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Search Results: 1 - 10 of 527514 matches for " M. D. Servinsky "
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Differing Roles for Clostridium acetobutylicum’s Galactose Utilization Pathways  [PDF]
C. J. Sund, M. D. Servinsky, E. S. Gerlach
Advances in Microbiology (AiM) , 2013, DOI: 10.4236/aim.2013.36065
Abstract: There has been a surge of interest in acetone-butanol-ethanol fermentations of Clostridium acetobutylicum due to its capacity to ferment many carbohydrates found in biomass. This metabolic diversity makes it a promising candidate for conversion of inexpensive, heterogeneous carbohydrate feedstocks to biofuels. Galactose is present in many such feedstocks due to its incorporation in plant cell walls. C. acetobutylicum encodes two galactose utilization pathways, the Leloir (LP) and the tagatose-6-P (T6P), and a previous study indicated genes for these pathways was differentially regulated during growth on galactose and lactose. In the current study we utilized quantitative PCR to further investigate gene expression levels and to show both pathways which were subject to carbon catabolite repression. During growth on galactose, mRNA for galactose-6-P isomerase from the T6P was induced to a greater extent than mRNA for glactokinase, the first enzyme in the LP. The galactose-6-P isomerase mRNAs were also more abundant than galactokinase mRNAs during growth on galactose. Analysis of theoretical ATP requirements to generate essential precursor metabolites indicated: 1) the LP is more efficient at generating upper glycolytic intermediates, 2) the T6P is more efficient at forming ATP, lower glycolytic intermediates and TCA cycle intermediates, 3) a combination of the two pathways is most efficient for forming precursor metabolites found in the pentose phosphate pathway. From this it can be suggested that the two pathways have different roles in the organism with the T6P generating most ATP and precursor metabolites and the LP providing upper glycolytic metabolites.
CD36 and Fyn Kinase Mediate Malaria-Induced Lung Endothelial Barrier Dysfunction in Mice Infected with Plasmodium berghei
Ifeanyi U. Anidi, Laura E. Servinsky, Otgonchimeg Rentsendorj, R. Scott Stephens, Alan L. Scott, David B. Pearse
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071010
Abstract: Severe malaria can trigger acute lung injury characterized by pulmonary edema resulting from increased endothelial permeability. However, the mechanism through which lung fluid conductance is altered during malaria remains unclear. To define the role that the scavenger receptor CD36 may play in mediating this response, C57BL/6J (WT) and CD36?/? mice were infected with P. berghei ANKA and monitored for changes in pulmonary endothelial barrier function employing an isolated perfused lung system. WT lungs demonstrated a >10-fold increase in two measures of paracellular fluid conductance and a decrease in the albumin reflection coefficient (σalb) compared to control lungs indicating a loss of barrier function. In contrast, malaria-infected CD36?/? mice had near normal fluid conductance but a similar reduction in σalb. In WT mice, lung sequestered iRBCs demonstrated production of reactive oxygen species (ROS). To determine whether knockout of CD36 could protect against ROS-induced endothelial barrier dysfunction, mouse lung microvascular endothelial monolayers (MLMVEC) from WT and CD36?/? mice were exposed to H2O2. Unlike WT monolayers, which showed dose-dependent decreases in transendothelial electrical resistance (TER) from H2O2 indicating loss of barrier function, CD36?/? MLMVEC demonstrated dose-dependent increases in TER. The differences between responses in WT and CD36?/? endothelial cells correlated with important differences in the intracellular compartmentalization of the CD36-associated Fyn kinase. Malaria infection increased total lung Fyn levels in CD36?/? lungs compared to WT, but this increase was due to elevated production of the inactive form of Fyn further suggesting a dysregulation of Fyn-mediated signaling. The importance of Fyn in CD36-dependent endothelial signaling was confirmed using in vitro Fyn knockdown as well as Fyn?/? mice, which were also protected from H2O2- and malaria-induced lung endothelial leak, respectively. Our results demonstrate that CD36 and Fyn kinase are critical mediators of the increased lung endothelial fluid conductance caused by malaria infection.
