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Search Results: 1 - 10 of 7506 matches for " Mahera Khan "
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Synthesis of Thiophene and NO-Curcuminoids for Antiinflammatory and Anti-Cancer Activities
Mahera M. Ahmed,M. Akram Khan,Kim Drummond Rainsford
Molecules , 2013, DOI: 10.3390/molecules18021483
Abstract: In search of better NSAIDs four novel nitric oxide donating derivatives of curcumin (compounds 9a– d), and four thiophene curcuminoids (compounds 10a– c, 11) have been synthesised. The cytotoxic effects of these compounds along with the lead compound curcumin ( 7) and their effect on the production of the reactive oxygen species nitric oxide and pro-inflammatory cytokines IL-1β, TNF-α and chemokine CXCL-8 were evaluated using human monocytic THP-1 and colon adenocarcinoma CACO-2 cell lines. All of the nitric oxide donating curcuminoids 9a– d and the thiophene curcuminoids 10a– c and 11 were non-cytotoxic to THP-1 cells over a concentration range of 10-100 μM and compared with curcumin compounds 10b and 10c, were more toxic. In CACO-2 cells, 10b and 11 appeared to be non-toxic at 10 to 50 μM, whereas 10a and 10c were non-cytotoxic at 10 μM only. These results clearly indicate that the introduction of a nitroxybutyl moiety to curcumin and replacement of phenyl rings with thiophene units reduces the cytotoxic effect of the parent curcumin, whereas a methyl substituted thiophene increases the cytotoxic effects. In THP-1 cells, drugs 10a and 11 significantly decreased IL-1-β production at their non-cytotoxic concentrations, whereas, they did not decrease TNF-α production in CACO-2 cells. Compound 11 showed a significant decrease in CXCL-8 production.
Appraisal of Techniques, Investigation and Analysis of Vitamin (B7) Biotin  [PDF]
Safila Naveed, Fatima Qamar, Syeda Sarah Abbas, Syed Hameez Jawed, Wajiha Raza, Mahera Khan, Bushra Iqbal
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101894
Abstract: Biotin is also called vitamin B7, vitamin B8 or vitamin H. Biotin is a water soluble compound and is colorless in appearance. Overall eight different types of biotin exist but only Biotin-D occurs naturally with its complete vitamin activity. It is mainly synthesized by mold, algae, bacteria, yeast and some plant species. There are different methods used to find the vitamins in nutrients and samples. This article is composed of the comprehensive review of the competitive techniques and various methods for the assay of biotin. High-pressure liquid chromatographic (HPLC), microbiological analysis and HPLC producer are adopted for the determination of biotin. An optimal analytical condition of biotin determination was performed by the HPCL method. The statistical parameters of the HPLC methods were compared and reviewed with other determination.
A Mathematical Approach to a Stocks Portfolio Selection: The Case of Uganda Securities Exchange (USE)  [PDF]
Fredrick Mayanja, Sure Mataramvura, Wilson Mahera Charles
Journal of Mathematical Finance (JMF) , 2013, DOI: 10.4236/jmf.2013.34051
Abstract:

In this paper, we present the problem of portfolio optimization under investment. This area of investment is traced with works of Professor Markowitz way back in 1952. First, we determine the probability distribution of the Uganda Securities Exchange (USE) stocks returns. Secondly, we develop unrestricted portfolio optimization model based on the classical Modern Portfolio Optimization (MPT) model, and then we incorporate certain restrictions typical of the USE trading or investment environment and hence, develop the modified restricted model. Thirdly, we explore the possibility of diversification under a portfolio of averagely correlated assets. Determination of the model parameters and model development is all done using Excel spreadsheets. We explicitly go through the mathematics of the solution methods for both models. Validation of the models is done using the USE stocks daily trading data, in which case we use a random sample of 6 stocks out of the 13 stocks listed at the USE. To start with, we prove that USE stocks log returns are normally distributed. Data analysis results and the frontier curves show that our modified (restricted) model is valid as the solutions are all consistent with the theoretical foundations of the classical MPT-model but inferior to the unrestricted model. To make the model more useful, accurate and easy to apply and robust, we programme the model using Visual Basic for Applications (VBA). We therefore recommend that before applying investment models such as the MPT, model modifications must be made so as to adapt them to particular investment environments. Moreover, to make

Wired and Wireless Parallel Simulation of Fluid Flow Problem on Heterogeneous Network Cluster
Fariha Quratulain Baloch,Mahera Erum Baloch
International Journal of Computer Science Issues , 2012,
Abstract: In this research Homogeneous and Heterogeneous networks will be analyzed using parallel processing technique for highly sophisticated research problem. During the analysis sample networks will be considered and QoS parameters will be observed using simulation for end-to-end services. Analysis of the wireless LAN system is carried out and its efficiency is measured compared to the wired systems, for the purpose of designing and implementing the parallel processing techniques used to solve general purpose engineering problems. The basic purpose for this research is to provide improved QoS in networks for research and academic learning.
