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Search Results: 1 - 10 of 738 matches for " MAC-FAC regimen "
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Vidyadhar B Bangal,Kunaal K Shinde,Sai K Borawake
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i5.393
Abstract: Choriocarcinoma is a highly malignant trophoblastic tumor that follows normal pregnancy,abortion or ectopic pregnancy. The risk is immeasurably greater following hydatidiform mole. We present a report of a young woman who developed gestational choriocarcinoma following repeated hydatidiform mole.After thorough assessment of risk factors, combination chemotherapy in the form of MAC-FAC regimen was given for six cycles. The woman showed good compliance for two years, regarding regular follow up, treatment and contraceptive advice. Patient became pregnant after two years of follow up and gave birth to a healthy baby.
Effect of ondansetron alone and in combination with domperidone in the prevention of chemotherapy-induced nausea and vomiting in breast cancer patients
Kaberi Das Gupta, A.K.M. Mosharrof Hossain, Saad Uddin Jaigirdar, Borhan Uddin, Tridiv Choudhury and Dipti Rani Saha
Bangladesh Journal of Pharmacology , 2007,
Abstract: The efficacy and safety of ondansetron, administered alone and in combination with domperidone to prevent chemotherapy-induced nausea and vomiting of breast cancer patients receiving chemotherapy FAC regimen (5-fluorouracil, adriamycin and cyclophosphamide) were evaluated. A consecutive open-label interventional study was conducted on a total number of 86 female breast cancer patients who were receiving chemotherapy. Forty two patients received ondansetron (8 mg) intravenously 30 min before chemotherapy which is followed by ondansetron (8 mg) administered orally every 8 hourly for 2 days from the day of start of chemotherapy. Another 44 patients received ondansetron (8 mg) intravenously 30 min before chemotherapy followed by ondansetron (8 mg) plus domperidone (20 mg) administered orally 8 hourly for 48 hours from the day of start of chemotherapy. The number of emetic episodes, severity of nausea, assessment of appetite and adverse events were recorded at 8 hour intervals for two days study period using specific scoring criteria. Ondansetron in combination with domperidone significantly decreased the chemotherapy-induced nausea and vomiting in comparison with ondansetron administered alone (P< 0.001). Appetite status was good with combination therapy (P<0.001). Improvement in appetite indicates that ondansetron plus domperidone exert protective effect against nausea and maintain normal appetite, while patients who were getting monotherapy experience loss of appetite. The common adverse event, headache was present in both the groups. No extrapyramidal reaction was observed in any group. This study showed that ondansetron plus domperidone exert more pronounced antiemetic effect in patients with breast cancer receiving moderately emetogenic chemotherapy (FAC regimen) with good appetite status and less adverse effect.
The Effects of Surface and Structural Features on the Access of Story Analogs

Tong Xiuli,Mo Lei Zhe Chen,
,莫雷,Zhe Chen

心理科学进展 , 2004,
Abstract: 在基于相似性的迁移研究中,表面特征和结构特征在类比提取过程中的作用是研究者关注的中心课题。自20世纪90年代以来,不同的研究者在故事类比通达研究的基础上,得出有关表面特征和结构特征的作用的不同结论。文章以表面特征和结构特征的概念为切入点,主要介绍表面特征和结构特征在故事类比通达中的作用的理论分歧与类比通达模型,指出当前的研究中存在的问题,并提出新的类比通达研究的框架。
心理科学进展 , 2004,
Abstract: ?在基于相似性的迁移研究中,表面特征和结构特征在类比提取过程中的作用是研究者关注的中心课题。自20世纪90年代以来,不同的研究者在故事类比通达研究的基础上,得出有关表面特征和结构特征的作用的不同结论。文章以表面特征和结构特征的概念为切入点,主要介绍表面特征和结构特征在故事类比通达中的作用的理论分歧与类比通达模型,指出当前的研究中存在的问题,并提出新的类比通达研究的框架。
Assesmenf of T.B Patients, Relation between their knowledge of disease and therapeutic regimers in TB/Controlcenter, Tehran, 1377
Hayat Journal of Faculty of Nursing & Midwifery , 2000,
Abstract: "nThis research is a descriptive- analytic study which has been conducted in"norder to determine the degree of tuberculous patients knowledge of their tubereulosis disease and its relation to therapeutic regimen in Tehran TB control centers."nIn this research , 120 tuberculous patients calling on tuberculosis control centers in Tehran and being under drug therdpyfor about 2-9 months were selected as subjects in this research . sampling has been easy as well as haphazardly data was gathered through a questionnaire. the questionnaire used in this research includes 3 section . After gathering the data, descriptive and deductive statistics used in order to analyse the data more over, chi-square and fisher Exact Test used to study the relation between the knowledge variables and therapeutic regimen in accordance with demographic characteristics and chouporof coefficient used to determine correlation intensity."nResearch results concerning units under investigation showed that the majority on insufficient knowledge of their disease which the minority (%18) had a sufficient knowledge, the majority (%62) had a proper drug therapy while the minority (%1) did not the majority (%72) did not Take a efficient diet while the minority (%2) took a proper diet, the majority (%58) medium personal Health care while the minority (%15) folllowed a good personal health care, and generally the majority (%47) had a medium therapeutic regimen while the minority (%11) did not have sufficient"nRegarding the relation between the degree of knowledge and thrapeutic therapy which was the main objective in this research,the result ofperson,s correlation coefficient (z= 7.88, r-o.62 jshowed a direct correlation in such a manner that the degree of knowledge will increase with quality of therapeutic regimen.
