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Search Results: 1 - 10 of 730633 matches for " M.A.;Souza "
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Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis
Moreira M.A.,Souza A.L.S.,Lana-Peixoto M.A.,Teixeira M.M.
Brazilian Journal of Medical and Biological Research , 2006,
Abstract: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system. Although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. Chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in inflammatory sites. They are divided into subfamilies on the basis of the location of conserved cysteine residues. We determined the levels of some CC and CXC chemokines in the cerebrospinal fluid (CSF) of 23 relapsing-remitting MS patients under interferon- -1a therapy and 16 control subjects using ELISA. MS patients were categorized as having active or stable disease. CXCL10 was significantly increased in the CSF of active MS patients (mean ± SEM, 369.5 ± 69.3 pg/mL) when compared with controls (178.5 ± 29.1 pg/mL, P < 0.05). CSF levels of CCL2 were significantly lower in active MS (144.7 ± 14.4 pg/mL) than in controls (237.1 ± 16.4 pg/mL, P < 0.01). There was no difference in the concentration of CCL2 and CXCL10 between patients with stable MS and controls. CCL5 was not detectable in the CSF of most patients or controls. The qualitative and quantitative differences of chemokines in CSF during relapses of MS suggest that they may be useful as a marker of disease activity and of the mechanisms involved in the pathogenesis of the disease.
Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis
Moreira, M.A.;Souza, A.L.S.;Lana-Peixoto, M.A.;Teixeira, M.M.;Teixeira, A.L.;
Brazilian Journal of Medical and Biological Research , 2006, DOI: 10.1590/S0100-879X2006000400003
Abstract: multiple sclerosis (ms) is a chronic inflammatory demyelinating disease of the human central nervous system. although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in inflammatory sites. they are divided into subfamilies on the basis of the location of conserved cysteine residues. we determined the levels of some cc and cxc chemokines in the cerebrospinal fluid (csf) of 23 relapsing-remitting ms patients under interferon-?-1a therapy and 16 control subjects using elisa. ms patients were categorized as having active or stable disease. cxcl10 was significantly increased in the csf of active ms patients (mean ± sem, 369.5 ± 69.3 pg/ml) when compared with controls (178.5 ± 29.1 pg/ml, p < 0.05). csf levels of ccl2 were significantly lower in active ms (144.7 ± 14.4 pg/ml) than in controls (237.1 ± 16.4 pg/ml, p < 0.01). there was no difference in the concentration of ccl2 and cxcl10 between patients with stable ms and controls. ccl5 was not detectable in the csf of most patients or controls. the qualitative and quantitative differences of chemokines in csf during relapses of ms suggest that they may be useful as a marker of disease activity and of the mechanisms involved in the pathogenesis of the disease.
The role of IL-12 in experimental Trypanosoma cruzi infection
Silva, J.S.;Aliberti, J.C.S.;Martins, G.A.;Souza, M.A.;Souto, J.T.;Pádua, M.A.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000100014
Abstract: host resistance to trypanosoma cruzi infection is dependent on both natural and acquired immune responses. during the early acute phase of infection in mice, natural killer (nk) cell-derived ifn-g is involved in controlling intracellular parasite replication, mainly through the induction of nitric oxide biosynthesis by activated macrophages. we have shown that il-12, a powerful inducer of ifn-g production by nk cells, is synthesized soon after trypomastigote-macrophage interaction. the role of il-12 in the control of t. cruzi infection in vivo was determined by treating infected mice with anti-il-12 monoclonal antibody (mab) and analyzing both parasitemia and mortality during the acute phase of infection. the anti-il-12 mab-treated mice had higher levels of parasitemia and mortality compared to control mice. also, treatment of infected mice with mab specific for ifn-g or tnf-a inhibited the protective effect of exogenous il-12. on the other hand, tgf-? and il-10 produced by infected macrophages inhibited the induction and effects of il-12. therefore, while il-12, tnf-a and ifn-g correlate with resistance to t. cruzi infection, tgf-? and il-10 promote susceptibility. these results provide support for a role of innate immunity in the control of t. cruzi infection. in addition to its protective role, il-12 may also be involved in the modulation of t. cruzi-induced myocarditis, since treatment of infected mice with il-12 or anti-il-12 mab leads to an enhanced or decreased inflammatory infiltrate in the heart, respectively. understanding the role of the cytokines produced during the acute phase of t. cruzi infection and their involvement in protection and pathogenesis would be essential to devise new vaccines or therapies.
Bancos de semillas en el suelo
De Souza Maia,M.; Maia,F.C.; Pérez,M.A.;
Agriscientia , 2006,
Abstract: in plant communities, the soil seed bank (ssb) represents their regenerative potential. the replacement of individuals from the seed bank may have profound effects on the composition and patterns of the vegetation within the community. many investigations about seed banks have been made within agricultural habitats or in natural communities. the attempt of this review about the seed banks in the soil is to analyze the concepts related to ssbs, their formation, the agricultural implications and how this information might be used for the conservation of the productive systems.
