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Search Results: 1 - 10 of 33563 matches for " Magda Oliveira Seixas "
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Sickle cell disease: Only one road, but different pathways for inflammation  [PDF]
Wendell Vilas-Boas, Bruno Ant?nio Veloso Cerqueira, Thassila Nogueira Pitanga, Magda Oliveira Seixas, Joelma Menezes, Cyntia Cajado de Souza, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.324071
Abstract: Sickle cell disease (SCD) is a genetic disorder characterized by a chronic inflammatory process, and new biomarkers have been studied as promising molecules for understanding the inflammation in its pathophysiology. The hemolysis and the release of molecules associated to the hemoglobin (Hb) catabolism, such as free Hb, iron, and heme, generating a oxidant environment with production of reactive oxygen and nitrogen species. The immune system plays a very important role in the inflammation, with cells secreting pro-inflammatory cytokines and chemokines. There is also a nitric oxide (NO) resistance state, with an impaired NO bioactivity, leading to a vascular dys-function; activation of platelet, leukocytes, erythrocytes, and endothelial cells, with expression of adhesion molecules and its ligands, and several receptors, that altogether participate at inflammatory process. During inflammation, there is an increase of dendritic cells (DCs) expresse toll like receptors (TLR), but the role of DCs and TLR in SCD pathogenesis is unclear. Also, there are molecules contributing for enhance the endothelium dysfunction, such as homocysteine that has been associated with vascular complications in the pathology of other diseases and it may contribute to the vascular complications presented by SCD patients. Circulating microparticules (MPs) levels are augmented in several diseases and have been described in SCD, where cells membrane compounds are associated to cell’s thrombotic and coagulation state, such as tissue factor and phosphatidylserine (PS), which may contribute to endothelial dysfunction. The knowledge of all these biomarkers may contribute to new therapeutic approach discover, improveing SCD patient life quality.
Cytokine profiles in sickle cell anemia: Pathways to be unraveled  [PDF]
Thassila Nogueira Pitanga, Wendell Vilas-Boas, Bruno Ant?nio Veloso Cerqueira, Magda Oliveira Seixas, Cynara Gomes Barbosa, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.47A1002
Abstract: Sickle cell anemia (SCA) is a genetically inherited hemolytic disorder characterized by chronic inflammation. Cytokine expression affects the pivotal pathways that contribute to disease pathogenesis, but the mechanisms involved are not well understood. SCA is associated with a proinflammatory state, and an enhanced inflammatory response occurs during vasoocclusive crisis. The immune system thus plays an important role in this inflammatory condition, with several cell types secreting pro-inflammatory cytokines that contribute to the occurrence of common cyclical events in SCA patients, such as hemolysis, vascular occlusion and inflammation. Studies of these cytokines and chemokines in SCA patients have clarified the mechanisms that underlie this disease and highlighted the need for a better understanding of cytokine participation in SCA pathophysiology.
Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil
Adorno, Elisangela Vitória;Zanette, ?ngela;Lyra, Isa;Seixas, Magda Oliveira;Reis, Mitermayer Galv?o;Gon?alves, Marilda Souza;
Genetics and Molecular Biology , 2008, DOI: 10.1590/S1415-47572008000400003
Abstract: beta s-globin gene (βs-globin) haplotypes, markers for severe sickle cell anemia (sca), and the alpha-thalassemia 2 gene 3.7 kb deletion (-α23.7 kb thal) along with demographic and clinical data were investigated in sca outpatients (n = 125, 63 female and 62 male) in the brazilian state of bahia, which has a high prevalence sca. pcr-rflp showed that the central african republic/benin (car/ben, 51.2%) haplotype was most frequent, followed by the benin/benin (ben/ben, 28.8%). at least one car haplotype was present in every outpatient with a history of cerebrovascular accident. the cameroon (cam), senegal (sen) and arab-india haplotypes occurred in small numbers, as did atypical haplotypes. fetal hemoglobin (hbf, %) was unevenly distributed. compared to those > 18 y, those aged < 18 y had had fewer erythrocyte transfusions and high hbf levels (12.3% ± 7.01 to 7.9% ± 4.36) but a higher frequency of spleen sequestration and pneumonia. compared with normal α - genes carriers values, the outpatients with -α23.7 kb thal (determined by pcr analysis) had significantly higher mean hemoglobin concentration (hb) (8.3 ± 1.34 g/dl, p = 0.018) and packed cell volume (pcv = 27.1% ± 4.26, p = 0.019) but low mean corpuscular volume (mcv = 86.1 fl = 10-15 l ± 9.56, p = 0.0004) and mean corpuscular hemoglobin (mch = 26.6% ± 4.60, p = 0.039).
Neural networks to identify particles using topological properties of calorimeters
Damazio, Denis Oliveira;Seixas, José Manoel de;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2004, DOI: 10.1590/S0103-17592004000100008
Abstract: the present work describes a neural particle classifier system based on topological mapping of the segmented information provided by a high-energy calorimeter, a detector that measures the energy of incoming particles. the achieved classification efficiencies are above 97.50% for the higher energy particle beams, even when experimental data exhibit unavoidable contamination due to the particle beam generation process, what could jeopardize the classifier performance. some deterioration in the performance for the lower energy range is also discussed. the reduction on the dimensionality of the data input space caused by the topological mapping may be very helpful when online implementation of the classifier is required.
