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Search Results: 1 - 10 of 489368 matches for " M. F. Asaolu "
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Hormonal Imbalance in Polycystic Ovarian Syndrome (Pcos) in Teaching Hospitals in Ekiti State, Nigeria  [PDF]
O. G. Oyebanji, M. F. Asaolu, E. O. Amonimo
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.813147
Abstract: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women at reproductive age and the major cause of anovulatory infertility. The aim of this study is to determine hormonal imbalance in women with PCOS in teaching hospitals in Ekiti State, Nigeria. Samples of 110 females (50 freshly diagnosed PCOS subjects and 60 healthy subjects) between the ages of 25 - 45 years old were collected from Ekiti State University Teaching Hospital, Ado Ekiti and Federal Teaching Hospital, Ido Ekiti, Ekiti State, Nigeria. Serum Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Total Testosterone, Prolactin, Progesterone, Estradiol and Insulin were evaluated in subjects’ blood sample using Enzyme-Linked Immunosorbent assay (ELISA). Results obtained were subjected to statistical analysis (p < 0.05). The PCOS subjects showed significant increase (p < 0.05) in the concentrations of Total Testosterone, Insulin, LH, Estradiol and LH/FSH ratio, while FSH and progesterone concentrations showed significant decrease (p < 0.05) in comparison with the healthy control group. However, there was no significant difference in the concentration of Prolactin when compared with the healthy control group. Also, the PCOS subjects’ age at Menarche was significantly decreased (p < 0.05) while their age showed no significant difference (p > 0.05) when compared with the
Trace Metal Distribution in Nigerian Leafy Vegetables
S.S. Asaolu,M.F. Asaolu
Pakistan Journal of Nutrition , 2010,
Abstract: Trace metal distribution in some selected Nigeria leafy vegetables were determined. All the minerals investigated were found present in all the components of the selected vegetables. On the average, zinc was the most abundant metal with averages of 2.82, 1.97 and 2.08 (mg/g) in roots, stem and leaf of the vegetables, while lead was the leafy with averages of 0.07, 0.06 and 0.07 (mg/g), in roots, stems and leaves respectively. Trace metal distribution number (TMDN) indicates that the roots concentrate most of the metals than the stems and leaves.
Comparison of Phytochemicals and Anti-Nutritional Factors in Some Selected Wild and Edible Bean in Nigeria  [PDF]
Awoyinka O. A., Ileola A. O., Imeoria C. N., Tijani T. D., Oladele F. C., Asaolu M. F.
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.72012
Abstract: This work aims at analyzing the bioactive and anti-nutritional compounds of edible and wild beans when unprocessed and malted. Qualitative screening of phytochemicals in the various bean samples was determined in ethanol and petroleum ether solvents. Results of the anti-nutritional compositions of unprocessed wild bean extracted with petroleum ether showed there were no traces of saponin and polyphenol, in Feregede and also in edible bean-IT07K-243-1-10 which also had no traces of saponin and tannin. After malting, saponin was totally absent in Pakala, Mucuna, IT97k-499-35, IT07k-243-1-10, and IT04k-333-2 respectively. Polyphenol was also found to be absent in IT07k-243-1-10. Mucuna has the highest phytic acid level (7.8867 ± 0.011) while Feregede has the lowest phytic acid level (2.9810 ± 0.004). Otili has the highest anti-trypsin level (12.001 ± 0.0013). This study showed varying levels of anti-nutrients on the respective bean samples when unprocessed but decreased marginally after malting. It was keenly noted that values derived, either before and after malting were not significantly different (P ≤ 0.05) from each other. In all, this study had further shown that malting process enhanced removal of anti-nutrients which invariably would lead to availability of nutrient for animal and human consumption.
