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Search Results: 1 - 10 of 537 matches for " Madhulika Dixit "
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Sociolinguistic Approach In English Language Teaching: A Critical Assessment
Indian Streams Research Journal , 2012,
Abstract: Today, English is recognized as an associate official language of the Union of India. It is the only language which is a window to the world of knowledge for Indians. In every sphere of life whether social, political, academic, cultural or economic, it holds a significant value. It has played a very important role in building modern India. It enjoys a previleged position. Higher Education in science, medicine, engineering, technology etc. is not possible without English. Higher studies in any discipline are not possible without English. In this era of Information Communication Technology, and the Internet, no country can afford to live without English. It is essential for e-education, e-learning, e-commerce and e-governance. English has become an international asset which can be called world English. English is spoken and understood all over the globe, so it has got international importance. Naturally its popularity on the basis of its utility all over the globe determines its strength. It is through English that we can establish political, cultural, intellectual and economic relations with the rest of the world. It is the means of international communication. After the initial turmoil and resistance against continuing English in India, there is a shift in the attitude of Indians who now recognize the significance of English for national growth.
Glucose challenge increases circulating progenitor cells in Asian Indian male subjects with normal glucose tolerance which is compromised in subjects with pre-diabetes: A pilot study
Abel A Nathan, Viswanathan Mohan, Subash S Babu, Soumi Bairagi, Madhulika Dixit
BMC Endocrine Disorders , 2011, DOI: 10.1186/1472-6823-11-2
Abstract: Asian Indian male subjects (n = 50) with no prior history of glucose imbalance were subjected to 2 hour oral glucose tolerance test (OGTT). 24 subjects had normal glucose tolerance (NGT), 17 subjects had impaired glucose tolerance (IGT) and 9 had impaired fasting glucose (IFG). The IGT and IFG subjects were grouped together as pre-diabetes group (n = 26). Progenitor cell counts in peripheral circulation at fasting and 2 hour post glucose challenge were measured using direct two-color flow cytometry.The pre-diabetes group was more insulin resistant (p < 0.0001) as measured by homeostasis assessment model (HOMA-IR) compared to NGT group. A 2.5-fold increase in CD34+ cells (p = 0.003) and CD133+CD34+ (p = 0.019) cells was seen 2 hours post glucose challenge in the NGT group. This increase for both the cell types was attenuated in subjects with IGT. CD34+ cell counts in response to glucose challenge inversely correlated with neutrophil counts (ρ = -0.330, p = 0.019), while post load counts of CD133+CD34+ cells inversely correlated with serum creatinine (ρ = -0.312, p = 0.023).There is a 2.5-fold increase in the circulating levels of haematopoietic stem cells in response to glucose challenge in healthy Asian Indian male subjects which is attenuated in subjects with pre-diabetes.Haematopoietic stem cell (HSCs) characterized by surface expression of CD34, or CD133 or both exhibit extreme plasticity. Upon receipt of physiological stimuli these cells mobilize from bone marrow into peripheral circulation to mediate multi-lineage engraftment of organs of even non-haematopoietic origin such as skeletal muscle, central nervous system, heart and liver [1]. This pool of immature stem cells is capable of giving rise to progenitors of the cardiovascular system such as the endothelial progenitor cells (EPCs), cardiomyocytes and smooth muscle cell progenitors [2]. They follow circadian kinetics [3] and get mobilized in response to ischemia imparted by acute myocardial infarction (MI)
Inhibition of Vascular Smooth Muscle Cell Proliferation by Gentiana lutea Root Extracts
Rushendhiran Kesavan, Uma Rani Potunuru, Branislav Nastasijevi?, Avaneesh T, Gordana Joksi?, Madhulika Dixit
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061393
Abstract: Gentiana lutea belonging to the Gentianaceae family of flowering plants are routinely used in traditional Serbian medicine for their beneficial gastro-intestinal and anti-inflammatory properties. The aim of the study was to determine whether aqueous root extracts of Gentiana lutea consisting of gentiopicroside, gentisin, bellidifolin-8-O-glucoside, demethylbellidifolin-8-O-glucoside, isovitexin, swertiamarin and amarogentin prevents proliferation of aortic smooth muscle cells in response to PDGF-BB. Cell proliferation and cell cycle analysis were performed based on alamar blue assay and propidium iodide labeling respectively. In primary cultures of rat aortic smooth muscle cells (RASMCs), PDGF-BB (20 ng/ml) induced a two-fold increase in cell proliferation which was significantly blocked by the root extract (1 mg/ml). The root extract also prevented the S-phase entry of synchronized cells in response to PDGF. Furthermore, PDGF-BB induced ERK1/2 activation and consequent increase in cellular nitric oxide (NO) levels were also blocked by the extract. These effects of extract were due to blockade of PDGF-BB induced expression of iNOS, cyclin D1 and proliferating cell nuclear antigen (PCNA). Docking analysis of the extract components on MEK1, the upstream ERK1/2 activating kinase using AutoDock4, indicated a likely binding of isovitexin to the inhibitor binding site of MEK1. Experiments performed with purified isovitexin demonstrated that it successfully blocks PDGF-induced ERK1/2 activation and proliferation of RASMCs in cell culture. Thus, Gentiana lutea can provide novel candidates for prevention and treatment of atherosclerosis.
