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Search Results: 1 - 10 of 672639 matches for " Ludmila L. de M.; "
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Estimativa das temperaturas máximas e mínimas do ar para a regi?o do Circuito das Frutas, SP
Bardin, Ludmila;Pedro Júnior, Mário J.;Moraes, Jener F. L. de;
Revista Brasileira de Engenharia Agrícola e Ambiental , 2010, DOI: 10.1590/S1415-43662010000600008
Abstract: multiple regression equations to estimate mean monthy and annual maximum and minimum temperatures were developed as a function of altitude, latitude, and longitude for the "pólo turístico do circuito das frutas" region. the obtained correlation coefficients varied from 0.91 to 0.96 and 0.71 to 0.94 of the maximum and minimum air temperature, respectively. also, maps with the spacial variability of the maximum and minimum mean monthly and annual temperatures are presented for the region.
Caracteriza??o físico-química de frutos de quatro cultivares de quiabo
Mota, Wagner F. da;Finger, Fernando Luiz;Silva, Derly José H. da;Corrêa, Paulo César;Firme, Lúcia P.;Neves, Ludmila L. de M.;
Horticultura Brasileira , 2005, DOI: 10.1590/S0102-05362005000300006
Abstract: in an experiment some physical and chemical characteristics of four okra cultivars were evaluated. the experimental design was of randomized blocks, where the treatments were the cultivars amarelinho, red velvet, star of david and mammoth spinless with five replications. at commercial maturity fruits of the cultivar star of david presented the largest diameter, total fresh matter, content of dry matter, smallest length, content of water and vitamin c in comparison to the other cultivars. the cultivar red velvet presented the smallest diameter, total fresh matter, content of dry matter, reducing sugars and content of chlorophyll a, b and total, but the largest content of water and vitamin c. the cultivar amarelinho produced the longest fruits and the smallest content of chlorophyll a, b and total. the cultivars amarelinho and mammoth spinless showed higher contents of total reducing sugars.
Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity
Ludmila G. de Oliveira,Meiriane M. Silva,Flávia C. S. de Paula,Elene C. Pereira-Maia,Cláudio L. Donnici,Carlos A. de Simone,Frédéric Frézard,Eufranio N. da Silva Júnior,Cynthia Demicheli
Molecules , 2011, DOI: 10.3390/molecules161210314
Abstract: Antimony(V) and bismuth(V) complexes of lapachol have been synthesized by the reaction of Ph3SbCl2 or Ph3BiCl2 with lapachol (Lp) and characterized by several physicochemical techniques such as IR, and NMR spectroscopy and X-ray crystallography. The compounds contain six-coordinated antimony and bismuth atoms. The antimony(V) complex is a monomeric derivative, (Lp)(Ph3Sb)OH, and the bismuth(V) complex is a dinuclear compound bridged by an oxygen atom, (Lp)2(Ph3Bi)2O. Both compounds inhibited the growth of a chronic myelogenous leukemia cell line and the complex of Bi(V) was about five times more active than free lapachol. This work provides a rare example of an organo-Bi(V) complex showing significant cytotoxic activity.
Armazenamento de frutos de quiabo embalados com filme de PVC em condi??o ambiente
Mota, Wagner F da;Finger, Fernando Luiz;Cecon, Paulo Roberto;Silva, Derly José H da;Corrêa, Paulo César;Firme, Lúcia P;Neves, Ludmila L de M;
Horticultura Brasileira , 2006, DOI: 10.1590/S0102-05362006000200028
Abstract: the present work evaluated the influence of pvc film on the postharvest shelf life of four cultivars of okra stored at room temperature. the experiment was arranged in random blocks, in sub split parcels, where the parcels were a factorial 2x4, with and without pvc film and the cvs. amarelinho, red velvet, star of david and mammoth spinless, and the subparcels the six sample time with four blocks. the characteristics evaluated were: percentage of weight loss, relative water content, total chlorophyll and chlorophyll a and b, content of vitamin c, visual browning. the pvc was efficient in controlling the weight loss and retained the water content through storage. the lowest losses were observed for the cvs. amarelinho and star of david, without and with pvc, respectively. there was higher retention of vitamin c in the fruits wrapped with pvc and the cvs. red velvet and star of david kept higher content of it. in general, the cv. mammoth spinless kept higher content of chlorophyll. the higher incidence of browning was in fruits stored without pvc. the red velvet had better shelf life due to lower browning.
