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Search Results: 1 - 10 of 210 matches for " Loic Giot "
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A Drosophila protein-interaction map centered on cell-cycle regulators
Clement A Stanyon, Guozhen Liu, Bernardo A Mangiola, Nishi Patel, Loic Giot, Bing Kuang, Huamei Zhang, Jinhui Zhong, Russell L Finley
Genome Biology , 2004, DOI: 10.1186/gb-2004-5-12-r96
Abstract: To complement the Gal4-based interaction data, we used the same set of Drosophila open reading frames to construct arrays for a LexA-based two-hybrid system. We screened the arrays using a novel pooled mating approach, initially focusing on proteins related to cell-cycle regulators. We detected 1,814 reproducible interactions among 488 proteins. The map includes a large number of novel interactions with potential biological significance. Informative regions of the map could be highlighted by searching for paralogous interactions and by clustering proteins on the basis of their interaction profiles. Surprisingly, only 28 interactions were found in common between the LexA- and Gal4-based screens, even though they had similar rates of true positives.The substantial number of new interactions discovered here supports the conclusion that previous interaction mapping studies were far from complete and that many more interactions remain to be found. Our results indicate that different two-hybrid systems and screening approaches applied to the same proteome can generate more comprehensive datasets with more cross-validated interactions. The cell-cycle map provides a guide for further defining important regulatory networks in Drosophila and other organisms.Protein-protein interactions have an essential role in a wide variety of biological processes. A wealth of data has emerged to show that most proteins function within networks of interacting proteins, and that many of these networks have been conserved throughout evolution. Although some of these networks constitute stable multi-protein complexes while others are more dynamic, they are all built from specific binary interactions between individual proteins. Maps depicting the possible binary interactions among proteins can therefore provide clues not only about the functions of individual proteins but also about the structure and function of entire protein networks and biological systems.One of the most powerful technologi
Agarose Gel Electrophoresis - Applications in Clinical Chemistry
Jean-Francois Giot
Journal of Medical Biochemistry , 2010, DOI: 10.2478/v10011-009-0033-8
Abstract: Agarose gel electrophoresis is a well established technique routinely used in clinical laboratories for screening protein abnormalities in various biological fluids (serum, urine, CSF). It is based on the principles of zone electrophoresis. Electrophoretograms are evaluated visually for the presence of quantitatively or qualitatively abnormal protein bands. The technique is used for electrophoresis of serum, urine, CSF proteins, enzymes (ALP, LDH and CK), lipoproteins and hemoglobin. Serum protein electrophoresis (SPE) is a very commonly used analytical method in clinical chemistry. Changes in the relative concentration of fractions allow easy recognition of pathological disorders associated with nephrotic syndrome, inflammatory reaction and hepatic diseases. SPE is a screening test for detecting the M component (MC). Immunofixation (IFE) with use of specific antisera allows detection of the type of MC. SPE is also a method for the quantification of MC and monitoring of disease that is essential for clinical evaluation and follow-up of patients with plasma cell disorders.
Genetic Programming for Multibiometrics
Romain Giot,Christophe Rosenberger
Computer Science , 2012, DOI: 10.1016/j.eswa.2011.08.066
Abstract: Biometric systems suffer from some drawbacks: a biometric system can provide in general good performances except with some individuals as its performance depends highly on the quality of the capture. One solution to solve some of these problems is to use multibiometrics where different biometric systems are combined together (multiple captures of the same biometric modality, multiple feature extraction algorithms, multiple biometric modalities...). In this paper, we are interested in score level fusion functions application (i.e., we use a multibiometric authentication scheme which accept or deny the claimant for using an application). In the state of the art, the weighted sum of scores (which is a linear classifier) and the use of an SVM (which is a non linear classifier) provided by different biometric systems provide one of the best performances. We present a new method based on the use of genetic programming giving similar or better performances (depending on the complexity of the database). We derive a score fusion function by assembling some classical primitives functions (+, *, -, ...). We have validated the proposed method on three significant biometric benchmark datasets from the state of the art.
Imagens de crian?as e crian?as nas imagens: representa??es da infancia na iconografia pedagógica nos séculos XVII e XVIII
Chalmel, Loic;
Educa??o & Sociedade , 2004, DOI: 10.1590/S0101-73302004000100005
Abstract: this text discusses how childhood was represented in the xviith century, when humanism determined a shift from sacred models to real ones, and in the xviiith century, when idealized images of childhood hid the children's real conditions of living, in order to analyze the evolution of image production for pedagogical purposes. from comenius on, the prevalent conception of image has been the representation of the real world, easier to read and understand than the written language and, therefore, useful as a pedagogical device. the text also discusses the meaning of the changes in such images as representative of the changes in the ways of thinking and conceiving knowledge itself and its transmission procedures.