CONTINUOUS FUNCTIONING OF SOFT SYSTEM BUS BASED CENTRALIZED PERSISTENT COMPUTING SYSTEM
Quazi Mahera Jabeen,Muhammad Anwarul Azim,Yuichi Goto,Jingde Cheng
International Journal of New Computer Architectures and their Applications , 2012,
Abstract: Persistent Computing Systems (PCSs) were proposed as a new generation of reactive systems to provide reliable and secure computing services continuously and persistently to their users anytime and anywhere during running, maintenance, upgrade, reconfiguration and even during various attacks. Soft System Bus Based systems (SSB-based System) were proposed to implement PCSs to be built by connecting components of the system using the SSB and can provide continuous functioning and dynamic adaptability that are the two most fundamental features of PCSs. Though an implementation method of SSB-based systems exists for distributed systems, there was none for centralized systems. This paper proposes an implementation method of SSB-based systems for centralized persistent computing systems (SSB-based CPCSs). that satisfies the two fundamental features. The paper gave an analysis of various events which obstruct continuous functioning of a system at first, and then presented requirements for and a design of SSB-based CPCS. The paper also presented our experimental results to measure the rate of continuous functioning, correctness and time delay and showed that the components can provide high continuous functioning with correct output where delays vary for each event.
Supported TritonX-100 Polyaniline Nano-Porous Electrically Active Film onto Indium-Tin-Oxide Probe for Sensors Application  [PDF]
Raju Khan
Advances in Chemical Engineering and Science (ACES) , 2011, DOI: 10.4236/aces.2011.13021
Abstract: Supported tritonX100 polyaniline nano-porous electrically active film has been fabricated successfully onto indium-tin-oxide conducting probe using electrochemical polymerization process. The doping of TX-100 in the polymeric network of PANI was suggested using cyclic voltammeter, UV-vis spectroscopy, and Fourier Transform Infrared spectroscopy. The change in the surface morphology of PANI thin film due to incorporation of tritonX-100 was investigated using Atomic Forced Microscopy and porosity has been confirmed scanning electron microscopy, respectively. The surface morphology, uniformly disperse hexagonal close packing of TX-100 in PANI matrices due to the incorporation of TX-100 in polymeric network of PANI was confirmed by Atomic Force Microscopy. The electrical conductivity of PANI-TX-100 increases from 1.06 x 10-2 S/cm-1 to 4.95 x 10-2 S/cm-1 as the amount of TX-100 increases during the polymerization. The change in the morphology and electrical conductivity of PANI due to incorporation of TX-100 prove as a promising material for the sensing application.
A Novel, Safe Way of Removing Non-Deflatable Bladder Catheter  [PDF]
Ziauddin Khan, Umair Tahir Khan, Imran Khan, Tahir Naeem Khan
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.24044
Abstract: Non-deflated balloon of a transurethral inserted bladder catheter is a problem that could be difficult to manage, especially in males. A variety of methods have been described to puncture the balloon and remove the catheter, though these can be associated with complications. We illustrate a simple and a safe method to overcome this problem using a flexible cystoscope under local anaesthesia.
Book Review on Pakistan and the New Nuclear Taboo: Regional Deterrence and the International Arms Control Regime  [PDF]
Zafar Khan
Advances in Historical Studies (AHS) , 2013, DOI: 10.4236/ahs.2013.21001
Abstract: Pakistan has always been the focus of international community, strategists, analysts, and academic scholars on various issues more especially on the nuclear issue since Pakistan has embarked its journey from covert to overt nuclearisation of South Asia. Any work in relation to Pakistan’s nuclear weapons program ranging from its nuclear policy to its nuclear security has gained a great significance in the realm of politics and international studies. Rizwana Abbasi’s maiden volume entitled, Pakistan and the New Nuclear Taboo: Regional Deterrence and the International Arms Control Regime is a welcome contribution that would certainly be embraced by the Pakistani security planners and strategic community in general and the wider international audience in particular. The key aim of this book is that norms, values, and regime still matter despite the presence and influence of hard core realism and neo-realism.
Comparison between the Personality Dimensions of Delinquents and Non-Delinquents of Khyber Pukhtunkhwa (KPK), Pakistan  [PDF]
Sehrish Khan
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.25027
Abstract: This study was an attempt to find out the comparison between the personality dimensions of delinquents and non delinquents of Khyber Pukhtonkhwa (KPK). Eysenck personality Questionnaire (junior) (Urdu Version 2007) was administered on the sample of 400 (Delinquents = 200, non-delinquents = 200). Delinquents were the inmates in different jails of KPK while non-delinquents
were the students of different colleges of KPK. It was hypothesized that the delinquents will score higher on all the four dimensions of Eysenck personality scale as compared to non delinquents. Findings of the study confirmed the said hypothesis. It was proved that delinquents have higher scores of psychoticism, neuroticism, extraversion, and lie as compared to non-delinquents. The findings of this study can help the parents, teachers, and the law departments to focus on the construction of healthy personality so that the rate of crimes among adolescents can be minimized.
Head Teachers’ Beliefs and Practices about Teaching and Learning in Pakistani Public Schools  [PDF]
Asif Khan
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.622237
Abstract: Very limited research focusing on instructional contribution of Pakistani public school administrators has emerged from the educational landscape of Pakistan. Therefore, the present study highlights some of the core issues related to the instructional contribution of two head teachers situated in public schools. While focusing on instruction-related practices, the two case studies particularly examine the head teachers’ engagements in supervisory processes and in-school capacity development initiatives. The study notes that despite the presence of required human and physical resources, the two head teachers make limited contributions towards the instructional quality of their respective schools. A vague understanding about their roles, a limited capacity building opportunities, and an absence of an accountability mechanism prevent the two head teachers from becoming more involved in the said processes. The study maintains that a new organizational culture needs to be introduced that re-conceptualizes the role of Pakistani head teachers while emphasizing the above-mentioned factors.
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