Membrane Cholesterol Regulates Lysosome-Plasma Membrane Fusion Events and Modulates Trypanosoma cruzi Invasion of Host Cells
Bárbara Hissa,Jacqueline G. Duarte,Ludmila F. Kelles,Fabio P. Santos,Helen L. del Puerto,Pedro H. Gazzinelli-Guimar?es,Ana M. de Paula,Ubirajara Agero,Oscar N. Mesquita,Cristina Guatimosim,Egler Chiari,Luciana O. Andrade
PLOS Neglected Tropical Diseases , 2012, DOI: 10.1371/journal.pntd.0001583
Abstract: Background Trypomastigotes of Trypanosoma cruzi are able to invade several types of non-phagocytic cells through a lysosomal dependent mechanism. It has been shown that, during invasion, parasites trigger host cell lysosome exocytosis, which initially occurs at the parasite-host contact site. Acid sphingomyelinase released from lysosomes then induces endocytosis and parasite internalization. Lysosomes continue to fuse with the newly formed parasitophorous vacuole until the parasite is completely enclosed by lysosomal membrane, a process indispensable for a stable infection. Previous work has shown that host membrane cholesterol is also important for the T. cruzi invasion process in both professional (macrophages) and non-professional (epithelial) phagocytic cells. However, the mechanism by which cholesterol-enriched microdomains participate in this process has remained unclear. Methodology/Principal Finding In the present work we show that cardiomyocytes treated with MβCD, a drug able to sequester cholesterol from cell membranes, leads to a 50% reduction in invasion by T. cruzi trypomastigotes, as well as a decrease in the number of recently internalized parasites co-localizing with lysosomal markers. Cholesterol depletion from host membranes was accompanied by a decrease in the labeling of host membrane lipid rafts, as well as excessive lysosome exocytic events during the earlier stages of treatment. Precocious lysosomal exocytosis in MβCD treated cells led to a change in lysosomal distribution, with a reduction in the number of these organelles at the cell periphery, and probably compromises the intracellular pool of lysosomes necessary for T. cruzi invasion. Conclusion/Significance Based on these results, we propose that cholesterol depletion leads to unregulated exocytic events, reducing lysosome availability at the cell cortex and consequently compromise T. cruzi entry into host cells. The results also suggest that two different pools of lysosomes are available in the cell and that cholesterol depletion may modulate the fusion of pre-docked lysosomes at the cell cortex.
Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections
Oliveira, Ludmila;Souza, Márcia Maria de;Andrade, Zilton A.;
Revista da Sociedade Brasileira de Medicina Tropical , 2004, DOI: 10.1590/S0037-86822004000200001
Abstract: multiple exposures to parasitic agents are considered an important factor in the genesis of the most severe forms of the diseases they cause. capillaria hepatica-induced septal fibrosis of the liver in rats usually runs without signs of portal hypertension or hepatic failure. after determining the hepatic profile of 15 animals during the course of a single infection, we submitted 20 rats to multiple capillaria hepatica infections to determine whether repeated exposures would augment fibrosis production, transforming septal hepatic fibrosis into a true cirrhosis. ten single-infection rats served as controls. a total of 5 exposures, with 45-day intervals, were made. histological changes were followed by means of surgical liver biopsies, collected prior to infection and to each re-infection. functional changes were minimal and transient. although a slight recrudescence of fibrosis was observed after the first two re-infections and when the single-infected control group was re-infected at the end of the experiment, subsequent re-infections failed to increase the amount of fibrosis. on the contrary, there occurred quantitative and qualitative evidence of collagen degradation and suppression of parasite development. these paradoxical results are in keeping with the hypothesis that a complex immunological modulation participates in the mechanism of hepatic fibrosis induced by capillaria hepatica infection in rats.
Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections
Oliveira Ludmila,Souza Márcia Maria de,Andrade Zilton A.
Revista da Sociedade Brasileira de Medicina Tropical , 2004,
Abstract: Multiple exposures to parasitic agents are considered an important factor in the genesis of the most severe forms of the diseases they cause. Capillaria hepatica-induced septal fibrosis of the liver in rats usually runs without signs of portal hypertension or hepatic failure. After determining the hepatic profile of 15 animals during the course of a single infection, we submitted 20 rats to multiple Capillaria hepatica infections to determine whether repeated exposures would augment fibrosis production, transforming septal hepatic fibrosis into a true cirrhosis. Ten single-infection rats served as controls. A total of 5 exposures, with 45-day intervals, were made. Histological changes were followed by means of surgical liver biopsies, collected prior to infection and to each re-infection. Functional changes were minimal and transient. Although a slight recrudescence of fibrosis was observed after the first two re-infections and when the single-infected control group was re-infected at the end of the experiment, subsequent re-infections failed to increase the amount of fibrosis. On the contrary, there occurred quantitative and qualitative evidence of collagen degradation and suppression of parasite development. These paradoxical results are in keeping with the hypothesis that a complex immunological modulation participates in the mechanism of hepatic fibrosis induced by Capillaria hepatica infection in rats.