Pharmacist Role in Pharmaceutical Care during Ramadan  [PDF]
Osama H. Mohamed Ibrahim
Pharmacology & Pharmacy (PP) , 2015, DOI: 10.4236/pp.2015.612061
Abstract: Introduction: Ramadan is the ninth month in the Islamic Hijri calendar where Muslims are ex-pected to fast every day from dawn to sunset. The eating behavior changes during Ramadan and the abstinence of food affects the oral drugs administration and other convenience dosage forms. There is a need to highlight and illustrate the role of the pharmacists in medication adjustment challenges that the patients conquer in the Holy month of Ramadan. Objectives: To estimate the awareness of pharmacists’ role in providing pharmaceutical care during Ramadan; moreover, to explore pharmacists’ perspective on the importance of medication regimen adjustment along with the proper counseling required to optimize patients’ health throughout fasting. Method: This is an observational study that was done through dissemination of a cross-sectional survey among 130 pharmacists covering Abu Dhabi, Dubai, Sharjah, Ajman, and Northern Emirates regions. The targeted population consisted of practicing community pharmacists and hospital pharmacists across UAE. Results: Among pharmacists participated in the study 115 pharmacists (88.5%) were Muslims and 79 pharmacists (60.8%) were Arabs. 126 pharmacists (97%) reported performing one or more kinds of medication regimen adjustment around Ramadan for at least one patient. Changing the frequency had the highest percentage by the pharmacist compared to other methods of regimen adjustment (39%). Moreover, the results revealed that 46.9% of the pharmacists chose not to change the medication itself. Nineteen percent of Muslim pharmacists initiated the conversation about medication regimen adjustment (P = 0.0448) compared to non-Muslims, while14% of pharmacists were Arabs who showed no statistically significant difference. Conclusion: In conclusion, pharmacists are more qualified to adjust and manage medication regimens than what they are presently performing. Utilization of such skill is required to adjust patients’ medication regimen during fasting the Holy month of Ramadan and to ensure safe transition for fasting patients into and out of Ramadan.
Oral Misoprostol 2 Hourly for Labor Induction  [PDF]
Souzan Kafy
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.86062
Abstract: The objective of this study was to assess the efficacy and safety of the 2 hourly oral misoprostol for labor induction. Between May and November 2013, the hospital records of 83 women who were induced for labor and met the eligibility criteria were retrospectively reviewed. Eligibility criteria were singleton pregnancy of at least 34 weeks’ gestation and a baseline Bishop score < 6. Women with a previous cesarean section or other uterine surgery, severe pregnancy-induced hypertension, and parity of 4 or more were excluded. Oral misoprostol was administered as 20 μg 2 hourly unless active labor. A maximum of 12 doses was allowed. The age of the women was 27.9 ± 5.3 years (mean ± SD). Vaginal delivery within 24 hours occurred in 38 (45.8%) women. Cesarean delivery occurred in 17 (20.5%) women. Although more parous women achieved vaginal delivery within 24 hours (52.6%) compared with nulliparous women (40.0%), the difference was not significant (P = .35). Uterine tachysystole occurred in 12 (14.5%) women. No perinatal deaths or neonatal intensive care unit admission occurred in the study group. Evidence supporting an optimal regimen is lacking, and additional research is warranted to optimize the use of oral misoprostol for the induction of labor.
