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Search Results: 1 - 10 of 222707 matches for " Luz del Carmen Alarcón-Romero "
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AgNOR polymorphism association with squamous intraepithelial lesions and invasive carcinoma with HPV infection
Alarcón-Romero,Luz del Carmen; Illades-Aguiar,Berenice; Flores-Alfaro,Eugenia; Terán-Porcayo,Marco Antonio; Antonio-Véjar,Verónica; Reyes-Maldonado,Elba;
Salud Pública de México , 2009, DOI: 10.1590/S0036-36342009000200009
Abstract: objective: evaluate the relationships between agnors polymorphisms and squamous intraepithelial lesions (sil) and squamous cell carcinoma (scc) with hpv infection. materials and methods: a study was carried out on sixty women from the state of guerrero, mexico. hpv detection was performed by pcr. agnors were identified by argentic impregnation. one hundred cells per slide were counted and classified according to the polymorphism of agnors dots; typical (spherical) and atypical (large, kidney-shaped and clustered). results: a total of 100% of the cases were positive for hpv infection. nine different high-risk hpv genotypes were found, type16 was the most common (48.6%). the agnors showed a significant decrease in spherical shape according to neoplastic development. the three atypical shapes showed a significant increase in sil and scc (p-trend<0.001). conclusions: agnors polymorphism rises progressively according to the grade of histological lesions that can be useful as a prognosis for progression of scc.
Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells
Miguel A Mendoza-Catalán, Gema R Cristóbal-Mondragón, Jesús Adame-Gómez, Heidi N del Valle-Flores, José Coppe, Laura Sierra-López, Mirna A Romero-Hernández, Luz del Carmen Alarcón-Romero, Berenice Illades-Aguiar, Eduardo Casta?eda-Saucedo
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-116
Abstract: Protein expression was analyzed by immunochemistry on 102 cervical paraffin-embedded biopsies: 20 without Squamous Intraepithelial Lesions (SIL), 51 Low- grade SIL, and 31 High-grade SIL; and in cervical cancer cell lines C33A and SiHa, and non-tumorigenic HaCat cells. Nuclear localization of Rac1 in HaCat, C33A and SiHa cells was assessed by cellular fractionation and Western blotting, in the presence or not of a chemical Rac1 inhibitor (NSC23766).Immunoreacivity for Rac1, RhoA, Tiam1 and beta-Pix was stronger in L-SIL and H-SIL, compared to samples without SIL, and it was significantly associated with the histological diagnosis. Nuclear expression of Rac1 was observed in 52.9% L-SIL and 48.4% H-SIL, but not in samples without SIL. Rac1 was found in the nucleus of C33A and SiHa cells but not in HaCat cells. Chemical inhibition of Rac1 resulted in reduced cell proliferation in HaCat, C33A and SiHa cells.Rac1 is expressed in the nucleus of epithelial cells in SILs and cervical cancer cell lines, and chemical inhibition of Rac1 reduces cellular proliferation. Further studies are needed to better understand the role of Rho-GTPases in cervical cancer progression.Cervical cancer is the second most common malignant neoplasia affecting woman worldwide. Infection with High-Risk Human Papillomavirus (HR-HPV) is considered the main risk factor for developing cervical cancer and its precursor lesions [1-3]. Development of cervical Low-grade Squamous Intraepithelial Lesions (L- SIL) and High-grade Squamous Intraepithelial Lesions (H-SIL), and progression to invasive carcinoma, are associated with alterations in the regulation of several cellular processes such as cell cycle progression, apoptosis, and DNA repair [2,4,5]. The HR-HPV oncoproteins E6 and E7 are responsible for many of these alterations, they act by binding to, and/or modifying the expression/activity of a growing number of cellular proteins [6], including p53 [7], pRb [8], p21 [9,10], and p27 [11,12]. Rho-GTPases
Total Reflection X-Ray Fluorescence Analysis of Toxic Metals in Fish Tissues  [PDF]
Graciela Zarazúa, Karina Girón-Romero, Samuel Tejeda, Carmen Carre?o-De León, Pedro ávila-Pérez
American Journal of Analytical Chemistry (AJAC) , 2014, DOI: 10.4236/ajac.2014.512089
Abstract: The concentration of Cr, Ni, Cu, Zn, Hg and Pb, considered like toxic, was evaluated in fish tissues by means the total reflection X-Ray Fluorescence technique (TXRF). Grass carp (Ctenopharygodon idella) samples were collected from six regions of the Tepuxtepec Dam which was used as a water reservoir and fish production for the local population. Fish tissues: gills, liver, kidney and muscle were analyzed in triplicate using a TXRF spectrometer “TX-2000 Ital Structures” with a Si(Li) detector and a resolution of 140 eV (FWHM) at Mn Kα and Mo tube (40 kV, 30 mA) with 17.4 KeV excitation energy. The mean concentration of metals in tissues decrease in the sequence: Kidney ≈ Gills > Liver > Muscle; the range of concentration for Zn was 26.68 - 816.67 mg/Kg followed by Cu: 1.18 - 35.81 mg/Kg, Cr: 1.10 - 9.30 mg/Kg, Ni: 0.40 - 3.80 mg/Kg, Pb: <0.02 - 1.92 mg/Kg and Hg: <0.03 - 1.97 mg/Kg. Chromium and mercury concentrations slightly exceed the limits for fish proposed by FAO/WHO and Mexican Legislation for human consumption in the edible parts of fish from each one of the regions of the Tepuxtepec Dam. The results show that metal accumulation in herbivorous carp tissues was higher in regions 1, 2 and 3 than the others, which could be due to the influence of Lerma River, one of the most polluted rivers of Mexico.
