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Search Results: 1 - 10 of 402164 matches for " M ángeles Figueredo "
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Evidence for the association of the SLC22A4 and SLC22A5 genes with Type 1 Diabetes: a case control study
Jose Santiago, Alfonso Martínez, Hermenegildo de la Calle, Miguel Fernández-Arquero, M ángeles Figueredo, Emilio G de la Concha, Elena Urcelay
BMC Medical Genetics , 2006, DOI: 10.1186/1471-2350-7-54
Abstract: A case-control study was performed in the Spanish population with 295 T1D patients and 508 healthy control subjects. Maximum-likelihood haplotype frequencies were estimated by applying the Expectation-Maximization (EM) algorithm implemented by the Arlequin software.When independently analyzed, one of the tested polymorphisms in the SLC22A4 gene at 1672 showed significant association with T1D in our Spanish cohort. The overall comparison of the inferred haplotypes was significantly different between patients and controls (χ2 = 10.43; p = 0.034) with one of the haplotypes showing a protective effect for T1D (rs3792876/rs1050152/rs2631367/rs274559, CCGA: OR = 0.62 (0.41–0.93); p = 0.02).The haplotype distribution in the carnitine transporter locus seems to be significantly different between T1D patients and controls; however, additional studies in independent populations would allow to confirm the role of these genes in T1D risk.Type 1 diabetes (T1D) is a multifactorial autoimmune T-cell-mediated disease resulting from selective destruction of the insulin producing β cells in the pancreatic islets, leading to an absolute insulin deficiency. The risk of developing T1D is determined by a complex interaction between multiple genetic and environmental factors. Although susceptibility to disease is strongly associated with alleles in the major histocompatibility complex (MHC) [1,2], there are more than 20 putative T1D susceptibility regions identified by linkage and association studies [3,4]. At present, several non-MHC susceptibility loci with modest genetic effects have been clearly defined. However, it is well known that many non-MHC loci predisposing to T1D remain as yet undefined [5].Type 1 diabetes is a chronic degenerative disease, with altered metabolism characterized by hyperglycemia and ketoacidosis and T1D patients depend on exogenous insulin to sustain life. The role of the carnitine system in cell metabolism is mainly known in the mitochondria, where the intera
Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population
Jose Santiago, Alfonso Martínez, Hermenegildo de la Calle, Miguel Fernández-Arquero, M ángeles Figueredo, Emilio G de la Concha, Elena Urcelay
BMC Medical Genetics , 2007, DOI: 10.1186/1471-2350-8-54
Abstract: A case-control was performed with 316 Spanish white T1D patients consecutively recruited and 554 healthy controls, all of them from the Madrid area. The PTPN22 C1858T SNP was genotyped in both patients and controls using a TaqMan Assay in a 7900 HT Fast Real-Time PCR System.We replicated for the first time in a Spanish population the association of the 1858T allele with an increased risk for developing T1D [carriers of allele T vs. CC: OR (95%) = 1.73 (1.17–2.54); p = 0.004]. Furthermore, this allele showed a significant association in female patients with diabetes onset before age 16 years [carriers of allele T vs. CC: OR (95%) = 2.95 (1.45–6.01), female patients vs female controls p = 0.0009]. No other association in specific subgroups stratified for gender, HLA susceptibility or age at onset were observed.Our results provide evidence that the PTPN22 1858T allele is a T1D susceptibility factor also in the Spanish population and it might play a different role in susceptibility to T1D according to gender in early-onset T1D patients.Type 1 diabetes (T1D) is an autoimmune disorder resulting from destruction of the insulin-producing β cells of the pancreas. T1D is a complex trait with both genetic and environmental factors contributing to the etiology of this disease. Several susceptibility loci involved in disease development have been identified and were consistently replicated in independent populations [1]. These efforts contribute to a better definition of the molecular pathways leading to increased T1D risk and this knowledge, in turn, may help in understanding the genetic basis of the disease. The MHC class II, the CTLA4 and the PTPN22 loci have all been proved important in the pathogenesis of autoimmunity globally considered, whereas the insulin gene is a disease-specific T1D predisposition locus. Most of the new general susceptibility loci identified in the past few years have a clear role in the modulation of T cell development and activation, indicating that
Th17-Related Genes and Celiac Disease Susceptibility
Luz María Medrano, Manuel García-Magari?os, Bárbara Dema, Laura Espino, Carlos Maluenda, Isabel Polanco, M. ángeles Figueredo, Miguel Fernández-Arquero, Concepción Nú?ez
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031244
Abstract: Th17 cells are known to be involved in several autoimmune or inflammatory diseases. In celiac disease (CD), recent studies suggest an implication of those cells in disease pathogenesis. We aimed at studying the role of genes relevant for the Th17 immune response in CD susceptibility. A total of 101 single nucleotide polymorphisms (SNPs), mainly selected to cover most of the variability present in 16 Th17-related genes (IL23R, RORC, IL6R, IL17A, IL17F, CCR6, IL6, JAK2, TNFSF15, IL23A, IL22, STAT3, TBX21, SOCS3, IL12RB1 and IL17RA), were genotyped in 735 CD patients and 549 ethnically matched healthy controls. Case-control comparisons for each SNP and for the haplotypes resulting from the SNPs studied in each gene were performed using chi-square tests. Gene-gene interactions were also evaluated following different methodological approaches. No significant results emerged after performing the appropriate statistical corrections. Our results seem to discard a relevant role of Th17 cells on CD risk.
