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Search Results: 1 - 10 of 22791 matches for " Ludmila Gon?alves Entiauspe "
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Papilomavírus humano: prevalência e genótipos encontrados em mulheres HIV positivas e negativas, em um centro de referência no extremo Sul do Brasil
Entiauspe, Ludmila Gonalves;Teixeira, Lisiane Ortiz;Mendoza-Sassi, Raul Andrés;Gonalves, Carla Vitola;Gonalves, Paulo;Martinez, Ana Maria Barral de;
Revista da Sociedade Brasileira de Medicina Tropical , 2010, DOI: 10.1590/S0037-86822010000300009
Abstract: introduction: the aim of this study was detect the presence of human papillomavirus and investigate the prevalence and distribution of the hpv-6, 11, 16 and 18 genotypes among hiv-1 positive and negative women. methods: samples of cervical smears from 98 women were analyzed using the nested polymerase chain reaction for the presence of hpv and using the type-specific technique for genotype detection. genotypes were confirmed by means of restriction fragment analysis. the chi-square and fisher tests were performed for the statistical analysis. results: hpv-dna was observed in 66.3% of the samples analyzed: 76.4% in the hiv-positive group and 60% in the hiv-negative group (p = 0.1). higher prevalence of viral infection due to oncogenic genotypes was observed in the hiv-positive group (65.2%) than in the hiv-negative group (28.6%), (p = 0.006), and hpv-16 was the most frequent in the two groups, followed by hpv-18. conclusions: it is suggested that hiv-positive women present a higher likelihood of infection by oncogenic hpv genotypes, and the importance of a screening and differential diagnosis program for this group is highlighted.
Evidence for an Epistatic Effect between TP53 R72P and MDM2 T309G SNPs in HIV Infection: A Cross-Sectional Study in Women from South Brazil
Fernando Pires Hartwig, Ludmila Gonalves Entiauspe, Emily Montosa Nunes, Fernanda Martins Rodrigues, Tiago Collares, Fabiana K?mmling Seixas, Mariangela Freitas da Silveira
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089489
Abstract: Objective To investigate the associations of TP53 R72P and MDM2 T309G SNPs with HPV infection status, HPV oncogenic risk and HIV infection status. Design Cross-sectional study combining two groups (150 HIV-negative and 100 HIV-positive) of women. Methods Data was collected using a closed questionnaire. DNA was extracted from cervical samples. HPV infection status was determined by nested-PCR, and HPV oncogenic risk group by Sanger sequencing. Both SNPS were genotyped by PCR-RFLP. Crude and adjusted associations involving each exposure (R72P and T309G SNPs, as well as 13 models of epistasis) and each outcome (HPV status, HPV oncogenic risk group and HIV infection) were assessed using logistic regression. Results R72P SNP was protectively associated with HPV status (overdominant model), as well as T309G SNP with HPV oncogenic risk (strongest in the overdominant model). No epistatic model was associated with HPV status, but a dominant (R72P over T309G) protective epistatic effect was observed for HPV oncogenic risk. HIV status was strongly associated (risk factor) with different epistatic models, especially in models based on a visual inspection of the results. Moreover, HIV status was evidenced to be an effect mediator of the associations involving HPV oncogenic risk. Conclusions We found evidence for a role of R72P and T309G SNPs in HPV status and HPV oncogenic risk (respectively), and strong associations were found for an epistatic effect in HIV status. Prospective studies in larger samples are warranted to validate our findings, which point to a novel role of these SNPs in HIV infection.
