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Search Results: 1 - 10 of 82276 matches for " Luiz Hildebrando Pereira da;Wunderlich "
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Microsatellite characterization of Plasmodium falciparum from symptomatic and non-symptomatic infections from the Western Amazon reveals the existence of non-symptomatic infection-associated genotypes
Martha, Rosimeire Cristina Dalla;Tada, Mauro Sughiro;Ferreira, Ricardo Godoi de Mattos;Silva, Luiz Hildebrando Pereira da;Wunderlich, Gerhard;
Memórias do Instituto Oswaldo Cruz , 2007, DOI: 10.1590/S0074-02762007005000044
Abstract: in western amazon areas with perennial malaria transmission, long term residents frequently develop partial immunity to malarial infection caused either by plasmodium falciparum or p. vivax, resulting in a considerable number of non-symptomatically infected individuals. for yet unknown reasons, these individuals sporadically develop symptomatic malaria. in order to identify if determined parasite genotypes, defined by a combination of eleven microsatellite markers, were associated to different outcomes - symptomatic or asymptomatic malaria - we analyzed infecting p. falciparum parasites in a suburban riverine population. despite of detecting a high degree of diversity in the analyzed samples, several microsatellite marker alleles appeared accumulated in parasites from non-symptomatic infections. this result may be interpreted that a number of microsatellites, which are not directly related to antigenic features, could be associated to the outcome of malarial infection. the result may also point to a low frequency of recombinatorial events which otherwise would dissociate genes under strong immune pressure from the relatively neutral microsatellite loci.
Asymptomatic infection with Plasmodium falciparum and Plasmodium vivax in the Brazilian Amazon Basin: to treat or not to treat?
Tada, Mauro Shugiro;Ferreira, Ricardo de Godoi Mattos;Katsuragawa, Tony Hiroshi;Martha, Rosimeire Cristina Dalla;Costa, Joana D?Arc Neves;Albrecht, Letusa;Wunderlich, Gerhard;Silva, Luiz Hildebrando Pereira da;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000500008
Abstract: in this study, we determined whether the treatment of asymptomatic parasites carriers (apcs), which are frequently found in the riverside localities of the brazilian amazon that are highly endemic for malaria, would decrease the local malaria incidence by decreasing the overall pool of parasites available to infect mosquitoes. in one village, the treatment of the 19 plasmodium falciparum-infected apcs identified among the 270 residents led to a clear reduction (z = -2.39, p = 0.017) in the incidence of clinical cases, suggesting that treatment of apcs is useful for controlling falciparum malaria. for vivax malaria, 120 apcs were identified among the 716 residents living in five villages. comparing the monthly incidence of vivax malaria in two villages where the apcs were treated with the incidence in two villages where apcs were not treated yielded contradictory results and no clear differences in the incidence were observed (z = -0.09, p = 0.933). interestingly, a follow-up study showed that the frequency of clinical relapse in both the treated and untreated apcs was similar to the frequency seen in patients treated for primary clinical infections, thus indicating that vivax clinical immunity in the population is not species specific but only strain specific.
Ciências biológicas e biotecnologia: realidades e virtualidades
SILVA, LUIZ HILDEBRANDO PEREIRA DA;
S?o Paulo em Perspectiva , 2000, DOI: 10.1590/S0102-88392000000300011
Abstract: os enormes progressos das ciências biológicas ocorridos nas últimas décadas abrem grandes perspectivas benéficas para o homem no terreno das aplica??es, em particular no domínio da agronomia e da biomedicina. a sociedade brasileira deverá romper com essa situa??o, em que os progressos beneficiam apenas setores privilegiados, e promover a educa??o e divulga??o científicas de qualidade a todos os níveis, concentrando sua aplica??o em domínios essenciais para vencer atrasos e deforma??es da sociedade brasileira. se a ciência e a tecnologia n?o tiverem rela??o direta com a realidade do dia-a-dia, traduzindo-se em melhoria da situa??o material e cultural do conjunto da sociedade, estar?o se arriscando a evoluir para uma situa??o de atividade apenas virtual.
