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Search Results: 1 - 10 of 7895 matches for " Lourdes Cecilia;Mandeville "
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Valor pronóstico del inmunofenotipo en la respuesta temprana de la leucemia aguda linfoblástica pre-B en ni?os
Correa-González, Lourdes Cecilia;Mandeville, Peter B;Manrique-Due?as, Javier;Alejo-González, Francisco;Salazar-Martínez, Abel;Pérez-Ramírez, Oscar de Jesús;Hernández-Sierra, Juan Francisco;
Gaceta médica de México , 2005,
Abstract: objective: to determine the prognostic value of pre b immunophenotype and its variants on early treatment response among of acute pediatric lymphoblast leukemia. patients and methods: a case control study nested in a cohort was carried out with male and female patients 15 years and younger with recently diagnosed pre b lymphoblast leukemia. a panel of b, t, monoclonal antibodies of the myelo monocytic and megakaryocytic cell type was used. response was assessed by bone marrow aspiration 14 days post treatment. results: 54 patients were included. the median age was 7 years (2 months - 14 years) median leukocyte count was 13,450/mm3 (1200-986,000/mm3). we identified 29 cases with late pre b immune phenotype, 19 cases with common pre b and 6 cases with early pre b immunophenotype. eleven patients also displayed myeloid antigens. a significant association (p=0.034) was found between early treatment response and the presence of myeloid antigens. no association was found between the pre b immunophenotype, age and leukocyte count with early treatment response (p=0.264). conclusions: we need to pay special emphasis on early treatment response in children with lymphoblast leukemia as our study did not corroborate the common finding that clinical factors and immune phenotype can be predictive factors.
Modern Probe-Assisted Methods for the Specific Detection of Bacteria  [PDF]
Arghavan Shabani, Christophe A. Marquette, Rosemonde Mandeville, Marcus F. Lawrence
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.82011
Abstract: This review intends to present an overview of methods currently under development for the specific and sensitive detection of pathogenic bacteria that exist in a variety of human environments. Bacteria continue to be a major health threat in general, and much effort is being deployed to counteract this problem. In a first instance, current and efficient techniques in use for the detection of bacteria are described. In a second instance, this review serves to compare the more conventional techniques to emerging technologies for the direct (non-labelled) detection of bacteria (referred to as “biosensors”). These approaches are mainly optical, piezoelectric, and electro-chemical in nature. They are cost-effective, quite sensitive, and potentially portable for rapid on-site/real-time detection, and rapid prevention. These devices are comprised of specific chemical/ biochemical probes immobilized onto physical transducers. This work also presents comparisons between the efficiencies (assay time and sensitivity) of various techniques being employed.
The Association of Psychosocial Risk Factors with the Burnout Syndrome in Dentists in Guadalajara, Jalisco Mexico  [PDF]
María de Lourdes Preciado-Serrano, Elizabeth Pozos-Radillo, Ana Rosa Plascencia-Campos, Cecilia Colunga-Rodríguez
Advances in Applied Sociology (AASoci) , 2016, DOI: 10.4236/aasoci.2016.63008
Abstract: The purpose of this study was to determine the association of psychosocial risk factors with the burnout syndrome in 144 dentists. Semi structured interviews were made and the Maslach Burnout Inventory and the Psychosocial Risk Factors Questionnaire were implemented. The results determined a direct relation between the Commuting to Work dimension of psychosocial risk factors and the MBI Burnout Syndrome (rp = 0.23; rp = 0.21 y rp = ?0.23; p < 0.05). The data classified 10% of the participants at a severe level of low Personal Realization in combination with Social Situations and Commuting of the psychosocial risk factors. They also reported Emotional Exhaustion of the burnout syndrome. Conclusion: The percentage of dentists with a high burnout level was similar to that reported in other studies and showed a significant relationship with Commute Situations as a psychosocial risk factor.
Estudio del oído con TC Multidetector de 64 canales
Mallo,María Lourdes; Giordanengo,Cecilia C.; Bertona,Carlos A.; Bertona,Juan José; Gigena,Cecilia; Florez,María Paula;
Revista argentina de radiolog?-a , 2010,
Abstract: the ear is a complex anatomic structure. its study and understanding represent a constant challenge for the radiologist. as a consequence the computed tomography becomes an essential tool for its examination. conventional tomographic examination with both axial and coronal reconstruction of the image allows a satisfactory visualization of the different structures. however, the study requires long periods of time for its acquisition and uncomfortable or intolerable positions for the patients. moreover, the characterization of some structures of the ear becomes limited. sixty-four slice multidetector computed tomography allows the optimal study of the small and complex ear anatomy. volumetric acquisitions with 0.5 mm slices, with multiplanar reconstructions in the three basic plans, in tri-dimensional reconstructions and curved plans, allow detailed visualization of structures in a few seconds, thuf avoiding patient discomfort. our purpose in this article is to demonstrate the utility of reconstructions particularly in oblique planes, and reaching an optimal visualization of the temporal bone.
