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Search Results: 1 - 10 of 4318 matches for " Lisa Fontaine-Bodin "
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Memory in Microbes: Quantifying History-Dependent Behavior in a Bacterium
Denise M. Wolf, Lisa Fontaine-Bodin, Ilka Bischofs, Gavin Price, Jay Keasling, Adam P. Arkin
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001700
Abstract: Memory is usually associated with higher organisms rather than bacteria. However, evidence is mounting that many regulatory networks within bacteria are capable of complex dynamics and multi-stable behaviors that have been linked to memory in other systems. Moreover, it is recognized that bacteria that have experienced different environmental histories may respond differently to current conditions. These “memory” effects may be more than incidental to the regulatory mechanisms controlling acclimation or to the status of the metabolic stores. Rather, they may be regulated by the cell and confer fitness to the organism in the evolutionary game it participates in. Here, we propose that history-dependent behavior is a potentially important manifestation of memory, worth classifying and quantifying. To this end, we develop an information-theory based conceptual framework for measuring both the persistence of memory in microbes and the amount of information about the past encoded in history-dependent dynamics. This method produces a phenomenological measure of cellular memory without regard to the specific cellular mechanisms encoding it. We then apply this framework to a strain of Bacillus subtilis engineered to report on commitment to sporulation and degradative enzyme (AprE) synthesis and estimate the capacity of these systems and growth dynamics to ‘remember’ 10 distinct cell histories prior to application of a common stressor. The analysis suggests that B. subtilis remembers, both in short and long term, aspects of its cell history, and that this memory is distributed differently among the observables. While this study does not examine the mechanistic bases for memory, it presents a framework for quantifying memory in cellular behaviors and is thus a starting point for studying new questions about cellular regulation and evolutionary strategy.
The Xanthomonas Ax21 protein is processed by the general secretory system and is secreted in association with outer membrane vesicles
Ofir Bahar,Rory N Pruitt,Dee Dee Luu,Benjamin Schwessinger,Randy Ruan,Lisa Fontaine-Bodin,Ralf Koebnik,Pamela Ronald
PeerJ , 2015, DOI: 10.7287/peerj.preprints.109v1
Abstract: Pattern recognition receptors (PRRs) play an important role in detecting invading pathogens and mounting a robust defense response to restrict infection. In rice, one of the best characterized PRRs is XA21, a leucine rich repeat receptor-like kinase that confers broad-spectrum resistance to multiple strains of the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo). In 2009 we reported that an Xoo protein, called Ax21, was secreted by a type I-secretion system and that it served to a ctivate X A 21 -mediated immunity. This report has recently been retracted. Here we present data that corrects our previous model. We first show that Ax21 secretion does not depend on the predicted type I secretion system and that it is processed by the general secretion (Sec) system. We further show that Ax21 is an outer membrane protein, secreted in association with outer membrane vesicles. Finally, we provide data showing that ax21 knockout strains do not overcome XA21-mediated immunity.
The Xanthomonas Ax21 protein is processed by the general secretory system and is secreted in association with outer membrane vesicles
Ofir Bahar,Rory Pruitt,Dee Dee Luu,Benjamin Schwessinger,Arsalan Daudi,Furong Liu,Randy Ruan,Lisa Fontaine-Bodin,Ralf Koebnik,Pamela Ronald
PeerJ , 2015, DOI: 10.7717/peerj.242
Abstract: Pattern recognition receptors (PRRs) play an important role in detecting invading pathogens and mounting a robust defense response to restrict infection. In rice, one of the best characterized PRRs is XA21, a leucine rich repeat receptor-like kinase that confers broad-spectrum resistance to multiple strains of the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo). In 2009 we reported that an Xoo protein, called Ax21, is secreted by a type I-secretion system and that it serves to activate XA21-mediated immunity. This report has recently been retracted. Here we present data that corrects our previous model. We first show that Ax21 secretion does not depend on the predicted type I secretion system and that it is processed by the general secretion (Sec) system. We further show that Ax21 is an outer membrane protein, secreted in association with outer membrane vesicles. Finally, we provide data showing that ax21 knockout strains do not overcome XA21-mediated immunity.
Estimation des paramètres génétiques de la taille de portée des agnelles Lacaune après fécondation sur ?strus naturel et induit
L Bodin
Genetics Selection Evolution , 1979, DOI: 10.1186/1297-9686-11-4-413
Abstract:
Editorial
Bodin Loys
Genetics Selection Evolution , 2005, DOI: 10.1186/1297-9686-37-s1-i2
Abstract: The Institut National de la Recherche Agronomique (INRA) was honoured to welcome scientists from all over the world who attended the International Workshop on major Genes and QTL in Sheep and Goats. Approximately 100 participants from 16 countries were registered, contributing 52 oral or poster presentations. A first session was dedicated to the tools available for identifying and localising major genes or QTL in these two species. Molecular techniques, marker panels, radiation hybrids, genome physical maps, and BAC libraries were presented along with genetic, comparative and cytogenetic maps. A second and largest session concerned different traits for which major genes or QTL have been found, i.e., ovulation and other reproduction traits, milk and meat characters, and resistance to disease and wool production. For each group, a guest's paper focused on one sub-trait gave the state of the art: the history, identification and localisation of sources of monogenic and oligogenic variability, genetic determinism (dominance, imprinting, ...), effects on the phenotype, physiological mechanisms implied, use in populations, etc. The third session was devoted to the strategies for the use of major genes and QTL in populations, while the last session covered future prospects. A CD (available on request to bodin@toulouse.inra.fr) of the full proceedings was available, and participants invited to give a main paper also had the opportunity to submit it for publication in this special issue of GSE. Nine articles were jointly selected by the Editorial Board of the journal and by the Guest Editor.
