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Pré-eclampsia precoce e tardia: uma classifica??o mais adequada para o prognóstico materno e perinatal?
Reis, Zilma Silveira Nogueira;Lage, Eura Martins;Teixeira, Patrícia Gon?alves;Porto, Ludmila Barcelos;Guedes, Ludmila Resende;Oliveira, érica Carla Lage de;Cabral, Ant?nio Carlos Vieira;
Revista Brasileira de Ginecologia e Obstetrícia , 2010, DOI: 10.1590/S0100-72032010001200004
Abstract: purpose: to evaluate the differences between the maternal and perinatal outcomes of pregnancies complicated by preeclampsia, according to the classification as the severe/mild form, and the early/late onset form. methods: a retrospective study with 211 pregnancies complicated by preeclampsia, assessed at a university reference center from 2000 to 2010. the diagnosis and disease severity were based on the values of blood pressure, proteinuria, and clinical and laboratory findings. the pregnant's age, skin color, parity, blood pressure, urine protein semiquantitative values, presence of bilateral notch in the uterine artery dopplervelocimetry and birth conditions were compared between patients with mild and severe disease, as well as between those of early/late onset. the disease was considered to be of early onset when diagnosed at less than 34 weeks of gestational age. results: most patients had the severe form of preeclampsia (82.8%), and the onset of the condition was early in 50.7%. blood pressure values (133.6±14.8 versus 115.4 mmhg, p=0.0004 and 132.2±16.5 versus 125.7 mmhg, p=0.0004) and semiquantitative proteinuria (p=0.0003 and p=0.0005) were higher in the early and severe forms compared to mild and late forms. infant birth weight (1,435.4±521.6 versus 2,710±605.0 g, 1,923.7±807.9 versus 2,415.0±925.0 g, p<0.0001 for both) and apgar score (p=0.01 for both) were smaller for severe and early preeclampsia compared to mild and late preeclampsia. on the other hand, the presence of a bilateral notch in the uterine arteries was linked to the forms of early onset (69.2 versus 47.9%, p=0.02), whereas fetal growth restriction was more frequent in the severe forms of preeclampsia (30 versus 4.4%, p=0.008). conclusion: the preeclampsia classification based on maternal clinical parameters better reflected the conditions of fetal nutrition, while the early onset of the condition was associated with placental vasculopathy detected by dopplervelocimetry.
Some Remarks to Numerical Solutions of the Equations of Mathematical Physics  [PDF]
Ludmila Petrova
American Journal of Computational Mathematics (AJCM) , 2013, DOI: 10.4236/ajcm.2013.33029

The equations of mathematical physics, which describe some actual processes, are defined on manifolds (tangent, a companying or others) that are not integrable. The derivatives on such manifolds turn out to be inconsistent, i.e. they don’t form a differential. Therefore, the solutions to equations obtained in numerical modelling the derivatives on such manifolds are not functions. They will depend on the commutator made up by noncommutative mixed derivatives, and this fact relates to inconsistence of derivatives. (As it will be shown, such solutions have a physical meaning). The exact solutions (functions) to the equations of mathematical physics are obtained only in the case when the integrable structures are realized. So called generalized solutions are solutions on integrable structures. They are functions (depend only on variables) but are defined only on integrable structure, and, hence, the derivatives of functions or the functions themselves have discontinuities in the direction normal to integrable structure. In numerical simulation of the derivatives of differential equations, one cannot obtain such generalized solutions by continuous way, since this is connected with going from initial nonintegrable manifold to integrable structures. In numerical solving the equations of mathematical physics, it is possible to obtain exact solutions to differential equations only with the help of additional methods. The analysis of the solutions to differential equations with the help of skew-symmetric forms [1,2] can give certain recommendations for numerical solving the differential equations.

