the crystal structure.
Novel germline CDK4 mutations in patients with head and neck cancer
Sabir Maimoona,Baig Ruqia,Mahjabeen Ishrat,Kayani Mahmood
Hereditary Cancer in Clinical Practice , 2012, DOI: 10.1186/1897-4287-10-11
Abstract: Background Cyclin-dependent kinase 4 (CDK4) together with its regulatory subunit cyclin D1, governs cell cycle progression through G1 phase. Cyclin-dependent kinase inhibitors, including p16INK4A in turn regulate CDK4. In particular, deregulation of the p16/CDK4/cyclin D1 complex has been established in a variety of human tumors including gliomas, sarcomas, melanoma, breast and colorectal cancer. However, changes in CDK4 have rarely been observed. Method In this study we used a combination of PCR-SSCP and direct sequencing for mutational screening of CDK4. DNA was isolated from peripheral blood leukocyte of patients with squamous cell carcinoma of head and neck, for screening germline mutations in coding regions of CDK4. Results Variations observed in exon 2 and 5 were three missense mutations, g5051G > C (Ser52Thr), g5095G > C (Glu67Gln), g5906C > A, g5907C > G (Pro194Ser) and novel frame shift mutations g7321_23delTGA, g7121_7122insG, g7143delG in exon 7 and 3′UTR respectively. Conclusion In conclusion, two novel mutations were found in N terminal domain which indicates that CDK4 mutation may play a major role in the development and progression of squamous cell carcinoma of head and neck.
Is pegylated interferon superior to interferon, with ribavarin, in chronic hepatitis C genotypes 2/3?
Ijaz S Jamall, Shafaq Yusuf, Maimoona Azhar, Selene Jamall
World Journal of Gastroenterology , 2008,
Abstract: Over the past decade, significant improvements have been made in the treatment of chronic hepatitis C (CHC), especially with the introduction of combined therapy using both interferon and ribavarin. The optimal dose and duration of treatment is still a matter of debate and, importantly, the efficacy of this combined treatment varies with the viral genotype responsible for infection. In general, patients infected with viral genotypes 2 or 3 more readily achieve a sustained viral response than those infected with viral genotype 1. The introduction of a pegylated version of interferon in the past decade has produced better clinical outcomes in patients infected with viral genotype 1. However, the published literature shows no improvement in clinical outcomes in patients infected with viral genotypes 2 or 3 when they are treated with pegylated interferon as opposed to non-pegylated interferon, both given in combination with ribavarin. This is significant because the cost of a 24-wk treatment with pegylated interferon in less-developed countries is between six and 30 times greater than that of treatment with interferon. Thus, clinicians need to carefully consider the cost-versus-benefit of using pegylated interferon to treat CHC, particularly when there is no evidence for clinically measurable benefits in patients with genotypes 2 and 3 infections.
Thermoacoustical and Excess Properties of Binary Mixtures of Ethyl Butyrate with Methanol and Vinyl Acetate
Shahla Parveen,Maimoona Yasmin,Manisha Gupta,Jagdish Prasad Shukla
International Journal of Thermodynamics , 2010, DOI: 10.5541/ijot.282
Abstract: This paper aims to portray the nature of interaction present in the mixture of ethyl butyrate with methanol and vinyl acetate by computing various thermodynamic parameters at 298.15 K. Excess thermodynamic properties correlated with Redlich–Kister polynomial equation reveals the extent of interaction present in the mixture. Acoustical relations giving the molecular radii of liquid mixtures suggest the change in structure with composition quite well. A comparative study of various empirical and semi-empirical relations such as Flory’s Statistical Theory, Goldsack and Sarvas, Sanchez theory etc. for predicting ultrasonic velocity of the mixtures with the experimental values have been done.
Rare case of deep pelvic retroperitoneal mature cystic teratoma
Shalini Mahana Valecha,Maimoona Ahmed,Mona Oswal,Manisha Gandhewar
International Journal of Reproduction, Contraception, Obstetrics and Gynecology , 2013, DOI: 10.5455/2320-1770.ijrcog20130946
Abstract: Mature cystic retroperitoneal teratomas are typically rare childhood tumours. Less than 20% of these occur in adults more than 30 yrs of age. Our adult patient presented with such a tumour, which had grown to a disproportionately large extent. It was deeply embedded in the true pelvis extending laterally to the pelvic wall and inferiorly till the ischiorectal fossa and was adherent to the surrounding structures displacing all. A provisional diagnosis was made after MRI scan and patient was posted for exploratory laparotomy. After extensive blunt and sharp dissection, the cyst wall could be separated from the surrounding structures and successfully excised. Histopathology confirmed the diagnosis. Being such a rare tumour, it is essential to have a high degree of suspicion in such cases that can be supported by advanced imaging modality. Early diagnosis and complete surgical removal are the mainstay of management that provide an excellent prognosis for such patients. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000): 460-462]
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