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Search Results: 1 - 10 of 815271 matches for " M.C.A.;Chimelli "
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Modulation of fibronectin expression in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis
De-Carvalho, M.C.A.;Chimelli, L.M.C.;Quirico-Santos, T.;
Brazilian Journal of Medical and Biological Research , 1999, DOI: 10.1590/S0100-879X1999000500012
Abstract: fibronectin (fn), a large family of plasma and extracellular matrix (ecm) glycoproteins, plays an important role in leukocyte migration. in normal central nervous system (cns), a fine and delicate mesh of fn is virtually restricted to the basal membrane of cerebral blood vessels and to the glial limitans externa. experimental autoimmune encephalomyelitis (eae), an inflammatory cns demyelinating disease, was induced in lewis rats with a spinal cord homogenate. during the preclinical phase and the onset of the disease, marked immunolabelling was observed on the endothelial luminal surface and basal lamina of spinal cord and brainstem microvasculature. in the paralytic phase, a discrete labelling was evident in blood vessels of spinal cord and brainstem associated or not with an inflammatory infiltrate. conversely, intense immunolabelling was present in cerebral and cerebellar blood vessels, which were still free from inflammatory cuffs. shortly after clinical recovery minimal labelling was observed in a few blood vessels. brainstem and spinal cord returned to normal, but numerous inflammatory foci and demyelination were still evident near the ventricle walls, in the cerebral cortex and in the cerebellum. intense expression of fn in brain vessels ascending from the spinal cord towards the encephalon preceded the appearance of inflammatory cells but faded away after the establishment of the inflammatory cuff. these results indicate an important role for fn in the pathogenesis of cns inflammatory demyelinating events occurring during eae.
Modulation of fibronectin expression in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis
De-Carvalho M.C.A.,Chimelli L.M.C.,Quirico-Santos T.
Brazilian Journal of Medical and Biological Research , 1999,
Abstract: Fibronectin (FN), a large family of plasma and extracellular matrix (ECM) glycoproteins, plays an important role in leukocyte migration. In normal central nervous system (CNS), a fine and delicate mesh of FN is virtually restricted to the basal membrane of cerebral blood vessels and to the glial limitans externa. Experimental autoimmune encephalomyelitis (EAE), an inflammatory CNS demyelinating disease, was induced in Lewis rats with a spinal cord homogenate. During the preclinical phase and the onset of the disease, marked immunolabelling was observed on the endothelial luminal surface and basal lamina of spinal cord and brainstem microvasculature. In the paralytic phase, a discrete labelling was evident in blood vessels of spinal cord and brainstem associated or not with an inflammatory infiltrate. Conversely, intense immunolabelling was present in cerebral and cerebellar blood vessels, which were still free from inflammatory cuffs. Shortly after clinical recovery minimal labelling was observed in a few blood vessels. Brainstem and spinal cord returned to normal, but numerous inflammatory foci and demyelination were still evident near the ventricle walls, in the cerebral cortex and in the cerebellum. Intense expression of FN in brain vessels ascending from the spinal cord towards the encephalon preceded the appearance of inflammatory cells but faded away after the establishment of the inflammatory cuff. These results indicate an important role for FN in the pathogenesis of CNS inflammatory demyelinating events occurring during EAE.
A numerical solution for the entrance region of non-newtonian flow in annuli
Maia, M.C.A.;Gasparetto, C.A.;
Brazilian Journal of Chemical Engineering , 2003, DOI: 10.1590/S0104-66322003000200014
Abstract: continuity and momentum equations applied to the entrance region of an axial, incompressible, isothermal, laminar and steady flow of a power-law fluid in a concentric annulus, were solved by a finite difference implicit method. the newtonian case was solved used for validation of the method and then compared to reported results. for the non-newtonian case a pseudoplastic power-law model was assumed and the equations were transformed to obtain a pseudo-newtonian system which enabled its solution using the same technique as that used for the newtonian case. comparison of the results for entrance length and pressure drop with those available in the literature showed a qualitative similarity, but significant quantitative differences. this can be attributed to the differences in entrance geometries and the definition of asymptotic entrance length.
