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Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice
Amini, Marzyeh;Nahrevanian, Hossein;Khatami, Shohreh;Farahmand, Mahin;Mirkhani, Fatemeh;Javadian, Seifoddin;
Brazilian Journal of Infectious Diseases , 2009, DOI: 10.1590/S1413-86702009000200002
Abstract: several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. we examined zinc and copper levels in two susceptible balb/c mouse lines and resistant c57bl/6 mice infected with leishmania major mrho/ir/75/er, a prevalent strain that causes cutaneous leishmaniasis in iran. serum zn and cu were determined by flame atomic absorption spectrophotometry. higher cu levels were found in infected c57bl/6 mice and higher zn levels were found in infected balb/c mice. also, cu/zn ratios were increased in both the balb/c and the c57bl/6 mice. we conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with susceptibility/resistance to leishmania major in balb/c and c57bl/6 mice. we detected zn deficiency in the plasma of infected balb/c mice; possibly, therapeutic administration of zn would be useful for treating this form of leishmaniasis. increases in cu level might increase resistance to leishmaniasis. based on our findings, the cu/zn ratio could be a useful marker for the pathophysiology of leishmaniasis.
Do Iranian and Canadian Females Make Different Personal Decisions?  [PDF]
Mahin Tavakoli
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.21016
Abstract: This study examined cultural differences and similarities in the number and types of personal decisions made by Iranian and Canadian females. Canadians made more decisions than did Iranians, indicating that Canadians are more autonomous and independent than are Iranians. The types of decisions made more by Canadians than by Iranians illustrate that, when making decisions, Canadians use primary control (trying to change their situation) more than Iranians do, while Iranians use secondary control (trying to adjust to the situation) more than Canadians do. The results support theories of cultural differences locating Canada and Iran at opposite ends of individualism-collectivism continuum, and are consistent with the individualistic-collectivist distinctions made by Heine (2008), Savani, Markus, and Conner (2008), and Triandis (2004).
Optimization costs of the single-machine scheduling problem with maintenance activities by using genetic algorithm
Mahin Esmaeili
Management Science Letters , 2012,
Abstract: This paper deals with a single-machine scheduling problem with maintenance activities. Our purpose is to provide a near optimal solution using metaheuristics approach. In this problem, there are n jobs and m machines (m≥n), each job must be assigned to one and only one machine, where the processing time of job (j) is (p_j). Furthermore there are M_G groups where each group has a fix periodic interval T and for each group, the maximum number of jobs processed in the machines available time interval (T) is K, (M_G=m/K). For finding the near optimal solution, we consider optimizing total cost scheduling problem. This problem has two types of costs, group cost and gap cost. In this study, first, proposed problem is formulated in a mathematical model. Next, a heuristic genetic algorithm is used to obtain the proposed problem and on example is presented to verify the efficiency of the algorithm.
The Effect of Noise on Fetus and Pregnancy of Women Working in Noisy Industrial Workplace
Mahin Sedaie
Audiology , 1999,
Abstract: Many pregnant women are exposed to noise in the workplace. Noise can affect both fetus and pregnancy of pregnant women. Hormonal disturbances and nanism are of devastating effects of noise. An increased risk of shortened gestation has been shown in four studies Results. In a third study showed the length of gestation in female infants to be inversely correlated to maternal residential noise exposure. Decreased birth weight has also been associated with noise exposure in pregnant women. Some of the adverse impacts of exposure to noise is discussed here as an investigation report.
Neonatal Hearing Screening Reports-Tehran 1379
Mahin Sedaei
Audiology , 2002,
Abstract: Objective: Infants hearing screening as one of the best methods of identification and hence early intervention to prevent side effects and appropriate rehabilitation if necessary. Methods and Materials: 175 0-7 day infants were tested in two groups (112 normal history and 63 high risked) with a dumb (for low frequencies)and receiver (for high Frequencies) at 90-95 dB SPL in three hospitals. The acceptable responses were auropalpebral reflex (APR) , startle and stop of movements. Results: Of the first group 51% showed APR, 10% startle, 22 % Both and 17% no response. Of the second group 47% showed APR, 24% startle, 11% both reflexes and 18% no response. Conclusion: 14 cases (8 girls and 6 boys) out of 175 infnats showed no response.
