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Search Results: 1 - 10 of 3753 matches for " Luisa Boldrin "
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Grafting of a Single Donor Myofibre Promotes Hypertrophy in Dystrophic Mouse Muscle
Luisa Boldrin, Jennifer E. Morgan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054599
Abstract: Skeletal muscle has a remarkable capability of regeneration following injury. Satellite cells, the principal muscle stem cells, are responsible for this process. However, this regenerative capacity is reduced in muscular dystrophies or in old age: in both these situations, there is a net loss of muscle fibres. Promoting skeletal muscle muscle hypertrophy could therefore have potential applications for treating muscular dystrophies or sarcopenia. Here, we observed that muscles of dystrophic mdx nude host mice that had been acutely injured by myotoxin and grafted with a single myofibre derived from a normal donor mouse exhibited increased muscle area. Transplantation experiments revealed that the hypertrophic effect is mediated by the grafted fibre and does not require either an imposed injury to the host muscle, or the contribution of donor cells to the host muscle. These results suggest the presence of a crucial cross-talk between the donor fibre and the host muscle environment.
The Satellite Cell in Male and Female, Developing and Adult Mouse Muscle: Distinct Stem Cells for Growth and Regeneration
Alice Neal, Luisa Boldrin, Jennifer Elizabeth Morgan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037950
Abstract: Satellite cells are myogenic cells found between the basal lamina and the sarcolemma of the muscle fibre. Satellite cells are the source of new myofibres; as such, satellite cell transplantation holds promise as a treatment for muscular dystrophies. We have investigated age and sex differences between mouse satellite cells in vitro and assessed the importance of these factors as mediators of donor cell engraftment in an in vivo model of satellite cell transplantation. We found that satellite cell numbers are increased in growing compared to adult and in male compared to female adult mice. We saw no difference in the expression of the myogenic regulatory factors between male and female mice, but distinct profiles were observed according to developmental stage. We show that, in contrast to adult mice, the majority of satellite cells from two week old mice are proliferating to facilitate myofibre growth; however a small proportion of these cells are quiescent and not contributing to this growth programme. Despite observed changes in satellite cell populations, there is no difference in engraftment efficiency either between satellite cells derived from adult or pre-weaned donor mice, male or female donor cells, or between male and female host muscle environments. We suggest there exist two distinct satellite cell populations: one for muscle growth and maintenance and one for muscle regeneration.
Seconda sessione - Il ruolo de La immobiliare veniziana nella trasformazione urbana di Mestre e Porto Marghera
Angelo Boldrin
Aestimum , 2002,
Integrated Functions of Pax3 and Pax7 in the Regulation of Proliferation, Cell Size and Myogenic Differentiation
Charlotte A. Collins, Viola F. Gnocchi, Robert B. White, Luisa Boldrin, Ana Perez-Ruiz, Frederic Relaix, Jennifer E. Morgan, Peter S. Zammit
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004475
Abstract: Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis. Pax3 and Pax7 are expressed by postnatal satellite cells or their progeny but are down regulated during myogenic differentiation. We now show that constitutive expression of Pax3 or Pax7 in either satellite cells or C2C12 myoblasts results in an increased proliferative rate and decreased cell size. Conversely, expression of dominant-negative constructs leads to slowing of cell division, a dramatic increase in cell size and altered morphology. Similarly to the effects of Pax7, retroviral expression of Pax3 increases levels of Myf5 mRNA and MyoD protein, but does not result in sustained inhibition of myogenic differentiation. However, expression of Pax3 or Pax7 dominant-negative constructs inhibits expression of Myf5, MyoD and myogenin, and prevents differentiation from proceeding. In fibroblasts, expression of Pax3 or Pax7, or dominant-negative inhibition of these factors, reproduce the effects on cell size, morphology and proliferation seen in myoblasts. Our results show that in muscle progenitor cells, Pax3 and Pax7 function to maintain expression of myogenic regulatory factors, and promote population expansion, but are also required for myogenic differentiation to proceed.
A indústria cultural em tempos de globaliza o The cultural industry in globalized times
Rodrigo Boldrin Bacchin
Estudos de Sociologia , 2007,
Zanoni Maria Valnice Boldrin
Journal of the Brazilian Chemical Society , 2003,
An Algebraic Semantics for Possibilistic Logic
Luca Boldrin,Claudio Sossai
Computer Science , 2013,
Abstract: The first contribution of this paper is the presentation of a Pavelka - like formulation of possibilistic logic in which the language is naturally enriched by two connectives which represent negation (eg) and a new type of conjunction (otimes). The space of truth values for this logic is the lattice of possibility functions, that, from an algebraic point of view, forms a quantal. A second contribution comes from the understanding of the new conjunction as the combination of tokens of information coming from different sources, which makes our language "dynamic". A Gentzen calculus is presented, which is proved sound and complete with respect to the given semantics. The problem of truth functionality is discussed in this context.
