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Search Results: 1 - 10 of 5335 matches for " Lung "
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The “Bedi-IMA Buttress”: Reinforcement of the Bronchial Stump with a Pedicled Internal Mammary Artery Buttress in Diabetic Patients after Lung Resection  [PDF]
Harinder Singh Bedi, Kamal Negi
World Journal of Cardiovascular Surgery (WJCS) , 2014, DOI: 10.4236/wjcs.2014.412032
Abstract: Objective: The development of a bronchopleural fistula is a devastating complication after lung resection. We describe a new method of buttressing the closure of the stump in diabetic patients using a pedicled internal mammary artery buttress flap to avoid a bronchopleural fistula. Methods: An internal mammary pedicled flap was used in 14 diabetic patients of lung resection to cover the bronchial stump. Results: The flap of viable vascularized muscle mass gave an excellent coverage of the bronchial stump. All patients recovered well with no bronchopleural fistula. Conclusions: We recommend this technique as a method of buttressing the bronchial stump in cases of lung resection, as the internal mammary artery is easily available and its use is not associated with any side effects.
The Correlation of Lung Function Indexes and Survival Time of Patients with Advanced Lung Cancer  [PDF]
Wenjing Xu, Zhenghua Jiang, Dongyun Huang, Muyun Zhu, Qian Huang, Hui Ge, Juan Liu, Yan Qin
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41029

Background: To those patients with advanced lung cancer, the ultimate objective is to improve the quality of life, and lung function is an important factor affecting quality of life. We detect lung function of patients with lung cancer and study the correlation between lung function and the patients’ survival time, to provide reference for evaluation of disease progression and prognosis. Methods: Lung function was detected on 59 cases of lung cancer and 63 normal controls. The relationship between lung function indexes and survival time was analyzed. Results: There was significant difference in ventilation function and diffusing capacity between lung cancer group and control group. Vital capacity (VC), Forced expiratory volume in one second (FEV1), Forced vital capacity (FVC), peak expiratory flow (PEF), peak expiratory flow% (PEF%), Maximal ventilatory volume (MVV) were positively correlated to survival time in patients with advanced lung cancer (r = 0.28522064, 0.28053851, 0.28289252, 0.26908133, 0.26335034, 0.28409036, P < 0.05), residual volume/total lung capacity was negatively correlated to survival time (r = ?0.30760097, P < 0.05). Conclusions: The lung function decrease in the patients with lung cancer. Vital capacity (VC), Forced expiratory volume in one second (FEV1), Forced vital capacity (FVC), peak expiratory flow (PEF), peak expiratory flow% (PEF%), Maximal ventilatory volume (MVV), and residual volume/total lung capacity are correlated to survival time in patients with advanced lung cancer. The lung function indexes are important marker of prognosis of patients with lung

Successful Use of Intercostal Muscle Flap in Cavitary Lung Lesions  [PDF]
Alaa Brik, Abdel-Maged Salem, Khaled Mostafa
Open Journal of Thoracic Surgery (OJTS) , 2013, DOI: 10.4236/ojts.2013.31002

Background: Lung cavities sometimes result from a number of pathological processes including suppurative necrosis, caseous necrosis, ischemic necrosis and cystic dilatation of lung structures. The aim of this study is to evaluate the use of intercostals muscle flap as a successful method to fill the lung cavity for reduction of symptoms and treatment of patients presented with symptomatic pulmonary cavity and to avoid the risk of pulmonary resection. Methods: This is a prospective study conducted between 2009 to 2012, in department of cardiothoracic surgery, Zagazig University Hospital. The study included 32 patients suffering from cavitary lung lesions divided into two groups, group (A): 14 patients treated by using intercostal muscle flap to fill the defect after Cavernostomy without lung resection; and group (B): 18 patients treated by traditional methods by lung resection. Patients with high risk of lung resection, suspicion of dense adhesion, symptomatic chronic lung abscess and patients with bad pulmonary function tests were included in group (A). Results: 20 patients were male and 12 were females in both groups, the large numbers of cases were lung abscess in group A (4 cases 28.5%) followed by Aspergilloma and TB cavity (3 cases 21.4%). Hemoptysis, persistent cough and expectoration were the main presentation of our patients. Poor pulmonary function was significant finding in group A (7 cases 50%). Complications reported in our study were bleeding, recurrent symptoms and one case mortality in group B after Pneuomenectomy. Conclusion: Using the intercostal muscle flap implanted inside the lung cavity after cavernostomy is a successful alternative curative method especially in cases with high risk of lung resection.