Interaction of Glucose/Sucrose Binding Lectin Isolated from Nigeria Wild Bean with E. coli and S. aureus  [PDF]
O. A. Awoyinka, J. O. Awe, O. A. Omosebi, O. Osukoya, F. C. Oladele, B. A. Olofinbiyi, M. F. Asaolu
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.812080
Lectin purified from wild underutilized local bean—Otili, Feregede, Pakalai was comparatively characterized and further evaluated for interaction with gastrointestinal bacteria—Esherichia coli and Staphylococcus aureus. The purified lectin in all the bean samples showed to be glucose and sucrose binding. The hemagglutinating activity, was non selective to type of blood group (A, B, AB and O). Anti-bacteria interaction with Escherichia coli showed clear zone of inhibition of about 1.5 ± 0.5 mm with lectin from Feregede and Otili while there was slight agglutination with lectin from Pakala. Staphylococcus aureus sensitivity to the lectin extracted from Otili with clear zone of inhibition of 2.0 ± 0.5 mm was also found in the control chloramphenicol. However there was pronounced agglutination with lectin from Feregede and Pakala with Staphylococcus auereus. This may be a clear indication that lectin from local underutilized wild bean understudy will agglutinate and interact with a gram positive bacteria more than gram negative bacteria.
Evaluation of in-vitro Antioxidant Activities of Methanol Extracts of Persea americana and Cnidosculus aconitifolius
M.F. Asaolu,S.S. Asaolu,J.B. Fakunle,B.O. Emman-Okon
Pakistan Journal of Nutrition , 2010,
Abstract: The present study was undertaken to investigate the antioxidant activities of Persea americana and Cnidosculous aconitifolius. The in-vitro antioxidant activity of the methanol extracts of the leaves of Persea americana and Cnidosculous aconitifolius was evaluated using various experimental methods such as 1,1-diphenyl-2-picryl-hydrazyl (DPPH), nitric oxide and reducing power radical- scavenging activity assay. Phytochemical screening as well as the amounts of total phenol and flavonoids were also determined. The present study revealed that both the methanol extracts of the leaves of Persea americana and Cnidosculous aconitifolius possess significant antioxidant activities. However, Persea americana was found to have higher radical scavenging activity than Cnidosculous aconitifolius but the phenol content of Cnidosculous aconitifolius was higher than that of Persea americana whereas Persea americana was observed to possess more flavonoids than Cnidosculous aconitifolius.
Chemical Compositions, Phytochemical Constituents and in vitro Biological Activity of Various Extracts of Cymbopogon citratus
M.F. Asaolu,O.A. Oyeyemi,J.O. Olanlokun
Pakistan Journal of Nutrition , 2009,
Abstract: Cymbopogon citratus was analyzed for its chemical constituents. Proximate analysis revealed that the sample contained moisture content: 5.76%; crude protein 4.56%, ash content: 20.00%, crude fat 5.10%, Carbohydrate 55.00% and crude fibre: 9:28. The food energy of the sample was 360.55 cal/100g. The phytochemical analysis of the ethanolic extracts of cymbopogon citratus indicates that it has alkaloids, saponins tannins, anthraquinones, steroids, phenols and flavonoids. Test for antibacterial activity using agar diffusion technique shows that antibacterial activity was active on S. typhi with Minimum Inhibitory Concentration (MIC) of 50 mg/ml but inactive on E. coli, L. monocytogenes and S. aureus.
Comparative Studies on Mineral and Scavenging Ability of Edible and Some Underexploited Wild Beans in Nigeria  [PDF]
O. A. Awoyinka, A. Ileola, C. N. Imeoria, M. F. Asaolu
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102318
Abstract: This work was set out to assay for some minerals essential for healthy state and biochemical indices that underlined degenerative diseases in some edible bean cultivar and nearly extinct local wild bean. Against this backdrop, ash composition was determined before Na , K , Ca2 , Mg2 , Zn2 , Fe2 , Pb2 and Cd were determined by Flame Photometer and Atomic Absorption Spectroscopy (AAS) respectively. 2,2-diphenyl-1-picrylhydrazyl (DPPH), Vitamin E and Vitamin C were also assayed to determine the scavenging ability of the bean samples. The proximate ash composition result of unprocessed and malted edible bean IT99K-573-2-1 had the highest ash content value of 6.90 ± 0.01 and 6.92 ± 0.01 respectively. In the bean samples Pb2 and Cd2 were not detected. The empirical mineral composition varies across both the wild and edible bean without significant difference (P ≤ 0.05) except IT07K-243-1-10 that had Ca2 to be significantly higher than other bean samples. K was found to be significantly higher in Feregede and IT07K-243-1-10 compared to other bean samples. Changes in the radical scavenging ability of the various sample in this study after malting, showed a slight reduction in DPPH content except for the edible beans—IT04K-333-2 and IT845-2246-4. Well, there was slight reduction of Vitamin E only in Otili, Mucuna and IT99K-573-1-1. Compared to others only Otili and IT845-2246-4 had slight reduction in Vitamin C after malting.
