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Search Results: 1 - 10 of 1473 matches for " Loan Dang "
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FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo
Raghuveer S Mali, Guang-Hua Peng, Xiao Zhang, Loan Dang, Shiming Chen, Kenneth P Mitton
BMC Molecular Biology , 2008, DOI: 10.1186/1471-2199-9-87
Abstract: FIZ1 is present in the nucleus of adult photoreceptors as well as other retinal neurons as shown by transmission electron microscopy with nano-gold labeling. FIZ1 and CRX were co-precipitated from retinal nuclear extracts with antibodies to either protein. Chromatin immunoprecipitation (ChIP) assays revealed that FIZ1 is part of the protein complex on several rod and cone gene promoters, within photoreceptor cells of the mouse retina. FIZ1 complexes with CRX or NRL on known NRL- and CRX-responsive elements, as shown by electrophoretic mobility shift assays with FIZ1 antibody. FIZ1 can directly bind to CRX, as demonstrated using yeast two-hybrid and GST pull-down assays. Co-transfection assays demonstrated that FIZ1 increases CRX-mediated activation of Opsin test promoters. Quantitative ChIP analysis revealed an increased association of FIZ1 with the Rhodopsin promoter in adult (P-25) neural retina versus immature (P-3) neural retina. The quantity of transcriptionally active RNA Polymerase-II within the Rhodopsin gene (Rho) was significantly increased in the adult neural retina, compared to the immature retina.FIZ1 directly interacts with CRX to enhance CRX's transactivation activity for target genes. Developmentally, in neural retina tissue, the increased association of FIZ1 with CRX target genes corresponds to an increased association of transcriptionally active Pol-II within the Rho gene. Together with previous findings, our results suggest that FIZ1 may act as a transcriptional co-regulator of photoreceptor-specific genes, recruited by at least two photoreceptor-specific transcription factors, CRX and NRL. Further studies are underway to elucidate the exact role of FIZ1 in photoreceptor gene expression, development and maintenance.The mammalian retina is an excellent paradigm to study both differentiation and maturation of neurons from common precursor cells [1]. Several transcription factors are clearly essential for photoreceptor development, and their mutation
ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects
Andrea C Klaver, Mary P Coffey, Lynnae M Smith, David A Bennett, John M Finke, Loan Dang, David A Loeffler
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-93
Abstract: Serum antibodies to Aβ1-42 monomer and soluble oligomers in AD, MCI, and NCI subjects (10/group) were measured by ELISA, subtracting polyvalent antibody binding and dissociating antibody-antigen complexes. Differences in mean antibody levels were assessed for significance with repeated measures ANOVA using restricted maximum likelihood estimation, using Tukey-Kramer tests and confidence intervals for multiple comparisons. Spearman's rank correlation was used to determine associations between anti-monomer and anti-oligomer antibody concentrations. Estimated sample sizes required to detect effects of various sizes were calculated.There were no significant differences between groups for mean anti-Aβ antibody levels, although these tended to be higher in AD than NCI specimens. Estimated group sizes of 328 and 150 for anti-Aβ monomer and oligomer antibodies, respectively, would have been required for 80% power for significance at 0.05 for a 25% increase in the AD mean relative to the NCI mean. Serum antibody concentrations to Aβ monomer and oligomers were strongly associated (correlations: 0.798 for undissociated sera, 0.564 for dissociated sera). Antibody-antigen dissociation significantly increased anti-Aβ monomer but not anti-Aβ oligomer antibody levels.The findings in this pilot study are consistent with relatively similar concentrations of specific, non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in AD, MCI, and NCI sera. The differences between groups for these antibodies would have required approximate group sizes of 328 and 150, respectively, for a high probability for statistical significance. These findings do not support the hypothesis that reduced levels of anti-Aβ antibodies might contribute to AD's pathogenesis.Amyloid-beta (Aβ), the major plaque-associated protein in the Alzheimer's disease (AD) brain, has become the main target for AD therapy since the formulation of the "amyloid hypothesis" [1]. The significance of serum antibodies t
Review of O. Vitandham (2005) On the Wings of a White Horse: A Cambodian Princess's Story of Surviving the Khmer Rouge Genocide
Loan Dao
Journal of Southeast Asian American Education and Advancement , 2008,
Delta-N Electromagnetic Transition
Mushtaq Loan
Physics , 1999,
Abstract: The EM ratio for a free Delta electromagnetic transition is discussed within the frame work of nonrelativistic approach. Such an approach gives a good account of data for a free Delta but is less important for an intrinsically relativistic nuclear many body problem.
Revisiting glueball wave functions at zero and finite temperature
Mushtaq Loan
Physics , 2008, DOI: 10.1140/epjc/s10052-008-0536-3
Abstract: We study the sizes and thermal properties of glueballs in a three dimensional compact Abelian gauge model on improved lattice. We predict the radii of $\sim 0.60$ and $\sim 1.12$ in the units of string tension, or $\sim 0.28$ and $\sim 0.52$ fm, for the scalar and tensor glueballs, respectively. We perform a well controlled extrapolation of the radii to the continuum limit and observe that our results agree with the predicted values. Using Monte Carlo simulations, we extract the pole-mass of the lowest scalar and tensor glueballs from the temporal correlators at finite temperature. We see a clear evidence of the deconfined phase, and the transition appears to be similar to that of the two-dimensional XY model as expected from universality arguments. Our results show no significant changes in the glueball wave functions and masses in the deconfined phase.