A numerical solution for the entrance region of non-newtonian flow in annuli
Maia M.C.A.,Gasparetto C.A.
Brazilian Journal of Chemical Engineering , 2003,
Abstract: Continuity and momentum equations applied to the entrance region of an axial, incompressible, isothermal, laminar and steady flow of a power-law fluid in a concentric annulus, were solved by a finite difference implicit method. The Newtonian case was solved used for validation of the method and then compared to reported results. For the non-Newtonian case a pseudoplastic power-law model was assumed and the equations were transformed to obtain a pseudo-Newtonian system which enabled its solution using the same technique as that used for the Newtonian case. Comparison of the results for entrance length and pressure drop with those available in the literature showed a qualitative similarity, but significant quantitative differences. This can be attributed to the differences in entrance geometries and the definition of asymptotic entrance length.
A bilevel decomposition technique for the optimal planning of offshore platforms
Carvalho, M.C.A.;Pinto, J.M.;
Brazilian Journal of Chemical Engineering , 2006, DOI: 10.1590/S0104-66322006000100008
Abstract: there is a great incentive for developing systematic approaches that effectively identify strategies for planning oilfield complexes. this paper proposes an milp that relies on a reformulation of the model developed by tsarbopoulou (ucl m.s. dissertation, london, 2000). moreover, a bilevel decomposition technique is applied to the milp. a master problem determines the assignment of platforms to wells and a planning subproblem calculates the timing for fixed assignments. furthermore, a heuristic search procedure that relies on the distance between platforms and wells is applied in order to reduce the search region. results show that the decomposition approach using heuristic generates optimal solutions for instances of up to 500 wells and 25 platforms in 10 discrete time periods that otherwise could not be solved with a full-scale approach. one important feature regarding these instances is that they correspond to problems of real-world dimension.
Resistência e tolerancia a impacto transversal de baixa energia de um laminado híbrido metal/fibra
Gualberto, A.R.M.;Gatt, M.C.A.;Tarpani, J.R.;
Matéria (Rio de Janeiro) , 2009, DOI: 10.1590/S1517-70762009000200004
Abstract: the absorbed energy during the low-velocity transversal impact of hybrid metal/fiber glaretm laminate was determined by three different analytical methods. the first method employs a sophisticated laser-doppler apparatus that registers the acceleration and deceleration of the impact tup along the drop-weight test, whereas the second one is based only on the impact load-time history. the third method relies solely on the pre- and post-impact velocity of the striker. it has been concluded that the first two methodologies produce very similar results, with the material generally absorbing approximately 70% of the available energy, while the third methodology generated unduly non-conservative results. residual flexural properties of previously impact damaged laminate specimens showed that the modulus of elasticity is the most valuable parameter for structural integrity monitoring of the hybrid composite.
Local order structure of a-SiOxNy:H grown by PECVD
Scopel, W.L.;Fantini, M.C.A.;Alayo, M.I.;Pereyra, I.;
Brazilian Journal of Physics , 2002, DOI: 10.1590/S0103-97332002000200033
Abstract: in this work we study the structural properties of amorphous oxynitride films (a-sioxny), grown by plasma enhanced chemical vapour deposition (pecvd)at 320° c. the films were deposited at different ow ratio of n2o and sih4. the atomic composition of the samples was determined by means of rutherford backscattering spectrometry (rbs). the local order structure was studied by x-ray absorption spectroscopy (xas) and the chemical bondings were investigated by fourier transform infrared (ftir) spectroscopy. the results evidence a tetrahedric arrangement of the oxynitride network. the tetrahedrons are similiar to sio3n for x values between 1.43 and 1.64. for x values higher than 1.64 the tetrahedrons are similar to sio4.
Local order structure of a-SiOxNy:H grown by PECVD
Scopel W.L.,Fantini M.C.A.,Alayo M.I.,Pereyra I.