Can Transthoracic Echocardiography Be Used to Predict Fluid Responsiveness in the Critically Ill Patient? A Systematic Review
Justin C. Mandeville,Claire L. Colebourn
Critical Care Research and Practice , 2012, DOI: 10.1155/2012/513480
Abstract: Introduction. We systematically evaluated the use of transthoracic echocardiography in the assessment of dynamic markers of preload to predict fluid responsiveness in the critically ill adult patient. Methods. Studies in the critically ill using transthoracic echocardiography (TTE) to predict a response in stroke volume or cardiac output to a fluid load were selected. Selection was limited to English language and adult patients. Studies on patients with an open thorax or abdomen were excluded. Results. The predictive power of diagnostic accuracy of inferior vena cava diameter and transaortic Doppler signal changes with the respiratory cycle or passive leg raising in mechanically ventilated patients was strong throughout the articles reviewed. Limitations of the technique relate to patient tolerance of the procedure, adequacy of acoustic windows, and operator skill. Conclusions. Transthoracic echocardiographic techniques accurately predict fluid responsiveness in critically ill patients. Discriminative power is not affected by the technique selected. 1. Introduction Our primary concern in the management of the critically ill patient is the optimisation of tissue oxygen delivery. Insufficient intravascular loading in the early resuscitation of acute sepsis results in tissue underperfusion, organ dysfunction, and acidosis. Excessive fluid administration has also been shown to be detrimental in the perioperative setting and in acute lung injury, prolonging both time on mechanical ventilation and time in intensive care [1]. It has been reported that as few as 40 percent of critically ill patients thought to be intravascularly deplete gain an improvement in cardiac output after a standard fluid bolus, exposing more than half of patients to the risks of excessive fluid administration [2]. Knowledge of static measures of preload such as central venous pressure, pulmonary artery wedge pressure, end-diastolic volumes, and intrathoracic blood volume has not translated into patient benefit [3–6]. This suggests that measurement of preload does not foretell preload responsiveness. Contemporary investigation has therefore focussed on the search for clinical markers which predict a useful response to a fluid bolus. These “dynamic” markers make use of provoked cardiac reaction assessed without the need for a fluid bolus, instead utilizing either the consequences of heart-lung interaction during ventilation or the response to postural change to mimic the effect of a fluid bolus on stroke volume. Firstly, in mechanically ventilated patients who have no spontaneous
Future career plans of Malawian medical students: a cross-sectional survey
Mandeville Kate L,Bartley Tim,Mipando Mwapatsa
Human Resources for Health , 2012, DOI: 10.1186/1478-4491-10-29
Abstract: Background Malawi has one of the lowest physician densities in the world, at 1.1 doctors per 100,000 population. Undergraduate training of doctors at the national medical school has increased considerably in recent years with donor support. However, qualified doctors continue to leave the public sector in order to work or train abroad. We explored the postgraduate plans of current medical students, and the extent to which this is influenced by their background. Methods A self-administered questionnaire was developed after discussion with students and senior staff. This included questions on background characteristics, education before medical school, and future career plans. This was distributed to all medical and premedical students on campus over 1 week and collected by an independent researcher. One reminder visit was made to each class. Chi-squared tests were performed to investigate the relationship of student characteristics with future career plans. Results One hundred and forty-nine students completed the questionnaire out of a student body of 312, a response rate of 48%. When questioned on their plans for after graduation, 49.0% of students plan to stay in Malawi. However, 38.9% plan to leave Malawi immediately. Medical students who completed a ‘premedical’ foundation year at the medical school were significantly more likely to have immediate plans to stay in Malawi compared to those who completed A-levels, an advanced school-leaving qualification (P = 0.037). Current premedical students were slightly more likely to have immediate plans to work or train in Malawi compared to medical students (P = 0.049). However, a trend test across all the years was not significant. When asked about future plans, nearly half of students intend to work or train outside Malawi. Conclusions The majority of respondents plan to leave Malawi in the future. The effectiveness of the substantial upscaling of medical education in Malawi may be diminished unless more medical students plan to work in Malawi after graduation.
The Effect of Torsion Deformity and Medial Knee Osteoarthritis on Lower Limb Extensor Moments during Gait  [PDF]
David S. Mandeville, Kenneth A. Krackow, Sridhar R. Rachala, Mary Bayers-Thering
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2013, DOI: 10.4236/ojra.2013.32018

The aim of this study was to quantify the effect of torsion deformity on the lower limb kinetics during the loading response phase of gait. A total of 24 subjects: 6 end-staged medial knee OA with torsion deformity (TKO), 8 without torsion deformity (KOA), and 10 controls (CON) were imaged using computed tomography (CT). Internal moment of support and sagittal hip, knee and ankle joint moments were assessed using gait analysis. TKO showed greater external rotations of the proximal tibia and the distal femur compared to subjects with medial knee OA without torsion deformity and controls. TKO showed greater moment of support and a greater knee extensor moment when compared to controls when supporting the weight of the body during gait. The TKO intorsion deformity occurred as a result of a proximal malrotation of the tibia. In the presence of torsion deformity, the kinetic synergy of the lower limb showed increased total moment of support for subjects with medial knee OA. The greater extensor output from TKO may be the result of an increased muscular response to overcome an interrupted inter-segmental exchange of accelerations during the loading response phase of gait.