Amadurecimento de filtros lentos de areia e remo??o de microrganismos indicadores de qualidade da água ao longo da profundidade do leito: uma avalia??o em instala??o piloto
Brito, Ludmila Ladeira Alves de;Cardoso, Allisson Badaró;Salvador, Daniella Pedrosa;Heller, Léo;
Engenharia Sanitaria e Ambiental , 2005, DOI: 10.1590/S1413-41522005000400007
Abstract: the potential of the slow sand filtration as technological option for drinking-water treatment in developing countries and its capacity of contaminants removal, mainly pathogens, are recognized.however, the knowledge concerning the predominant mechanisms that act in microorganism's removal still remains incomplete. aiming to advance in the understanding of these themes, an experimental investigation was carried out, working with pilot plants of downflow and upflow slow sand filters, operated with synthetic water and two filtration rates (3 and 6 m3/m2.d). the microorganisms indicators removal was evaluated in five layers, with 0.15 m of thickness each, in two run phases. the biological maturation of the filter media was less favoured by the highest rate and by the upflow filter. the initial 0.45 m of the filter media were important in the microorganism's removal in the conditions evaluated, but removal was not limited to these layers, since all indicators were retained also in 0.45-0.60 m and 0.60-0.75 m layers, in different proportions among the filter runs.the schmutzdecke seems to play an effective role in the microbiological indicators removal only when well developed. an indication of the role of the support layer in solids and microorganisms retention was observed in the upflow filter.
Desempenho da filtra??o lenta em areia submetida a cargas de pico de oocistos de Cryptosporidium sp, bactérias e sólidos: uma avalia??o em instala??o piloto
Heller, Léo;Vieira, Maria Berenice Cardoso Martins;Brito, Ludmila Ladeira Alves de;Salvador, Daniella Pedrosa;
Engenharia Sanitaria e Ambiental , 2006, DOI: 10.1590/S1413-41522006000100005
Abstract: temporal and space variation in the concentrations of pathogens is a key theme in the monitoring of drinking-water systems, resulting in underestimation of the infection risk in those monitoring programs based on punctual samples. regarding this issue, the paper presents research carried out in pilot plant, aiming to verify the performance of the slow sand filtration, in a sudden increase in the cryptosporidium oocysts concentration and in water turbidity. the pilot plant was operated in stationary conditions followed by the increase in the cryptosporidium parvum oocysts concentration and, after 48h, with the same oocysts concentration, by the increase in the turbidity level. the tests revealed, for the oocysts, that, while in the stationary condition the effluent presented null concentrations medians, in the two transient conditions the effluent presented oocysts, however this difference did not accuse statistical significance. despite the transient conditions, high average removal of cryptosporidium sp oocysts (99,988-99,998%) was observed.
Association between the concentration of protozoa and surrogates in effluents of the slow sand filtration for water treatment
Heller, Léo;Vieira, Maria Berenice Cardoso Martins;Brito, Ludmila Ladeira Alves de;Salvador, Daniella Pedrosa;
Brazilian Journal of Microbiology , 2007, DOI: 10.1590/S1517-83822007000200029
Abstract: currently, a major challenge on producing high-quality drinking water is to monitor pathogens, such as giardia, cryptosporidium and enteric viruses. due to limitations of the analytical methods available to detect pathogens in water, the research of surrogate indicators is an up-to-date subject. in view of these aspects, a pilot scale study was performed to evaluate the association between microbiological and physical indicators and the presence of giardia spp and cryptosporidium sp in the effluent of upflow and downflow slow sand filters. the results showed that efficient bacterial removal could indicate suitable protozoa removal. although coliforms and escherichia coli do not present the appropriate physiological profile for an "ideal" indicator, they are still good references for drinking water microbiological quality, specifically for slow sand filtration. the results also point out to the need of deeper researches about the use of anaerobic spores as routine indicator. regarding the control of cryptosporidium outbreaks, the expectation that a single indicator will satisfy all purposes is unreal. it may be more useful to know the advantages and disadvantages of several indicators, and integrate them appropriately.
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