Evaluation of Oxidative Stress and Antioxidant Level of Stroke Patients in Osun State, South-Western Nigeria  [PDF]
I. Akinlua, M. F. Asaolu, O. C. Ojo, G. O. Oyebanji
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.75020
Abstract: Stroke is a leading cause of morbidity and mortality worldwide. Oxidative stress which is as a result of increased activity of free radicals and decreased antioxidant mechanism plays a major role in the pathogenesis of stroke. This study determined the plasma level of malondialdehyde (MDA), a marker of lipid peroxidation and oxidative stress and enzymatic Antioxidants namely, superoxide dismutase (SOD), Glutathione peroxidase (GPx), and Catalase (CAT) in sixty stroke patients of both sexes attending Wesley Guide Hospital, Obafemi Awolowo University Teaching Hospital, Ilesa, Osun State. An equal number of healthy subjects were used as control. The result of this study revealed a significantly (p < 0.05) high plasma level of MDA in stroke patients when compared with the control subjects. Plasma level of SOD in stroke patients was significantly higher (p < 0.05) than the control subjects while plasma GPx and CAT level were found to be significantly lower (p < 0.05) in stroke patients than the control subjects. The result of the study indicated high level of lipid peroxidation and oxidative stress in stroke patients and high degree of free radicals presence as indicated by the high level of SOD.
Functional Properties and Nutritional Quality of Some Wild and Edible Bean in Nigeria  [PDF]
O. A. Awoyinka, A. O. Ileola, C. N. Imeoria, S. T. Olumakinde, F. C. Oladele, M. F. Asaolu
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102411
Abstract: In this study on bean, four wild types were compared with the edible for their functional and nutritional characteristics in unprocessed and malted form. Results obtained in functional properties showed that bulk density was higher in wild types compared to edibles types. Feregede has the least dispersibility compared to all the bean samples. The swelling power of all the wild and edible types was almost the same with the edible bean IT845-2246-4 having the highest value of 26.15 ± 0.02. Pakala had the broadest foaming stability even up to the region of alkaline pH. In proximate compositions, the entire edible bean had more carbohydrate and crude fibre content than the wild types but after malting, there was no significant difference (P < 0.05) in the crude fibre content between the edible and the wild type beans. After malting, it was observed that Pakala and edible bean IT99K-573-1-1 had more moisture content with the values 9.2 ± 0.14 and 9 ± 0.15 respectively. There was no significant difference in the protein content across both the wild and edible bean and ranged between 28.45 ± 0.012 and 30.70 ± 0.014 while these values were slightly reduced after malting. This study reveals that Mucuna and other types of underutilized wild beans— Otili, Feregede, and Pakala are important food sources that can be exploited to mitigate shortage in animal protein and under nutrition facing families in many developing countries particularly in Nigeria.
Comparative Study on Nigerian Wild and Edible Beans in Reversing Incidence of Colon Cancer in Albino Rats  [PDF]
O. A. Awoyinka, A. Ileola, C. N. Imeoria, A. E. Omonisi, F. C. Oladele, M. F. Asaolu
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102708
This work is an investigation of the curative effects of some edible and wild type beans on colonic inflammation induced by Dextran Sulphate Sodium (DSS) in wister albino rats. Macroscopic examination performed on the colon after seven-day exposure of the animals to both DSS and bean sample revealed a high incidence of colonic inflammation in rats fed with macuna compared to other groups. However, from the histological examination, the groups fed with Otili and Feregede had a low incidence of dysplasia showing Otili and Feregede to be good candidates that could mitigate effect of Dextran Sodium Sulphate.
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