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Search Results: 1 - 10 of 7490 matches for " Maha Ragab Ismail Ibrahim "
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Role of Multidetector CT in Staging of Gastric Carcinoma  [PDF]
Hisham Mostafa Kamel Emam, Ehab Mansour Mohammed Moussa, Mohammed Abouelmaged, Maha Ragab Ismail Ibrahim
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.107046
Abstract: Background: Radiology plays an essential role in the diagnosis, staging and surveillance of oncology patients. CT is the most sensitive imaging modality in the workup of these patients. Aim of the Study: The aim of this work is to detect the role of MDCT (multidetector computed tomography) in the preoperative investigation of gastric adenocarcinoma patients according to TNM staging. Patients and Methods: This is a prospective study enrolling 20 patients who had histologically proven adenocarcinoma based upon an upper gastrointestinal endoscopic biopsy for MDCT staging of gastric carcinoma during the period from June 2016 to June 2017. The MSCT data were correlated and compared with the histopathological results. The study was conducted in the Radiology Department of Assiut University Hospital using 64-MDCT (Toshiba Aquilion). Results: According to our study results, the sensitivity of determining T1 stage on CT scan can’t be detected as there was only 1 case pathologically proved T1 and overstaged as T2 by MSCT; however, accuracy and specificity are quite high, which was 95% and 100% respectively. For T2 stage tumors (25.0% of cases), accuracy is 95%, sensitivity—100%, and specificity—93.7%. According to our results the accuracy and sensitivity of T3 staging are 75% and 100%, while those of T4 stage were 75% and 44.4% respectively. Tumor was correctly staged in 14 of 20 patients (the valid T staging rate was 70.0%). Tumor was under-staged in 5 of 20 patients (25.0%) (staged as T3, but pathologically proven to be T4a). As regards N staging accuracy found results for N0 (62.5%), N2 (87.5%) and N3 (75%), while N1 accuracy recorded 37.5%. As regards the nodal staging sensitivity which had a range from (0% for N4) to (66% for N2) this wide range of sensitivity demonstrates the problem of CT in nodal staging. As regards sensitivity of M0, accuracy was 100% and 85% respectively. While that of M1 was (62.5%) and (85%) respectively. Conclusion: MSCT can be the first choice for the preoperative evaluation of
Histological study of effects of storage duration and temperature on the rabbits blood cells
Ibrahim K. I. Ragab
Egyptian Journal of Hospital Medicine , 2008,
Abstract: Introduction: The temperature of the blood and its components during storage or processing is a very important factor affecting hemolysis. During storage, leukocytes break down and release a number of chemicals and enzymes, that have been reported to lysis RBC. With increasing duration of storage, the change of RBC shape becomes permanent. RBCs from different species behave differently during storage. So, this study aimed to investigate the histological effects of storage duration and temperature on the rabbit blood cells. Material and Methods: Blood samples from five adult male healthy rabbits were divided into (Group I) stored at 4 for 12 and 48 hours, (Group ) at a room temperature of about 24 for 12 and 48 hours and (Group ) at 36 for 12 and 48 hours. Blood films made and stained by Leishman's stain immediately as a control group (A), after 12 hours (B) and after 48 hours (C) from each group respectively and examined for any morphological changes. Leukocytes counted totally immediately as a control group (A), after 12 hours (B) and after 48 hours (C) from each group respectively for detection of any histological changes. Results: no morphological changes of red blood cells, leukocytes and platelets of group was observed. The changes of mean of total leukocytic counts of group were non significant. Changes in total leukocytic counts and morphology of red blood cells, leukocytes and platelets of groups and were observed. The morphological degenerative changes of group involved red blood cells, neutrophils and platelets at 12 and 48 hours. The morphological degenerative changes of group involved red blood cells and leukocytes at 12 and 48 hours. The mean of total leukocytic counts of group was significantly decreased at 48 hours while the mean of total leukocytic counts of group was significantly decreased at 12 and 48 hours. Conclusion: blood samples from rabbits should be tested within 12 hours of collection if stored at a room temperature of about 24 . Where testing is to be delayed for more than 12 hours, samples should be refrigerated as soon as possible. Exposure of samples to heat in excess of 24 should be avoided at all times.
