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Search Results: 1 - 10 of 764 matches for " MONOCLONAL "
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Alemtuzumab: A Place in Therapy for Treatment of Multiple Sclerosis  [PDF]
Teya M. Tietje, Douglas R. Allington, Michael P. Rivey
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.410082
Abstract: Alemtuzumab is a humanized mononclonal antibody known to cause rapid depletion of B-and T-cell lymphocytes. Subsequent repletion of these lymphocytes leads to changes in adaptive immunity. Alemtuzumab is approved by the United States Food and Drug Administration (FDA) for the treatment of B-cell lymphocytic leukemia but has been investigated off-label in recent years for treatment of autoimmune diseases, including multiple sclerosis (MS). In MS treatment, alemtuzumab is administered as pulsed therapy, given once daily initially for 5 consecutive days and then for 3 consecutive days at 12-month intervals. Alemtuzumab has recently been compared to interferon beta 1-a in one phase II and two phase III trials in patients with relapsing-remitting MS. Results from the studies show alemtuzumab compared to interferon beta 1-a is associated with a greater reduction in the risk of sustained accumulation of disability and is more effective in reducing disease relapse rates. The treatment of MS continues to be a healthcare challenge due to the modest clinical benefit and adverse effect profiles of available disease modifying treatment options. Available data suggest alemtuzumab may offer better efficacy outcomes compared to traditional disease modifying therapies in patients with MS. However, the agent has not been compared to other new disease modifying medications that have been recently introduced.
JC virus: A brief review  [PDF]
Basilio Vagner Ramírez, Viviana Casta?o Palacio
World Journal of Neuroscience (WJNS) , 2013, DOI: 10.4236/wjns.2013.32015

Proportional to the growth rate of its clinical expression, the last decades have seen an increase on JC Virus diagnosis testing, and on therapeutic and symptoms management plans. Whether isolated or associated to retroviral therapy, the relationship of JC Virus to HIV allowed us to delve a little deeper into the knowledge of its behavior. Now as new immune-modulating and immune-suppressing therapies are developed, its clinical expression has become broader and more complexly, thereby our need is to develop more precise diagnosis and therapeutic plans.

Diagnóstico diferencial de las gammapatías monoclonales
Molina Garrido,M. J.; Guillén Ponce,C.; Guirado-Risue?o,M.; Martínez y Sevila,C.; Carrato Mena,A.;
Anales de Medicina Interna , 2006, DOI: 10.4321/S0212-71992006001100010
Abstract: the presence of a monoclonal pike in blood is very habitual in our daily medical activity. there are a lot of causes of that. if we know which kind of pathology had originated the monoclonal pike, we could be able to bring a suitable treatment and to change the prognosis of the patient. if we are able to exclude a malignant disease, the patient will not suffer unnecessary aggressive tests. in this report, we describe the main diseases which are associated to monoclonal pike and the clues to get a definitive diagnosis.
Assessment of immunity induced in mice by glycoproteins derived from different strains and species of Leishmania
Guimar?es, Tania Mara Pinto Dabés;Toledo, Vicente de Paulo Coelho Peixoto de;Costa, Carlos Alberto da;Costa, Roberto Teodoro da;Genaro, Odair;Williams, Paul;Mayrink, Wilson;
Memórias do Instituto Oswaldo Cruz , 1996, DOI: 10.1590/S0074-02761996000100010
Abstract: a comparative study was undertaken on the immunogenic properties of 63kda glycoproteins obtained from five different strains/species of leishmania and assessed in c57bl/10 mice. the humoral immune response was assessed by elisa against the five different antigens of the immunized animals. the cellular immune response was derived from leishmania. the response was found to be species-specific in all of determined by means of the cytokine profiles secreted by the spleen cells of immunized animals. the presence of 3-ifn and il-2, and the absence of il-4 in the supernatants of cells stimulated by l. amazonensis antigen established that the cellular response is of th1 type. the five glycoproteins tested were equally effective in protecting c57bl/10 mice against challenge by l. amazonensis. about 50% of the immunized animals were protected for six months.
Uveítis recurrentes y tratamiento con anticuerpos monoclonales (Daclizumab)
Hernández Garfella,ML; Díaz Llopis,M; Salom Alonso,D; Cervera Taulet,E;
Archivos de la Sociedad Espa?ola de Oftalmología , 2004, DOI: 10.4321/S0365-66912004001200004
Abstract: purpose: assess the efficacy of monoclonal antibody (daclizumab) therapy in the treatment of patients with non-infectious uveitis who do not respond to other immunosuppressive agents. material and method: ten patients with non-infectious intermediate and posterior uveitis were treated with intravenous daclizumab (humanized anti-il-2 receptor monoclonal antibody) monthly for two years. results: 70% of the patients have had some improvement in their inflammatory activity being maintained without recurrence. 10% of the patients improved their visual acuity in two lines and the macular edema decreased. 20% of the patients continued to have recurrences, but not worse than the year before. 40% of the patients gave up having the treatment with corticosteroids and 30% with minimum dose (5 mg). no secondary effects were noted during the treatment. conclusions: daclizumab is effective and safe for long-term use in the treatment of uveitis which cannot be kept under control by other treatments. in time, it allows the dose of corticosteroids to be decreased or even discontinued.