Niveles de plomo sanguíneo en madres y recién nacidos derechohabientes del Instituto Mexicano del Seguro Social
Navarrete-Espinosa Joel,Sanín-Aguirre Luz Helena,Escandón-Romero Celia,Benitez-Martínez Guadalupe
Salud Pública de México , 2000,
Abstract: OBJETIVO: Establecer la relación entre el nivel de plomo sanguíneo materno (PSM) y el de sangre en cordón umbilical (PSC) al momento del parto, así como determinar los principales predictores del PSM en derechohabientes del Instituto Mexicano del Seguro Social (IMSS), en el Distrito Federal (D.F.). MATERIAL Y MéTODOS: Se realizó un estudio transversal en el que se reclutaron voluntarias con embarazo normoevolutivo y se les tomaron muestras de sangre al momento del parto, en cuatro hospitales del IMSS en el D.F., de 1991 a 1993. Se tomó, además, muestra de sangre de cordón umbilical. Los datos fueron analizados mediante regresión lineal simple y múltiple. RESULTADOS: Se estudiaron un total de 1 404 binomios madre-hijo; el promedio de edad de las madres fue de 25 a os. La media de PSM fue 10.7 ± 6.5 μg/dl; no se encontraron variaciones significativas por hospital, edad o estado civil. Para el PSC la media fue de 10.4 ± 6.2 μg/dl. Por cada aumento en una unidad logarítmica de PSM, el PSC aumenta 0.62 (p<0.01) unidades logarítmicas. La correlación entre ambos fue de 0.61 (p<0.01). Los principales predictores de PSM fueron el uso de loza vidriada, el consumo de leche y jugo de naranja, estos últimos se asociaron inversamente con el PSM. Un 47% de las madres y 50% de los ni os tuvieron valores superiores a 10 μg/dl. En 578 recién nacidos se registraron niveles de plomo superiores a los de la madre. CONCLUSIONES: Se sugiere continuar la línea de investigación para proponer tipos de intervención.
Francisco Sacristán-Romero
Journal of applied research and technology , 2007,
Abstract: Tele-detection offers great possibilities for the accomplishment of progress in the knowledge of Nature.However, all expected benefits have not yet been obtained since improvement in matters of data space,spectral and temporal resolution still need to be made. In addition, greater scientific rigor in theinterpretation of the results obtained is needed, attempting not to draw definite conclusions from existentenvironmental studies made by means of Tele-detection techniques.Models developed to process Tele-detection data will have to aim at eliminating the effects caused bythe variability in the conditions of data collection, the distortion caused by the atmosphere, and theinfluence of parameters such as the position of the Sun, slope, exhibition and altitude.The present article attempts to look at the different and various applications of Tele-detection to theresiduum control for energetic and environmental purposes.
Conjugate Gradient Algorithm for Solving a Optimal Multiply Control Problem on a System of Partial Differential Equations
Carlos Barrón-Romero
Mathematics , 2014,
Abstract: I development a Conjugate Gradient Method for solving a partial differential system with multiply controls. Some numerical results are depicted. Also, I present an explication of why the control over a partial differential equations system is necessary.
Classical and Quantum Algorithms for the Boolean Satisfiability Problem
Carlos Barrón-Romero
Computer Science , 2015,
Abstract: This paper presents a complete algorithmic study of the decision Boolean Satisfiability Problem under the classical computation and quantum computation theories. The paper depicts deterministic and probabilistic algorithms, propositions of their properties and the main result is that the problem has not an efficient algorithm (NP is not P). Novel quantum algorithms and propositions depict that the complexity by quantum computation approach for solving the Boolean Satisfiability Problem or any NP problem is lineal time.