Sequelas neurocognitivas em crian?as com tumores cerebrais: Uma revis?o da literatura
Oliveira,Magda; Almeida,Susana; Silva,Eunice;
Psicologia, Saúde & Doen?as , 2010,
Abstract: the success of medical interventions during the past three decades allowed an improvement in the survival rates of pediatric cancer. this fact has brought more attention to new issues related to quality of life, as well as to the range of effectiveness of the implemented interventions. these ones obey to the cost-benefit dynamics, at short, medium and long-term, for each child. studies have been demonstrating that approximately one quarter to two thirds of survivors of childhood cancer experience moderate to severe life-threatening late effects (between them, the neurocognitive ones), which are a consequence of the disease and of the therapeutic interventions, and most of which can only be identified a few years later. the aim of this paper is to proceed to a review of the literature and systematization of the outcomes produced in the field of neurocognitive sequelae resulting from disease and treatments in children diagnosed with brain tumours. the results of the research made by the cross of the major descriptors defined, conducted to the identification of 13 published articles between the years of 2003 and 2007. having the analysis of these articles as starting point, it was concluded that: (a) neurocognitive alterations may result from the tumour itself, the surgery, the cerebral radiotherapy and/or chemotherapy, and (b) there are variables mediating the nature, intensity and extension of the detected deficits. however, despite the growing interest in the study of neurocognitive sequelae in children with brain tumors in recent years, it is important to continue to develop studies with fewer methodological limitations that bring new contributions to the area, and to implement projects for evaluation and neurocognitive rehabilitation in health services to minimize the deficits and promote a better overall quality of life.
Um classificador neuronal compacto e eficiente com capacidade de identificar contamina??o em dados experimentais
Damazio, Denis Oliveira;Seixas, José Manoel de;Soares, A. C.;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2003, DOI: 10.1590/S0103-17592003000400003
Abstract: a neural classifying system is developed to identify three particle classes in experimental high-energy physics. the system makes use of the extraction of principal discriminating components to obtain compactness and high classification efficiency, even identifying outsiders in experimental data sets. more than 97% of analysed events are correctly classified.
Um classificador neuronal compacto e eficiente com capacidade de identificar contamina o em dados experimentais
Damazio Denis Oliveira,Seixas José Manoel de,Soares A. C.
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2003,
Abstract: Um sistema classificador neuronal é desenvolvido para identificar três classes de partículas em física experimental de altas energias. O sistema usa a extra o de componentes principais de discrimina o para combinar compacticidade e alta eficiência de classifica o, identificando, inclusive, a contamina o presente nos dados experimentais. Mais de 97% dos eventos analisados s o corretamente classificados.
Moral Judgment: Truth, Order and Consequence  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.65061
Abstract: Often we make snap moral judgments based on limited information. For instance upon reading a newspaper headline we very quickly decide on whether the implied outcome is good or bad. However, in situations like this we are also likely to revise our judgments when we read the main story and the conclusion of the article. One question yet to be answered is whether we adjust our moral judgments in a systematic way as we gain more details about a moral scenario. Two experiments (lab-based, online) addressed this question along with the influence of other factors on moral judgments (the origin of the moral scenario, the severity of the consequence of the scenario). Across both experiments, moral judgments were: 1) generally adjusted downwards as more information was presented; 2) more severe for headlines than the main story or the conclusion; 3) more severe for scenarios that were fabricated than real life stories; 4) more severe when the conclusion involved a severe consequence than a non-severe consequence.
Dynamic Moral Judgments and Emotions  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.68090
Abstract: We may experience strong moral outrage when we read a news headline that describes a prohibited action, but when we gain additional information by reading the main news story, do our emotional experiences change at all, and if they do in what way do they change? In a single online study with 80 participants the aim was to examine the extent to which emotional experiences (disgust, anger) and moral judgments track changes in information about a moral scenario. The evidence from the present study suggests that we systematically adjust our moral judgments and our emotional experiences as a result of exposure to further information about the morally dubious action referred to in a moral scenario. More specifically, the way in which we adjust our moral judgments and emotions appears to be based on information signalling whether a morally dubious act is permitted or prohibited.
Behavioral Economics: Where Is It Heading?  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.69109
Abstract: The addition of “behavioral” to economics has given rise to a highly successful field of research. But, is it just a fashionable new trend or is it here to stay? More to the point, how does it differ from its close relative psychology? To answer these questions, the present article considers what behavioral economics is, and where it started, with the aim of trying to forecast what the status of it will be in the future. In forecasting where behavioral economics might be heading, the argument proposed here is that the best clues can be found in psychological research. If, as has been proposed here, behavioral economics partners research trends in psychology, then the futures of both will almost certainly be moving in the same direction. Both are beginning to, and will start to rely on online tools/mobile phone applications to collect richer data revealing dynamic tends over long time horizons, and as technology continues to facilitate ways of looking at group behaviour online, then larger scale studies examining interactions amongst multiple groups of people will become the norm rather than the exception. More specifically this article speculates on the future research focus of researchers in behavioral economics and the extent to which this will overlap with psychological research on judgment and decision-making.
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