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Search Results: 1 - 10 of 821 matches for " Madhavi LY Bangaru "
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Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons
Geza Gemes, Katherine D Oyster, Bin Pan, Hsiang-En Wu, Madhavi LY Bangaru, Qingbo Tang, Quinn H Hogan
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-46
Abstract: PMCA function was isolated in dissociated sensory neurons by blocking intracellular Ca2+ sequestration with thapsigargin, and cytoplasmic Ca2+ concentration was recorded with Fura-2 fluorometry. Compared to control neurons, the rate at which depolarization-induced Ca2+ transients resolved was increased in axotomized neurons after spinal nerve ligation, indicating accelerated PMCA function. Electrophysiological recordings showed that blockade of PMCA by vanadate prolonged the action potential afterhyperpolarization, and also decreased the rate at which neurons could fire repetitively.We found that PMCA function is elevated in axotomized sensory neurons, which contributes to neuronal hyperexcitability. Accelerated PMCA function in the primary sensory neuron may contribute to the generation of neuropathic pain, and thus its modulation could provide a new pathway for peripheral treatment of post-traumatic neuropathic pain.
Growth Suppression of Mouse Pituitary Corticotroph Tumor AtT20 Cells by Curcumin: A Model for Treating Cushing's Disease
Madhavi Latha Yadav Bangaru,Jeffrey Woodliff,Hershel Raff,Sanjay Kansra
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009893
Abstract: Pituitary corticotroph tumors secrete excess adrenocorticotrophic hormone (ACTH) resulting in Cushing's disease (CD). Standard treatment includes surgery and, if not successful, radiotherapy, both of which have undesirable side effects and frequent recurrence of the tumor. Pharmacotherapy using PPARγ agonists, dopamine receptor agonists, retinoic acid or somatostatin analogs is still experimental. Curcumin, a commonly used food additive in South Asian cooking, has potent growth inhibitory effects on cell proliferation. Our laboratory recently demonstrated that curcumin inhibited growth and induced apoptosis in prolactin- and growth hormone-producing tumor cells [1]. Subsequently, Schaaf et.al. confirmed our findings and also showed the in vivo effectiveness of curcumin to suppress pituitary tumorigenesis. However the molecular mechanism that mediate this effect of curcumin are still unknown.
Selective Estrogen Receptor Down-Regulator and Selective Estrogen Receptor Modulators Differentially Regulate Lactotroph Proliferation
Sanjay Kansra,Shenglin Chen,Madhavi Latha Yadav Bangaru,Leighton Sneade,Joseph A. Dunckley,Nira Ben-Jonathan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010060
Abstract: We recently reported that estrogen receptor α (ERα), even in absence of estrogen (E2), plays a critical role in lactotroph homeostasis. The anti-estrogen ICI 182780 (ICI), but not tamoxifen or raloxifene, rapidly promoted the degradation of ERα, and inhibited cell proliferation. However, all three ER antagonists suppressed PRL release, suggesting that receptor occupation is sufficient to inhibit prl gene expression whereas receptor degradation is required to suppress lactotroph proliferation. In this study our objective was to determine whether ERα degradation versus occupation, differentially modulates the biological outcome of anti-estrogens.
Stem cell technologies in human health: Boon or bane?  [PDF]
Madhavi Tripathi, Sangeeta Singh
Journal of Biosciences and Medicines (JBM) , 2015, DOI: 10.4236/jbm.2015.311002
Abstract: The stem cells of an organism only possess extraordinary capacity to change into different cell types during the early life and growth of an organism. When these stem cells divide into different new cells, these either remain as stem cells or develop to become other cells with specialized function. For this reason, stem cells offer direct relevance to human health, as theoretically, using stem cell technology, different organs are expected to be regenerated. To this, the Human Embryonic Stem Cells (HESCs) are natural pluripotent cell, but ethical issues covering many countries have put research work on a bit back-foot. However, the Induced Pluripotent Stem Cells (iPSCs) technology has completely revitalized the world to use this technology universally and it therefore seems that more research on this technology will surely be of enormous help in public health. In addition, application of the stem cell technology in personalized-medicine has been started recently. In this concern, the stem cell banking facilities have provided new avenues for preserving the cord blood of the new-borne child and treat them in future by using her/his own preserved stem cells. However, like all new technologies, the output from stem cell research requires to be evaluated more closely. Furthermore, with proper guidelines on ethical issues and extended research following these strategies, the stem cell technology is expected to not only be of huge benefit to human health, but also the benefit can be extended to the survival of endangered animals as well.
Parents’ Perspective on Effects and Benefits of “Brighter Minds” Cognitive Training Program: Results from an Online Survey in India  [PDF]
Madhavi Bongarala, Krishnamurthy Jayanna
Creative Education (CE) , 2019, DOI: 10.4236/ce.2019.101018
Abstract: We assessed parents’ experience and satisfaction with the?Brighter Minds?program, a cognitive training for children between 5 and 15 years of age, offered over eight weekends for a total of 30 hours. A cross-sectional, online survey was administered randomly to 100 parents between March and June 2017. 71 parents responded:?more than 80% reported improvements in various cognitive traits i.e. focus, planning, emotional stability, memory, comprehension, empathy, expression, self-confidence and calmness. Highest improvements were reported for comprehension (93%) and Planning and Preparation (92.9%).?The?older?children (11 - 15 years) showed greater improvements in focus, planning, emotional stability, self-confidence and calmness than younger ones; similarly, girls performed better than boys in planning, emotional stability and self-confidence. About 50% of parents reported that they were extremely satisfied,?and 62% were extremely likely to recommend the program to others. The parents’ feedback from the study provides valuable insights into redesigning and shaping cognitive programs for children.