Power Efficient Scheduled-Based Medium Access Control Protocol over Wireless Sensor Networks  [PDF]
Muhammad Shoaib Khan, Abrar Alajlan, Marwah Almasri
Wireless Sensor Network (WSN) , 2016, DOI: 10.4236/wsn.2016.82002
Abstract: The flexible use of sensors has made them an attractive device to be deployed in almost every field of life such as health, military and home. Recent advancement in electronics and wireless communications has witnessed the development of low cost-sensor devices. While wireless sensor networks (WSNs) are flexible to use and less costly, they need to be more energy-efficient as they are operated by the battery. Mostly they are deployed in harsh environments where it is very difficult to change the batteries frequently. Several medium access control (MAC) algorithms have been developed for the energy-efficient acquisition of the wireless channel, however, none of them are satisfactory. In this paper, we proposed a medium access control algorithm called MAC-PE. MAC-PE is based on the concept of prioritized frames where prioritized frames are transmitted urgently. In addition, it uses scheduled-based MAC instead of accessing channel randomly. We found MAC-PE (Power-Efficient MAC) was efficient in terms of power consumption without sacrificing on the performance using NS-2.
A New Regimen in the Treatment of Psoriasis Using Oral Methotrexate  [PDF]
Khalifa E. Sharquie, Adil A. Noaimi, Mays H. Alobaidi
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2019, DOI: 10.4236/jcdsa.2019.92014
Abstract: Background: Methotrexate is a well-known standard therapy for psoriasis. The standard regimen is using six (2.5 mg) tablets/week that might be with many side effects. Objective: Finding a new regimen for oral methotrexate aiming to decrease side effects and increase its effectiveness. Patients and Methods: This therapeutic, comparative study done at the Center of Dermatology, Medical city, from October 2017 to October 2018. Fifty-three patients with moderate to severe psoriasis completed the study. They were divided into: Group (A) (27) patients were treated with the new oral regimen and Group (B) (26) patients were treated with the six tablets/week. Investigations including CBC, LFT and RFT were done. PASI score, BSA and side effects especially gastrointestinal ones were recorded. Results: They were 29 males and 24 females. Age ranged from 18 - 67 years. Disease duration ranged from 1 - 30 years. BSA involved ranged from 20% - 79%. The PASI score ranged from 10.2 - 45.7. After 8 weeks of treatment, there was statistically significant difference (p-value > 0.001) regarding PASI score and gastrointestinal side effects being less in Group (A). Group A patients were more satisfied. Conclusion: The new regimen used in the present study has lower gastrointestinal side effects and more efficacy.
Randomized Trial Comparing Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF) Regimen with Rotational CMFEV Regimen (E=Epirubicin, V=Vincristine) as Adjuvant Chemotherapy in Moderate Risk Operable Breast Carcinoma  [PDF]
Giorgio Cocconi, Corrado Boni, Maurizio Tonato, Rodolfo Passalacqua, Mariantonietta Colozza, Anna M. Mosconi, Giancarlo Bisagni, Ermanno Rondini, Lina Rodinò, Amalia Carpi, Francesco Di Costanzo, Mauro Brugia, Giuseppe Attardo, Luigi Acito, Riccardo Rossetti, Maria Bella, Roberta Camisa, Francesco Cardinale, Beatrice Dozin
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.23047
Abstract: Objectives: The CMFEV (cyclophosphamide, methotrexate, 5-fluorouracil, epirubicin, vincristine) regimen is an innovative schedule, designed by our Group, aimed at administering five partially or totally no cross-resistant cytotoxic agents in breast carcinoma. It was randomly compared to CMF (cyclophosphamide, methotrexate, 5-fluorouracil) as primary treatment in operable disease and demonstrated a short-term significant increase in clinical complete response rate and a long-term significant locoregional relapse-free survival in premenopausal patients. So, it seemed worth comparing this regimen with CMF as adjuvant chemotherapy in moderate risk operable breast carcinoma. Methods: Four hundred and eighty-nine patients with stage I or II moderate risk breast carcinoma were randomized to receive CMF or CMFEV regimen for 6 cycles after surgery. Main end points were overall survival (OS), invasive disease-free survival (IDFS) and recurrence-free interval (RFI), as estimated by Kaplan-Meier analyses and log-rank tests. Results: At a median observation time of 7.3 years (range 5.4 months-10.3 years), no significant differences in OS and IDFS were observed between the two arms. Deaths from breast carcinoma were more frequent with CMF (58.5%) than with CMFEV regimen (41.7%) as well as recurrences from breast carcinoma (58.8% with CMF and 41.2% with CMFEV). These differences were not statistically significant. Conclusion: CMFEV appears more effective than CMF in preventing recurrences from primary disease in patients with moderate risk stage I-II breast carcinoma. The lack of statistical significance of the observed differences was probably due to the limited number of patients enrolled which rendered the study underpowdered.
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