A Form of Information Entropy  [PDF]
M. Divari, D. Vivona
Natural Science (NS) , 2014, DOI: 10.4236/ns.2014.617118
Abstract: In this paper, by axiomatic way, a form of information entropy will be presented on crisp and fuzzy setting. Information entropy is the unavailability of information about a crisp or fuzzy event. It will use measure of information defined without any probability or fuzzy measure: for this reason it is called general information.
Design of Efficient Router with Low Power and Low Latency for Network on Chip  [PDF]
M. Deivakani, D. Shanthi
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.74029
Abstract: The NoC consists of processing element (PE), network interface (NI) and router. This paper proposes a hybrid scheme for Netwok of Chip (NoC), which aims at obtaining low latency and low power consumption by concerning wired and wireless links between routers. The main objective of this paper is to reduce the latency and power consumption of the network on chip architecture using wireless link between routers. In this paper, the power consumption is reduced by designing a low power router and latency is reduced by implementing a on-chip wireless communication as express links for transferring data from one subnet routers to another subnet routers. The average packet latency and normalized power consumption of proposed hybrid NoC router are analyzed for synthetic traffic loads as shuffle traffic, bitcomp traffic, transpose traffic and bitrev traffic. The proposed hybrid NoC router reduces the normalized power over the wired NoC by 12.18% in consumer traffic, 12.80% in AutoIndust traffic and 12.5% in MPEG2 traffic. The performance is also analyzed with real time traffic environments using Network simulator 2 tool.
Spacetime Geometry and the Laws of Physics  [PDF]
D. M. Kalassa
Journal of Modern Physics (JMP) , 2017, DOI: 10.4236/jmp.2017.83022
Abstract: The Laws of Classical and Quantum Mechanics are well known. However, their origin remains mysterious and their interpretation controversial. It has been argued that this situation will continue until one manages to derive the Laws of Physics from some very first principles. In this paper, we use basic concepts of Differential Geometry to yield the Klein-Gordon equation and the Lagrange equations of Relativistic Mechanics without using the standard postulates of Quantum Mechanics, Special Relativity or even General Relativity.
A Brief Parametric Analysis of Catastrophic or Disastrous Hurricanes That Have Hit the Florida Keys between 1900 and 2000  [PDF]
J. M. D’Andrea
American Journal of Computational Mathematics (AJCM) , 2018, DOI: 10.4236/ajcm.2018.81001
Abstract: The most intense and catastrophic hurricanes on record to hit the Florida Keys during 1900 to 1950 were in 1919, and 1935. From 1950 to 2000, the most intense hurricanes to hit or affect the Florida Keys were in 1960, 1965, and 1992. In this paper, we will present a brief parametric analysis of the hurricanes that have hit the Florida Keys in the last 100 years. This analysis will include the descriptive statistics, best fit probability distribution of the latitude of the catastrophic hurricanes and a confidence interval that detects the average latitude of hurricanes (category 3 or higher) which have hit the Florida Keys in the last 100 years.
Crossover from Weak to Strong Nonlinear Disorder in the Viscoelasticity of Glucose Incubated Erythrocytes  [PDF]
A. M. Korol, B. D. Riquelme, M. D’Arrigo
Open Journal of Biophysics (OJBIPHY) , 2013, DOI: 10.4236/ojbiphy.2013.33022
Abstract:

Biomechanics is a wide interdisciplinary field, which includes all mechanical aspects from living organisms. As traditional erythrocytes viscoelastic analysis is mostly qualitative, the development of new quantitative methods capable of analyzing at the same time biological and mechanical aspects of the cells in flow, when changing from healthy controls to glucose incubated at different concentrations, is crucial for restricting the subjectivity in the study of the cell behaviour. On the other hand, it is important to appreciate the role of mathematics in the analysis of tissues and cells. Recent developed non linear mathematical methods are particularly fruitful when they are strongly correlated with cells sensitivity to initial conditions. An optic system called Erythrodeformeter has been developed and constructed in our laboratory, in order to evaluate the erythrocytes viscoelastic properties. To analyze the erythrocytes viscoelastic dynamics we used the technique of Time Delay Coordinates suggested by Takens, False Nearest Neighbours proposed by Abarbanel and co-workers, and the forecasting procedure proposed by Sugihara and May, the so called Correlation Coefficient. The results suggest that through this random walk analysis, apparent noise associated with deterministic chaos can be used not only to distinguish but also to characterize at the same time biological and mechanical aspects of the cells in flow, when changing from healthy controls to glucose incubated at different concentrations.