Sistema de cotas: uma perspectiva de análise a partir do caso da Universidade Estadual do Norte Fluminense Darcy Ribeiro Racial quota system: an analysis of the case of the “Universidade Estadual do Norte Fluminense Darcy Ribeiro”
Ludmila Gonalves da Matta
Vértices , 2010,
Abstract: Este trabalho tem por objetivo oferecer uma introdu o à discuss o sobre políticas de a o afirmativa e condi o socioecon mica a partir da abordagem do caso específico da implementa o da política de cotas para estudantes negros ou pardos na Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF). Neste trabalho, além da discuss o teórica, realizamos um trabalho de pesquisa em que tra amos o perfil socioecon mico dos alunos beneficiados pelas cotas para negros e pardos, o qual foi analisado em termos comparativos com um estudo realizado na Universidade Federal Fluminense (UFF). This paper aims to provide an introduction to the discussion of affirmative action policies and socioeconomic conditions based on the case of the implementation of quotas for black and mulatto students at the Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF). Besides the theoretical discussion, the work presents the research project in wich we mapped the socio-economic profile of students who benefited from the quota system, and a comparative analysis with a similar study conducted at the University Federal Fluminense (UFF).
Pré-eclampsia precoce e tardia: uma classifica??o mais adequada para o prognóstico materno e perinatal?
Reis, Zilma Silveira Nogueira;Lage, Eura Martins;Teixeira, Patrícia Gonalves;Porto, Ludmila Barcelos;Guedes, Ludmila Resende;Oliveira, érica Carla Lage de;Cabral, Ant?nio Carlos Vieira;
Revista Brasileira de Ginecologia e Obstetrícia , 2010, DOI: 10.1590/S0100-72032010001200004
Abstract: purpose: to evaluate the differences between the maternal and perinatal outcomes of pregnancies complicated by preeclampsia, according to the classification as the severe/mild form, and the early/late onset form. methods: a retrospective study with 211 pregnancies complicated by preeclampsia, assessed at a university reference center from 2000 to 2010. the diagnosis and disease severity were based on the values of blood pressure, proteinuria, and clinical and laboratory findings. the pregnant's age, skin color, parity, blood pressure, urine protein semiquantitative values, presence of bilateral notch in the uterine artery dopplervelocimetry and birth conditions were compared between patients with mild and severe disease, as well as between those of early/late onset. the disease was considered to be of early onset when diagnosed at less than 34 weeks of gestational age. results: most patients had the severe form of preeclampsia (82.8%), and the onset of the condition was early in 50.7%. blood pressure values (133.6±14.8 versus 115.4 mmhg, p=0.0004 and 132.2±16.5 versus 125.7 mmhg, p=0.0004) and semiquantitative proteinuria (p=0.0003 and p=0.0005) were higher in the early and severe forms compared to mild and late forms. infant birth weight (1,435.4±521.6 versus 2,710±605.0 g, 1,923.7±807.9 versus 2,415.0±925.0 g, p<0.0001 for both) and apgar score (p=0.01 for both) were smaller for severe and early preeclampsia compared to mild and late preeclampsia. on the other hand, the presence of a bilateral notch in the uterine arteries was linked to the forms of early onset (69.2 versus 47.9%, p=0.02), whereas fetal growth restriction was more frequent in the severe forms of preeclampsia (30 versus 4.4%, p=0.008). conclusion: the preeclampsia classification based on maternal clinical parameters better reflected the conditions of fetal nutrition, while the early onset of the condition was associated with placental vasculopathy detected by dopplervelocimetry.
The nursing in the context of the programs of encouragement to the research from cnpq: retrospective study
Kriscie Kriscianne Venturi, Anelise Ludmila Vieczorek, Lillian Daisy Gonalves Wolff, Aida Maris Peres, Juliana Helena Montezeli
Revista de Enfermagem UFPE On Line , 2009,
Abstract: Objective: exposing the Programs and issuances capable of insertion of the area of health, and specifically in the nursing from 2006 to November 2008, as well as weaveeing some reflections on the Nursing in this context. Methods: quantitative retrospective documentary research developed during November 2008 by means of search in the site of the CNPq, referring to the report of 2006 and the proclamations published during 2007 and 2008. Results: 19 proclamations had been found in 2006, with 596 projects and only 15 of them with possible linkage with the area of the health. In 2007 42 proclamations had been launched, being that in 10 the Nursing could be enrolled. Already in 2008, 7 programs with possibility of insertion of the Nursing had been verified; e 24 of the 70 divulged proclamations had presented affinity with this professional category. Conclusion: It is possible to verify that the Nursing must adjust its lines of research and projects to the programs and proclamations of the CNPq and thus to concur for the financing. It is recommended undertaking studies that specify which programs and issuances Nursing have been inserted, and make an exploration on how scientific research in this profession can be developed, with a view to greater participation in bids to promote the research and scholarship.