Intestinal Staple Line Reinforcement Using MatriStem  [PDF]
Kent C. Sasse, David Warner, Sean M. Ward, Walter Mandeville, Rebecca Evans
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.62011

Background: Staple line reinforcement material has been demonstrated to raise the burst pressure threshold after linear intestinal stapling. Numerous bioprosthetic materials have been utilized in surgical practice. Porcine urinary bladder matrix (ACell, Inc.) is an extracellular matrix material derived from porcine bladder used to reinforce surgically repaired soft tissue, and facilitate the body’s regenerative capacity. Objective: This study represents the first evaluation of urinary bladder matrix in gastrointestinal staple line reinforcement. Methods: Pathogen-free pigs underwent midline laparotomy under general anesthesia. Small intestinal division was performed with an endoscopic linear stapler. Nineteen intestinal divisions were performed with urinary bladder matrix staple line reinforcement, and twenty divisions were unreinforced. Staple lines were then subjected to burst pressure analysis by intraluminal infusion of dyed Krebs solution at an infusion rate of 20 ml·min-1 under manometric monitoring. Upon visible staple line extravasation, intraluminal pressure was recorded. Results: Intestinal staple lines reinforced with urinary bladder matrix exhibited significantly higher burst pressure threshold (p < 0.05). Reinforced staple lines had an average burst pressure of 99 ± 33 mmHg, compared to 61 ± 37 mmHg for unreinforced staple lines. Conclusion: Staple line reinforcement using urinary bladder matrix acutely improves burst pressures of intestinal staple lines when compared with unreinforced staple lines. Its regenerative properties may confer a long-term advantage to staple line reinforcement. These findings, along with previous findings of constructive remodeling in the presence of urinary bladder matrix in treatment of the gastrointestinal system, suggest that UBM may serve a role in gastrointestinal staple line reinforcement.

Impactos del cambio climático en la floración y desarrollo del fruto del café en Veracruz, México
Villers,Lourdes; Arizpe,Nancy; Orellana,Roger; Conde,Cecilia; Hernández,Josefina;
Interciencia , 2009,
Abstract: the region of huatusco, in veracruz, mexico, is an area of high coffee production. coffee trees are sensitive to temperature and precipitation variations. those climatic elements are related to the altitude, aspect and slope in the agroecological shadow system. a baseline climatic scenario was introduced on ombrothermic diagrams to relate the periods in which the reproductive phases of the coffee tree develops with the climatology of the region. this method was developed in order to achieve a better knowledge of the possible impacts of climate change on the flowering and fruit development in the species coffea arabica and c. canephora. increases of temperature and changes in precipitation were obtained using the outputs of two general circulation models, and applied to the basic ombrothermic diagram, in order to measure the possible impacts on the stated reproductive phases. according to those two climate change scenarios, important differences in regional climatology can be projected, and therefore strong impacts were detected: changes of the beginning of flowering which is related to the mean rainfall, and the extent of the preestival drought during the winter months. also, climatic change could impact the water availability during the fruit growing period, which is related the modifications in water surplus and to the increase of the intraestival drought during the rainy season of the year
Dimensionamento da popula??o de c?es e gatos do interior do Estado de S?o Paulo
Alves,Maria Cecilia Goi Porto; Matos,Marina Ruiz de; Reichmann,Maria de Lourdes; Dominguez,Margareth Harrison;
Revista de Saúde Pública , 2005, DOI: 10.1590/S0034-89102005000600004
Abstract: objective: to estimate the total dog and cat population with owners in order to enable better planning of the control actions against diseases involving these animals. methods: the study was carried out in the non-metropolitan regions of the state of s?o paulo, brazil, from may to december 2002. forty-one municipalities and 100 census tracts were surveyed. these were selected by probabilistic stratified cluster sampling in two stages. the strata were formed by grouping the municipalities according to their populations and living conditions. the pasteur s?o paulo technique was used to obtain data on the canine population. this technique was developed to estimate and classify dogs according to their degree of dependence and restriction. results: almost 53% of the 20,958 households visited owned a dog, and the average was 1.6 dogs per household. a total of 4,624 cats were found, concentrated in 12.6% of the households. the results indicate a dog/inhabitant ratio of 1:4.0 and a cat/inhabitant ratio of 1:16.4. conclusions: the animal/inhabitant ratios were much higher than expected. incorporation of these ratios into evaluations of the vaccination campaign against rabies has revealed more realistic coverage patterns, thus leading to renewed discussion of the vaccination targets for municipalities. an association was observed between the size of the municipality or its inhabitant's living conditions and the level of restrictions on dogs.
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