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Search Results: 1 - 10 of 328556 matches for " Lucas Sánchez "
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Study on Child Abuse in Children and Adolescents in the Province of Buenos Aires:
Sánchez, Norma Inés,Cuenya, Lucas
Revista Argentina de Ciencias del Comportamiento , 2011,
Abstract: The principal aim of this study was to provide a current description of the child and teenager maltreatment phenomenon in the Buenos Aires Province. The sample was composed by 5341 cases of children and teenagers from 0 to 20 years old, whose were treated in 2010 for having been victims of maltreatment. Physical maltreatment was the most frequent one. The girls presented major proportion of sexual abuse, whereas boys registered major proportions of negligence, physical maltreatment and desertion situation. An increase of the sexual abuse frequency in teenagers from 12 years was observed. As a whole, the information demonstrates that sex and age of victims are differentially associated with different types of maltreatment, and these are pertinent variables to have into account by future investigations, and prevention and protection organisms.
Effect of the Gene doublesex of Anastrepha on the Somatic Sexual Development of Drosophila
Mercedes Alvarez, María Fernanda Ruiz, Lucas Sánchez
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005141
Abstract: Background The gene doublesex (dsx) is at the bottom of the sex determination genetic cascade and is transcribed in both sexes, but gives rise to two different proteins, DsxF and DsxM, which impose female and male sexual development respectively via the sex-specific regulation of the so-called sexual cyto-differentiation genes. The present manuscript addressed the question about the functional conservation of the tephritid Anastrepha DsxF and DsxM proteins to direct the sexual development in Drosophila (Drosophilidae). Methodology To express these proteins in Drosophila, the GAL4-UAS system was used. The effect of these proteins was monitored in the sexually dimorphic regions of the fly: the foreleg basitarsus, the 5th, 6th and 7th tergites, and the external terminalia. In addition, we analysed the effect of Anastrepha DsxF and DsxM proteins on the regulation of Drosophila yolk protein genes, which are expressed in the fat body of adult females under the control of dsx. Conclusions The Anastrepha DsxF and DsxM proteins transformed doublesex intersexual Drosophila flies into females and males respectively, though this transformation was incomplete and the extent of their influence varied in the different sexually dimorphic regions of the adult fly. The Anastrepha DsxF and DsxM proteins also behaved as activators and repressors, respectively, of the Drosophila yolk protein genes, as do the DsxF and DsxM proteins of Drosophila itself. Finally, the Anastrepha DsxF and DsxM proteins were found to counteract the functions of Drosophila DsxM and DsxF respectively, reflecting the normal behaviour of the latter proteins towards one another. Collectively, these results indicate that the Anastrepha DsxF and DsxM proteins show conserved female and male sex-determination function respectively in Drosophila, though it appears that they cannot fully substitute the latter's own Dsx proteins. This incomplete function might be partly due to a reduced capacity of the Anastrepha Dsx proteins to completely control the Drosophila sexual cyto-differentiation genes, a consequence of the accumulation of divergence between these species resulting in the formation of different co-adapted complexes between the Dsx proteins and their target genes.
The gene transformer-2 of Sciara (Diptera, Nematocera) and its effect on Drosophila sexual development
Iker Martín, María F Ruiz, Lucas Sánchez
BMC Developmental Biology , 2011, DOI: 10.1186/1471-213x-11-19
Abstract: The transformer-2 genes of the studied Sciara species were found to be transcribed in both sexes during development and adult life, in both the soma and germ lines. They produced a single primary transcript, which follows the same alternative splicing in both sexes, giving rise to different mRNAs isoforms. In S. ocellaris the most abundant mRNA isoform encoded a full-length protein of 251 amino acids, while that of B. coprophila encoded a protein of 246 amino acids. Both showed the features of the SR protein family. The less significant mRNA isoforms of both species encoded truncated, presumably non-functional Transformer-2 proteins. The comparison of the functional Sciara Transformer-2 proteins among themselves and those of other insects revealed the greatest degree of conservation in the RRM domain and linker region. In contrast, the RS1 and RS2 domains showed extensive variation with respect to their number of amino acids and their arginine-serine (RS) dipeptide content. The expression of S. ocellaris Transformer-2 protein in Drosophila XX pseudomales lacking the endogenous transformer-2 function caused their partial feminisation.The transformer-2 genes of both Sciaridae species encode a single protein in both sexes that shares the characteristics of the Transformer-2 proteins of other insects. These proteins showed conserved sex-determination function in Drosophila; i.e., they were able to form a complex with the endogenous Drosophila Transformer protein that controls the female-specific splicing of the Drosophila doublesex pre-mRNA. However, it appears that the complex formed between the Drosophila Transformer protein and the Sciara Transformer-2 protein is less effective at inducing the female-specific splicing of the endogenous Drosophila doublesex pre-mRNA than the DrosophilaTransformer-Transformer2 complex. This suggests the existence of species-specific co-evolution of the Transformer and Transformer-2 proteins.Sex determination refers to the developmental