Stress prevention by modulation of autonomic nervous system (heart rate variability): A preliminary study using transcranial direct current stimulation  [PDF]
Eduardo Manuel Gonalves
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.22016
Abstract: Introduction: Transcranial Direct Current Stimulation (tDCS) is a non-invasive, technique for brain stimulation. Anodal stimulation causes neuronal depolarisation and long-term potentiation, while cathodal stimulation causes hyperpolarisation and long-term depression. Stressors are associated with an increase in sympathetic cardiac control, a decrease in parasympathetic control, or both. Associated with these reactions is a frequently reported increase in Low Frequency (LF) Heart Rate Variability (HRV), a decrease in High Frequency (HF) power, and/or an increase in the LF/HF ratio. Objectives and aims: The present work aims to explore the tDCS potential in the modulation of the Autonomic Nervous System (ANS), through indirect stimulation of Anterior Cingulate Cortex (ACC). Methods: Two subjects, a 39 year old female and a 49 year old male, gave informed consent. Saline soaked synthetic sponges involving two, thick, metalic (stainless steel) rectangles, with an area of 25 cm2 each have been used as electrodes, connected to Iomed Phoresor II Auto device. It has been delivered a 2 mA current, for 20 minutes, over the left Dorsolateral Prefrontal Cortex (DLPFC) (Anode). Spectrum analysis (cStress software) of HRV has been performed before and after tDCS administration. Results: The female/male subject results of LF power, HF power and LF/HF ratio, before tDCS administration, were, respectively: 50.1 nu/60 nu, 46.1 nu/21.7 nu and 1.087/2.771; and, after tDCS administration, respectively: 33.5 nu/52.7 nu, 47.6 nu/ 22.8 nu and 0.704/2.312. Conclusions: tDCS over the left DLPFC (left ACC) increased parasympathetic activity and decreased sympathetic activity, suggesting the importance of tDCS in the management of stress-related disorders.
Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development
Augusto Henriques Fulgêncio Brand?o,Ludmila Maria Guimar?es Pereira,Alessandra Cristina de Oliveira Gonalves,Zilma Silveira Nogueira Reis,Henrique Vítor Leite,Ant?nio Carlos Vieira Cabral
Journal of Pregnancy , 2012, DOI: 10.1155/2012/909315
Abstract: Background. Poor placentation and systemic endothelial dysfunction have been identified as main events in Preeclampsia (PE). The relationship and chronology of these phenomena are important if we are to understand the pathophysiological mechanisms underlying this major clinical problem. Objectives. To compare the evolution of placentation and endothelial function in normotensive and preeclamptic pregnancies. Patients and methods. In a prospective cohort study, 59 pregnant women with a high risk of developing PE were subjected to flow-mediated dilation (FMD) and to Doppler velocimetry of uterine arteries in order to obtain their Pulsatility Index (UtA-PI). The variations in the FMD and UtA-PI values, between 16+0 and 19+6 and 24+0 and 27+6 weeks of gestation, were compared, taking PE development into consideration. Results. Nine patients developed PE and the other 50 women remained normotensive. At 16+0 to 19+6 weeks of pregnancy, patients that developed PE presented higher values of UtA-PI than the normotensive group, but there was no difference in FMD results between them. At 24+0 to 27+6 weeks, the patients that developed PE presented higher values of UtA-PI and lower values of FMD than the women that remained normotensive. Conclusions. These results corroborate the evidence that endothelial injury is secondary to poor placentation. 