Clinical Outcome of Definitive Radiotherapy and/or Surgery in T1-2N0M0 Glottic Squamous Cell Carcinoma: A Single Institution Retrospective Report  [PDF]
Dina Ragab Diab Ibrahim, Anas Mohamed Askoura, Mohammed Aleem
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.92017
Abstract: Background: The current treatment options of early glottic carcinoma are radiotherapy; trans laser microsurgery, and open surgery. However, the best treatment is still controversial due to lack of randomized controlled trials. We aimed to evaluate the treatment results and the prognostic factors of local control of early glottic squamous cell carcinoma patients (GSCC) T1-2N0M0 treated at our institution. Material and Methods: We retrospectively studied the charts of 52 patients with early GSCC T1-T2N0M0 from 2010-2015 at the Clinical Oncology Department, Ain-Shams University. 24 patients had T1 and 28 had T2 early glottic carcinoma. The overall survival OS, local control rate, and laryngeal preservation rate were evaluated. Kaplan-Meier method, Cox proportional hazards model were used to analyze the data. Results: Median duration of follow-up was 13 months. Thirty-eight patients received radiation treatment alone (73.1%), 7.7% of the patients underwent surgery alone, and 19.2% of the patients had surgery combined with radiotherapy. Local recurrence after radiation failure developed in 6/52 patients, all had T2 disease and were salvaged by total laryngectomy. The ultimate local control rate was 88.5%, and the ultimate laryngeal preservation rate was 77.2% (40/52 patients). The median OS of the 52 patients was 13 months (range 2 - 46 months). Univariate analysis of factors associated with poor local control showed that age > 60 years was the only significant factor (
Spinal Cord Schistosomiasis: Report on Seven Adult Patients  [PDF]
Mahmoud H. Ragab, Khaled Ismail
Open Journal of Modern Neurosurgery (OJMN) , 2019, DOI: 10.4236/ojmn.2019.93028
Abstract: Background: Spinal Cord Schistosomiasis (SCS) is the most disabling ectopic form of Schistosomal infection. It may or may not have clinical manifestations. They include low back pain and/or lower limb pain and weakness, and double incontinence. Early diagnosis and treatment provide a good outcome. Aim: To describe the clinical, radiologic, and therapeutic data of 7 patients with Spinal Schistosomiasis. Patients and Methods: In this retrospective clinical case study, the medical records of 7 patients with spinal cord pathologies admitted to Aswan University Hospital from May 2014 to May 2017 were reviewed. All were male aged from 17 to 30 years old (mean ± SD, 20 ± 9.5 yr.; median 21 yr.), with neurological deficit in the form of lower limb weakness and sphincter disturbance. All were treated by decompressive laminectomy and debulking of the intramedullary lesion followed by medical treatment. Results: The outcome of our patients was good as 4/7 patients (57%) presented a full recovery, 3/7 patients (43%) presented a partial recovery without functional limitations and none presented a partial recovery with limitations or no response. Conclusion: High index of suspicion should be raised in the differential diagnosis of patients with clinical or radiological evidence of Spinal Cord Schistosomiasis, as early diagnosis can guarantee a better prognosis and avoid the occurrence of serious sequels. The association of corticosteroids and antischistosomal drugs is related to the best outcome. The role of surgery is decompression, particularly in the granulomatous or pseudotumoral form, and to obtain material for definite histopathological diagnosis in doubtful cases.
Relation between serum progranulin, inflammatory markers and visceral fat in childhood obesity  [PDF]
Nagwa Abdallah Ismail, Shadia Ragab, Abeer Nour Eldin Abd El Baky, Mona Hamed, Dina F. Ayoub
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.412138

Aim: To study serum progranulin (PGRN) level in children with obesity and its relationship to inflamamatory markers and visceral fat. Methods: Fifty obese children and 50 controls aged 10-18 years were recruited. Demographic, anthropometric and biochemical features were collected according to a standard protocol. Serum progranulin levels, serum IL-6 and hsCRP were measured using ELISA. Insulin resistance was calculated by the homeostasis model (HOMA-IR) using the following formula: HOMA-IR = fasting insulin (mU/L) × fasting glucose (mmoL/L)/ 22.5. The maximum visceral fat thickness (VFT) and the minimum subcutaneous fat thickness (SFT) were measured by ultrasonography. Results: In the obese group, a significant increase was found in serum PGRN (48.87 ± 42.33 ng/mL) compared to control group (30.18 ± 23.82 ng/mL). Progranulin correlated significantly with VFT (r = 0.475), IL6 (r = 0.368), Insulin(r = 0.440) and HOMA-IR (r = 0.379). The mean serum progranulin in the high tertile VFT group was significantly higher than those in the low tertile and middle tertile groups (P = 0.030 and P = 0.039 respectively). VFT was highly positively correlated to progranulin, SFT, IL6, insulin, HOMA-IR and hsCRP (P = 0.001, 0.000, 0.001, 0.001, 0.003 and 0.003). However, the correlation coefficient between SFT and progranulin was insignificant. Summary: we demonstrated for the first time that serum PGRN concentrations increased in Egyptian obese children. The concentrations of serum PGRN correlated closely with visceral fat and IL6. Conclusion: PGRN may contribute to the pathogenesis of chronic inflammation in obesity. It could be a novel marker of visceral fat in obesity. Thus PGRN could be a potential therapeutic target for management of chronic inflammation in obesity.