Causes and effects of the corrosion of a plumbing galvanised steel
Alejandre Sánchez, F. J.,Lucas Ruiz, R
Materiales de Construccion , 2002,
Abstract: Hot dip galvanising life as a corrosion protective coatings on steel depends basically on three factors: coatings quality (thickness), correct installation of the galvanised article, and weathering effects. The aim of this research it is to study the decaying causes and effects of a plumbing installation made with hot dip galvanised steel tubes. The mentioned installation was of use during 30 years in the water supply system of the Parque Alcosa market (Sevilla, Spain). The research was divided in three parts: in the first one, shape analysis and XDR of internal decayed products was carried out: in the second one, physical properties were determined according to UNE 37- 505-89, corrosion morphology was conducted by metalographic microscopy, and it was evaluated also water quality: and finally, in the third one, diameter, section, and internal volume decrease was calculated in order to evaluate friction increase and pressure decrease in the installation. The results obtained show the correct plumbing installation according to quality requirements (UNE 37-509-89), so corrosion causes are mainly attributed to an aggressive environment for the hot dip galvanising. La durabilidad de los galvanizados en caliente como recubrimientos protectores de la corrosión del acero dependen básicamente de tres factores: la calidad del recubrimiento (espesor), la correcta instalación del elemento galvanizado, y la agresividad del medio al que se encuentren expuestos. En este trabajo se estudian las causas y consecuencias del deterioro sufrido por una tubería de acero galvanizado, destinada durante unos 30 a os a la conducción de agua potable de la red en el mercado del Parque Al cosa (Sevilla). La investigación se ha dividido en tres etapas: en la primera, se ha realizado el análisis formal y la caracterización mediante DRX de los productos de alteración generados en el interior del tubo: en la segunda, se han determinado las características físicas del galvanizado según UNE 37-505-89, se ha estudiado la morfología del ataque corrosivo mediante microscopía metalográfica y se ha evaluado la calidad del agua circulante: y, por último, en la tercera, se han efectuado los cálculos relativos a la disminución real de diámetro, sección y volumen interno, así como consideraciones sobre la pérdida de carga generadas en la tubería. Los resultados obtenidos indican que la tubería estaba correctamente instalada y cumplía los requisitos de calidad exigidos, por lo que las causas de su corrosión son atribuibles a la existencia de un medio agresivo para el galvanizado.
Complexation of Eugenol (EG), as Main Component of Clove Oil and as Pure Compound, with β- and HP-β-CDs  [PDF]
Pilar Hernández-Sánchez, Santiago López-Miranda, Carmen Lucas-Abellán, Estrella Nú?ez-Delicado
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.36097
Abstract: Eugenol, both in its pure form (EG) and included in essential clove oil (CO) was successfully solubilized in aqueous solution by forming inclusion complexes with β-cyclodextrins (β-CDs) and its modified hydroxy-propyl-β-CDs (HP-β-CDs). To investigate the molecular association between β-CDs/HP-β-CDs with pure EG and essential CO, phase solubility studies were undertaken. Essential CO formed insoluble complexes with β-CDs, but not with HP-β-CDs. The work clearly demonstrates complexes formation follow an order higher than 1:1 when high essential CO and β-CDs concentrations were used, however it was 1:1 in the case of essential CO-HP-β-CDs complexes. When pure EG was studied the results indicated that EG could form 1:1 inclusion complexes with β-CDs and HP-β-CDs. Based on the studies, the Kc values for pure EG were 4555 ± 225 M-1 and 10,633 ± 614 M-1 for β-CDs and HP-β-CDs, respectively, and 2005 ± 199 M-1 for essential CO-HP-β-CDs. These finding indicate that CDs are suitable for encapsulating EG.
Actividades de enfermería en el paciente en programa de diálisis peritoneal
Jesús Lucas Martín Espejo,álvaro Pérez Baena,Nuria Sánchez Flores
Enfermería Nefrológica , 2012,
TcTASV-C, a Protein Family in Trypanosoma cruzi that Is Predominantly Trypomastigote-Stage Specific and Secreted to the Medium
Guillermo Bernabó, Gabriela Levy, María Ziliani, Lucas D. Caeiro, Daniel O. Sánchez, Valeria Tekiel
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071192
Abstract: Among the several multigene families codified by the genome of T. cruzi, the TcTASV family was the latest discovered. The TcTASV (Trypomastigote, Alanine, Serine, Valine) family is composed of ~40 members, with conserved carboxi- and amino-termini but with a variable central core. According to the length and sequence of the central region the family is split into 3 subfamilies. The TcTASV family is conserved in the genomes of – at least – lineages TcI and TcVI and has no orthologues in other trypanosomatids. In the present work we focus on the study of the TcTASV-C subfamily, composed by 16 genes in the CL Brener strain. We determined that TcTASV-C is preferentially expressed in trypomastigotes, but it is not a major component of the parasite. Both immunoflourescence and flow cytometry experiments indicated that TcTASV-C has a clonal expression, i.e. it is not expressed by all the parasites of a certain population at the same time. We also determined that TcTASV-C is phosphorylated and glycosylated. TASV-C is attached to the parasite surface by a GPI anchor and is shed spontaneously into the medium. About 30% of sera from infected hosts reacted with TcTASV-C, confirming its exposition to the immune system. Its superficial localization and secretory nature suggest a possible role in host-parasite interactions.