Increased Endothelial Inflammation, sTie-2 and Arginase Activity in Umbilical Cords Obtained from Gestational Diabetic Mothers
Hemant Giri, Shivam Chandel, Linga S. Dwarakanath, Sooriyakala Sreekumar, Madhulika Dixit
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084546
Abstract: Objective The aim of this study was to determine subclinical inflammation in umbilical vein derived endothelial cells (HUVECs) obtained from Asian Indian subjects with gestational diabetes (GDM) and to determine levels of angiogenic factors and arginase activity in their cord blood. Methods This case-control study included 38 control and 30 GDM subjects. Subjects were confirmed as GDM based on 75g oral glucose tolerance test (OGTT) conducted in the second trimester of pregnancy. Angiogenic markers and arginase activity were measured in cord blood by ELISA and colorimetric methods respectively. Endothelial inflammation was assessed through adhesion of PKH26-labelled leukocytes onto HUVEC monolayer obtained from the study groups. Gene and surface expression of adhesion molecules were confirmed via reverse transcription polymerase chain reaction (RT-PCR) and flow cytometry respectively. Results The study revealed increased adhesion of leukocytes to HUVECs isolated from GDM subjects compared to controls. HUVECs of babies born to GDM mothers had increased surface and mRNA expression of E-selectin. sTie2 levels were significantly higher in the cord blood for GDM subjects (3869 ± 370 ng/L) compared to controls (3045 ± 296 ng/L). Furthermore, arginase activity was higher in cord blood of GDM mothers as opposed to the control group (7.75 ± 2.4 μmoles of urea/ml/hour vs 2.88 ±0.49 μmoles of urea/ml/hour; p-value= 0.019). Spearman’s correlation analysis revealed positive correlation of cord blood arginase activity with glucose intolerance (ρ=0.596, p=0.004) and post load glucose values (ρ=0.472, p=0.031) of mothers observed during the second trimester of pregnancy. Conclusions HUVECs derived from Asian Indian GDM mothers, exhibit signs of sub-clinical endothelial inflammation along with increased levels of sTie2 and arginase activity in their cord blood serum.
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Public relation' is an additional weapon at the UCB's hands in meeting theutility challenges while floating its financial products for more useful purpose. Ascommunications grew from word of mouth to fast reporting of corporate ills and skills, somarketing of goods and services and its utilities kept pace with UCBs and otherorganizations .Now UCB's are aware of the speed of public and media communication;people are experiencing unprecedented levels of good services from these organizationsowing to good training and monitoring of staff and facilities. There will always be badexperiences, rude or apathetic staff, arrogant management, and so on, but this isbecoming more and more confined to few UCBs and their business.If a UCB desires to procure funds and use it advantageously he has no otheroption but to keep up the Public Relations and boost utility .In the competitive marketingworld, Public Relations have occupied a predominant role to gain the goodwill of thepeople by enhancing utility of UCB. Public Relations in UCB Marketing always aim atharmonious blending of relationship between the UCB and the customer. In fact we cansay that Public Relations are present whenever banker comes into contact with thepeople. Thus, today, Public Relations to gain utility have emerged as key factor in everyUCB with which the public are concerned in one or other way. The banking goals,services or products are required to be promoted in a harmonious way by utilizing thePublic Relations techniques at banking floors. This assists to increase utility andthereby marketing efficiency.