1. Introduction Preeclampsia (PE) is a multisystemic disorder that accounts for a large number of maternal deaths in developed and developing countries worldwide [1–3]. Although its etiology remains unclear, several events in PE physiopathology are well studied and can be evaluated using biochemical or biophysical methods. In order to prevent PE complications, there are many early detection markers, which include maternal demographics, past medical, obstetric, family history, and some current pregnancy characteristics [4–6]. Maternal factors and history alone can be used as a PE risk stratification method. Elevated body mass index, maternal age extremes and Afro-American ethnicity are associated with a higher risk of PE [7]. Some diseases such as diabetes and chronic hypertension also significantly increase the risk [8]. The patients that present these conditions are the ones who will most benefit from a satisfactory and specific level of care, once the risk of developing PE in this groups rises threefold, reaching a PE prevalence of 45% [3]. Preeclampsia is essentially an endothelial disease [9, 10]. Progressive endothelial dysfunction leads to arterial hypertension, glomerular lesion, hepatic failure, and cerebral edema
Factorial Validation of Warr’s (1990) Well-Being Measure: A Sample Study on Police Officers  [PDF]
Sónia P. Gonalves, José Neves
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.27108
Abstract: The purpose of this study was to test the factorial validity of the job-related affective well-being scale—the IWP Multi-Affect Indicator. The sample was composed of 1466 police officers and collected through self-report questionnaires. With the objective of validating the factorial structure of the IWP Multi-Affect Indicator, several models were tested using confirmatory factor analysis. The results supported a four-factor structure: anxiety, comfort, depression and enthusiasm, as well as a five-factor structure including the same four factors plus a second-order factor called global affective well-being.
Mental disorders and sociodemographic variables in pop-ulation assisted by the Family Health Program in Brazil  [PDF]
Daniel Maffasioli Gonalves, Suzi Camey
Open Journal of Psychiatry (OJPsych) , 2013, DOI: 10.4236/ojpsych.2013.31006
Abstract:

Objectives: This paper aims to estimate the associations between common mental disorders (CMD) as well as cases of alcohol abuse/dependence (ADD) with sociodemographic variables in population assisted by Family Health Program (FHP) in Santa Cruz do Sul, Southern Brazil. Methods: All residents over 14 years of age from 3 areas assisted by the FHP were invited to participate between 10 February 2006 to 10 February 2007. Results: Of 2921 participants, the prevalence estimates of suspected cases of CMD and ADD were 29.93% and 12.07%, respectively. Female, unfavorable employment situation, low schooling and low income showed a positive and independent association with CMD. Male, unfavorable employment situation and CMD showed an independent association with ADD. Conclusions: Groups with unfavorable socioeconomic conditions present the highest risk and should be taken into account when planning public mental health policies.


Stress, Executive Function, Resilience and Quality of Life in Portuguese Subjects in Situations of Economic Insufficiency and Unemployment  [PDF]
Eduardo Gonalves, Saul Neves de Jesus
Open Journal of Psychiatry (OJPsych) , 2015, DOI: 10.4236/ojpsych.2015.54040
Abstract: The aim of this study is the investigation of the impact of stress of Portuguese subjects in situations of economic insufficiency and unemployment on executive function and quality of life and the coping strategies and resilience skills used. The sample consists of 41 participants. The psychometric instruments used are validated for Portuguese population, measure (perceived) stress, coping, material deprivation, resilience and quality of life, defined by World Health Organization. Executive function has been evaluated through performances at Stroop and Berg tasks. It has been concluded that, in this population, resilience skills and active coping strategies are positively correlated with quality of life. Quality of life is negatively correlated with material deprivation. Active coping strategies are supported by adequate executive function, which neurobiological substrate is dorso-lateral prefrontal cortex. Not active coping strategies correlate negatively with cognitive flexibility, suggesting the presence of a deficit at infero-lateral prefrontal cortex.
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