Biochemical and Functional Analysis of Drosophila-Sciara Chimeric Sex-Lethal Proteins
María Fernanda Ruiz, Francesca Sarno, Silvia Zorrilla, Germán Rivas, Lucas Sánchez
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065171
Abstract: Background The Drosophila SXL protein controls sex determination and dosage compensation. It is a sex-specific factor controlling splicing of its own Sxl pre-mRNA (auto-regulation), tra pre-mRNA (sex determination) and msl-2 pre-mRNA plus translation of msl-2 mRNA (dosage compensation). Outside the drosophilids, the same SXL protein has been found in both sexes so that, in the non-drosophilids, SXL does not appear to play the key discriminating role in sex determination and dosage compensation that it plays in Drosophila. Comparison of SXL proteins revealed that its spatial organisation is conserved, with the RNA-binding domains being highly conserved, whereas the N- and C-terminal domains showing significant variation. This manuscript focuses on the evolution of the SXL protein itself and not on regulation of its expression. Methodology Drosophila-Sciara chimeric SXL proteins were produced. Sciara SXL represents the non-sex-specific function of ancient SXL in the non-drosophilids from which presumably Drosophila SXL evolved. Two questions were addressed. Did the Drosophila SXL protein have affected their functions when their N- and C-terminal domains were replaced by the corresponding ones of Sciara? Did the Sciara SXL protein acquire Drosophila sex-specific functions when the Drosophila N- and C-terminal domains replaced those of Sciara? The chimeric SXL proteins were analysed in vitro to study their binding affinity and cooperative properties, and in vivo to analyse their effect on sex determination and dosage compensation by producing Drosophila flies that were transgenic for the chimeric SXL proteins. Conclusions The sex-specific properties of extant Drosophila SXL protein depend on its global structure rather than on a specific domain. This implies that the modifications, mainly in the N- and C-terminal domains, that occurred in the SXL protein during its evolution within the drosophilid lineage represent co-evolutionary changes that determine the appropriate folding of SXL to carry out its sex-specific functions.
Contamination of Dark Matter Experiments from Atmospheric Magnetic Dipoles
A. Bueno,M. Masip,P. Sánchez-Lucas,N. Setzer
Physics , 2013, DOI: 10.1103/PhysRevD.88.073010
Abstract: Dark matter collisions with heavy nuclei (Xe, Ge, Si, Na) may produce recoils observable at direct-search experiments. Given that some of these experiments are yielding conflicting information, however, it is worth asking if physics other than dark matter may produce similar nuclear recoils. We examine under what conditions an atmospherically-produced neutral particle with a relatively large magnetic dipole moment could fake a dark matter signal. We argue that a very definite flux could explain the signals seen at DAMA/LIBRA, CDMS/Si and CoGeNT consistently with the bounds from XENON100 and CDMS/Ge. To explore the plausibility of this scenario, we discuss a concrete model with 10-50 MeV sterile neutrinos that was recently proposed to explain the LSND and MiniBooNE anomalies.
Estandarización de cuidados del síndrome metabólico en diálisis peritoneal
Cirera Segura,Francisco; Ruiz Montes,Myriam; Rosales Sánchez,Verónica; Martín Espejo,Jesús Lucas;
Enfermería Nefrológica , 2012, DOI: 10.4321/S2254-28842012000200008
Abstract: introduction: we detected a high prevalence of cardiovascular risk factors in both incidental and prevalent cases in peritoneal dialysis. aim: to draw up a standardised care plan for patients in peritoneal dialysis to deal with the problems arising from metabolic syndrome. material and method: the target population consisted of patients in peritoneal dialysis. a needs assessment was carried out using marjory gordon's approach, in which the nanda, nic and noc classifications were used to establish the most frequent diagnoses, interventions and criteria for outcomes. results: the most prevalent diagnoses were: lack of knowledge, ineffective management of the therapy regime, nutritional imbalance due to excess and deterioration in physical mobility. the interventions to be performed in the nursing consulting room and the criteria for expected outcomes were drawn up. the interventions were based on educating patients about altering their lifestyle, proper management of their diet, doing physical exercise appropriate to their age and in matters concerning their basic pathology and its treatment, such as administering and managing medication and peritoneal dialysis liquids. conclusion: through a care plan we standardised care of the health problems arising from metabolic syndrome in patients on a peritoneal dialysis programme.
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