HLA and Celiac Disease Susceptibility: New Genetic Factors Bring Open Questions about the HLA Influence and Gene-Dosage Effects
Luz María Medrano, Bárbara Dema, Arturo López-Larios, Carlos Maluenda, Andrés Bodas, Natalia López-Palacios, M. ángeles Figueredo, Miguel Fernández-Arquero, Concepción Nú?ez
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048403
Abstract: Celiac disease (CD) is a chronic inflammatory disorder triggered after gluten ingestion in genetically susceptible individuals. The major genetic determinants are HLA-DQA1*05 and HLA-DQB1*02, which encode the DQ2 heterodimer. These alleles are commonly inherited in cis with DRB1*03:01, which is associated with numerous immune-related disorders, in some cases contributing with a different amount of risk depending on the haplotype context. We aimed at investigating those possible differences involving DRB1*03:01-carrying haplotypes in CD susceptibility. A family (274 trios) and a case-control sample (369 CD cases/461 controls) were analyzed. DRB1*03:01-carrying individuals were classified according to the haplotype present (ancestral haplotype (AH) 8.1, AH 18.2 or non-conserved haplotype) after genotyping of HLA-DRB1, -DQA1, -DQB1, -B8, TNF -308, TNF -376 and the TNFa and TNFb microsatellites. We observe that the AH 8.1 confers higher risk than the remaining DRB1*03:01-carrying haplotypes, and this effect only involves individuals possessing a single copy of DQB1*02. CD risk for these individuals is similar to the one conferred by inherit DQA1*05 and DQB1*02 in trans. It seems that an additional CD susceptibility factor is present in the AH 8.1 but not in other DRB1*03:01-carrying haplotypes. This factor could be shared with individuals possessing DQ2.5 trans, according to the similar risk observed in those two groups of individuals.
Research proposal: quantitative and qualitative evaluation of the ART in infants
Figueredo, Márcia Can?ado;
Journal of Applied Oral Science , 2006, DOI: 10.1590/S1678-77572006000700005
Abstract: the accomplishment of the atraumatic restorative treatment (art) approach during the early childhood may represent a remarkably less traumatic and less expensive therapeutic choice. the purpose of this study is to investigate the mothers' perceptions about the art technique in the oral health/disease process of their children diagnosed with early childhood caries (ecc), and to evaluate the clinical performance of the atraumatic restorations placed in these children at six-, twelve- and twenty-four-month intervals.
