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Search Results: 1 - 10 of 34756 matches for " Luigi Antonio Morrone "
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Impairment of Neuronal Glutamate Uptake and Modulation of the Glutamate Transporter GLT-1 Induced by Retinal Ischemia
Rossella Russo, Federica Cavaliere, Giuseppe Pasquale Varano, Marco Milanese, Annagrazia Adornetto, Carlo Nucci, Giambattista Bonanno, Luigi Antonio Morrone, Maria Tiziana Corasaniti, Giacinto Bagetta
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069250
Abstract: Excitotoxicity has been implicated in the retinal neuronal loss in several ocular pathologies including glaucoma. Dysfunction of Excitatory Amino Acid Transporters is often a key component of the cascade leading to excitotoxic cell death. In the retina, glutamate transport is mainly operated by the glial glutamate transporter GLAST and the neuronal transporter GLT-1. In this study we evaluated the expression of GLAST and GLT-1 in a rat model of acute glaucoma based on the transient increase of intraocular pressure (IOP) and characterized by high glutamate levels during the reperfusion that follows the ischemic event associated with raised IOP. No changes were reported in GLAST expression while, at neuronal level, a reduction of glutamate uptake and of transporter reversal-mediated glutamate release was observed in isolated retinal synaptosomes. This was accompanied by modulation of GLT-1 expression leading to the reduction of the canonical 65 kDa form and upregulation of a GLT-1-related 38 kDa protein. These results support a role for neuronal transporters in glutamate accumulation observed in the retina following an ischemic event and suggest the presence of a GLT-1 neuronal new alternative splice variant, induced in response to the detrimental stimulus.
Altruism, Selfishness and Social Cohesion  [PDF]
Antonio Luigi Paolilli
Sociology Mind (SM) , 2011, DOI: 10.4236/sm.2011.14018
Abstract: Recently has been shown that, given certain conditions, altruism can prevail in a population even without the help of mechanisms as kin selection, reciprocal altruism and group selection. At the light of this hypothesis, it is shown how altruism and cooperative aptitudes can favor the concentration of a population and how an (incomplete) evolution of altruism, caused by group selection, into the Benthamian form, determining the emergence of sentiments and behaviors, such as a sense of justice, as well as envy and gossip, can lead to the formation of a regulated society. From this standpoint, altruism leads to group selection, and not the contrary.
Economic and Cultural Peripheralization in the Eurozone  [PDF]
Antonio Luigi Paolilli
Sociology Mind (SM) , 2014, DOI: 10.4236/sm.2014.41006
Abstract:

In this paper, we will discuss the reasonableness of the decision by Italy and other southern and western EU states to become members of the eurozone. We will also discuss whether this economic choice can be socially and culturally sustainable in a Europe characterized by cultures which, despite their shared substratum, are in competition with each other.

Finance and Centre-Periphery Dynamics: A Model  [PDF]
Antonio Luigi Paolilli, Fabio Pollice
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.33033
Abstract: In the last few decades we have witnessed a marked process of economic globalization (that is the growing interrelation and integration of the economic systems of the whole world), accompanied and favoured by what is called financialization (whose definition is more problematic, but we can identify it as the growing relative importance of financial profits compared to those deriving from trade and production of real goods). In this paper, after briefly discussing and defining the two phenomena in the light of the debate about them, we will present a mathematical model to study their effects on the economic development of regions with a different initial capital set-up, which includes human and organizational capital. The model shows that low wages in certain conditions can determine high interest rates, favouring financial flows from peripheral areas to developed countries.