Impact of Pre-Radiotherapy and/or Chemoradiotherapy Hemoglobin Level on Response to Treatment in Laryngeal and Hypophayrngeal Squamous Cell Carcinoma  [PDF]
Dina Ragab Diab Ibrahim, Mohamed Saad Hasaballah, Marwa Mohamed El-Begermy, Ahmed Abdel Aziz Ahmed, Soha Ahmed Abuelela
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.94033
Abstract: Background: Anemia is reported by many studies as an important risk factor for poor locoregional disease control and survival in head and neck carcinoma. We aimed to study the frequency and prognostic effect of low hemoglobin (Hb) level in head and neck squamous cell carcinoma (HNSCC) before radiotherapy (RT) and/or chemoradiotherapy (CRT). Material and Methods: We retrospectively studied the charts of 86 patients diagnosed with laryngeal and hypopharyngeal SCC in a university hospital in Cairo, Egypt. Based on the World Health Organization (WHO), anemia was diagnosed in males at Hb levels < 13 g/dl and <12 g/dl in females. We examined the Hb levels before radiotherapy alone or combined with chemotherapy and its impact on re-sponse to treatment and survival. Results: The median age was 56 years. 75/86 (87.2%) patients were males with performance status1 in 73/86 (84.9%) patients. The median Hb level was 13.1 g/dl. The pre-RT/CRT Hb level in female patients (n = 11) was <12g/dl in 4/11 (36.4%) and >12 g/dl in 7/11 (63.6%) patients. Pre-RT/CRT Hb level in male patients was <13 g/dl in 31/75 (41.3%) and >13 g/dl in 44/75 (58.7%). Tumor sites were larynx in 77 (89.5%) and hypopharynx in 9 (10.5%) patients. Disease stage 3, 4 was common in 59/86 (68.6%) patients. Thirty-six (41.8%) patients had surgery. 13/86 (15.1%) patients received induction chemotherapy, while 31/86 (36.0%) had concomitant chemoradiotherapy. Radiotherapy was given in 65/86 (75.58%) patients. The mean RT dose was 66 Gy. Non-anemic patients had significant higher inci-dence of complete response (CR) to treatment (p = 0.034). 25.8% of male pa-tients with Hb < 13 g/dl had higher incidence of recurrence (p = 0.036) com-pared to recurrence in 39.5% of male patients with Hb > 13 g/dl (p = 0.403). Female patients whether anemic or non-anemic had no recurrence (p = 0.036 and p = 0.403 respectively). The median duration of DFS and OS was 6.52 and 9.33 months respectively. Pretreatment Hb level had statistical significant effect on response to treatment and overall survival, but not disease free survival. Conclusion: Nutritional anemia is common in developing countries. Our results support the positive prognostic effect of Hb level > 12 g/dl and >13 g/dl before radiation therapy and/or chemoradiotherapy on response to treatment and overall survival but not the disease free survival.