Bancos de semillas en el suelo Soil seed banks
M. De Souza Maia,F.C. Maia,M.A. Pérez
Agriscientia , 2006,
Abstract: En las comunidades vegetales, el banco de semillas en el suelo (BSS) constituye el potencial regenerativo. La reposición de los individuos a partir del BSS puede tener un efecto marcado en la composición y en los patrones de vegetación de la comunidad. Numerosas investigaciones se han llevado a cabo en bancos de semillas en hábitats agrícolas o en comunidades naturales. Esta revisión tiene como objetivo analizar los conceptos relacionados a BSS, los procesos de formación de éstos, las implicancias agrícolas y cómo esta información puede ser usada para la conservación de los sistemas productivos. In plant communities, the soil seed bank (SSB) represents their regenerative potential. The replacement of individuals from the seed bank may have profound effects on the composition and patterns of the vegetation within the community. Many investigations about seed banks have been made within agricultural habitats or in natural communities. The attempt of this review about the seed banks in the soil is to analyze the concepts related to SSBs, their formation, the agricultural implications and how this information might be used for the conservation of the productive systems.
Determination of Total Acid in Palygorskite Chemically Modified by N-Butylamine Thermodesorption
Ruiz, Juan A.C.;Melo, Dulce M.A.;Souza, José R.;Alcazar, Leopoldo O.;
Materials Research , 2002, DOI: 10.1590/S1516-14392002000200014
Abstract: the acid properties of palygorskite clay (r1) were studied using n-butylamine as probe molecule. a comparison was made of these properties in palygorskite clay (r1), in an acidified palygorskite (r2) and in acid palygorskite loaded with 2% of lanthanum (r3). the total acid properties were determined by ftir (fourier transform infrared) and tg-dta (thermogravimetry). the acidity increased as follows: r3>r2>r1. the acid strength sites were classified as physisorbed, weak, medium and strong. the acid treatment did not change the site distribution, apparently only removing channel impurities. the introduction of lanthanum created many more acid sites and increased the specific area. both weak and strong sites, which increased significantly, were considered new active acid sites produced by the lanthanum.
Recent updated aspects of colicins of Enterobacteriaceae
Cursino, Luciana;?marda, Jan;Chartone-Souza, Edmar;Nascimento, Andréa M.A.;
Brazilian Journal of Microbiology , 2002, DOI: 10.1590/S1517-83822002000300001
Abstract: the colicins are protein compounds produced by, and active against, escherichia coli and others members of enterobacteriaceae family. at least 34 different colicins have been described and found to share an interesting number of features. in the present review we focus on the major characteristics of colicins of gram-negative bacteria and explore their production and practical applications.the colicins are protein compounds produced by, and active against, escherichia coli and others members of enterobacteriaceae family. at least 34 different colicins have been described and found to share an interesting number of features. in the present review we focus on the major characteristics of colicins of gram-negative bacteria and explore their production and practical applications.
Determination of Total Acid in Palygorskite Chemically Modified by N-Butylamine Thermodesorption
Ruiz Juan A.C.,Melo Dulce M.A.,Souza José R.,Alcazar Leopoldo O.
Materials Research , 2002,
Abstract: The acid properties of palygorskite clay (R1) were studied using n-butylamine as probe molecule. A comparison was made of these properties in palygorskite clay (R1), in an acidified palygorskite (R2) and in acid palygorskite loaded with 2% of lanthanum (R3). The total acid properties were determined by FTIR (Fourier Transform Infrared) and TG-DTA (thermogravimetry). The acidity increased as follows: R3>R2>R1. The acid strength sites were classified as physisorbed, weak, medium and strong. The acid treatment did not change the site distribution, apparently only removing channel impurities. The introduction of lanthanum created many more acid sites and increased the specific area. Both weak and strong sites, which increased significantly, were considered new active acid sites produced by the lanthanum.
Recent updated aspects of colicins of Enterobacteriaceae
Cursino Luciana,?marda Jan,Chartone-Souza Edmar,Nascimento Andréa M.A.
Brazilian Journal of Microbiology , 2002,
Abstract: The colicins are protein compounds produced by, and active against, Escherichia coli and others members of Enterobacteriaceae family. At least 34 different colicins have been described and found to share an interesting number of features. In the present review we focus on the major characteristics of colicins of gram-negative bacteria and explore their production and practical applications.The colicins are protein compounds produced by, and active against, Escherichia coli and others members of Enterobacteriaceae family. At least 34 different colicins have been described and found to share an interesting number of features. In the present review we focus on the major characteristics of colicins of gram-negative bacteria and explore their production and practical applications.
Vivencias y significados del primer ba?o dado por la puérpera a su hijo recién nacido
Souza Carvalhêdo,D.; Monteiro Lotufo,F.; Rodrigues da Silva Barbosa,M.A.; Munhoz Gaíva,M.A.; Lisboa,S.R.;
Enfermería Global , 2010, DOI: 10.4321/S1695-61412010000200009
Abstract: trátase de un estudio descriptivo-exploratorio de abordaje cualitativo, realizado en el alojamiento conjunto de un hospital escuela de cuiaba-mt. tuvo como finalidad comprender las vivencias y los significados del primer ba?o dado por la puérpera a su hijo recién nacido, en alojamiento conjunto, bajo supervisión de la enfermera. la colecta de los datos fue realizada a través de la observación participante y entrevista. los resultados mostraron que deben implementarse nuevas prácticas relacionadas con la educación en salud para que las puérperas se sientan más seguras, respetadas en su singularidad y tengan mayor aprovechamiento en relación con los cuidados a su recién nacido.
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