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Search Results: 1 - 10 of 113761 matches for " MS;Brand?o "
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Comparative study of 1+PRN ranibizumab versus bevacizumab in the clinical setting
Carneiro AM, Mendon a LS, Falc o MS, Fonseca SL, Brand o EM, Falc o-Reis FM
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S33017
Abstract: mparative study of 1+PRN ranibizumab versus bevacizumab in the clinical setting Original Research (1449) Total Article Views Authors: Carneiro AM, Mendon a LS, Falc o MS, Fonseca SL, Brand o EM, Falc o-Reis FM Published Date July 2012 Volume 2012:6 Pages 1149 - 1157 DOI: http://dx.doi.org/10.2147/OPTH.S33017 Received: 16 April 2012 Accepted: 05 June 2012 Published: 19 July 2012 Angela M Carneiro,1,2 Luis S Mendon a,1 Manuel S Falc o,1,2 Sofia L Fonseca,1 Elisete M Brand o,1 Fernando M Falc o-Reis1,2 1Department of Ophthalmology of Hospital de S o Jo o, Porto, Portugal; 2Faculty of Medicine of University of Porto, Porto, Portugal Purpose: We compared the efficacy of intravitreal ranibizumab and bevacizumab for treating neovascular age-related macular degeneration using an on-demand regimen. Methods: A total of 186 wet age-related macular degeneration eyes of 186 treatment-na ve patients were compared retrospectively (67 eyes treated with ranibizumab with 91 treated with bevacizumab). At baseline, mean age, best corrected visual acuity, and angiographic lesion types were similar in both groups. Best corrected visual acuity and ocular coherence tomography were evaluated. Results: Sixty eyes treated with ranibizumab and 85 eyes treated with bevacizumab completed a 12-month evaluation. At 12 months, mean best corrected visual acuity increased by +6.65 letters with ranibizumab treatment and by +5.59 with bevacizumab treatment (P = 0.64). Visual acuity improved by ≥15 letters in 15 eyes treated with ranibizumab and in 21 eyes treated with bevacizumab (P = 0.75). An overall reduction in ocular coherence tomography central thickness occurred for all time points. The mean number of injections per eye was 5.97 with ranibizumab and 5.92 with bevacizumab (P = 0.90). Conclusion: Intravitreal therapies with ranibizumab or bevacizumab have similar visual and anatomical results. These results confirm those of comparison of Age-Related Macular Degeneration Treatment Trials in as-needed cohorts in clinical practice. Randomized long-term clinical trials are necessary to examine the systemic safety of these treatments.
The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
Krettli, Antoniana U;Andrade-Neto, Valter F;Brando, Maria das Gra?as L;Ferrari, Wanêssa MS;
Memórias do Instituto Oswaldo Cruz , 2001, DOI: 10.1590/S0074-02762001000800002
Abstract: in this review we discuss the ongoing situation of human malaria in the brazilian amazon, where it is endemic causing over 610,000 new acute cases yearly, a number which is on the increase. this is partly a result of drug resistant parasites and new antimalarial drugs are urgently needed. the approaches we have used in the search of new drugs during decades are now reviewed and include ethnopharmocology, plants randomly selected, extracts or isolated substances from plants shown to be active against the blood stage parasites in our previous studies. emphasis is given on the medicinal plant bidens pilosa, proven to be active against the parasite blood stages in tests using freshly prepared plant extracts. the anti-sporozoite activity of one plant used in the brazilian endemic area to prevent malaria is also described, the so called "indian beer" (ampelozizyphus amazonicus, rhamnaceae). freshly prepared extracts from the roots of this plant were totally inactive against blood stage parasites, but active against sporozoites of plasmodium gallinaceum or the primary exoerythrocytic stages reducing tissue parasitism in inoculated chickens. this result will be of practical importance if confirmed in mammalian malaria. problems and perspectives in the search for antimalarial drugs are discussed as well as the toxicological and clinical trials to validate some of the active plants for public health use in brazil.
