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Search Results: 1 - 10 of 5344 matches for " Luca Zangrandi "
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Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons
Carla Letizia Busceti, Domenico Bucci, Gemma Molinaro, Paola Di Pietro, Luca Zangrandi, Roberto Gradini, Rosario Moratalla, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, Francesco Fornai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044025
Abstract: We examined the role of endogenous dopamine (DA) in regulating the number of intrinsic tyrosine hydroxylase-positive (TH+) striatal neurons using mice at postnatal day (PND) 4 to 8, a period that corresponds to the developmental peak in the number of these neurons. We adopted the strategy of depleting endogenous DA by a 2-day treatment with α-methyl-p-tyrosine (αMpT, 150 mg/kg, i.p.). This treatment markedly increased the number of striatal TH+ neurons, assessed by stereological counting, and the increase was highly correlated to the extent of DA loss. Interestingly, TH+ neurons were found closer to the clusters of DA fibers after DA depletion, indicating that the concentration gradient of extracellular DA critically regulates the distribution of striatal TH+ neurons. A single i.p. injection of the D1 receptor antagonist, SCH23390 (0.1 mg/kg), the D2/D3 receptor antagonist, raclopride (0.1 mg/kg), or the D4 receptor antagonist, L-745,870 (5 mg/kg) in mice at PND4 also increased the number of TH+ neurons after 4 days. Treatment with the D1-like receptor agonist SKF38393 (10 mg/kg) or with the D2-like receptor agonist, quinpirole (1 mg/kg) did not change the number of TH+ neurons. At least the effects of SCH23390 were prevented by a combined treatment with SKF38393. Immunohistochemical analysis indicated that striatal TH+ neurons expressed D2 and D4 receptors, but not D1 receptors. Moreover, treatment with the α4β2 receptor antagonist dihydro-β-erythroidine (DHβE) (3.2 mg/kg) also increased the number of TH+ neurons. The evidence that DHβE mimicked the action of SCH23390 in increasing the number of TH+ neurons supports the hypothesis that activation of D1 receptors controls the number of striatal TH+ neurons by enhancing the release of acetylcholine. These data demonstrate for the first time that endogenous DA negatively regulates the number of striatal TH+ neurons by direct and indirect mechanisms mediated by multiple DA receptor subtypes.
High grade B-cell gastric lymphoma with complete pathologic remission after eradication of helicobacter pylori infection: Report of a case and review of the literature
Luigi Cavanna, Raffaella Pagani, Pietro Seghini, Adriano Zangrandi, Carlo Paties
World Journal of Surgical Oncology , 2008, DOI: 10.1186/1477-7819-6-35
Abstract: We report here a case with primary diffuse large B-cell lymphoma that showed a complete pathologic remission after HP eradication and we reviewed the literature. A computerized literature reach through Medline, Cancerlit and Embase were performed, applying the words: high grade gastric lymphoma, or diffuse large B cell, MALT gastric lymphoma, DLBCLL (MALT) lymphoma and Helicobacter. Articles and abstracts were also identified by back-referencing from original and relevant papers. Selected for the present review were papers published in English before January 2007.Forty two cases of primary high grade gastric lymphoma that regressed with anti HP treatment were found. There were anedoctal cases reported and patients belonging to prospective studies; four trials studied the effect of eradication of Helicobacter pylori as first line therapy in high grade gastric lymphoma: 22 of a total of 38 enrolled patients obtained complete remission. Depth of gastric wall infiltration and clinical stage were important factors to predict the response to antibiotic therapy. Our case and the review of the literature show that high-grade transformation is not necessarily associated with the loss HP dependence. In early stage, for high-grade B-cell HP-positive gastric lymphomas, given the limited toxicity of anti-HP therapy, this treatment may be considered as one of the first line treatment options.Helicobacter pylori (HP) infection plays an important role in the development and growth of gastric mucosa-associated lymphoid tissue (MALT) lymphomas [1,2]. Eradication of HP infection has been shown to result in durable tumor regression in 77% of patients with low-grade gastric MALT lymphoma [3].It has been demonstrated by laboratory and clinical studies that primary gastric large B cell MALT lymphomas are transformed, antigen independent, autonomously growing tumors that are unlikely to respond to eradication therapy of the HP infection. An in vitro study by Hussell et al [4] showed that t