Mapping university students’ epistemic framing of computational physics using network analysis
Madelen Bodin*
Physical Review Special Topics. Physics Education Research , 2012,
Abstract: Solving physics problem in university physics education using a computational approach requires knowledge and skills in several domains, for example, physics, mathematics, programming, and modeling. These competences are in turn related to students’ beliefs about the domains as well as about learning. These knowledge and beliefs components are referred to here as epistemic elements, which together represent the students’ epistemic framing of the situation. The purpose of this study was to investigate university physics students’ epistemic framing when solving and visualizing a physics problem using a particle-spring model system. Students’ epistemic framings are analyzed before and after the task using a network analysis approach on interview transcripts, producing visual representations as epistemic networks. The results show that students change their epistemic framing from a modeling task, with expectancies about learning programming, to a physics task, in which they are challenged to use physics principles and conservation laws in order to troubleshoot and understand their simulations. This implies that the task, even though it is not introducing any new physics, helps the students to develop a more coherent view of the importance of using physics principles in problem solving. The network analysis method used in this study is shown to give intelligible representations of the students’ epistemic framing and is proposed as a useful method of analysis of textual data.
Seeking Byzantium on the Borders of Narration, Identity, Space and Time in Julia Kristeva's Novel Murder in Byzantium
Helena Bodin
Nordlit : Tidsskrift i litteratur og kultur , 2009,
Abstract: This article discusses the notion of Byzantium and Byzantium's potential capacities as a multifaceted borderland, as shaped and perceived in Julia Kristeva's novel Murder in Byzantium. In spite of its title, this is not a historical, but rather a so-called total novel, which reconciles several different plots - romantic, criminal, political and philosophical. It relies on both fictive and historical texts, especially on The Alexiad, written in the 12th century by the Byzantine princess and the first female historian ever, Anna Comnena. Through a literary analysis, this article shows how Byzantium is shaped in the novel by transgressions of the borders of narration, identity, space and time. Byzantium is thus of great interest to the general public and an academic discussion of borders, origin, history and culture, so important for the discussion of Europe's role today in - or, as suggested in the novel, perhaps between - Eastern and Western cultures.
Seeking Byzantium on the Borders of Narration, Identity, Space and Time in Julia Kristeva's Novel Murder in Byzantium
Helena Bodin
Nordlit : Tidsskrift i litteratur og kultur , 2009,
Abstract: This article discusses the notion of Byzantium and Byzantium's potential capacities as a multifaceted borderland, as shaped and perceived in Julia Kristeva's novel Murder in Byzantium. In spite of its title, this is not a historical, but rather a so-called total novel, which reconciles several different plots - romantic, criminal, political and philosophical. It relies on both fictive and historical texts, especially on The Alexiad, written in the 12th century by the Byzantine princess and the first female historian ever, Anna Comnena. Through a literary analysis, this article shows how Byzantium is shaped in the novel by transgressions of the borders of narration, identity, space and time. Byzantium is thus of great interest to the general public and an academic discussion of borders, origin, history and culture, so important for the discussion of Europe's role today in - or, as suggested in the novel, perhaps between - Eastern and Western cultures.
La conversion au christianisme comme articulation des dynamiques individuelles et collectives (IIIe - Ve siècle) The Conversion to Christianity as a Link between group and individuals dynamics from 3rd to 5th Centuries
Ariane Bodin
Cahiers d'études du Religieux , 2011, DOI: 10.4000/cerri.841
Abstract: Les récits de conversion de l’Antiquité tardive tendent à stéréotyper le processus, au point que la relation entre le converti et Dieu semble être la seule explication pour analyser un tel retournement. Or, les spéculations purement théologiques ne nous permettent pas de comprendre les origines de la conversion. Néanmoins, en étudiant les entourages et les milieux des néophytes, il appara t manifestement que d’autres explications sociales peuvent rentrer en ligne de compte. L’étude de certains réseaux sociaux – comme celui des Pélagiens ou des dames de l’Aventin –, de la famille au sens large ou encore des hiérarchies sociales sont autant de facteurs permettant de mettre en lumière des incitations à la conversion. The tales of Christian conversions during Late Antiquity tend to stereotype the process, so that the relationship between the convert and God appears as the only motive explaining such a reversal. However purely theological explanations are not sufficient to thoroughly understand the origins of the process. Nevertheless, by studying the neophyte’s social environment, it appears without a doubt that other social explanations can be taken into account to understand this phenomenon. Focusing on certain social networks – such as the Pelagian’s or the Aventine circle –, on extended families or even on the social pyramid allows us to shed light on the incentives to conversion.
Jump of Milnor numbers
Arnaud Bodin
Mathematics , 2005,
Abstract: In this note we study a problem of A'Campo about the minimal non-zero difference between the Milnor numbers of a germ of plane curve and one of its deformation.
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