A Harbinger of change: Internet Marketing and E-commerce
Madhulika Shankar
Indian Streams Research Journal , 2012,
Abstract: Internet marketing, also known as web marketing, online marketing, webvertising, or e-marketing, is referred to as the marketing generally promotion of products or services over the Internet . I Marketing is used as an abbreviated form for Internet Marketing. Internet marketing is considered to be broad in scope because it not only refers to Marketing on the Internet , but also includes maketing done via e-mail and wireless media. Digital customer data and electronic customer relationship management ( ) systems are also often grouped together under internet marketing. marketing Internetmarketing Internet marketingECRM
An IT Governance in Co-operative Banks
Madhulika Shahoo Gupta
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Technology has turned into the vigor of the Indian co-operative banks since the past decade with the financial sector reforms providing the basis. The question of putting into practice the technology has now changed into 'how' from the former 'why'. It is a confirmed truth that technology lessens the cost of servicing. Furthermore, technology has resulted in enhanced quality of services, any time/anywhere banking, focused product delivery, cross selling opportunities, multi-channel touch points for using up of services, etc.As the triumph of the co-operative banks is more and more inclined on the proper adoption and utilization of technology, IT Governance has assumed immense importance. Merely, IT Governance is nothing but a division of Corporate Governance apprehensive about guaranteeing suitable track and management of IT activities to the advantage of a Bank. As the overseas banks operating in India made the start, the new banks assertively started offering services based on technology. Though, the public/cooperative sector banks had to move over from the load of the past inheritance. Nevertheless, the speedy walk made by the technology sector and their quick espousal by the competitors have enforced these banks also to get into the act by commencing to offer IT-oriented products and services. Today, nearly all commercial banks and some cooperatives are at some phase of technology embracement, be it Automated Ledger Posting Machines, Total Branch Automation or Core Banking solution (CBS). According to latest estimates, CBS covers around 40% of the bank branches accounting for nearly 70% of the business volume. ATMs (including shared ATMs aided further by the National Financial Switch initiative of RBI), internet banking, any branch banking, credit cards, debit cards, etc. are being increasingly offered. There are over 11,000 ATMs across the country and 11 million net connections with around 23 million users.
Evaluation of Cassia occidentalis for in vitro cytotoxicity against human cancer cell lines and antibacterial activity
Bhagat Madhulika,Saxena Ajit
Indian Journal of Pharmacology , 2010,
Abstract: Objective : To evaluate the in vitro cytotoxicity and antibacterial properties of Cassia occidentalis (whole plant) via alcoholic, hydro-alcoholic, and aqueous extracts against eight human cancer cell lines from six different tissues and four bacterial strains. Material and Methods : In vitro cytotoxicity against the human cancer cells, cultured for 48h in presence of different concentrations C. occidentalis extracts and percentage of cell viability, was evaluated using the sulforhodamine-B (SRB) assay. The antibacterial activity was performed using the standard protocol against bacterial strains. Results : It was observed that aqueous extract of C. occidentalis (whole plant) had more potential than hydro-alcoholic and alcoholic extracts against HCT-15, SW-620, PC-3, MCF-7, SiHa, and OVCAR-5 human cancer cell lines at 100, 30, and 10 μg/ml in a dose-dependent manner. The hydro-alcoholic extract showed potential against Bacillus subtillis. Conclusion : The plant can be explored for the possible development of lead molecules for drug discovery.
Antioxidant Potential Some Medicinal Plants of Central India  [PDF]
Savita Dixit, Huma Ali
Journal of Cancer Therapy (JCT) , 2010, DOI: 10.4236/jct.2010.12014
Abstract: Cellular damage or oxidative injury arising from free radicals or reactive oxygen species (ROS) now appears the fun-damental mechanism underlying a number of human neurodegenerative disorder, diabetes, inflammation, viral infec-tions, autoimmune pathologies and digestive system disorders. Free radicals are generated through normal metabolism of drugs, environmental chemicals and other xenobiotics as well as endogenous chemicals, especially stress hormones (adrenalin and noradrenalin). Accumulated evidence suggests that ROS can be scavenged through chemoprevention utilizing natural antioxidant compounds present in foods and medicinal plants. In this review, research on the antioxi-dant potential of some medicinal plants of origin of Central India is considered.4CdBw3
Biological evaluation of 8-alkyl xanthines as potential cytotoxic agents  [PDF]
Renuka Suravajhala, Nitasha Suri, Madhulika Bhagat, Ajit Kumar Saxena
Advances in Biological Chemistry (ABC) , 2013, DOI: 10.4236/abc.2013.33035

A series of 8-substituted alkyl xanthines were evaluated in vitro to test the cytotoxocity in cells. For this experiment, we utilized different mammalian cancer cell lines primarily representing prostrate and lung. One of the compounds synthesized, viz. 8-tertbutyl caffeine showed potent anticancer activity at low concentrations against DU145 when compared to adriamycin. Further experiments were carried out to check the cell cycle arrest in the DU145 cells treated with adriamycin, caffeine and 8-tert butyl caffeine. We observed that there was an arrest in G1 phase of cell cycle at 24 hours while at 48 hours of incubation, the cells were constantly distributed (59.71% -70.79%). We conclude that the effect of 8-tertbutyl caffeine is relatively comparable to caffeine whereas in adriamycin treated cells, we observed the cells underwent G2 arrest. We evaluate the studies on these effects by showing potent analogues which could be used as promising anticancer agents.

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