Utilizing simulation curriculum to decentralize mental health concepts  [PDF]
D. M. H. Michelle Beckford
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.32031
Abstract:

The International Society of Psychiatric Nurses as well as The American Psychiatric Nurses Association called for decentralization of psychiatric concepts in undergraduate nursing education. The author developed a series of simulation scenarios to address therapeutic communication and psychosocial needs in a variety of patient care settings. In terms of holistic care, psychological well-being is relevant to all realms of nursing practice. Mental health assessment and intervention need to be included in all areas of an undergraduate-nursing curriculum. The purpose of this project was to create a BSN curriculum that reflects the mental health needs of patients not only in acute care psychiatric facilities but also in medical-surgical disciplines, maternity units, and community settings. The curriculum is designed to also cover mental health throughout the lifespan-from infancy to end of life. A goal was to develop educational techniques, which translate into safe practice. A series of five simulations have been created with additional scenarios to be established in the following academic year. Topics include: alcohol withdrawal, end of life care, post-traumatic stress disorder, post-partum depression, serotonin syndrome, benzodiazepine over dose, elder abuse, depression in military veterans, and geriatric depression. All incorporate QSEN competencies [1]. The overall learning objectives are for undergraduate nursing students to initiate and implement an appropriate mental status assessment using therapeutic communication, and also to provide safe care by identifying risk factors and using clinical decision making to establish requisite nursing interventions. The methodology included relevant documentation through the use of appropriate assessment tools. Learning objectives were assessed through pre-simulation and post-simulation ten-question inventory and anecdotal feedback. QSEN competencies were utilized in creating scenarios as well as pre and post testing. Students voiced an ability to connect the didactic material to their clinical experiences following simulation.

Investigation of Natural Convection Heat Transfer Coefficient on Extended Vertical Base Plates  [PDF]
M. Fahiminia, M. M. Naserian, H. R. Goshayeshi, D. Majidian
Energy and Power Engineering (EPE) , 2011, DOI: 10.4236/epe.2011.32022
Abstract: In this research, Computational analysis of the laminar natural convection on vertical surfaces has been in-vestigated. Natural convection is observed when density gradients are present in a fluid acted upon by a gravitational field. Our example of this phenomenon is the heated vertical plate exposed to air, which, far from the plate, is motionless. The CFD simulations are carried out using fluent software. Governing equa-tions are solved using a finite volume approach. Coupling between the velocity and pressure is made with SIMPLE algorithm. The resultant system of discretized linear algebraic equations is solved with an alternat-ing direction implicit scheme. Then a configuration of rectangular fins is put in different ways on the surface and natural convection heat transfer coefficient on these no slope surfaces is studied and finally optimization is done.
Energy Aware Clustered Based Multipath Routing in Mobile Ad Hoc Networks  [PDF]
M. BHEEMALINGAIAH, M. M. NAIDU, D. Sreenivasa RAO
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2009, DOI: 10.4236/ijcns.2009.22014
Abstract: With the advance of wireless communication technologies, small-size and high-performance computing and communication devices are increasingly used in daily life. After the success of second generation mobile system, more interest was started in wireless communications. A Mobile Ad hoc Network (MANET) is a wireless network without any fixed infrastructure or centralized control; it contains mobile nodes that are connected dynamically in an arbitrary manner. The Mobile Ad hoc Networks are essentially suitable when infrastructure is not present or difficult or costly to setup or when network setup is to be done quickly within a short period, they are very attractive for tactical communication in the military and rescue missions. They are also expected to play an important role in the civilian for as convention centers, conferences, and elec-tronic classrooms. The clustering is an important research area in mobile ad hoc networks because it im-proves the performance of flexibility and scalability when network size is huge with high mobility. All mo-bile nodes operate on battery power; hence, the power consumption becomes an important issue in Mobile Ad hoc Network. In this article we proposed an Energy Aware Clustered-Based Multipath Routing (EACMR), which forms several clusters, finds energy aware node-disjoint multiple routes from a source to destination and increases the network life time by using optimal routes.
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