Increased Levels of Hyaluronic Acid in Bronchoalveolar Lavage from Patients with Interstitial Lung Diseases, Relationship with Lung Function and Inflammatory Cells Recruitment  [PDF]
Glenda Ernst, Jancic Carolina, Auteri Santiago, Rodriguez Moncalvo Juan, Galíndez Fernando, Grynblat Pedro, E. Hajos Silvia
Modern Research in Inflammation (MRI) , 2014, DOI: 10.4236/mri.2014.32004
Abstract: Purpose: Interstitial Lung Diseases (ILD) are characterized by inflammation and fibrosis. It described the role of hyaluronic acid (HA) as an immune-regulator. It is not known if HA contributes to the recruitment of inflammatory cells associated with ILD. If this hypothesis was correct, then concentrations of HA in bronchoalveolar lavage (BAL) should correlate with the severity of ILD. Methods: We collected BAL from 22 ILD patients and 15 control subjects. We determined HA and cytokine levels by ELISA. In vitro chemotaxis assays were performed by using a transwell system. Results: We found that ILD patients showed a significant increase in HA, IL-6 levels and the amount of cells in BAL compared to control subjects. We detected a significant positive correlation between HA and IL-6 levels (r = 0.53 and p < 0.001) and an inverse relationship between HA levels and diffusion capacity (r = -0.59, p < 0.01). In vitro, HA induced migration of macrophages and monocytes through a CD44-dependent process. BAL from patients with ILD stimulated macro-phage migration and this was abrogated by hyaluronidase. Conclusions: Our results support the hypothesis that HA contributes to the recruitment of monocytes towards the alveolar space, leading to exacerbation of lung inflammation in ILD patients.
Leptomeningeal Carcinomatosis Presenting Early in Non-Small Cell Lung Cancer  [PDF]
Ezra N. Teitelbaum, Susan M. Hasselquist, Imad A. Tabbara, Gregory D. Trachiotis
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.28093
Abstract: Purpose: We present the case of a patient presenting with altered mental status on post-operative day seven after a diagnostic lung biopsy. The diagnosis of carcinomatous letomeningeal metastasis was confirmed. Methods: We discuss meningeal carcinomatosis in lung cancer, and describe challenges to diagnosis, therapy, and prognosis. Results: A review of the literature describing the clinical and oncologic principles of letomeningeal carcinomatosis in lung cancer is performed. Discussion: Leptomeningeal carcinomatosis (LC) occurs in approximately 5% of patients with non-small cell lung cancer and incurs a bleak prognosis. Presenting neurologic symptoms can be varied and diagnosis is confirmed via lumbar puncture and cerebrospinal fluid cytology. Few data exist regarding optimal treatment, although intrathecal chemotherapy has been shown to provide a modest improvement in median survival.
A rare clinical presentation of pulmonary hypoplasia  [PDF]
Figen Gülen, Sakine Kar, Levent Midyat, Esen Demir, Süphan ?zyurt, Arif Ruhi ?zyürek, Remziye Tana?, Naim Ceylan
Open Journal of Pediatrics (OJPed) , 2011, DOI: 10.4236/ojped.2011.14018
Abstract: Pulmonary hypoplasia is a rare congenital anomaly, which is frequently associated with other congenital anomalies. Clinical symptoms vary depending on the other system anomalies and severity of pulmonary hypoplasia. Although it is usually diagnosed in infancy and childhood, some cases do not show any symptoms until the adolescent ages. In adolescents and adults with unilateral hypolucent lung, although it is seen rarely, pulmonary hypoplasia should always be kept in mind. In this article, we present a case with pulmonary hypoplasia who remained asymptomatic until puberty.
Lung Cancer: Facts, Figures and Reflections on Spending  [PDF]
Usman Ahmad, Michael Ruschel, Frank C. Detterbeck
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.32016
Abstract: The war on cancer was declared 40 years ago. While the potential for reducing deaths is increasing, so are the costs. Finding the right prioritization in our complex world is difficult; we present some interesting facts regarding other wars and aspects of society that are worth reflecting on as we struggle to find the right balance.
Lung Transplant and Outcomes: A Single-Center Experience  [PDF]
Iskander Al-Githmi
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.36062
Abstract: Introduction: Lung transplant is the preferred treatment for several end-stage pulmonary diseases. The first successful human lung transplant was performed by the Toronto Group in 1983 [1]. Objectives: This article discusses our initial experience with single and double lung transplant. Study Design: A retrospective analysis was done on 11 consecutive lung transplants for end-stage pulmonary diseases performed at our institution between 2008 and 2010. Materials and Methods: Major indications were idiopathic pulmonary fibrosis (n = 6), bronchiectasis (n = 2), primary pulmonary hypertension (n = 1), lymphangioleiomyomatosis (n = 1), and scleroderma (n = 1). Results: Two patients (18.2%) died within 30 days of surgery. One- and 2-year survival rates for the recipients were 81.8% and 72.7%. Sepsis caused the deaths of 2 recipients. Conclusions: Although sepsis and chronic rejection limit the benefits, lung transplant gives many patients with end-stage pulmonary disease the ability for a better quality of life.
Fatal Complications and Early Death after Surgical Treatment of Lung Cancer in 2000 and 2010. A Population Based Study  [PDF]
Hans Rostad
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.41019