The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
Krettli Antoniana U,Andrade-Neto Valter F,Brando Maria das Gra?as L,Ferrari Wanêssa MS
Memórias do Instituto Oswaldo Cruz , 2001,
Abstract: In this review we discuss the ongoing situation of human malaria in the Brazilian Amazon, where it is endemic causing over 610,000 new acute cases yearly, a number which is on the increase. This is partly a result of drug resistant parasites and new antimalarial drugs are urgently needed. The approaches we have used in the search of new drugs during decades are now reviewed and include ethnopharmocology, plants randomly selected, extracts or isolated substances from plants shown to be active against the blood stage parasites in our previous studies. Emphasis is given on the medicinal plant Bidens pilosa, proven to be active against the parasite blood stages in tests using freshly prepared plant extracts. The anti-sporozoite activity of one plant used in the Brazilian endemic area to prevent malaria is also described, the so called "Indian beer" (Ampelozizyphus amazonicus, Rhamnaceae). Freshly prepared extracts from the roots of this plant were totally inactive against blood stage parasites, but active against sporozoites of Plasmodium gallinaceum or the primary exoerythrocytic stages reducing tissue parasitism in inoculated chickens. This result will be of practical importance if confirmed in mammalian malaria. Problems and perspectives in the search for antimalarial drugs are discussed as well as the toxicological and clinical trials to validate some of the active plants for public health use in Brazil.
Identification of turkey astrovirus and turkey coronavirus in an outbreak of Poult Enteritis and Mortality Syndrome
Villarreal, LYB;Assayag, MS;Brando, PE;Chacón, JLV;Bunger, AND;Astolfi-Ferreira, CS;Gomes, CR;Jones, RC;Ferreira, AJP;
Revista Brasileira de Ciência Avícola , 2006, DOI: 10.1590/S1516-635X2006000200010
Abstract: this article reports a survey on turkey astrovirus (tastv) and turkey coronavirus (tcov) infections with rt-pcr in 17 turkey flocks affected by acute enteritis and two apparently normal turkey flocks located in the southeastern region of brazil by pcr (tastv and tcov). seven out of the 17 affected flocks were positive for tastv and 14 for tcov, with seven co-infections. in one of the two apparently normal flocks, a tastv-tcov co-infection was found. although a definitive association of these agents and the signs can not be made, the implications of these findings are discussed.
ética e pesquisa
Schnaider, Taylor Brando;
Acta Cirurgica Brasileira , 2008, DOI: 10.1590/S0102-86502008000100017
Abstract: purpose: this research explains ethics aspects of experiments in animals and human beings. contents: it is considered to be a very important issue because it focuses on the mental, spiritual, social and physical well being of humans, without forgetting the animal rights. the majority of the international health research codes mentions that human research must be based on previous laboratory animal testing or on scientific evidences. the author is reviewing the ethics concepts in humans and animal testing. he refers to the international policies for medical research on human beings, helsinki declaration, 8.080 and 8.142 of the 1990 federal law, 9.974 of the 1995 federal law and also to the 196/96 health department resolution. then, a historical retrospective is drawn about the first attempt to establish regulation on animal testing, which happened in the mid of the 19th century, in london. he also emphasizes that some of the criteria used at that time remains up to the present. the first ethics commission in animal testing was established in sweeden in 1979 and in the united states in 1984. in brazil, the ethics animal testing committees were established in the early 90s. since may 1979, there is the 6.638 federal law which establishes regulations for the practice of animal use in research or teaching. this law is still waiting to be enforced. in addition to it, there are some drafts being analyzed by the congress to regulate the use of animal for the purpose of teaching and researching. finally the policies adopted by the brazilian college of animal experiments are presented by the author. conclusions: the professors, post-graduates, residents and medical students , as well as other students from health related courses enrolled in human and animal testing researches must be aware of ethics principles aiming to protect researchers, research subjects and the animals selected for scientific work.
Os jogos de escalas na sociologia da educa??o
Brando, Zaia;
Educa??o & Sociedade , 2008, DOI: 10.1590/S0101-73302008000200015
Abstract: as argued by revel in his "games of scales" (jeux d'échelles), the complexity of social phenomena indicates that a social reality is not always the same, depending on the analysis level. this article emphasizes that the aggregated data used in the construction of socio-economic indicators and scales of social stratification using surveys, central for the analysis of educational phenomena, offer an illusion of objectivity, since equivalent positions on these scales result in very different social experiences in real life, and require fieldwork strategies of research. the text presents the example of a research experience in the field of sociology of education from the perspective of the "game of scales".
