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Search Results: 1 - 10 of 403448 matches for " Mónica Betanzos "
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Identification of a biomarker panel for colorectal cancer diagnosis
Amaia García-Bilbao, Rubén Arma?anzas, Ziortza Ispizua, Bego?a Calvo, Ana Alonso-Varona, I?aki Inza, Pedro Larra?aga, Guillermo López-Vivanco, Blanca Suárez-Merino, Mónica Betanzos
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-43
Abstract: A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples. The study was carried out by hybridisation of the tumour samples against a reference pool of non-tumoral samples using Agilent Human 1A 60-mer oligo microarrays. The results obtained were validated by qRT-PCR. In the subsequent bioinformatics analysis, gene networks by means of Bayesian classifiers, variable selection and bootstrap resampling were built. The consensus among all the induced models produced a hierarchy of dependences and, thus, of variables.After an exhaustive process of pre-processing to ensure data quality--lost values imputation, probes quality, data smoothing and intraclass variability filtering--the final dataset comprised a total of 8, 104 probes. Next, a supervised classification approach and data analysis was carried out to obtain the most relevant genes. Two of them are directly involved in cancer progression and in particular in colorectal cancer. Finally, a supervised classifier was induced to classify new unseen samples.We have developed a tentative model for the diagnosis of colorectal cancer based on a biomarker panel. Our results indicate that the gene profile described herein can discriminate between non-cancerous and cancerous samples with 94.45% accuracy using different supervised classifiers (AUC values in the range of 0.997 and 0.955).Colorectal cancer (CRC), is the third most common form of cancer and the second leading cause of death among cancers worldwide, with approximately 1, 000, 000 new cases of CRC and 50, 000 deaths related to CRC each year [1,2]. Sporadic colon cancer represents the 70% of newly diagnosed cases, and it is believed to slowly develop via a progressive accumulation of multiple mutations that affect tumour suppressor genes, as well as oncogenes or mismatch repair genes (MMR) [3].Statistics concerning colon cancer survival show differen
La malaria en México. Progresos y desafíos hacia su eliminación
Betanzos Reyes, ángel Francisco;
Boletín médico del Hospital Infantil de México , 2011,
Abstract: malaria continues to be a leading parasite disease in the tropics and subtropics including latin america. in this region, most cases of malaria are due to plasmodium vivax, however, cases of plasmodium falciparum continue to lead to cases of severe malaria in many countries in south america. control and elimination of malaria in latin america has been focused on the key steps of the parasite life cycle and transmission mechanism including vector control, decreasing the number of parasites during treatment and human reservoirs with intermittent preventive therapy with antimalarial drugs. in this effort, mexico has collaborated with many countries in central america towards the potential elimination of this parasitic infection. in this review, we discuss the achievements and remaining challenges in controlling and potentially eliminating malaria in mexico.
Facts and Perceptions Regarding Software Measurement in Education and in Practice: Preliminary Results  [PDF]
Mónica Villavicencio, Alain Abran
Journal of Software Engineering and Applications (JSEA) , 2011, DOI: 10.4236/jsea.2011.44025
Abstract: How is software measurement addressed in undergraduate and graduate programs in universities? Do organizations consider that the graduating students they hire have an adequate knowledge of software measurement? To answer these and related questions, a survey was administered to participants who attended the IWSM-MENSURA 2010 conference in Stuttgart, Germany. Forty-seven of the 69 conference participants (including software development practitioners, software measurement consultants, university professors, and graduate students) took part in the survey. The results indicate that software measurement topics are: 1) covered mostly at the graduate level and not at the undergraduate level, and 2) not mandatory. Graduate students and professors consider that, of the measurement topics covered in university curricula, specific topics, such as measures for the requirements phase, and measurement techniques and tools, receive more attention in the academic context. A common observation of the practitioners who participated in the survey was that students hired as new employees bring limited software measurement-related knowledge to their organizations. Discussion of the findings and directions for future research are presented.
Relevance of Epistemological Pluralism for Resource Management Policies  [PDF]
Mónica Gómez Salazar
Open Journal of Philosophy (OJPP) , 2015, DOI: 10.4236/ojpp.2015.56039
Abstract: The common believe of a single successful form of knowing the reality is misleading. A brief analysis of many human activities reveals a pluralistic perspective of several coexisting conceptual schemes that underlie the form in which women and men know and constitute the world in which we live. Here, I will discuss the necessity of taking seriously this pluralistic perspective when developing conceptual frameworks of human activities. As an example of great interest and importance, I will consider the case of resource management that has to contemplate the conservation and the response of ecosystems to human activities that may lead to irreversible damage. Ecosystems’ activity occurs over a wide range of space and time scales and, hence, policies and proposals of solutions to ecological problems should avoid narrow and monochromatic approaches. Specifically, the Pemon perspective of fire is a good example to show that for more robust and flexible resource management we need the knowledge and experience of different cultural and disciplinary groups.
Factors affecting luminescence and aurophilicity on digold(I) complexes and their potential as cation probes
M Cristina Lagunas,Claudio Mendicute Fierro,Aranzazu Pintado-Alba,Héctor de la Riva,Soledad Betanzos-Lara
Gold Bulletin , 2007, DOI: 10.1007/BF03215570
Abstract: In the last few years we have analysed the factors that affect the structures and luminescence properties of Au(I) compounds, specifically in relation with the presence of aurophilic contacts and their application as cation probes. EXAFS studies have allowed us to obtain for the first time direct structural data of dissolved Au(I) compounds. An overview of the work reported to date is presented here. The optical properties of complex [Au2Cl2(μ-dpephos)] (dpephos =bis(2-diphenylphosphino) phenylether, 1) have been revisited and new results are now included. New aspects on the use of the complexes as Ag(I) probes are also discussed.