Diagnostic Workup for Disorders of Bone and Mineral Metabolism in Patients with Chronic Kidney Disease in the Era of KDIGO Guidelines
Luigi Francesco Morrone,Domenico Russo,Biagio Di Iorio
International Journal of Nephrology , 2011, DOI: 10.4061/2011/958798
Abstract: KDIGO (Kidney Disease: Improving Global Outcomes) is an international nonprofit organization devoted to “improve the care and outcomes of kidney disease patients worldwide through promoting coordination, collaboration, and integration of initiatives to develop and implement clinical practice guidelines.” The mineral and bone disorder (MBD) in patients with chronic kidney disease (CKD) has been the first area of interest of KDIGO international initiative. KDIGO guidelines on CKD-MBD were published in 2009 with the intent to modify the previous KDOQI guidelines that had failed to consistently change the global outcome of CKD patients. After the publication of KDOQI guidelines for bone metabolism and disease in 2003, a large number of observational data emerged in literature linking disordered mineral metabolism with adverse clinical outcomes. Notwithstanding this large body of observational data, a paucity of evidence from high-quality clinical trials was available for the development of KDIGO guidelines. Herein, a summary will be provided of the most important findings of KDIGO guidelines regarding the diagnostic workup and clinical monitoring of CKD-MBD patients. 1. Introduction The nonprofit foundation KDIGO (Kidney Disease: Improving Global Outcomes) was established in 2003 with the aim to improve outcomes in CKD patients through the optimization of care. The mineral and bone disorder (MBD) in CKD has been the first area of interest of the KDIGO international initiative. A KDIGO position statement published in 2006 defined CKD-MBD disease as due to either one or a combination of the following clinical situations: (a) abnormalities of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D metabolism; (b) abnormalities in bone turnover, mineralization, volume, linear growth, or strength; (c) vascular or other soft tissue calcification [1]. The term renal osteodystrophy was limited to the diagnosis of alterations in bone morphology and their histomorphometric quantification by bone biopsy. With regard to the volume and quality of evidence, a KDIGO Work Group of international experts and an Evidence Review Team (ERT) were set up to collaborate for the development of a set of new guidelines for the care of adults and children with CKD stages 3–5 and for patients on chronic dialysis therapy or with a kidney transplant. To this purpose, the end points of direct importance to patients were identified as follows: mortality, cardiovascular disease events, fractures, hospitalisation, and quality of life. Intermediate and biochemical end points were also
Gaseous and Particulate Exhaust Emissions of Hybrid and Conventional Cars over Legislative and Real Driving Cycles  [PDF]
Maria Antonietta Costagliola, Maria Vittoria Prati, Antonio Mariani, Andrea Unich, Biagio Morrone
Energy and Power Engineering (EPE) , 2015, DOI: 10.4236/epe.2015.75018
Abstract: Road transport exhaust emissions represent the main sources of atmospheric pollution in urban areas, due to the growing number of circulating vehicles and travelled distances. In order to reduce this pollution source, stricter emission standards are periodically set by governments through- out the world. Consequently, the concentrations of gaseous pollutants and particulate mass to be measured during type-approval tests of new vehicles are becoming progressively lower; moreover from 2011, diesel cars have to comply with particle number limit. In order to assess emission levels of different technology vehicles and investigate the use of a particulate number measurement technique at the exhaust of very low-emitting vehicles, an experimental activity was carried out on three in-use vehicles: a diesel car equipped with a particulate trap (DPF), a hybrid gasoline-elec- tric car and a bi-fuel passenger car fuelled with compressed natural gas (CNG). Cold and hot gaseous and particulate emission factors and fuel consumption were measured during the execution of real and regulatory driving cycles on a chassis dynamometer. Particulate was characterized in terms of mass only for the diesel car and of particle number for all vehicles. The emissions measured over the NEDC show that all three vehicles comply with their standard limits, except CO for CNG passenger car and NOx for diesel car. Cold start influences CO and HC emissions and fuel consumption for all the tested vehicles and in particular for the hybrid car. The real driving cycle is the most critical pattern for the emissions of almost all pollutants. During constant speed tests, the emissions of particles of hybrid car are an order of magnitude lower than those of the CNG car.