Magnesium Chlorate Decrease the Sound Induced Stress and Control the Concentration of Cortisol and Glucose After Hatching
Mahin Gharavi
Audiology , 1999,
Abstract: We prepared 300 eggs from Isfahan Poultry farm industrial complex. All the eggs were fertilized and their average weight in the first turn was 61±2gr, in the second turn was 60±.5gr and in the third turn was 59.5±.5gr which was measured 6 hours after laying eggs. We were aimed at studying the effect of magnesium chlorate on the fetus chicken in preventing stress induced sound 6 weeks after birth. The eggs were divided into four groups and prepared magnesium chlorate with a concentration of 2.5 /100 ml. the first group contained of 25 eggs drilled in the air Sac with a small hole and 1cc of magnesium chlorate was injected and the hole was sealed with paraffin. The same procedure was performed for the second group in the 4th embryonic age and in the two control groups. All groups were hatched in the days 21 and 22. The effect of sound was studied in all groups.our research demonstrated that the chickens who received magnesium chlorate during their embryonic stage had more resistance toward noise exposure.
Low Frequency Fluctuated Hearing Loss in a Case with Vestibular Schwannomas
Mahin Sedaei
Audiology , 1998,
Abstract: A 34-year-old female with a history of a sudden mild left-sided hearing loss and high-pitched tinnitus along with fullness in the same ear was referred to the audiology clinic. Hearing fluctuation and variability in other symptoms were also reported. Although no complain of any vertigo or balance disorder was mentioned, light headedness was implied. Differential diagnosis of endolymphatic Fistula and retro cochlear lesion was demanded. Audiologic and radiologic findings of this patient are presented in the article to discuss findings regarding the diagnosis of the suspected disorder.
Toward Recovering Complete SRS for Softbody Simulation System and a Sample Application -- a Team 9a SOEN6481 W13 Project Report
Mahin Abbasipour
Computer Science , 2013,
Abstract: This document aims at specifying the requirements and capturing the needs of users for building a softbody simulation system. This system has different applications ranging from computer games to surgery training which facilitates the creation and visualization of a certain softbody object. It also allows users to interact with created object at real time. A softbody or deformable object is an object whose shape changes due to an external force. Deformation type varies depending on the amount of object deformation. Each object can have multiple layers and each layer can have its own properties. So layers can be different in pressure, density and motion.
The Effect of Tempol Administration on the Aortic Contractile Responses in Rat Preeclampsia Model
Mohammad Sharif Talebianpoor,Hossein Mirkhani
ISRN Pharmacology , 2012, DOI: 10.5402/2012/187208
The Effect of Tempol Administration on the Aortic Contractile Responses in Rat Preeclampsia Model
Mohammad Sharif Talebianpoor,Hossein Mirkhani
ISRN Pharmacology , 2012, DOI: 10.5402/2012/187208
Abstract: It is reported that reactive oxygen species production has a critical role in the manifestations and complications of preeclampsia. In the present study, the effect of tempol on the response changes of aortic rings of preeclamptic rats has been studied. Preeclamptic rats (induced by L-NAME) were treated with three different oral doses of tempol (20, 60 and 180?mg/kg/day) from the Day 10 of gestation. Systolic blood pressure, plasma malondialdehyde and 8-isoprostane and the vascular effects of phenylephrine, calcium, acetylcholine and diazoxide were the studied parameters. L-NAME administration resulted in hypertension, proteinuria, increased oxidative stress markers, increased vascular sensitivity to phenylephrine and decreased sensitivity to acetylcholine in pregnant rats. No significant changes in response to calcium and diazoxide were observed. Tempol at doses of 20 and 60?mg/kg/day significantly reversed these changes but at a high dose (180?mg/kg/day), it had no significant effect and in some cases intensified the effect. These results revealed that in the experimental preeclampsia, the sensitivity of rat aorta to alpha- adrenergic receptor agonists was increased and its endothelium-dependent relaxation was decreased. Tempol at lower used doses reduced the blood pressure and oxidative stress and restored the normal responsiveness of vascular tissue in preeclamptic rats. 1. Introduction Preeclampsia (PE) is defined as the onset of hypertension and proteinuria after 20 weeks of gestation in previously normotensive nonproteinuric pregnant women. This syndrome is a leading cause of maternal and fetal morbidity and mortality [1]. The etiology of this disorder is not known. Poor placental perfusion along with the endothelial cell dysfunction and a disturbed balance of angiogenic factors may all contribute to this disorder. Poor placental perfusion is a stimulus of reactive oxygen species (ROS) production. It is believed that the latter has a critical role in the manifestations and complications of PE [2]. In contrast to normal pregnancy, preeclampsia is characterized by generalized vasoconstriction, increased systemic vascular resistance, increased pressor response to vasoconstrictor agonists such as angiotensin II, endothelin, thromboxane, and widespread vascular endothelial damage [3]. To study the various aspects of PE, several animal models have been proposed [4]. One of the most popular models is administration of N (G)-nitro-L-arginine methyl ester (L-NAME) as a nitric oxide synthase (NOS) inhibitor during mid to late period of gestation of the
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