A Matching Model on the Use of Immigrant Social Networks and Referral Hiring  [PDF]
Mónica García-Pérez
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.24070
Abstract: Using a simple search model, with urn-ball derived matching function, this paper investigates the effect of firm owner’s and coworkers’ nativity on hiring patterns and wages. In the model, social networks reduce search frictions and wages are derived endogenously as a function of the efficiency of the social ties of current employees. As a result, individuals with more efficient connections tend to receive higher wages and lower unemployment rate. However, because this efficiency depends on matching with same-type owners and coworkers, there is also a differential effect among workers’ wages in the same firm. This analysis highlights the potential importance of social connections and social capital for understanding employment opportunities and wage differentials between these groups.
Assessing spatial genetic structure from molecular marker data via principal component analyses: A case study in a Prosopis sp. forest  [PDF]
Ingrid Teich, Aníbal Verga, Mónica Balzarini
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.52013
Abstract:

Advances in genotyping technology, such as molecular markers, have noticeably improved our capacity to characterize genomes at multiple loci. Concomitantly, the methodological framework to analyze genetic data has expanded, and keeping abreast with the latest statistical developments to analyze molecular marker data in the context of spatial genetics has become a difficult task. Most methods in spatial statistics are devoted to univariate data whereas the nature of molecular marker data is highly dimensional. Multivariate methods are aimed at finding proximities between entities characterized by multiple variables by summarizing information in few synthetic variables. In particular, Principal Component analysis (PCA) has been used to study genetic structure of geo-referenced allele frequency profiles, incorporating spatial information with a posteriori analysis. Conversely, the recently developed spatially restricted PCA (sPCA) explicitly includes spatial data in the optimization criterion. In this work, we compared the results of the application of PCA and sPCA in the study of the spatial genetic structure at fine scale of a Prosopis flexuosa and P. chilensis hybrid swarm. Data consisted in the genetic characterization of 87 trees sampled in Córdoba, Argentina and genotyped at six microsatellites, which yielded 72 alleles. As expected, principal components explained more variance than sPCA components, but were less spatially autocorrelated. The maps obtained by the interpolation of sPC1 values allowed a better visualization of a patchy spatial pattern of genetic variability than the PC1 synthetic map. We also proposed a PC-sPC scatter plot of allele loadings to better understand the allele contributions to spatial genetic variability.

Recognition in the Communication Processes of Diverse Young the Experience of Living in a Park in the City of Cali  [PDF]
Mónica Marión Cata?o
Advances in Journalism and Communication (AJC) , 2015, DOI: 10.4236/ajc.2015.31004
Abstract: Artisan Park La Loma de la Cruz, is a park located in a suburb of the city of Cali, a place where different groups converge youth from youth cultures. The park is a place for meeting, socializing, communication practices through which young people interact and build relationships. The park is set up as a stage of “coexistence” in which rockers, punks, emos, skaters and members of the LGBTI community stay together and share the same dwelling place (Figure 1). In the worlds of life of these young people, the words in different languages are a part of his being and his feelings, hence the affectations of joy and sadness, as defined by Spinoza (1980)1, are a way of weaving links and establish relationships communication. It is also possible to identify forms of recognition, Honneth’s way, recognition of love and solidarity2. These forms of recognition collide when young people, relate to the adult world, in the park, are made by artisans, police and neighbors. From the adult world, the form of contempt is evident in the rejection of the young by their expressions, especially those with expressing his affectations manifest. If young people recognize the existence of other people, as well as their own differences in the way they think, if they recognize the action in their own inter-subjective relationships and in the same way they construct a “we”, we would be spectators of new ways of being together; of ethical and political linking which go through new ways of living together and in which the sense and the shared meaning of life are negotiated that show a way of understanding in communication.
Co-infec??o HIV/tuberculose: necessidade de uma vigilancia mais efetiva
Lima,Mnica M.;
Revista de Saúde Pública , 1997, DOI: 10.1590/S0034-89101997000300001
Abstract: the increasing endemicity of tuberculosis resulting from causes such as immigration, poverty, a declining public health infrastructure and co-infection by hiv/mycobacterium tuberculosis, is leading to a change in tuberculosis control programmes. one of the main reasons for the resurgence of tuberculosis is hiv infection - the risk of tuberculosis is greater in hiv patients than in the majority of the population as can be seen from numerous research projects. the need for systematic testing for hiv infection in all tuberculosis patients by undertaking confidential hiv tests on admission to a tuberculosis programme is brought out. this measure would increase the number of cases diagnosed and provide data for better surveillance of the co-infection.
Entanglements of right whales, Eubalaena australis (Cetacea, Mysticeti), in the 2010 breeding season in Santa Catarina state, Brazil
Mnica Pontalti,Mnica Danielski
Biotemas , 2011,
Abstract: Right whales (Eubalaena australis) have been suffering with anthropogenic activities such as pollution, marine traffic and entanglement in fishing nets. The entanglement of right whales grows each breeding season on the southern coast of Santa Catarina state, and can cause strands and even death. During the 2010 breeding season, six entanglements among immature and adult whales were recorded. In most of the cases, the whales kept swimming slowly and didn’t want to approximate the whale watching boat. Fishing activities in the area during the right whale breeding season need to be regularized to avoid conflicts and injuries to the whales.
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