The Peculiarity of Numerical Solving the Euler and Navier-Stokes Equations  [PDF]
Ludmila Petrova
American Journal of Computational Mathematics (AJCM) , 2014, DOI: 10.4236/ajcm.2014.44026
Abstract: The analysis of integrability of the Euler and Navier-Stokes equations shows that these equations have the solutions of two types: 1) solutions that are defined on the tangent nonintegrable manifold and 2) solutions that are defined on integrable structures (that are realized discretely under the conditions related to some degrees of freedom). Since such solutions are defined on different spatial objects, they cannot be obtained by a continuous numerical simulation of derivatives. To obtain a complete solution of the Euler and Navier-Stokes equations by numerical simulation, it is necessary to use two different frames of reference.
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility
Dutra, Ludmila Alves Sanches;Costa, Patrícia Godoy Garcia;Velasco, Lara Franciele Ribeiro;Amato, Angélica Amorim;Barra, Gustavo Barcelos;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2008, DOI: 10.1590/S0004-27302008000800026
Abstract: objective: the aim of the present study is to validate a rapid and simple allele-specific pcr that genotypes tcf7/l2 rs7903146 (c/t) polymorphism with standard pcr instruments. methods: two forward primers with variations in their 3' nucleotides were designed in such a way that each was specific for one of the two variants. they were combined with a common reverse primer into two pcr reactions. specific amplification indicates the presence of the allele. one hundred and four dna samples were genotyped by this method. to evaluate the assay, the polymorphism spanning region of 63 dna samples representing the three possible genotypes was sequenced. results: the rs7903146 allele assignments derived from the allele-specific pcr were in complete agreement with sequencing. conclusions: the assay described here is a suitable strategy for the tcf7/l2 rs7903146 (c/t) genotyping also allowing rapid and reliable identification.
Thermochemistry of Heteroatomic Compounds: the Heats of Combustion and Formation of Glycoside and Adenosine Phosphates  [PDF]
Vitaly Ovchinnikov, Ludmila Lapteva
International Journal of Organic Chemistry (IJOC) , 2011, DOI: 10.4236/ijoc.2011.13011
Abstract: The heats of combustion of 4th glycoside in the condensed state with the use of the equation ΔcombH=15.7-117.2(N-g) , in which N is a number bond-forming (valence) electrons less the number (g) of lone electron pairs of nitrogen (g = 1) and oxygen (g = 2), have been determined. Such dependence is deduced previously joint for the description of the combustion enthalpies of 17 simple ethers of a cyclic structure and different sugars. The heats of formation ( ΔfHo ) of the mentioned above glycosides were calculated according to the Hess law via two ways: 1) through the use their heats of hydrolysis ( ΔhydrH ), which have been investigated earlier experimentally, 2) with the use the calculated the heats of combustion. The last procedure has been used also for the calculation of the heats of formation of the adenosine tri(ATP)-, di(ADP)- and mono(AMP)phosphates because of such thermochemical parameter is often hard achieved experimentally. The heats of hydrolysis ( ΔfH°hydr ) of ATP into ADP and ADP into AMP were calculated on the basis of their heats of formation in water ( ΔfH°aq ). The free energies of the same process ( ΔhydrG ) were known in literature. Last circumstance give us a possibility to calculate the hydrolysis entropies ( ΔhydrS ) using the Gibbs equation. The entropy values are a large negative, that pointed on the preliminary complex formation between adenosine phosphates and water before the breaking of P-O bonds or P-O-C fragments in its.
Model of the singular current source—The indicator of geodynamic processes in Japan in 2009-2011  [PDF]
Ludmila F. Moskovskaya
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.58A1005

The calculation method of the location of the singular generalized current source according to synchronous measurements of the magnetic field in the remote points is proposed. It is designed for the continuous monitoring of changes of the degree of electromagnetic heterogeneity of the geophysical environment. Regular fluctuations of the apparent distance to the effective single source were recorded according to the magnetic data of the observatories in Japan 2009-2011. They are connected with the rhythm of the geodynamic processes in the vicinity of the station Kakioka. The most significant decrease in the apparent distance was registered in connection with the seismic activation of the region, including the catastrophic earthquake of March 11, 2011 with a magnitude of M = 9.1. The anomalous behavior of the apparent parameters of the generalized source was displayed not less than two weeks before the earthquake. Characteristic changes of the curves were registered in the period of three months.