Nitrogen Nutrition, Its Regulation and Biotechnological Approaches to Improve Crop Productivity  [PDF]
Mettu Madhavi Reddy, Kandasamy Ulaganathan
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.618275
Abstract: Nitrogen is the most important macronutrient needed for plant growth and development. The availability of nitrogen in the soil fluctuates greatly in both time and space. Crop plants, except leguminous plants, depend on supply of nitrogen as fertilizers. Large quantities of nitrogen fertilizers are applied to crop plants, but only 33% of it is utilized by the plant. Plants have developed efficient mechanisms to sense the varying levels of nitrogen forms and uptake them. They also have well developed mechanisms to assimilate the incoming nitrogen immediately or translocate to different parts of the plant wherever it is needed. Maintenance of nitrogen homeostasis is essential to avoid toxicity. Apart from translocation and assimilation, plants have developed different mechanisms, nitrogen efflux; vacuolar nitrogen storage and downward transport of nitrogen from aerial parts to roots, for maintaining nitrogen homeostasis. In crop plants the “grain yield per unit of available nitrogen in the soil” is referred as the nitrogen use efficiency (NUE) for which remobilization of nitrogen, mediated by various transporters plays a crucial role. All these processes are tightly regulated by proteins and microRNA in response to both external and internal nitrogen levels, carbon status of the plant and hormones. As most crop plants are non-leguminous and depend on soil nitrogen, more production could be achieved if crop plants can be made to utilize the available nitrogen efficiently. The recent explosion of research information and the mechanisms behind nitrogen sensing, signaling, transport and utilization enables biotechnological interventions for better nitrogen nutrition of crop plants. This review discusses such possibilities in the context of recent understanding of nitrogen nutrition and the genomic revolution sweeping the crop science.
Effect of Cell Size on the Fundamental Natural Frequency of FRP Honeycomb Sandwich Panels  [PDF]
Sourabha S. Havaldar, Ramesh S Sharma, Arul Prakash M. D. Antony, Mohan Bangaru
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2012, DOI: 10.4236/jmmce.2012.117048
Abstract: In the present work, the effect of hexagonal cell size of the core on the fundamental natural frequency of FRP honey-comb sandwich panels has been analyzed both experimentally and by finite element technique. Experimental Modal tests were conducted on hexagonal cell honeycombs ranging in size from 8 mm to 20 mm maintaining the facing thickness constant at around 1mm with two different boundary conditions viz C-F-F-F and C-F-C-F. The traditional “strike method” has been used to measure the vibration properties. The modal characteristics of the specimens have been obtained by studying its impulse response. Each specimen has been subjected to impulses through a hard tipped hammer which is provided with a force transducer and the response has been measured through the accelerometer. The impulse and the response are processed through a computer aided FFT Analyzing test system in order to extract the modal parameters with the aid of software. Theoretical investigations have been attempted with appropriate assumptions to understand the behavior of the honeycomb sandwich panels during dynamic loading and to validate experimental results. Finite Element modeling has been done treating the facing as an orthotropic laminate and Core as orthotropic with different elastic constants as recommended in the literature. The results are presented which show that the theoretical model can accurately predict the fundamental frequency and how honeycombs with difference cell size will perform under dynamic loads.
Vaccine Policy in India
Yennapu Madhavi
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020127
Parallel Processing of cluster by Map Reduce
Madhavi Vaidya
International Journal of Distributed and Parallel Systems , 2012,
Abstract: MapReduce is a parallel programming model and an associated implementation introduced by Google. In the programming model, a user specifies the computation by two functions, Map and Reduce. The underlying MapReduce library automatically parallelizes the computation, and handles complicated issues like data distribution, load balancing and fault tolerance. Massive input, spread across many machines, need to parallelize. Moves the data, and provides scheduling, fault tolerance. The original MapReduce implementation by Google, as well as its open-source counterpart, Hadoop, is aimed for parallelizing computing in large clusters of commodity machines. Map Reduce has gained a great popularity as it gracefully and automatically achieves fault tolerance. It automatically handles the gathering of results across the multiple nodes and returns a single result or set. This paper gives an overview of MapReduce programming model and its applications. The author has described here the workflow of MapReduce process. Some important issues, like fault tolerance, arestudied in more detail. Even the illustration of working of Map Reduce is given. The data locality issue in heterogeneous environments can noticeably reduce the Map Reduce performance. In this paper, the author has addressed the illustration of data across nodes in a way that each node has a balanced data processing load stored in a parallel manner. Given a data intensive application running on a Hadoop Map Reduce cluster, the auhor has exemplified how data placement is done in Hadoop architecture and the role of Map Reduce in the Hadoop Architecture. The amount of data stored in each node to achieve improved data-processing performance is explained here.
Madhavi Dasari
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v3i9.416
Abstract: The incidence of the uterine malformations is estimated to be 3% to 5% in the general population. Abnormal fusion of the mesonefric duct (mullarian duct) during embryonic life results in a variety of congenital uterine malformations like septate uterus, unicornuate uterus, and bicoruate uterus. In the present case the patient has history of 7 miscarriages. She is 34 years old. Married life is 11 years .Due to bad obstetric history ,after through investigations ,the cause for it is diagnosed as having bicornuate uterus. It was found by histerosalpingography.
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