In the year 2000 lung cancer was operated in 349 patients in Norway, in 2010 the number was 461. In the first period fatal surgical hemorrhage occurred in eight patients, in four of them peroperatively. Postoperative hemorrhage occurred in four patients in the year 2000 and in two in 2010. Ten patients died intra- or postoperatively in the two periods which is a mortality rate within 30 days after surgery of 4.3% in the first and 1.1% in the second period. Pneumonectomy was performed in 34 patients in 2000 and eight in 2010, respectively. Altogether 19 patients died within six months after surgery without having experienced surgical complications. Pneumonectomy should not be performed in elderly and debilitated persons.

Case report: Metastatic adenocarcinoma of the lung with filiform “ciliated” tumor cells in the cerebrospinal fluid  [PDF]
Daniel A. Zlotoff, Cynthia Kelly, Malca Kierson, Cindy McGrath, Prabodh Gupta
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.23055

Occurrence of cilia on the cell surface is usually considered evidence of a non-neoplastic process. Rarely, ciliated malignant tumors cells have been reported in pleural and ascitic fluids from ovarian and endometrial adenocarcinomas, though not from the cerebrospinal fluid (CSF) in association with pulmonary adenocarcinoma. We now present a case report of a patient who initially presented with neurologic symptoms. A CSF specimen revealed atypical cells with peripheral cilia and some cytoplasmic pigment. Cytologic, morphologic, and immunohistochemical analyses established this to be a metastatic adenocarcinoma of pulmonary origin with metastases to the meninges, pelvis, and the vertebrae. Cilia are generally the antithesis of malignancy as their presence is considered to be evidence of proper regulation of the cell cycle within a well-differentiated cell. This case offers the first described example of malignant ciliated cells derived from a metastatic lung adenocarcinoma. An awareness of this unusual presentation should aid in diagnosis and management when similar situations are prospectively encountered.

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