Mitochondrial Signaling in Hypoxia  [PDF]
Ludmila D. Lukyanova
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2013, DOI: 10.4236/ojemd.2013.32A004

This paper focuses on a bioenergetic mechanism responding to hypoxia. This response involves hypoxia-induced reprogramming of respiratory chain function and switching from oxidation of complex I (NAD-related substrates) to complex II (succinate oxidation). Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of urgent adaptation to hypoxia, which is necessary for 1) succinate-related energy synthesis in the conditions of oxygen shortage and formation of urgent resistance; 2) succinate-related stabilization of HIF-1α and initiation of its transcriptional activity related with formation of long-term adaptation; 3) succinate-dependent activation of the succinate-specific receptor GPR91. Thus, mitochondria perform a signaling function with succinate as a signaling molecule. Effects of succinate in hypoxia occur at three levels, intramitochondrial, intracellular and intercellular. In these settings, succinate displays antihypoxic activity. The review is focused on tactics and strategy for development of the antihypoxic defense and antihypoxants with energotropic properties.

Algebraic Cryptanalysis of GOST Encryption Algorithm  [PDF]
Ludmila Babenko, Ekaterina Maro
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.24002

This paper observes approaches to algebraic analysis of GOST 28147-89 encryption algorithm (also known as simply GOST), which is the basis of most secure information systems in Russia. The general idea of algebraic analysis is based on the representation of initial encryption algorithm as a system of multivariate quadratic equations, which define relations between a secret key and a cipher text. Extended linearization method is evaluated as a method for solving the nonlinear sys- tem of equations.

Conhecimento dos profissionais da enfermagem que assistem pacientes com altera??es da degluti??o em um Hospital Universitário de Belo Horizonte
Guedes, Luciana Ulh?a;Vicente, Laélia Cristina Caseiro;Paula, Cassiana Maria de;Oliveria, Elizete de;Andrade, Emilene Aparecida de;Barcelos, Wanessa Concei??o de Oliveira;
Revista da Sociedade Brasileira de Fonoaudiologia , 2009, DOI: 10.1590/S1516-80342009000300014
Abstract: purpose: to describe the performance of nursing professionals with patients with swallowing disorders. methods: cross-sectional, comparative study of stratified sampling, where 130 nursing professionals of a university hospital were interviewed. the mean age of the groups was 29.16 years, with a standard deviation of 11.81. from the professionals interviewed, 64% were female, and 23% were male. data were statistically analyzed using the exact fischer's test, with a significance level of 5%. results: from the interviewed professionals, 92.33% reported that the speech therapist is the professional responsible for the rehabilitation of patients with swallowing disorders; 87% showed appropriate knowledge about the diseases that might cause swallowing disorders, and 94.66% declared to know how to identify patients with signs or symptoms of swallowing disorders. the present study allowed demonstrating that nurses are more prepared than technicians, who are more prepared than nursing assistants, in some related items regarding swallowing disorders. conclusions: in general, the nursing professionals interviewed have an adequate intervention before swallowing disorders in hospitalized patients.
Implantosuported Rehabilitation after Marginal Recession of Mandibular Calcifying Epithelial Odontogenic Tumor: Case Report  [PDF]
Bruna Barcelos Ferreira, Victor Tieghi Neto, Andréa Guedes Barreto Gon?ales, Denise Tostes Oliveira, Fábio Sanches Magalh?es Tunes, Eduardo Sanches Gon?ales
Open Journal of Stomatology (OJST) , 2019, DOI: 10.4236/ojst.2019.99021
Abstract: The Calcifying Epithelial Odontogenic Tumor (CEOT) also called the Pindborg’s Tumor represents a rare benign epithelial odontogenic neoplasm with locally aggressive behavior. Surgical excision with a safety margin is one of the treatment options, requiring bone and soft tissue reconstruction for implant-supported rehabilitation, providing the individual with a return to adequate oral functions. The objective of the present study is to report on the case of the treatment stages and the factors involved in the rehabilitation of a 23-year-old man with a history of mandibular lesion diagnosed as CEOT. A marginal resection of the mandible lesion was performed, with posterior reconstruction with iliac crest bone graft and soft tissue graft to allow the implant-supported rehabilitation. Currently, in the postoperative control, the individual shows no signs of tumor recurrence and is rehabilitated without functional and/or aesthetic complaints. Surgical excision should be framed as a form of treatment, aiming for better resolution in the more complex cases of these invasive tumors.
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