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Search Results: 1 - 10 of 2589 matches for " Luigi Tubani "
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Circadian rhythm of the autonomic nervous system in insulin resistant subjects with normoglycemia, impaired fasting glycemia, impaired glucose tolerance, type 2 diabetes mellitus
Antonio Perciaccante, Alessandra Fiorentini, Alberto Paris, Pietro Serra, Luigi Tubani
BMC Cardiovascular Disorders , 2006, DOI: 10.1186/1471-2261-6-19
Abstract: Eighty Caucasian insulin resistant subjects (IR) and twenty five control subjects were recruited for the study. IR subjects were divided into four groups according to the outcoming results of oral glucose tests (OGTTs): IR subjects with normal glucose regulation (NGR), IR subjects with impaired fasting glycemia (IFG), IR subjects with impaired glucose tolerance (IGT) and subjects with type 2 diabetes mellitus (DM). Autonomic nervous activity was studied by 24-hours ECG recording. Heart rate variability analysis was performed in time and frequency domains: SDNN, RMS-SD, low frequency (LF) and high frequency (HF) were calculated.The total SDNN showed statistically significant reduction in all four groups with insulin resistant subjects (IR) when compared to the control group (p <0,001). During night LF normalized units (n.u.) were found to be higher in all four groups including IR subjects than in the control group (all p < 0,001) and subjects with normal glucose regulation (NGR), with impaired fasting glycemia (IFG) and with impaired glucose tolerance (IGT) were found to have higher LF n.u. than those in the type 2 diabetes mellitus group. The linear regression model demonstrated direct association between LF values and the homeostasis model assessment-index (HOMA-I), in the insulin resistant group (r = 0,715, p <0,0001).The results of our study suggest that insulin resistance might cause global autonomic dysfunction which increases along with worsening glucose metabolic impairment. The analysis of sympathetic and parasympathetic components and the sympathovagal balance demonstrated an association between insulin resistance and sympathetic over-activity, especially during night. The results indicated that the sympathetic over-activity is directly correlated to the grade of insulin resistance calculated according to the HOMA-I. Since increased sympathetic activity is related to major cardiovascular accidents, early diagnosis of all insulin resistant patients should be
Circadian rhythm of autonomic activity in non diabetic offsprings of type 2 diabetic patients
A Fiorentini, A Perciaccante, A Paris, P Serra, L Tubani
Cardiovascular Diabetology , 2005, DOI: 10.1186/1475-2840-4-15
Abstract: Sympathetic and parasympathetic components of neurovegetative system regulate cardiac activity. Spectral analysis of heart rate variability (HRV) is a non invasive metodic used to assess cardiac autonomic activity. The autonomic activities can be assessed in HRV by the relative distribution (evaluated in normalized units) of low frequency (LF), as an index of sympathetic modulation and of high frequency (HF), as an index of parasympathetic modulation. The analysis of HRV has been used for evaluate the autonomic cardiac activity in numerous pathophisyologic conditions [1-9]: an impaired heart rate variation is a marker of autonomic neuropathy [10,11] as in diabetic subjects [12-16].Several studies have showed a sympathetic overactivity also in non diabetic insulin resistant group [17-19]. However, little is known about the association between the familiarity for type 2 diabetes mellitus and the autonomic activity. An increased LF/ HF ratio (low frequency/high frequency ratio) has identified in only insulin resistant offsprings of type 2 diabetic subjects [20]. De Angelis et al [21] has showed this condition at rest but not under stimulated conditions. Laitinen et al [22] has identified a sympathetic overactivity during acute hyperinsulinemia both in insulin resistant and non insulin resistant offsprings of type 2 diabetic subjects.The aim of the present study was to evaluate, by heart rate variability with 24-hours ECG Holter registration, the autonomic activity and circadian autonomic rhythm in offspring of type 2 diabetic subjects and to evaluate the possible impact of sympathetic activity on insulin resistance. We tested the hypothesis that in non insulin resistant offsprings of type 2 diabetic subjects an alteration of circadian rhythm of autonomic activity are present and that the impairment of autonomic system activity could precede the insulin resistance.70 consecutive caucasian offsprings of type 2 diabetic subjects, admitted to our department, were screened.
DANTE’s Medical Knowledge: The Case of INFERNO, Canto XXX  [PDF]
Luigi Roffi
Advances in Historical Studies (AHS) , 2018, DOI: 10.4236/ahs.2018.71002

The Divine Comedy, by Dante Alighieri, describes an imaginative journey in afterlife. In Hell, canto XXX, Dante meets the falsifiers and sees a man who has the shape of a lute, a rotting face, and an abdomen bloated by “dropsy”. This horribly deformed sinner is Master Adam, who counterfeited Florentine money, and for this crime was burned at the stake. Previous critics had ascribed Master Adam’s punishment to various real or imaginary diseases, but an alternative possibility is that it may represent one of the most ancient, yet accurate, descriptions of tense ascites in the literature.