Los mecanismos de protección del patrimonio arqueológico
Querol, M. ángeles
Trabajos de Prehistoria , 1992,
Abstract: This article briefly discusses three different sections which are worth emphasizing for their role in the general protection of our Historical Heritage and, more specifically, of our Archaeological Heritage. 1o Legal Protection. In this section, the actual definition of Archaeological Heritage is discussed under the terms of the 16/85 Act, as well as the Regulations regarding the Evaluation of the Environmental Impact on public Works, as published in 1988 by MOPU (Ministry of Works and Urban Development). Naturally, recent legislation concerning our Heritage and published by certain Autonomous Regions is also mentioned. Special reference is made to Article XIII of the Penal Code. 2o Preventive-Conservative Protection. In close relation to the polices of Autonomous Regions, emphasis is placed here on how the importance, as well as the incidence of this subject, have grown dramatically in recent years. Of all the composing factors, stress is placed on those which relate specifically to our Archaeological Heritage by means of the preparation of relevant inventories. 3o Educational Protection. This is emphasized as the most important of the three sections. Proposals are made for a series of measures to follow, and a course of action to take, in order to prevent inmediate failure, since the necessity for long term investment could act as a deterrent. En este artículo se desarrollan, de modo sumario, los tres apartados que cabe destacar por su papel en la protección del Patrimonio Histórico en general y Arqueológico en particular. 1o Protección legal. Se comenta aquí desde la propia definición de Patrimonio Arqueológico por parte de la Ley 16 / 85, hasta el Reglamento sobre Evaluación del Impacto Ambiental de las Obras Públicas publicado por el MOPU en 1988, pasando por supuesto por las recientes Leyes sobre Patrimonio publicadas por algunas Comunidades Autónomas. Se hace especial alusión al Título XIII del Código Penal. 2o Protección preventiva-conservadora. Estrechamente ligada a la política de las Comunidades Autónomas, destaca como un aspecto cuyo ritmo de importancia y de incidencia se ha multiplicado enormemente en los últimos a os. De todos los factores que lo conforman, se insiste aquí en los relativos al conocimiento del propio Patrimonio Arqueológico a través de la confección de adecuados inventarios. 3o Protección educativa. Destacada como la más importante de las tres, se proponen una serie de líneas a seguir y de medidas a tomar para evitar que su puesta en práctica, poco atractiva por lo que supone de inversión a muy largo plazo, no la convierta
Los epónimos en medicina
M. ángeles Alcaraz Ariza
Ibérica , 2002,
Abstract: Uno de los rasgos más característicos del lenguaje de las ciencias de la salud es la presencia de epónimos o términos construidos sobre nombres propios. En nuestro trabajo hemos examinado esta clase de expresiones con el propósito de proponer su inclusión en los programas de LFM (Lenguas para Fines Médicos). Con ese fin, hemos analizado varios diccionarios médicos en diversas lenguas, y nos hemos fijado un doble objetivo: 1) relacionar las formas más representativas de la aparición eponímica; 2) llevar a cabo una comparación entre las lenguas consideradas. Nuestro análisis ha puesto de relieve que la variación, tanto conceptual como formal, es una característica inherente a la formación eponímica, no sólo entre lenguas diferentes sino también en el seno de una misma lengua, y que, una vez acu ados, los epónimos se comportan como cualquier otro signo lingüístico, estando por tanto sujetos a fenómenos de homonimia, polisemia y sinonimia.
Posibilidades etnoliterarias en un soneto de Quevedo
Hermosilla álvarez, M. ángeles
Revista de Dialectología y Tradiciones Populares , 2005,
Abstract: Following the postulates of Reception Aesthetics, which enables us to connect acts of perception with conceptual ones, the author poses the possibility of viewing literature as a vehicle to get to know human beings in a specific situation, as illustrated by the reading process of one of Quevedo's sonnets. A partir de los postulados de la Estética de la Recepción, que permite unir los actos perceptivos y conceptuales, se plantea la posibilidad de considerar la literatura como una vía de conocimiento del ser humano en una determinada situación, tal como se muestra en el proceso de lectura de un soneto de Quevedo.
La muralla enterrada: Carlos Franz (2001)
ángeles Donoso M
EURE (Santiago) , 2004,
TIC y el aprendizaje basado en problemas como agentes significativos en el desarrollo de competencias
Boude Figueredo,Oscar; Ruiz,Mónica;
Index de Enfermería , 2009, DOI: 10.4321/S1132-12962009000100004
Abstract: introduction: today's world demands professionals who are capable of self-learning, generating and interchanging knowledge collabarating through virtual spaces. nursing professionals are not concerned? about this demand. objective: identify the abilities that the nursing students could obtain through independant work in a learning environment. which makes use of digital educational material, based on problems about computer networks. method: 22 nursing students from universidad de la sabana which are studying the subject, "telemática" throughout the second semester of 2007. they turned to the subject in question, now that they are allowed to see the learning environment from all sides. they also understand internships and imaginativeness of the actors who intervene. moreover thier relationships, strains and transformations. results: 27% of the students exceeded the expected levels in the development of the given abilities. 63% reached the expected levels and only 14% reached the minumun level. these achievments were related with factors such as interchanging of knowledge, in pairs, outlines of thier own thoughts, the student's availablilty and attitude as the main person in the learning process. currently, we found that the students developed other ways of learning that were not given. conclusion: the environment helps to develop abilities in students, if it stimulates the process of sharing with peers.
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