Operando com conceitos: com e para além de Bourdieu
Brando, Zaia;
Educa??o e Pesquisa , 2010, DOI: 10.1590/S1517-97022010000100003
Abstract: the main objective of this article is highlighting the importance of operating with concepts, accepting the challenges posed by the empirical reality. for that, the study was based on empirical material that resulted from researches conducted by the research group in the sociology of education - soced/puc-rio. on several occasions, bourdieu questioned the purely theoretical interpretation of his concepts. "to put the theoretical things in play" was the author's recommendation many a time. in the present text we try to exemplify the results of the experience of operating with his concepts, focusing on two main aspects: the conditions for the transformation of the habitus, and the empirical outline of the cultural capital of the school elites studied in prestige institutions in rio de janeiro. in studying the latter aspect, bourdieu's proposal of working "with and against the authors" came to the forefront. as much as we value his work in the sociology of education, the empirical description of cultural capital in his vast production issues from the french reality of the decades during which he developed his studies. to operate with the concept of cultural capital in a way adequate to the empirical challenges that we faced, we made use of authors that discussed the transformations of the cultural field beyond the perspective of the boundaries between high culture and popular culture as analyzed by bourdieu.
On the interference of clinical outcome on rabies transmission an perpetuation
Brando, PE;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2009, DOI: 10.1590/S1678-91992009000200003
Abstract: rabies is a viral zoonotic infectious disease that affects mammals and is caused by genotypes/species of the lyssavirus genus (rhabdoviridae, mononegavirales), with the genotype 1 (classic rabies virus - rabv) being the most prevalent. despite continuous efforts, rabies is still an incurable disease that causes thousands of deaths amongst humans worldwide. due to a wide range of hosts and the different evolutionary paths of rabv in each host, several host-specific variants have arisen in an ongoing process. the result of rabv replication in nervous tissues may lead to two opposite clinical outcomes, i.e., paralytic/dumb form and encephalitic/furious one. the paralytic form creates dead-end hosts mainly amongst herbivores, while the furious form of the disease allows for augmented transmission when manifested in gregarious carnivores, as their natural aggressive behavior is accentuated by the disease itself. the aim of this article is to propose a theoretical model intended to explore how the rabies virus intrinsically modulates the immune system of different host classes, the pathological changes that the virus causes in these animals and how these elements favor its own perpetuation in nature, thus providing a basis for better prediction of the patterns this disease may present.
Travessias do grande sert?o
Brando, Carlos Rodrigues;
Estudos Avan?ados , 2006, DOI: 10.1590/S0103-40142006000300004
Abstract: manuelz?o, a real person from the hinterlands of minas gerais who was later rendered a literary character by jo?o guimar?es rosa and, later still, became kind of an emblematic figure of rosa's backcountry "general mines", is here brought to life through his own words, in interviews made at his home and the environs of his world, the village of andrequicé, and through the notes of his field diary. other characters from the same region speak complementarily of their past and present life in the area.
Competências no trabalho: uma análise da produ??o científica brasileira
Brando, Hugo Pena;
Estudos de Psicologia (Natal) , 2007, DOI: 10.1590/S1413-294X2007000200007
Abstract: this paper aimed to review the brazilian scientific studies on competencies at work that were published between 1996 and 2004 in important brazilian journals from the areas of psychology and business administration. empirical studies on the subject were identified and systematically analyzed, characterizing these inquiries, the theoretical approaches adopted by the authors, their intentions and methodological options used, the instruments of data collection and the procedures of analysis, among other aspects. problems and limitations of the inquiries were discussed, aiming to disclose gaps and relevant questions for study, as well as presenting recommendations on research strategies. it has been evidenced the predominance of studies that attempted to identify relevant competencies to some occupational positions, as well as those that examined the contribution of learning processes for the development of competencies. considering the lack of empirical inquiries on this subject, an agenda for future research is suggested in the end.
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