Security Engineering of SOA Applications Via Reliability Patterns  [PDF]
Luigi Coppolino, Luigi Romano, Valerio Vianello
Journal of Software Engineering and Applications (JSEA) , 2011, DOI: 10.4236/jsea.2011.41001
Abstract: Providing reliable compositions of Web Services is a challenging issue since the workflow architect often has only a limited control over the reliability of the composed services. The architect can instead achieve reliability by properly planning the workflow architecture. To this end he must be able to evaluate and compare the reliability of multiple architectural solutions. In this paper we present a useful tool which allows to conduct reliability analysis on planned workflows, as well as to compare the reliability of alternative solutions in a what-if analysis. The tool is implemented as a plug-in for the widely adopted Active BPEL Designer and exploits the concept of reliability pattern to evaluate the reliability formula of the workflow. The effectiveness of the approach and the operation of the tool are demonstrated with respect to a case study of a business security infrastructure realized by orchestrating simple security services.
Altruism, Selfishness and Social Cohesion  [PDF]
Antonio Luigi Paolilli
Sociology Mind (SM) , 2011, DOI: 10.4236/sm.2011.14018
Abstract: Recently has been shown that, given certain conditions, altruism can prevail in a population even without the help of mechanisms as kin selection, reciprocal altruism and group selection. At the light of this hypothesis, it is shown how altruism and cooperative aptitudes can favor the concentration of a population and how an (incomplete) evolution of altruism, caused by group selection, into the Benthamian form, determining the emergence of sentiments and behaviors, such as a sense of justice, as well as envy and gossip, can lead to the formation of a regulated society. From this standpoint, altruism leads to group selection, and not the contrary.
Clinical, radiological and histological diagnoses of periapical periodontitis spreading to the adjacent tooth: A case of endodontic failure  [PDF]
Luigi Cianconi, Manuele Mancini
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.35048

Aims: This article describes the apical infection in endodontically treated tooth 4.5 that spread to adjacent tooth 4.4. Case Report: A 52-year-old woman was referred for the presence of radiolucency extending from tooth 4.5 and mental foramen. Spontaneous symptoms were present. Tooth 4.5 showed poor-quality endodontics. The vitality of tooth 4.4 was negative, even though no mechanical trauma had been reported, nor was caries present. Both teeth were sensitive to percussion. Endodontic re-treatment of 4.5 and endodontic treatment of 4.4 were performed in a single visit. A large amount of endodontic sealer squeezed mesially from the root of tooth 4.5, where a partial horizontal root fracture was hypothesized. 6-, 12-, and 18-month radiographic follow-ups, by both periapical and cone-beam computed tomography (CBCT) analyses, showed incomplete osseous healing. CBCT excluded root fracture on 4.5. Local symptoms were still present. Clinical and radiological conditions led to extractions, and a cystic lesion was enucleated for histopathologic analyses. Histopathologic diagnosis was a periapical cyst. The supposed partial horizontal root fracture of 4.5 was actually a large lateral canal. Although the root canal treatments followed high standards in terms of quality, a persistent chronic infection developed histologically. The cystic lesion was one consistent reason for the unsuccessful healing of 4.5.

