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Search Results: 1 - 10 of 720655 matches for " M. A.;ROCHA "
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Snai-1 and Epithelial-Mesenchymal Transition-Related Protein Immunoexpression in Canine Mammary Carcinomas  [PDF]
Breno S. Salgado, Rafael M. Rocha, Fernando A. Soares, Fátima G?rtner, Noeme S. Rocha
Advances in Breast Cancer Research (ABCR) , 2014, DOI: 10.4236/abcr.2014.34017
Abstract: Epithelial-mesenchymal transition (EMT) is defined as switching of polarized epithelial cells to a migratory fibroblastoid phenotype. EMT is known to be involved in the progression and metastasis of various cancers in humans, but this specific process is still little explored in the veterinary literature. The aim of this research was to evaluate the expression of EMT-related proteins in canine mammary carcinomas (CMCs). The expression of six EMT-related proteins in 94 CMCs of female dogs was evaluated by immunohistochemistry using a tissue array method. Additionally, clinicopathological characteristics were compared with the expression of EMT-related proteins. Loss of epithelial protein and/or acquisition of the expression of mesenchymal proteins were observed in CMCs. Loss of epithelial protein and/or acquisition of the expression of mesenchymal proteins were observed, particularly in tumors with evidence of stromal invasion; however, significance was only observed between the S100A4 and vascular invasion. In addition, Snai-1 nuclear immunoexpression was significantly related to E-cadherin loss. In conclusion, loss of epithelial proteins and/or the acquisition of mesenchymal proteins are associated with EMT and may have an important role in the evaluation of CMC patients. The unique immunoexpression pattern of Snai-1 could help to distinguish between an adenoma and a non-metastatic carcinoma and seems to be related to conversion of myoepithelial cells to a complete mesenchymal-like phenotype. Loss of E-cadherin and cytokeratin and change of immunoexpression pattern of Snai-1, N-cadherin, S100A4 and MMP-2 indicate the occurrence of EMT in canine mammary carcinomas and should result in an en bloc resection or a close follow-up.
Hospitaliza??o: efeito sobre o estado nutricional em crian?as
Rocha, Geila A.;Rocha, Edmundo J. M.;Martins, Ceci V.;
Jornal de Pediatria , 2006, DOI: 10.2223/JPED.1440
Abstract: objective: to evaluate the nutritional status of children at hospital admission and again at hospital discharge and to investigate factors associated with the onset and/or exacerbation of malnutrition. method: an observational study of 203 children under 5 years old admitted to a hospital in the city of fortaleza between august and december 2003. nutritional status, expressed in z-scores for weight/age, stature/age and weight/stature, was compared at the time of admission and on hospital discharge and broken down by sex, age, condition responsible for hospitalization and length of hospital stay. results: on admission prevalence rates for moderate and/or severe malnutrition (z-score < -2) were 18.7, 18.2 and 6.9%, for weight/age, stature/age and weight/stature, respectively. during their stay in hospital 51.6% of the 186 children who completed the study lost weight, with most weight being lost by those with prolonged hospital stays and pneumonia as the disease responsible for their hospitalization. children who had malnutrition on admission were still malnourished at hospital discharge and 10 (9.17%) well-nourished children developed mild malnutrition while hospitalized. conclusions: the prevalence of malnutrition at the time of admission was elevated and remained unchanged by discharge. prolonged hospitalization and pneumonia were linked with weight loss in hospital.
Hospitaliza o: efeito sobre o estado nutricional em crian as
Rocha Geila A.,Rocha Edmundo J. M.,Martins Ceci V.