Anomalous Hall Effect in Geometrically Frustrated Magnets
D. Boldrin,A. S. Wills
Advances in Condensed Matter Physics , 2012, DOI: 10.1155/2012/615295
Abstract: Geometrically frustrated conducting magnets display extraordinarily large anomalous Hall effects (AHEs) that could be used to realise materials required for the emerging field of spintronics. While the intrinsic Berry phase developed in collinear ferromagnets is well explained through the effects of spin-orbit interactions within the Karplus and Luttinger model, its origins in frustrated magnets are not. The direct space mechanism based on spin chirality that was originally applied to the pyrochlore Nd2Mo2O7 appears unsatisfactory. Recently, an orbital description based on the Aharonov-Bohm effect has been proposed and applied to both the ferromagnetic pyrochlores Nd2Mo2O7 and Pr2Ir2O7; the first of which features long-ranged magnetic order while the latter is a chiral spin liquid. Two further examples of geometrically frustrated conducting magnets are presented in this paper—the kagome-like Fe3Sn2 and the triangular PdCrO2. These possess very different electronic structures to the 3-dimensional heavy-metal pyrochlores and provide new opportunities to explore the different origins of the AHE. This paper summarises the experimental findings in these materials in an attempt to unite the conflicting theoretical arguments. 1. Introduction As the shrinking of components in integrated circuits characterised by Moore’s law reaches its physical limit, the search is on for new properties and materials that can be used to carry, process, and store information. One of the key areas for research that could allow these improvements to continue is the field of magnetism where information is encoded in electronic spin rather than charge [1]. Current technologies have already benefited from some of this potential with the improvements in hard disk capacity being based on the developments of giant magneto-resistance (GMR) devices and in the synthesis of highly anisotropic magnetic nanoparticles that store the data. Magnetic random access memory (MRAM) based on spin-dependent tunneling is also becoming more affordable and shows advantages in power consumption and stability over conventional silicon-based electronics [2]. Developing the required suite of spin-dependent electronic, spintronic devices, requires the discovery of materials that display strong spin-dependent electronic properties at room temperature. Following on from initial work on the ferromagnetic pyrochlore Nd2Mo2O7, geometrically frustrated magnetism has been shown to provide new ways to engineer such effects with its characteristic noncollinear spin structures leading to unconventional types of the
O gênero Eleocharis R. Br. (Cyperaceae) no Rio Grande do Sul, Brasil
Rafael Trevisan,Ilsi Iob Boldrin
Revista Brasileira de Biociências , 2008,
Abstract: O estudo taxon mico do gênero Eleocharis R. Br. para o Rio Grande do Sul foi desenvolvido através dos métodos tradicionais em taxonomia. Os dados foram obtidos através da bibliografia, revis o de herbários regionais e coleta de exemplares a campo. O gênero está representado no Rio Grande do Sul por 27 espécies: Eleocharis acutangula (Roxb.) Schult., E. bonariensis Nees, E. contracta Maury, E. dunensis Kük., E. elegans (Kunth) Roem. & Schult., E. filiculmis Kunth, E. flavescens (Poir.) Urb., E. geniculata (L.) Roem. & Schult., E. interstincta (Vahl) Roem. & Schult., E. laeviglumis R. Trevis. & Boldrini, E. loefgreniana Boeck., E. maculosa (Vahl) Roem. & Schult., E. minima Kunth var. minima, E. montana (Kunth) Roem. & Schult., E. montevidensis Kunth, E. nudipes (Kunth) Palla, E. obtusetrigona (Lindl. & Nees) Steud., E. parodii Barros, E. quinquangularis Boeck., E. rabenii Boeck., E. radicans (Poir.) Kunth, E. sellowiana Kunth, E. squamigera Svenson, E. subarticulata (Nees) Boeck., E. viridans Kük. ex Osten, Eleocharis sp.1 e Eleocharis sp.2. O trabalho apresenta descri es, ilustra es, dados sobre distribui o geográfica, habitat e períodos de flora o e frutifica o das espécies, além de uma chave dicot mica para diferenciá-las.
Effect of Ionic Liquid on the Determination of Aromatic Amines as Contaminants in Hair Dyes by Liquid Chromatography Coupled to Electrochemical Detection
Thiago Mescoloto Lizier,Maria Valnice Boldrin Zanoni
Molecules , 2012, DOI: 10.3390/molecules17077961
Abstract: The room temperature ionic liquid (IL) 1-butyl-3-methylimidazolium bis-(trifluorometanesulfonyl)imide BMIm[NTf2] was used as a novel medium for improvement of separation and quantization of 16 aromatic amines typically present as contaminants in consumer products and detected by HPLC coupled to an electrochemical detector. The aromatic amines, namely 4,4'-diaminodiphenylmethane, 4-chloroaniline, 2-methoxy-5-methyl-aniline, 3,3'-dimethylbenzidine, 2,4-diaminotoluidine, 2-chloro-4-nitroaniline, 4,4'-oxydianiline, aniline, 3,3'-dichlorobenzidine, benzidine, 4-aminobiphenyl, o-dianisidine, o-anisidine, o-toluidine, 4,4'-methylene-bis-2-chloroaniline and 2-naphthyl-amine are oxidized in methanol/BMIm[NTf2] at a potential around +0.68V to +0.93V vs. Ag/AgCl at a glassy carbon electrode, which is the base for their determination by HPLC/ED. Using the optimized conditions of methanol/BMIm[NTf2] 70:30 (v/v) as mobile phase, flow-rate of 0.8 mL·min?1, column CLC-ODS, Eap = +1.0 V and T = 40 °C analytical curves were constructed for each of the tested amines. Good linearity was obtained in the concentration range of 1.09 mg·L?1 to 217 mg·L?1, with excellent correlation coefficients. The limits of detection reached 0.021 mg·L?1 to 0.246 mg·L?1 and good relative standard deviations (RSD, n = 3) were obtained from the measurements. Satisfactory recovery for each aromatic amine was achieved, ranging from 95 to 103%. The developed method was successfully applied to determine six aromatic amines present as contaminants in commercial hair dye samples.
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