Learning from experience: A simple effective protocol to test footwear prescriptions for the Diabetic foot by using the Pedar system  [PDF]
Claudia Giacomozzi, Luigi Uccioli
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.65A008

Adherence of patients to treatment and appropriateness of prescribed footwear are mandatory for successful prevention of Diabetic foot ulceration. In a Public Healthcare Service, footwear approval is under the responsibility of the clinician. In some cases kinetic measurements are taken inside the shoes to support the clinical decision; however, an overall agreement is still missing with respect to a simple, reliable and effective test protocol based on proper threshold values. Authors’ past experiences, specific needs of the Diabetic outpatient service, and suggestions from valuable literature led to an instrumental test protocol based on reference peak pressure (PP) thresholds and gait line (GL) specific for each level of risk. Permission was obtained for one preliminary validation session at the Authors’ outpatient service, during which 11 patients at high/very high risk of ulceration were examined—9 for testing new footwear, 2 for monitoring 12-month-old footwear. The protocol was well accepted by patients and operators, fast and easy to be used. Based on the instrumental, clinical and visual inspection data; 4 new footwear did not pass the test; 5 passed the test but integration or minor changes were requested; the 2 old footwear were found no more effective. As a first positive feedback, after 4 months of wearing the modified prescriptions none of the patients had developed plantar ulcers or signs of tissue damage. Successive data processing proved that in all patients altered PPs and deviated GLs did correlate with alterations of other kinetic parameters. The protocol, which is proved to be sensitive and valuable for the Diabetic foot care, may have a general validity; the delivered specific PP thresholds and reference data, instead, can be reliably used if the test is performed with a calibrated Pedar Insole System and with the wide Insoles in the range UW-YW (EU size 36 - 45).

SEM evaluation of apical intraradicular dentine cleanliness and degree of erosion after the application of three irrigating solutions  [PDF]
Manuele Mancini, Luigi Cianconi
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.32030

Aims: The aim of the study was to compare the efficacy of 37% phosphoric acid, 12% nitric acid, 17% EDTA in endodontic smear layer removal and degree of erosion in the apical third of endodontic canals. Methods and Material: One hundred and four extracted single-rooted human teeth were randomized into four groups (n = 26) and instrumented using ProTaper Universal Ni-Ti rotary instruments. Each canal was irrigated with one of the following solutions: 37% phosphoric acid, 12% nitric acid, 17% EDTA, 5.25% NaOCl (control). All specimens were then irrigated with 5 mL distilled water and dried with sterile paper points. Kruskal-Wallis and Mann-WhitneyU statistical tests were used. Results: Scanning electron microscopy (SEM) evaluation showed no significant differences among test reagents in smear layer removal. However, the efficacy of 12% nitric acid and 17% EDTA in removing the smear layer was significantly greater than 5.25% NaOCl (control). Degree of erosion could not be evaluated. Conclusion: Protocols used in this study were not sufficient to completely remove the smear layer in the apical third of shaped root canals.

Economic and Cultural Peripheralization in the Eurozone  [PDF]
Antonio Luigi Paolilli
Sociology Mind (SM) , 2014, DOI: 10.4236/sm.2014.41006

In this paper, we will discuss the reasonableness of the decision by Italy and other southern and western EU states to become members of the eurozone. We will also discuss whether this economic choice can be socially and culturally sustainable in a Europe characterized by cultures which, despite their shared substratum, are in competition with each other.

Zero-Point Field, QED Coherence, Living Systems and Biophotons Emission  [PDF]
Luigi Maxmilian Caligiuri
Open Journal of Biophysics (OJBIPHY) , 2015, DOI: 10.4236/ojbiphy.2015.51002
Abstract: Living organisms are high ordered and organized systems accumulating and successively using low entropy energy to support all the processes needed for life. This low level of entropy is a required condition in order to make possible the use of endogenous energy for producing, for example, mechanical work. The commonly accepted picture of condensed matter physics, exclusively considering the perturbative coupling between QED Zero-Point-Field also known as “Quantum Vacuum” and the matter system, is unable to thoroughly explain the true origin of this low entropy energy reservoir and its dynamics. Recent researches instead suggested that energy and mass of every particle or body could be actually considered as arising from Quantum Vacuum dynamics which, in turn, can exhibit, under suitable conditions always occurring in the case of living systems, a coherent behavior characterized by a strong phase correlation between matter and an electromagnetic field trapped inside this ensemble. In this paper the preliminary model of Quantum Vacuum already proposed by author is reformulated in terms of QED coherence in condensed matter showing it is able to explain the origin of internal energy stock of living organisms. Within this theoretical framework, an interpretation of some important experimental results about biophotons emission by living systems under the influence of external stimuli is also proposed, suggesting their origin could also arise from Quantum Vacuum dynamics. This model, as shown, opens very interesting and exciting scenarios of further developments in the understanding of the birth and dynamics of life.
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