Ginecomastia: um efeito colateral raro da isoniazida
Morrone, Nelson;Morrone Junior, Nelson;Braz, Alessandra Garcia;Maia, José Antonio Freire;
Jornal Brasileiro de Pneumologia , 2008, DOI: 10.1590/S1806-37132008001100014
Abstract: we report the case of a patient who twice developed gynecomastia following tuberculosis treatment. an 18-year-old male developed painful bilateral gynecomastia after three months of treatment with the isoniazid-rifampin-pyrazinamide regimen. partial resolution of gynecomastia was achieved at the end of treatment. the patient was retreated with the same regimen eight years later, and gynecomastia recurred after six months of treatment. hormone levels were normal, and a mammogram revealed bilateral gynecomastia. the isoniazid was discontinued, and the gynecomastia was partially resolved by the end of treatment. four years later, gynecomastia was not detected. we conclude that isoniazid-related gynecomastia completely resolves when the medication is discontinued. therefore, pharmacological and surgical treatment should be avoided.
Pneumopatia causada por Mycobacterium kansasii
Morrone Nelson,Cruvinel Maria do Carmo,Morrone Junior Nelson,Freire José Antonio dos Santos
Jornal de Pneumologia , 2003,
Abstract: INTRODU O: O Mycobacterium kansasii é uma micobactéria n o tuberculosa que pode causar coloniza o ou infec o pulmonar. OBJETIVO: Relatar experiência com doen a pulmonar causada pelo M. kansasii em uma série de seis pacientes diagnosticados ao longo de cinco anos. MéTODO: Entre junho de 1995 e junho de 2000 foram admitidos 1.349 pacientes no Dispensário do Ipiranga Ari Nogueira da Silva-Sanatorinhos, com o diagnóstico de tuberculose pulmonar, dos quais seis tiveram cultura positiva para M. kansasii. RESULTADOS: Cinco pacientes eram homens e a idade variou entre 25 e 77 anos. Todos apresentavam pneumopatia cr nica e eram sintomáticos respiratórios com teste negativo para síndrome de imunodeficiência humana. As radiografias de tórax eram compatíveis com a presen a de doen a pulmonar prévia: cavidades de paredes finas foram notadas em todos e espessamento pleural subjacente às cavidades foi observado em dois pacientes. Todos foram tratados inicialmente com isoniazida, rifampicina, pirazinamida (INH-RMP-PZA) e etambutol (EMB) foi introduzido precocemente em dois pacientes por intolerancia à pirazinamida, enquanto que em outros dois a introdu o foi feita ao ser conhecido o resultado da cultura. Todos os pacientes foram tratados por mais de nove meses, tendo sido observada recidiva em um deles. Um paciente com silicose faleceu após dois anos por insuficiência respiratória, depois de ter sido considerado curado. CONCLUS ES: A micobacteriose por M. kansasii foi encontrada com baixa freqüência, podendo estar relacionada às características dos pacientes encaminhados ao nosso servi o. O esquema INH-RMP-PZA, com substitui o eventual da PZA por etambutol, mostrou sucesso terapêutico.
Gagaku, de Olivier Messiaen
Irlandini, Luigi Antonio;
Per Musi , 2012, DOI: 10.1590/S1517-75992012000100005
Abstract: the tension between nostalgia and innovation is uniquely manifested in olivier messiaen's gagaku, the fourth movement of his 1962 composition sept haikai. messiaen's religiosity represented a form of nostalgia to the intellectual french avant-garde. messiaen considers the sense of ritual and stasis as musical expressions of sacredness. by comparing the structure of messiaen's gagaku (analyzed in the light of his writings about his compositional methods) and that of ancient japanese gagaku court music, this paper will show how this sense of ritual and stasis constitutes the aesthetic common ground existing independently in both forms. the existence of common elements between a non-western "source" and the western composition inspired by that source provides the necessary condition for the transformation of nostalgia into innovation. the concept of écriture plays an important role in the past/future dialectic of this transformation, causing structure and style to differ based on the principle of non-imitation and asserting itself as the shaping element that makes gagaku a piece of distinctly french music.
Skills or culture? An analysis of the decision to work by immigrant women in Italy
Antonio Accetturo and Luigi Infante
IZA Journal of Migration , 2013, DOI: 10.1186/2193-9039-2-2
Abstract: JEL: J22, J61, J15
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