Jornal de Pediatria , 2006,
Abstract: OBJETIVO: Avaliar o estado nutricional de crian as, por ocasi o da admiss o e da alta hospitalar, e fatores associados com o aparecimento e/ou agravamento da desnutri o MéTODO: Estudo observacional de 203 crian as, menores de 5 anos de idade, internadas em um hospital na cidade de Fortaleza, entre agosto e dezembro de 2003. Comparou-se o estado nutricional, expresso em escore z, dos índices peso/idade, estatura/idade e peso/estatura no momento da admiss o e da alta hospitalar, de acordo com sexo, idade, doen a que motivou a interna o e tempo de permanência no hospital. RESULTADOS: Na admiss o, as prevalências de desnutri o moderada e/ou grave (< -2 z escore) foram 18,7, 18,2 e 6,9%, para os índices peso/idade, estatura/idade e peso/estatura, respectivamente. Das 186 crian as que completaram o estudo, 51,6% apresentaram perda ponderal, em especial as que tiveram interna o prolongada e pneumonia como doen a determinante da interna o. Na alta hospitalar, as crian as com desnutri o permaneceram com seu estado nutricional inalterado, e 10 (9,17%) eutróficas evoluíram para desnutri o leve. CONCLUS ES: A prevalência de desnutri o à admiss o foi elevada, permanecendo inalterada por ocasi o da alta. Hospitaliza o prolongada e pneumonia associaram-se à perda de peso durante a interna o.
Is angiography still the best method to stratify stroke risk in symptomatic atherosclerotic carotid plaque?  [PDF]
Gustavo W. Kuster, A. J. Da Rocha, A. S. F. Silva, R. A. Valiente, M. S. G. Rocha, A. R. Massaro
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.28124
Abstract: The degree of vessel lumen narrowing is an independent predictor of ischemic stroke. New developments in carotid plaque morphology imaging (MR, CT), may bring new insights to the relationship between carotid atherosclerotic disease and stroke risk. Our aim is to review the stroke risk in a symptomatic patient with moderate carotid stenosis by CT imaging and histopathology. A 72-year-old patient with low ABCD2 scores TIA and moderate left internal carotid stenosis (50% by carotid ultrasound), was discharged with an optimized medical therapy. Four months later, he presented an ischemic stroke in the left frontal area. Carotid angiography showed a 60% stenosis in the left-internal carotid artery with a regular surface. CT plaque imaging detected a thin fibrous cap with calcification and an intraplaque hemorrhage (high-risk plaque). These findings were confirmed in the histolopathological study of the atherosclerotic plaque performed after the endarterectomy. After 1 year of follow-up, the patient returned independently to his daily activities. We propose, in this study, the inclusion of noninvasive plaque imaging in the evaluation of acute TIA with moderate carotid stenosis to better select patients with higher risk of stroke recurrence.
Charged Gravastar in a Dark Energy Universe  [PDF]
C. F. C. Brandt, R. Chan, M. F. A. da Silva, P. Rocha
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.46118
Abstract:

Here we constructed a charged gravastar model formed by an interior de Sitter spacetime, a charged dynamical infinitely thin shell with an equation of state and an exterior de Sitter-Reissner-Nordstrom spacetime. We find that the presence of the charge is crucial to the stability of these structures. It can as much favor the stability of a bounded excursion gravastar, and still converting it in a stable gravastar, as make disappear a stable gravastar, depending on the range of the charge considered. There is also formation of black holes and, above certain values, the presence of the charge allows the formation of naked singularity. This is an important example in which a naked singularity emerges as a consequence of unstabilities of a gravastar model, which reinforces that gravastar is not an alternative model to black hole.

McArdle disease: a case report and review
Leite A, Oliveira N, Rocha M
International Medical Case Reports Journal , 2012, DOI: http://dx.doi.org/10.2147/IMCRJ.S28664
Abstract: Ardle disease: a case report and review Case report (2074) Total Article Views Authors: Leite A, Oliveira N, Rocha M Published Date January 2012 Volume 2012:5 Pages 1 - 4 DOI: http://dx.doi.org/10.2147/IMCRJ.S28664 Received: 29 November 2011 Accepted: 12 December 2011 Published: 20 January 2012 Alberto Leite, Narciso Oliveira, Manuela Rocha Internal Medicine Department, Hospital de Braga, Portugal Abstract: McArdle disease (glycogen storage disease type V) is a pure myopathy caused by an inherited deficit of myophosphorylase. The disease exhibits clinical heterogeneity, but patients typically experience exercise intolerance, acute crises of early fatigue, and contractures, sometimes with rhabdomyolysis and myoglobinuria, triggered by static muscle contractions or dynamic exercise. We present the case of a 54-year-old man with a lifelong history of fatigability, worsening on exertion. Laboratory evaluation revealed significant elevations in levels of creatine kinase (7924 U/L), lactate dehydrogenase (624 U/L), and myoglobulin (671 ng/mL). A muscle biopsy confirmed the presence of McArdle disease. This case report illustrates how, due to embarrassment, the patient hid his symptoms for many years and was eventually extremely relieved and “liberated” once McArdle disease was diagnosed 40 years later.