Study of Possible Proton-Antiproton Hexaquark State in Lattice QCD
Mushtaq Loan
Physics , 2006,
Abstract: We have used standard techniques of lattice quantum chromodynamics to look for evidence of the spin-zero six quark flavour singlet state ($J^{PC}=0^{-+}$) observed by BES Collaboration, and to determine the splitting between the mass of the possible proton-antiproton and the mass of two protons, its threshold. Using the various interpolating fields we find indications that for sufficiently light quarks proton-antiproton is slightly above the $2m_{p}$ threshold. The lattice resonance signal of binding observed near the physical and continuum regimes do not support the existence of proton-antiproton state as a spin-zero hexaquark state.
Evaluation of the Efficacy and Safety of 1% Sodium Chloride (LiceFreee Spray) against 1% Permethrin Crème Rinse on Head Lice Infested Individuals  [PDF]
Lidia Serrano, Lorraine S. Decesar, Loan Pham
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.42038
Abstract: Head lice are a public health issue, and resistance to available over-the-counter pediculicides is a concern. The objective of this randomized study was to evaluate the pediculicidal activity and safety of 1% Sodium Chloride spray (0.1709 M), (LiceFreee Spray?) compared to the current recommended treatment for head lice with 1% Permethrin Crème Rinse. Forty-two subjects were randomized equally into Sodium Chloride or Permethrin group. Products were applied to hair according to the label instructions. After application of the products at Day 1 and Day 8, pediculicidal efficacy and safety were assessed at Day 1, Day 8 and Day 15. Second treatment was only applied on Day 8 to individuals with observed live lice using the same products and protocols as Day 1. Proportion of lice free subjects per group, the reduction in number of live lice per head and adverse effects were recorded after each visit. The results showed significantly higher pediculicidal activity for Sodium Chloride spray (85%) as compared to Permethrin (45%) at Day 15 (p <
Molecular Epidemiology and Disease Severity of Human Respiratory Syncytial Virus in Vietnam
Dinh Nguyen Tran, Thi Minh Hong Pham, Manh Tuan Ha, Thi Thu Loan Tran, Thi Kim Huyen Dang, Lay-Myint Yoshida, Shoko Okitsu, Satoshi Hayakawa, Masashi Mizuguchi, Hiroshi Ushijima
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0045436
Abstract: Respiratory syncytial virus (RSV) is a major cause of acute respiratory infections (ARIs) in children worldwide and can cause high mortality, especially in developing countries. However, information on the clinical and molecular characteristics of RSV infection in developing countries is limited. From April 2010 to May 2011, 1,082 nasopharyngeal swabs were collected from children with ARI admitted to the Children's Hospital 2, Ho Chi Minh City, Vietnam. Samples were screened for RSV and genotyped by reverse transcription-PCR and sequencing. Demographic and clinical data was also recorded. RSV was found in 23.8% (257/1,082) of samples. RSV A was the dominant subgroup, accounting for 91.4% (235/257), followed by RSV B, 5.1% (13/257), and 9 cases (3.5%) were mixed infection of these subgroups. The phylogenetic analysis revealed that all group A strains belonged to the GA2 genotype. All group B strains belonged to the recently identified BA genotype, and further clustered into 2 recently described subgenotypes BA9 and BA10. One GA2 genotype strain had a premature stop codon which shortened the G protein length. RSV infection was significantly associated with younger age and higher severity score than those without. Co-infection with other viruses did not affect disease severity. RSV A caused more severe disease than RSV B. The results from this study will not only contribute to the growing database on the molecular diversity of RSV circulating worldwide but may be also useful in clinical management and vaccine development.
Impact of the Internet surfing on reading practices and choices
Fayaz Ahmad Loan
Webology , 2012,
Abstract: Reading in the 21st century networked society is no longer confined to the print reading. The scope of the reading has extended to the Internet sources that changed the traditional reading culture of the readers. The present study was conducted to identify the impact of the Internet surfing on reading practices and choices of the net generation college students. The survey method was applied to conduct the study and a questionnaire was used as a data collection tool. A sample of 676 students was selected from different strata based on gender, region and faculty in the degree colleges of the Kashmir region, Jammu and Kashmir state, India. In the sample size only 302 confirmed themselves as the e-readers and their responses were analyzed. Results reveal that the reading behavior of the online readers is in transition as the Internet surfing has increased non-sequential reading, interactive reading, superficial reading, and extensive reading and at the same rates is responsible for decreasing concentrated and in-depth reading. Plus, the Internet surfing has increased reading of the news & views, general knowledge, selected fields, sexual content, spiritual/religious text and has decreased reading of literature. To validate the results, the findings were correlated with earlier studies and hypotheses were formed and tested using the Chi-square test. However, the students have not experienced any electronic reading device like kindle (of Amazon) or iPod (of Apple) during browsing the electronic sources and it could be the future area of research.
[Special Issue on SEA Demographics] Response - Counseling/Psychology
Loan T. Phan
Journal of Southeast Asian American Education and Advancement , 2008,
Abstract: Response to Mark E. Pfeifer's featured article
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