Brazilian Journal of Physics , 2002,
Abstract: In this work we study the structural properties of amorphous oxynitride films (a-SiOxNy), grown by plasma enhanced chemical vapour deposition (PECVD)at 320° C. The films were deposited at different ow ratio of N2O and SiH4. The atomic composition of the samples was determined by means of Rutherford backscattering spectrometry (RBS). The local order structure was studied by X-ray absorption spectroscopy (XAS) and the chemical bondings were investigated by Fourier transform infrared (FTIR) spectroscopy. The results evidence a tetrahedric arrangement of the oxynitride network. The tetrahedrons are similiar to SiO3N for x values between 1.43 and 1.64. For x values higher than 1.64 the tetrahedrons are similar to SiO4.
Potentiation of carbon tetrachloride hepatotoxicity by pentosan polysulfate in rats
Zim, M.C.A.;Silveira, T.R.;Schwartsmann, G.;Cerski, T.;Motta, A.;
Brazilian Journal of Medical and Biological Research , 2002, DOI: 10.1590/S0100-879X2002001100012
Abstract: few data are available in the literature regarding the effect of pentosan polysulfate (pps) on normal and fibrotic rat livers. in addition, the combination of pps and carbon tetrachloride (ccl4) has not been studied so far. the objective of this study was to assess the effect of pps on rat livers treated or not with ccl4 for the induction of liver fibrosis. the study consisted of four stages: 1) hepatic fibrosis induction with ccl4 (n = 36 rats); 2) evaluation of the effect of pps on ccl4-induced hepatic fibrosis (n = 36 rats); 3) evaluation of the effect of higher doses of pps in combination with ccl4 (n = 50 rats); 4) evaluation of the presence of an enzymatic inductor effect by pps (n = 18 rats) using the sodium pentobarbital test which indirectly evaluates hepatic microsomal enzyme activity in vivo. adult (60 to 70 days) male wistar rats weighing 180 to 220 g were used. all animals receiving 0.5 ml 8% ccl4 (n = 36) developed hepatic fibrosis, and after 8 weeks they also developed cirrhosis. no delay or prevention of hepatic fibrosis was observed with the administration of 5 mg/kg pps (n = 8) and 1 mg/kg pps (n = 8) 1 h after the administration of ccl4, but the increased hepatotoxicity resulting from the combination of the two substances caused massive hepatic necrosis in most rats (n = 45). pps (40 mg/kg) alone caused hepatic congestion only after 8 weeks, but massive hepatic necrosis was again observed in association with 0.5 ml ccl4 after 1 to 4 weeks of treatment. unexpectedly, sleeping time increased with time of pps administration (1, 2, or 3 weeks). this suggests that pps does not function as an activator of the hepatic microsomal enzymatic system. further studies are necessary in order to clarify the unexpected increase in hepatotoxicity caused by the combination of ccl4 and high doses of pps, which results in massive hepatic necrosis.
ASPECTOS DO DESENVOLVIMENTO IMUNOLóGICO DE LEIT?ES RECéM-NASCIDOS SUBMETIDOS A DIFERENTES DIETAS DE LEITE EM Pó
ESTEVES, M.C.A.;MACHADO NETO, R.;MYIADA, V.S.;
Scientia Agricola , 1996, DOI: 10.1590/S0103-90161996000200008
Abstract: eighty six piglets born from a crossbread landrace x large white sows were assigned to four treatments using a randomized block design (4 blocks/treatment). besides the control treatment (t4), two other treatments (t1 and t2) had powder milk incorporated to the rations (14.4% and 9.6% in the pre-initial phase and 9.6% and 4.8% in the initial phase). the fourth treatment (t3) did not have powder milk in the ration but diluted in water at 10%, only in the pre-initial phase. the pre-initial diet was used between 21 and 49 days of life and the initial in the period between 49 and 61 days of life. blood samples were collected for serum immunoglobulin (ig) determination at 1, 2, 10, 21, 28, 35 and 61 days of life. in the period 1 to 28 days the concentration of ig in t4 was superior (p < 0,05), compared to the other treatments, while in the period 28 to 61 days, no difference was detected. this result reflects the influence of ig acquisition from colostrum in this period. at day 21 the difference between t2 and t4 was significative. the lowest concentrations of ig ocurred between 28 and 35 days in treatments t1, t3 and t4, and between 21 and 28 days in treatment t2. this result suggests that lower levels of ig in the exogenous phase and catabolic phase of ig adquired from colostrum, determine an earlier beginning of antibodies synthesis.
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