Saliva Components Reestablish the Basal Production of IL-6 by Mononuclear cells, 72 Hours after Nitinol Archiwire Placement: A Preliminary Study
Luis C. León-Romero,Alain R. Rodríguez-Orozco,Ma. De la Luz Vargas-Purecko,Héctor Ruiz-Reyes
Iranian Journal Of Allergy, Asthma and Immunology , 2012,
Abstract: The purpose of the study was to evaluate interleukin-6 production, in saliva-activated mononuclear cell cultures from malocclusion patients, before and after placement of .014 NiTi archwires.Four patients receiving .014 Nitinol archwire to correct malocclusion participated in this study. Samples of their blood and saliva were collected before and after placement of the apparatus. Mononuclear cells were obtained from the blood using the Ficoll-Paque (1.077 g/ml) density gradient separation method. Mononuclear Cells were activated with saliva from each patient and were cultured in 96-well plates for 72 hours. Samples were collected at 24 hours before apparatus placement, and at 24 hours and 72 hours after placement. IL-6 expression levels in the cell culture supernatants were quantified by ELISA.An increase in IL-6 levels in the cell culture supernatants was observed 24 hours after placement of the orthodontic apparatus relative to the negative control (p= 0.002) and IL-6 came to basal limits 72 hours after apparatus placement.IL-6 quantification may be useful as a biomarker to estimate the inflammatory response caused by forces applied during orthodontic treatment and their levels came to basal limits 72 hours after apparatus placement in patients without systemic diseases. The isolation of saliva components involved in such effects is important to study the mechanisms to control the acute inflammation in oral cavity after apparatus placement.
Polimorfismos de nucleótido simple en moléculas de adhesión y parámetros clínicos en artritis reumatoide
Navarro-Hernández,Rosa Elena; Vázquez-Del Mercado,Mónica; Oregón-Romero,Edith; Mu?oz-Valle,José Francisco;
Acta bioqu?-mica cl?-nica latinoamericana , 2007,
Abstract: the genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphisms (pcr-rflp) technique. the esr (erythrocyte sedimentation rate), rf (rheumatoid factor), fibrinogen (fb), c-reactive protein (crp) and lipid profile were measured by routine methods. statistical analysis was performed using spss v10.0. the significant pearson′s correlations were: esr with crp, rf, fb and hdlc, (r=0.507, 0.296, 0.475, and -0.308, respectively); crp with fb (r=0.613), p<0.05. the results showed an association with a allele of icam1 polymorphism and serum levels of hdlc and ldlc; and apo-b and fr showed an association with c allele of vcam1 polymorphism (p<0.05). data shows that fb and hdlc levels, and icam1 polymorphism allele 721a and vcam1 polymorphism allele 1238g are associated with clinical inflammation markers in ra. our mexican-mestizo population showed differences with many reports (from english, american, turkish, japanese, chinese, italian, and korean populations).
Polimorfismos de nucleótido simple en moléculas de adhesión y parámetros clínicos en artritis reumatoide Single nucleotid polymorphisms of adhesion molecules and clinical parameters in rheumatoid arthritis
Rosa Elena Navarro-Hernández,Mónica Vázquez-Del Mercado,Edith Oregón-Romero,José Francisco Mu?oz-Valle
Acta bioqu?-mica cl?-nica latinoamericana , 2007,
Abstract: Se investigó la relación entre los polimorfismos de E-selectina, la molécula de adhesión vascular-1 (VCAM1) y la molécula de adhesión intercelular-1 (ICAM1) con el perfil de lípidos y marcadores clínicos de inflamación en artritis reumatoide (AR). Se incluyeron 60 pacientes con AR clasificados de acuerdo a los criterios del American College of Rheumatology (ACR, 1987) y 60 controles clínicamente sanos (CCS), no relacionados entre sí, definidos como población de mestizos mexicanos. Los genotipos se caracterizaron por la técnica de PCR-RFLP. La velocidad de sedimentación globular (VSG), factor reumatoideo (FR), concentración de fibrinógeno (FB), proteína C reactiva (PCR) y perfil de lípidos, se realizaron por métodos convencionales. El análisis estadístico se efectuó con SPSS v10.0. La VSG correlacionó con PCR, FR, FB y cHDL, (r=0,507; 0,296; 0,475 y -0,308, respectivamente); PCR con FB (r=0,613), p<0,05. El alelo 1238G se asoció con FR y Apo-B; y el alelo 721A, con cHDL y cLDL (p<0,05). Los datos muestran que los niveles de FB, cHDL, y los alelos 721A de ICAM1 y 1238G de VCAM1 se asocian con los marcadores clínicos de inflamación. Existen diferencias entre la distribución de los polimorfismos en este estudio y las reportadas para población oriental, caucásica y turca. The genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) technique. The ESR (erythrocyte sedimentation rate), RF (rheumatoid factor), fibrinogen (FB), C-reactive protein (CRP) and lipid profile were measured by routine methods. Statistical analysis was performed using SPSS v10.0. The significant Pearson′s correlations were: ESR with CRP, RF, FB and HDLc, (r=0.507, 0.296, 0.475, and -0.308, respectively); CRP with FB (r=0.613), p<0.05. The results showed an association with A allele of ICAM1 polymorphism and serum levels of HDLc and LDLc; and Apo-B and FR showed an association with C allele of VCAM1 polymorphism (p<0.05). Data shows that FB and HDLc levels, and ICAM1 polymorphism allele 721A and VCAM1 polymorphism allele 1238G are associated with clinical inflammation markers in RA. Our Mexican-mestizo population showed differences with many reports (from English, American, Turkish, Japanese, Chinese, Italian, and Korean populations).
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