McArdle disease: a case report and review
Leite A,Oliveira N,Rocha M
International Medical Case Reports Journal , 2012,
Abstract: Alberto Leite, Narciso Oliveira, Manuela RochaInternal Medicine Department, Hospital de Braga, PortugalAbstract: McArdle disease (glycogen storage disease type V) is a pure myopathy caused by an inherited deficit of myophosphorylase. The disease exhibits clinical heterogeneity, but patients typically experience exercise intolerance, acute crises of early fatigue, and contractures, sometimes with rhabdomyolysis and myoglobinuria, triggered by static muscle contractions or dynamic exercise. We present the case of a 54-year-old man with a lifelong history of fatigability, worsening on exertion. Laboratory evaluation revealed significant elevations in levels of creatine kinase (7924 U/L), lactate dehydrogenase (624 U/L), and myoglobulin (671 ng/mL). A muscle biopsy confirmed the presence of McArdle disease. This case report illustrates how, due to embarrassment, the patient hid his symptoms for many years and was eventually extremely relieved and “liberated” once McArdle disease was diagnosed 40 years later.Keywords: McArdle disease, glycogen storage disease, myophosphorylase
CHIRAL BACKGROUND FOR THE TWO PION EXCHANGE NUCLEAR POTENTIAL: A PARAMETRIZED VERSION
C. A. da Rocha,M. R. Robilotta
Physics , 1995, DOI: 10.1103/PhysRevC.52.531
Abstract: We argue that the minimal chiral background for the two-pion exchange nucleon-nucleon interaction has nowadays a rather firm conceptual basis, which entitles it to become a standard ingredient of any modern potential. In order to facilitate applications, we present a parametrized version of a configuration space potential derived previously. We then use it to assess the phenomenological contents of some existing NN potentials.
Scalar-isoscalar mesons in pion production at threshold
Claudio M. Maekawa,Carlos A. da Rocha
Physics , 1999,
Abstract: We present the contributions of the non-linear chiral scalar field S to cross sections of $pp\to d\pi ^{+}, pp\to pn\pi ^{+}$ and $pp\to pp\pi ^0$ reactions at threshold. We compare our results with the meson $\sigma$ contribution from the $\sigma$-linear model. We show that the chiral scalar field S is almost 5 times bigger than the other contributions, which indicates that the two-pion exchange dynamics embebbed in the S field is the most important term for the pion production at threshold.
Generalized non-associative structures on the 7-sphere
Roldao da Rocha,M. A. Traesel
Mathematics , 2011, DOI: 10.1088/1742-6596/343/1/012026
Abstract: In this paper we provide a more general class of non-associative products using the exterior and Clifford bundles on the 7-sphere. Some additional properties encompass previous formalisms in the Clifford algebra context, and wider classes of non-associative structures on the 7-sphere are investigated, evinced by the directional non-associative products and the mixed composition of generalized non-associative products between Clifford algebra multivectors. These non-associative products are further generalized by considering the non-associative shear of arbitrary Clifford bundle Cl(0,7) elements into octonions. We assert new properties inherited from the non-associative structure introduced in the whole Clifford bundle on S7, which naturally induce involutions on the Clifford bundle and provide immediate generalizations concerning well-established formal results and potential applications in physics.
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