O desafio da malária: o caso brasileiro e o que se pode esperar dos progressos da era gen?mica
Silva,Luiz Hildebrando Pereira da; Oliveira,Vera Engracia Gama de;
Ciência & Saúde Coletiva , 2002, DOI: 10.1590/S1413-81232002000100005
Abstract: malaria endemic areas in brazil are restricted to the amazon region, with an average of 500 thousand new cases every year. the situation can be defined as unstable hipoendemic with, however, foci of high endemicity. demographic and socio economic factors are main determinants in the malaria challenge for the public health system. in the present paper, biological and social factors responsible for the unstable endemic situation are discussed. the need for a permanent surveillance and intervention of public health services are stressed to avoid the occurrence of local epidemics and spreading of endemic areas. in the paper, are also summarised recent lines of research developed in the post genomic era in the studies of parasite, vector and human molecular genetics that would favour the development, in the future, of new tools and procedures for malaria control
O desafio da malária: o caso brasileiro e o que se pode esperar dos progressos da era gen mica
Silva Luiz Hildebrando Pereira da,Oliveira Vera Engracia Gama de
Ciência & Saúde Coletiva , 2002,
Abstract: A área endêmica de malária no Brasil se estende atualmente à totalidade da regi o amaz nica, com cerca de 500 mil casos anuais, em geral com situa es de baixa e média endemicidade mas ainda apresentando focos de alto risco. Fatores demográficos e socioecon micos s o dominantes nos desafios que enfrentam os Servi os de Saúde Pública no controle da malária. No presente artigo s o discutidos fatores determinantes da instabilidade da situa o endêmica bem como a necessidade de a es permanentes de vigilancia e de interven o dos Servi os de Saúde para que se evitem surtos epidêmicos e alastramento das áreas endêmicas. No artigo, em seguida, apresenta-se uma síntese de progressos recentes nos estudos da era gen mica e pós-gen mica sobre o parasita, o vetor e o hospedeiro humano que podem favorecer, no futuro, o desenvolvimento e a melhoria dos métodos de controle da malária.
Endemias e epidemias na Amaz?nia: malária e doen?as emergentes em áreas ribeirinhas do Rio Madeira. Um caso de escola
Katsuragawa, Tony Hiroshi;Gil, Luiz Herman Soares;Tada, Mauro Shugiro;Silva, Luiz Hildebrando Pereira da;
Estudos Avan?ados , 2008, DOI: 10.1590/S0103-40142008000300008
Abstract: the authors present a short review on the evolution of malaria incidence in the brazilian amazon, with particular reference to the rond?nia state and the municipality of porto velho, where dramatic epidemics of malaria and other tropical diseases have been registered in the past. next, they analyze the present endemic malaria situation in the madeira river valley where two important hydroelectric power plants will be constructed in the localities of santo ant?nio and jirau. longitudinal surveys performed in the last four years in this area allow to demonstrate a high prevalence of symptomatic and asymptomatic malaria carriers in the area, associated to the presence of high densities of the malaria vector anopheles darlingi all over the year. these elements are correlated to the expected arrival of a large number of human migrants originated from non endemic areas of rond?nia and other brazilian states, attracted by the possibility of jobs in the hydroelectric power plants and by secondary opportunities in commerce, leisure, education and domestic activities. these associations create favorable conditions for malaria outbreaks and other tropical diseases that must be avoided by the establishment of additional control measures, in particular in the sanitation domain
Urban and suburban malaria in Rond?nia (Brazilian Western Amazon) II: perennial transmissions with high anopheline densities are associated with human environmental changes
Gil, Luiz Herman Soares;Tada, Mauro Shugiro;Katsuragawa, Tony Hiroshi;Ribolla, Paulo Eduardo Martins;Silva, Luiz Hildebrando Pereira da;
Memórias do Instituto Oswaldo Cruz , 2007, DOI: 10.1590/S0074-02762007005000013
Abstract: longitudinal entomological surveys were performed in vila candelária and adjacent rural locality of bate estaca concomitantly with a clinical epidemiologic malaria survey. vila candelária is a riverside periurban neighborhood of porto velho, capital of the state of rond?nia in the brazilian amazon. high anopheline densities were found accompanying the peak of rainfall, as reported in rural areas of the region. moreover, several minor peaks of anophelines were recorded between the end of the dry season and the beginning of the next rainy season. these secondary peaks were related to permanent anopheline breeding sites resulting from human activities. malaria transmission is, therefore, observed all over the year. in vila candelária, the risk of malaria infection both indoors and outdoors was calculated as being 2 and 10/infecting bites per year per inhabitant respectively. urban malaria in riverside areas was associated with two factors: (1) high prevalence of asymptomatic carriers in a stable human population and (2) high anopheline densities related to human environmental changes. this association is probably found in other amazonian urban and suburban communities. the implementation of control measures should include environmental sanitation and better characterization of the role of asymptomatic carriers in malaria transmission.
Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex
Patrícia Soares de Maria de Medeiros,Rodrigo Gay Ducati,Luiz Augusto Basso,Diógenes Santiago Santos,Luiz Hildebrando Pereira da Silva
Enzyme Research , 2011, DOI: 10.4061/2011/642758
Abstract: Malaria continues to be a major cause of children's morbidity and mortality worldwide, causing nearly one million deaths annually. The human malaria parasite, Plasmodium falciparum, synthesizes fatty acids employing the Type II fatty acid biosynthesis system (FAS II), unlike humans that rely on the Type I (FAS I) pathway. The FAS II system elongates acyl fatty acid precursors of the cell membrane in Plasmodium. Enoyl reductase (ENR) enzyme is a member of the FAS II system. Here we present steady-state kinetics, pre-steady-state kinetics, and equilibrium fluorescence spectroscopy data that allowed proposal of P. falciparum ENR (PfENR) enzyme mechanism. Moreover, building on previous results, the present study also evaluates the PfENR inhibition by the pentacyano(isoniazid)ferrateII compound. This inorganic complex represents a new class of lead compounds for the development of antimalarial agents focused on the inhibition of PfENR.
Amazonian biodiversity: a view of drug development for Leishmaniasis and malaria
Calderon, Leonardo de Azevedo;Silva-Jardim, Izaltina;Zuliani, Juliana Pavan;Silva, Alexandre de Almeida e;Ciancaglini, Pietro;Silva, Luiz Hildebrando Pereira da;Stábeli, Rodrigo Guerino;
Journal of the Brazilian Chemical Society , 2009, DOI: 10.1590/S0103-50532009000600003
Abstract: chemotherapy is the only validated therapy for the treatment for the neglected diseases leishmaniasis and malaria. however, the emergence of drug resistance, collateral effects and long-term treatment encourage the development of new and more efficient drugs. the amazon tropical forest includes the richest areas of biodiversity in the world, including a great number of microbes, plant and animal species that produce a source of interesting biologically active molecules. several of these molecules, obtained from plant extracts and frog venom have leishmanicidal and plasmodicidal activity, highlighting the potential of this biodiversity for the development of new drugs. in research, modern approaches in new drug development are carried out using combinatorial chemistry, high-throughput screening, bioinformatics, molecular interaction, crystallography and dynamic studies of cellular and systemic toxicity. in brazil, these techniques are mainly present in only a few academic groups with no efficient connection to industry. the problem associated with over-regulation for accessing the biological material in restricted areas, local populations and indigenous areas places major barriers in the path of research and development of new drugs. thus, the association of academic research groups in brazil, encouraged and supported by government and industry, is essential to overcome these major barriers related to the development of new products for treatment of neglected diseases from amazonian biodiversity in future years.
Rotavirus and adenovirus in Rond?nia
Magalh?es, Gleiciene Félix;Nogueira, Paulo Afonso;Grava, Andréa Fagundes;Penati, Marilene;Silva, Luiz Hildebrando Pereira da;Orlandi, Patricia Puccinelli;
Memórias do Instituto Oswaldo Cruz , 2007, DOI: 10.1590/S0074-02762007005000067
Abstract: acute gastroenteritis is one of the most common diseases in humans worldwide. viral gastroenteritis is a global problem in infants and young children. in this study the incidence of diarrhea was assessed in 877 hospitalized children under five years old, over a period of 24 months and distributed in 470 cases of diarrhea and 407 age-matched group with other pathologies, as control group. two antigen detection techniques based on enzyme immunoassay (eia) and latex particles were used for detection of rotavirus and adenovirus. rotavirus a was a major cause of gastroenteritis with 23.6% of cases, being 90% of these cases in young children. adenovirus infections was detected by eia with frequency of 6.4%. rotavirus and adenovirus were detected in 10.1 and 1.7% of stools from control group, respectively. interestingly, the frequency of the youngest children in the control group excreting rotavirus a was comparable to that detected in stools from diarrheic children. we cannot rule out the existence of other enteric viruses because the etiology of 171 cases of diarrhea was not determined and active search for astrovirus and calicivirus was not done. this is the first study that shows the presence of enteric viruses in the infantile population from western brazilian amazonia and it was important to help physicians in the treatment of viral gastroenteritis.
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