Haemostatic activation in acute coronary syndrome patients in relation to physical exercise
Amany H. Mansour (1), Maha Ragab , (2 )Rokiah Anwer ,(3) Maha M. Abd El mohsen,(4) and Mostafa M. Shaaban
Egyptian Journal of Hospital Medicine , 2012,
Abstract: Backgound: Thrombosis is regarded to be a key factor in the development of acute coronary syndromes in patients with coronary artery disease (CAD), Platelets are known to play a fundamental role in acute coronary syndromes(ACS). After atherosclerotic plaque rupture, platelets can form pathogenic, occlusive thrombi leading to acute ischemic events. The precise mechanisms of platelet activation in acute coronary syndromes are still under investigation. Physical activity could regulate the development of ACS via effects on platelet function. Several studies have shown that acute physical exercise increases platelet reactivity, typically assessed by aggregation assays, in both healthy individuals and in patients with cardiovascular disease. The aim of this study was to investigated the effect of moderate and strenuous exercise on arterial thrombus formation.Subjects and Methods: Assay of some hemostatic marker as Platelet activation , thrombin generation (TF(pg/ml),TAT_ μ g/l and dimerand tPA concentration ) von Willebrand factor,platelet aggregation tests, Coronary Angiography. haemostatic parameters in patients with ACS correlated with other clinical parameters under physical exercise .Results: Patients with ACS showed higher values for fibrinogen , tPA , TAT_ , as indicators for a thrombin synthesis, and a marker for prothrombotic conditions, was elevated in patients with ACS,. Von Willebrand factor and D-dimer showed no statistical significant differences during rest., Exercise increased hemostatic parameters in an strenuous physical exercise in ACS Patients( < 0.05). Exercise also increased plasma levels of fibrinogen and von Willebrand factor ,but there was an increase in the generation of T-AT complexes,. (P < 0.05). Exercise did not affect platelet aggregation regardless of its intensity when triggered by the agonists ADP or collagen. Conclusion: Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers
Characterization of Ceramic Filled Polymer Matrix Composite Used for Biomedical Applications  [PDF]
Waleed Asim Hanna, Faiza E. Gharib, Ismail Ibrahim Marhoon
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.1012089
Abstract: A particulate composite material was prepared by adding (CaCO3, CaO, MgCO3, MgO) ceramic particles with particle size of (< 53 μm) to unsaturated polyester resin with weight fraction of (3, 6, 9, 12, 15)% and fixed amount of CaF2 (0.5% wt.). The results had revealed that the maximum values of tensile strength, compression, bending strength, hardness, impact energy and water absorption%, were (57.6828 N/mm2 at 3% wt. CaCO3, 124.0965 N/mm2 at 9% wt. CaCO3, 102.188 N/mm2 at 9% wt. MgO, 88.2 Shore D at 9% wt. CaCO3, 0.27 J at 6%wt. CaCO3 and 0.8432 % at 15%wt.CaO) compared with reference values, i.e.( 37.4742 N/mm2, 100.3563 N/mm2, 34.194 N/mm2, 83 Shore D, 0.36 J and 0.2626%) respectively.
Data Mining in Electronic Commerce: Benefits and Challenges  [PDF]
Mustapha Ismail, Mohammed Mansur Ibrahim, Zayyan Mahmoud Sanusi, Muesser Nat
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2015, DOI: 10.4236/ijcns.2015.812045
Abstract: Huge volume of structured and unstructured data which is called big data, nowadays, provides opportunities for companies especially those that use electronic commerce (e-commerce). The data is collected from customer’s internal processes, vendors, markets and business environment. This paper presents a data mining (DM) process for e-commerce including the three common algorithms: association, clustering and prediction. It also highlights some of the benefits of DM to e-commerce companies in terms of merchandise planning, sale forecasting, basket analysis, customer relationship management and market segmentation which can be achieved with the three data mining algorithms. The main aim of this paper is to review the application of data mining in e-commerce by focusing on structured and unstructured data collected thorough various resources and cloud computing services in order to justify the importance of data mining. Moreover, this study evaluates certain challenges of data mining like spider identification, data transformations and making data model comprehensible to business users. Other challenges which are supporting the slow changing dimensions of data, making the data transformation and model building accessible to business users are also evaluated. A clear guide to e-commerce companies sitting on huge volume of data to easily manipulate the data for business improvement which in return will place them highly competitive among their competitors is also provided in this paper.
Dosimetric Comparison of Amorphous Silicon EPID and 2D Array Detector for Pre-Treatment Verification of Intensity Modulated Radiation Therapy  [PDF]
Ayman G. Ibrahim, Ismail E. Mohamed, Hamdy M. Zidan
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2018, DOI: 10.4236/ijmpcero.2018.74037
Abstract: Purpose: To study the dosimetric characteristics of amorphous silicon Electronic Portal Imaging Device EPID and 2D array detector for dose verification of radiotherapy treatment plans, and the quality assurance QA testing of IMRT was investigated. Materials and methods: All measurements were done with Varian IX linear accelerator, aSi-1000 EPID and 2D array detector. The dose linearity, reproducibility, output factors, dose rate, SDD and response with slap phantom thickness have been measured and compared against those measured by ion chamber. Results: The characteristics of EPID and 2D array: the response of EPID agreed with 2D array and ion chamber 0.6cc. EPID and 2D array showed short-term output reproducibility with SD = 0.1%. The dose rates of 2D array SD = ±0.7%, EPID = ±0.4% compared with a 0.6 cc SD = ±0.5%. Output factor measurements for the central chamber of the EPID and 2D array showed no considerable deviation from ion chamber measurements. Measurement of beam profiles with the EPID and 2D array matched very well with the ion chamber measurements in the water phantom. The EPID is more sensitive to lower energy photons by increasing solid water phantom thickness. The mean and standard deviation passing rates (γ%≤1) for film, 2D array and EPID for 30 IMRT fields of five patients were 95.93 ±
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