Imagens de crian as e crian as nas imagens: representa es da infancia na iconografia pedagógica nos séculos XVII e XVIII
Chalmel Loic
Educa??o & Sociedade , 2004,
Abstract: O texto discute a trajetória das representa es da infancia do Século das Luzes (XVII), quando o humanismo originou mudan as na representa o da infancia, antes sacra e que ent o se torna real, e as do século XVIII, no qual uma infancia idealizada esconde a rudeza da vida real das crian as da época, para afunilar este debate na produ o iconográfica com objetivos pedagógicos. Da produ o imagética proposta por Comenius ao que se fez a partir dele no século seguinte, destaca-se a permanência da idéia do uso da imagem como representa o do real, de leitura e compreens o mais fáceis que o código escrito, sendo, portanto, uma ferramenta pedagógica útil. Ao mesmo tempo, discute-se o significado das mudan as operadas nas imagens como representativo de mudan as nos modos de pensar e de conceber o próprio conhecimento e seus processos de transmiss o.
A ra a como crime cívico
Loic Wacquant
Revista da Faculdade de Letras : Sociologia , 2005,
Abstract: By assuming a central role in the post-Keynesian government of racial division and poverty, the overgrown carceral system has become a preeminent force in the (re)making of race and citizenship in the United States. It not only signifies and enforces blackness through its practical conflation of color with criminality and devious violence. Much as slavery effected the “social death” of imported African captives and their descendants prior to abolition, the mass incarceration of African Americans induces the civic death of those it ensnares by extruding them from the social compact. Inmates are the target of a threefold movement of exclusionary closure that denies them access to institutionalized cultural capital, bars them from social redistribution, and disqualifies them from political participation. The felon disenfranchisement statutes that prohibit nearly 2 million black Americans from voting (re)cast them in the historic role of the living antithesis to the “model American.” The close kinship between the rhetoric and policy of political expurgation of convicts at century”s end and those of Negro exclusion in earlier eras suggests that blackness is best understood as America”s primeval civic felony in accord with the Durkheimian conception of crime as “an act” that “offends strong states of the collective conscience” – here America”s idealized representation of itself as the promised land of freedom, equality, and self-determination. By reactivating and updating the logic of racialized infamia, felon excommunication reminds us that caste division is a constitutive and not a teratological feature of American republicanism. It testifies to the stratified and restrictive complexion of American citizenship at the dawn of the new millennium.
J/ψ production in pp collisions and in Pb-Pb collisions at the LHC with the ALICE experiment
Manceau Loic
Physics , 2012,
Abstract: We report the recent measurements of the inclusive J/{\psi} production in pp collisions at \sqrt{s} = 2.76 TeV, in pp collisions at \sqrt{s} = 7 TeV and in Pb-Pb collisions at \sqrt{s_{NN}} = 2.76 TeV with the ALICE detector at the LHC. The J/{\psi} mesons are detected down to pT = 0 GeV/c via their di-muon decay channel at forward rapidity (2.5 < y < 4) and via their di-electron decay channel at mid-rapidity (|y| < 0.9). A special emphasis is put on the nuclear modification factor which is compared to the predictions of current J/{\psi} production models.
Mean number of encounters of N random walkers and intersection of strongly anisotropic fractals
Loic Turban
Physics , 2013,
Abstract: We study the mean number of encounters up to time t, E_N(t), taking place in a subspace with dimension d* of a d-dimensional lattice, for N independent random walkers starting simultaneously from the same origin. E_N is first evaluated analytically in a continuum approximation and numerically through Monte Carlo simulations in one and two dimensions. Then we introduce the notion of the intersection of strongly anisotropic fractals and use it to calculate the long-time behaviour of E_N.
Recursive calculation of the microcanonical density of states
Loic Turban
Physics , 2013,
Abstract: For a classical system of noninteracting particles we establish recursive integral equations for the density of states on the microcanonical ensemble. The recursion can be either on the number of particles or on the dimension of the system. The solution of the integral equations is particularly simple when the single-particle density of states in one dimension follows a power law. Otherwise it can be obtained using a Laplace transform method. Since the Laplace transform of the microcanonical density of states is the canonical partition function, it factorizes for a system of noninteracting particles and the solution of the problem is straightforward. The results are illustrated on several classical examples.
Quarkonium measurements in Pb-Pb and p-Pb collisions with ALICE at the LHC
Loic Manceau
Physics , 2013, DOI: 10.1051/epjconf/20136013002
Abstract: The ALICE experiment has measured quarkonium production in Pb-Pb collisions at \sqrt{sNN} = 2.76 TeV and in p-Pb collisions at \sqrt{sNN} = 5.02 TeV. The measurements are performed in the dielectron de- cay channel at mid-rapidity (|yLAB| < 0.9) and in the dimuon decay channel at forward rapidity (2.5 < yLAB < 4). We focus in particular on the J/{\psi} nuclear modification factor measured both in Pb-Pb and p- -Pb collisions and on the {\Upsilon}(1S) nuclear modification factor measured in Pb-Pb collisions.
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