A comparison of abundance estimators for small mammal populations
Marcelle Pacheco,Maja Kajin,Rosana Gentile,Priscilla L. Zangrandi
Zoologia (Curitiba) , 2013,
Abstract: A major difficulty in the application of probabilistic models to estimations of mammal abundance is obtaining a data set that meets all of the assumptions of the model. In this paper, we evaluated the concordance correlation among three population size estimators, the minimum number alive (MNA), jackknife and the model suggested by the selection algorithm in CAPTURE (the best-fit model), using long-term data on three Brazilian small mammal species obtained from three different studies. The concordance correlation coefficients between the abundance estimates indicated that the probabilistic and enumeration estimators were highly correlated, giving concordant population estimates, except for one species in one of the studies. The results indicate the adequacy of using enumeration estimates as indexes for population size when scarce data do not allow for the use of probabilistic methods. Differences observed in the behavior of enumeration and probabilistic methods among species and studies can be related to the exclusive sampling design of each area, species-specific movement characteristics and whether a significant portion of the population could be sampled.
Deregulated Electricity Market and Auctions: The Italian Case  [PDF]
Luca Grilli
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.23030
Abstract: The Electricity Market (in Europe) undergoes a period of transformations never seen before. The competitive model suggested by the European Commission is based on a gradual increase in the classes of consumers able to choice, freely, their providers. In general, liberalization, deregulation, competition result in a spur to development and low prices for consumers. The Electricity Market isn’t likely to follow such a rule. Electricity Markets are best described and analyzed as first-price multi-unit procurement iterated auctions. In this paper we present an analysis of the Italian case in order to show the effects of deregulation on final prices for users.
Positional release techniques as a diagnostic-therapeutic approach in physiotherapy  [PDF]
Luca Collebrusco
Open Journal of Therapy and Rehabilitation (OJTR) , 2014, DOI: 10.4236/ojtr.2014.21004
Abstract: Manual Therapy is a rehabilitative approach based on the use of therapeutic procedures that includes several techniques, but this paper focuses on what is known as Positional Release (PR), a therapeutic model that includes a series of manoeuvres that are mainly used for the treatment of soft tissue. A deeper understanding of this type of therapeutic approach, especially its well known and widespread variant, Strain-Counterstrain, could, through controlled trials and systematic reviews, confirm its effectiveness, definitively explain the neurophysiological mechanism, and therefore make Positional Release another indispensable option in the professional expertise of the physiotherapist.
An Integrated Rehabilitation Model: An Ideal Framework for Limiting Health Care Costs  [PDF]
Luca Collebrusco
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.31002
Abstract: The financial crisis has caused a severe limitation of resources for the public health service and rehabilitation. The proposal of integrated diagnosis and treatment in rehabilitation, involving the introduction of new therapeutic models alongside orthodox models, could lead to a reduction in health care costs through better patient compliance. In rehabilitative assistance in health care, the limiting of financial resources can be simplified, given its multifaceted nature and the need to integrate clinical experience with research. In addition, the phases of rehabilitative recovery do not focus on organ damage, but improved participation and the reduction of disability. For this reason, we have considered incorporating narrative based medicine (NBM) and Psycho-Neuro-Immuno-Endocrinology (PNEI) in the rehabilitation process through an empathetic approach, taking evidence based medicine (EBM) into account, thus creating a “framework” of reference. Managing patients through this “framework” would be a move towards an integrated model of care that could lead to a reduction in health care costs, given the aging population and the rise in patients with chronic pain. The decision to modify health care in rehabilitative assistance through a new “framework” will require time, organizational capacity and experimentation, but may represent the appropriate response for an improved quality of life for patients and a better allocation of resources.