Monoclonal gammopathy associated with visceral leishmaniasis
Sharma, Vishal;Agarwal, Mukul P;Giri, Subhash;
Brazilian Journal of Infectious Diseases , 2010, DOI: 10.1590/S1413-86702010000300018
Abstract: monoclonal gammopathy can accompany diverse conditions and is usually benign. it should be distinguished from monoclonal gammopathy of undetermined significance (mgus) which can rarely turn malignant. visceral leishmaniasis has only rarely been associated with monoclonal gammopathy. we describe the case of a 55-year-old male who had monoclonal gammopathy associated with visceral leishmanisais, which reversed with stibogluconate therapy.
Production of monoclonal antibodies against Streptococcus mutans antigens
Canettieri, Antonio Carlos Victor;Kretchetoff, Fujiko Yamasiro;Koga-Ito, Cristiane Yumi;Moreira, Daniella;Fujarra, Fabio José Condino;Unterkircher, Carmelinda Schmidt;
Brazilian Oral Research , 2006, DOI: 10.1590/S1806-83242006000400003
Abstract: several studies have been conducted in the last decades aiming to obtain an anti-caries vaccine, however some studies have demonstrated cross reactivity between streptococcus mutans surface antigens and the human cardiac tissue. in this work, the reactivity of five anti-streptococcus mutans monoclonal antibodies (moab) (24a, 56g, c8, e8 and f6) was tested against oral streptococci, cardiac antigens and skeletal and cardiac myosins, aiming to evaluate the specificity of these moab. the hybrid producers of immunoglobulins of the igg2b class were cloned by limit dilution and expanded in vivo. moab were tested by elisa. the hybrid 24a reacted with s. mutans cct 1910, s. salivarius cct 0365 and s. pyogenes t23. no reactivity difference was observed among the tested species. cross reactivity with heart and cardiac myosin was not confirmed and only reaction with myosin of skeletal muscle was observed (p = 0.0381). the hybrid 56g reacted with all the tested microorganisms and there was statistically significant difference between s. mutans and s. pyogenes t23 (p < 0.001). this hybrid also reacted with myosin of skeletal muscle (p = 0.0095). c8, e8 and f6 presented low reactivity against oral streptococci strains and no reactivity against cardiac antigens. the data of this study showed that the 24a and 56g anti-s. mutans moab presented reactivity with s. pyogenes and s. salivarius, reinforcing the occurrence of common antigens between these species. the tested moab presented low cross-reactivity with myosin of skeletal muscle, but anti-heart activity could not be confirmed.
Estabilidad del producto hemoclasificador Hemo-CIM? Anti-B: Evaluación durante 2 a?os
Suárez Batista,Lilia E; Rivero Jiménez,René A; Bencomo Hernández,Antonio A; Martínez Solís,Marta N; González Sampedro,Renée; Rodríguez Obaya,Teresita;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2001,
Abstract: the stability studies of the reagents made from monoclonal antibodies of murine origin allow to establish the life of these products adequately and are an indispensable requisite for the fulfillment of the good practices of production. the hemagglutination methods were used to measure the biological activity of the anti-b hemo-cima product expressed in the potency, avidity and intensity against a panel of erythrocytes of the group b and a1b in order to show in a more effective way any deterioration of the reagent. it was established that the useful life of the hemoclassifier produced at the center of mollecular biology is of 2 years at a storage temperature between 2 and 8oc. the evaluation that simulates the conditions to which the users subject these reagents showed that the reagent maintains the quality characteristics required for its use. the stability attained with the anti-b hemo-cima is similiar to that reported with the murine monoclonal anti-a hemo-cima hemoclassifier product
Sistema analítico de evaluación de la actividad biológica del reactivo hemoclasificador HEMO-CIM ANTI-A
Suárez Batista,Lilia; Hernández Santana,Alina; Rivero Jiménez,René; Bencomo Hernández,Antonio; Rodríguez Obaya,Teresita;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: with the objective of carrying out industrial scaling of hemoclassifier products from murin monoclonal antibodies, a number of activities were performed to create the conditions for their manufacture in compliance with good manufacturing practices of the molecular immunology center. the analytical methods were introduced to determine the quality of anti-a hemo-cim hemoclassifier in the quality assurance department. staff responsible for this work was trained in the use of these evaluation methods of the biological action of anti-a monoclonal antibody in supernatant, ascitic fluid and finished product; the documents that are part of the documentation system were designed and prepared, among them standard operating procedures, master production batch records, documents for data-gathering, batch records, quality certificates and biological activity measurement registers to file lab results
Amplificación dependiente de anticuerpos del virus dengue en cepas cubanas utilizando anticuerpos monoclonales
Pupo,Maritza; Amín,Nevis; álvarez,Mailing; Morier,Luis; Rodríguez,Hermis; González,Zolia; Guzmán,María Guadalupe;
Revista Cubana de Medicina Tropical , 2004,
Abstract: the different behaviors of antidengue monoclonal antibodies serotype 2 (h3/6, 4g3) and antiprotein recombinant from the dengue virus sheath were described when they faced diverse strains from the serotypes 2 and 4 of this virus (d2 new guinea c, a15 cuban strain and a15 propagated 53 times in culture of beagley dog kidney and d4 h-22412 prototype strain) in an immunoamplification assay dependent of antibodies. themonoclonal antibodies have prove to be an efficient tool to explain that the neutralizatrion and increase of viral multiplicity may be carried out as separate biological functions. only the h3/6 monoclonal antibdoy was capable of producing the amplification assay dependent phenomenon against the a15 strain with a significant rise in the viral multiplication. the 4g3 and 4b6 monoclonal antibodies were not capable of immunoamplifying the viral multiplication of the studied strains.
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