New Risks and the Reframing of Local Welfare as Social Investment: The Case of the FORJAD Program in Switzerland  [PDF]
Luca Martignani
Open Journal of Political Science (OJPS) , 2016, DOI: 10.4236/ojps.2016.61002
Abstract: FORJAD (Formation Professionelle pour le Jeunes Adults en Difficulté) was a program of social policy implemented in Switzerland since 2006. Its specific aim is to sustain the professional training of young unemployed adults (18 - 25) in order to allow them to become autonomous from the social assistance and to (re)entry into the labour market. This paper deals with specific dimensions of this program, with particular reference to its complex and plural governance and to the cultural framework of the Social Investment Welfare State (SIWS). This paradigm tries to connect the logics of activation and training with the necessity to realize a better quality of welfare services and to invest in personal capabilities of welfare recipients. In this framework, FORJAD seems to represent a social innovation realized to contrast at a local level the young unemployment as an example of emergent new social risks.
A History of Italian Citizenship Laws during the Era of the Monarchy (1861-1946)  [PDF]
Luca Bussotti
Advances in Historical Studies (AHS) , 2016, DOI: 10.4236/ahs.2016.54014
Abstract: This article aims to present the evolution of Italian citizenship from political unification to the end of the Second World War, which in Italy corresponds with the end of the monarchy and the advent of the Republic. In this long period, the central definition of Italian citizenship was given by the Civil Code (1865), the basis of which was Ius sanguinis and the patrilineal system. The 1912 Law on Citizenship changed some aspects of the previous legislation, but did not alter the general legal scenario, despite great pressure from some organised movements such as those formed by Italian expatriates in the Americas. With the advent of fascism (1922), the discourse on the Italian nation became radicalised, but Mussolini’s regime did not pass any organic laws on citizenship. The innovations introduced under fascism were relatively modest; many were directed towards limiting the rights of particular categories of citizens, such as political opponents and Jewish people. Italy reached the beginning of the republican period with a legal apparatus on citizenship that was very similar to the one established for the first time in the Civil Code of 1865. This shows how Italian political classes have given more attention to the orthodoxy of the law than to the need to adapt it to the numerous transformations in Italian society.
Sistema de baixo custo para nuclea??o de pré-trincas por fadiga em corpos de prova de tenacidade à fratura
Guimar?es, V.A.;Hein, L.R.O.;Zangrandi Filho, J.;
Materials Research , 2001, DOI: 10.1590/S1516-14392001000300011
Abstract: fracture toughness testing becomes a very important parameter for mechanical design and maintenance of parts and structures. this work presents the design and construction of a machine device to perform the pre-crack nucleation on se(b) specimens for fracture toughness testing. employing this device, it is possible to test materials for kic, ctod and jic in a conventional tensile test equipment, assisted by a data acquisition system. the device is based on the concept of loading from an eccentric mechanism, controlling the displacement by means of a marking ring. the main contribution of this work is the low cost technology offered for laboratories, without high priced servo-hydraulic testing machines, giving them autonomy for the execution of fracture toughness tests. the experimental results satisfied the expectation about crack nucleation on se(b) and applied loading control.
Sistema de baixo custo para nuclea o de pré-trincas por fadiga em corpos de prova de tenacidade à fratura
Guimar?es V.A.,Hein L.R.O.,Zangrandi Filho J.
Materials Research , 2001,
Abstract: Fracture toughness testing becomes a very important parameter for mechanical design and maintenance of parts and structures. This work presents the design and construction of a machine device to perform the pre-crack nucleation on SE(B) specimens for fracture toughness testing. Employing this device, it is possible to test materials for K Ic, CTOD and J Ic in a conventional tensile test equipment, assisted by a data acquisition system. The device is based on the concept of loading from an eccentric mechanism, controlling the displacement by means of a marking ring. The main contribution of this work is the low cost technology offered for laboratories, without high priced servo-hydraulic testing machines, giving them autonomy for the execution of fracture toughness tests. The experimental results satisfied the expectation about crack nucleation on SE(B) and applied loading control.
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