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Search Results: 1 - 10 of 5392 matches for " Lipid profile "
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Fasting and Non-Fasting Lipid Profile among Health Care Workers at Teaching Hospital Batticaloa SriLanka  [PDF]
Maheswaran Umakanth, Majitha Ibrahim
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.67002
Abstract: Requesting patients to come with long fasting state (12 - 14 hours) for lipid profile measurements are a major inconvenience. However, most blood tests, even glycemic management, can be done in a non-fasting state, for example by requesting an HbA1C. It is understandable that when we order lipid profile test, laboratories are very rigid on fasting (12 - 14 h) or refuse to do the test if fasting is not enough. To answer these delusions, we conducted a cross-sectional study among the health care workers at Teaching Hospital Batticaloa, SriLanka, after an overnight fast (12 - 14 hours) blood taken for lipid profile. Following weeks, we collected blood from the same healthcare workers, after breakfast (2 - 4 hours after meal). In this study, measurements of fasting lipid profile, including high-density lipoproteins (HDL), low-density lipoproteins (LDL), total cholesterol (TC), triglyceride (TG) and non-HDL significantly (p < 0.05) differ from non-fasting lipid profile measurement. The mean difference in lipid profile in fasting versus non-fasting among healthcare workers was 34.13 mg/dl for TG, -5.65 mg/dl for total TC, -1.94 mg/dl for HDL-cholesterol, 3.71 mg/dl for non-HDL and 12.3 mg/dl for LDL-cholesterol. This momentous change of different meanings does not play any significant role in cardiovascular risk assessment. However, a patient with a family history of the premature atherosclerotic cardiovascular disease (ASCVD), or familial hyperlipidemia, screening and follow-up should preferably be performed with fasting.
Maternal Plasma Lipid Profile in Women Screened for Gestational Diabetes Mellitus (GDM)  [PDF]
Adeniran Samuel Atiba, Babatunde Ajayi Olofinbiyi, Akindele Rasaq Akintunde, Aduloju Olusola Peter, Ojo Olubunmi Clementinah, Akinlua Ibikunle
Open Journal of Obstetrics and Gynecology (OJOG) , 2017, DOI: 10.4236/ojog.2017.712123
Abstract: Objective: This is to determine the plasma lipid profile status of patients diagnosed with gestational diabetes mellitus. Methodology: Seventy-nine pregnant women between gestational age of 24 and 28 weeks out of which 23 and 16 were diagnosed of having GDM using IADAPSG and WHO guidelines respectively were recruited into the study. Plasma lipid profile was determined among the study groups using standard laboratory techniques. Results: Higher numbers of women were diagnosed with GDM using IASDAPG criteria than when WHO criteria were used. Plasma lipid profile showed no significant difference between women with GDM and Non-GDM irrespective of guidelines used in the diagnosis of GDM. Conclusion: Pregnancy and Gestational Diabetes Mellitus may have influence on lipid metabolism but not likely in the second trimester of pregnancy as observed in our study.
Effect of Peaches, Pears and Green Tea on Plasma Lipids Profile and Antioxidant Content in Rats Fed High Sucrose Diet  [PDF]
Nada A. Al Zunaidy, Noorah S. Al-Sowayan, Hassan M. Mousa
Food and Nutrition Sciences (FNS) , 2015, DOI: 10.4236/fns.2015.610094
Abstract: The beneficial effects of feeding syrup of peaches and pears (peel and pulp) & green tea on the restoration of the changes produced by feeding high sucrose diet on plasma lipid profile, plasma antioxidant activity, and antioxidant enzymes in red blood cells (RBC) hemolysate were studied. High sucrose diet induced hyperlipidemia as manifested by significant (P ≤ 0.05) increases in the levels of cholesterol, triglycerides (TG) and low density lipoproteins (LDL) in plasma from 103.33 ± 1.8, 61.17 ± 0.48 and 26.6 ± 5.01 mg/dl to 136.67 ± 2.2, 81.3 ± 1.5 and 64.6 ± 6.5 mg/dl respectively. The high density lipoproteins (HDL) level was not significantly affected. TG levels in heart muscles increased significantly P ≤ 0.05 from the level of 194.14 ± 4.35 μg/g in the negative control to 269.72 ± 5.39 μg/g. Administration of fruits syrup and green tea resulted in a significant variable reduction in the elevated levels of cholesterol, TG and LDL and TG in the heart. Administration of sucrose resulted also in elevation of Malondialdehyde (MDA) in plasma from 5.06 ± 0.18 in the negative control to 14.81 ± 0.48 μmol/L in the positive control. This was also accompanied by reduction in the activities of supper oxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and a decrease in the concentration of reduced glutathione (GSH) in plasma, indicating lipid peroxidation. The activities of SOD, GSH-Px, CAT in the negative control were 8.96 ± 0.19, 315.67 ± 5.86, 209 ± 2.18 U/gHb respectively and were reduced significantly in the positive control to 4.7 ± 0.2, 273.83 ± 7.85, 207 ± 2.53 U/g Hb. There was a significant decrease in the level of total antioxidant status (TAS) in plasma from 1.45 ± 0.09 to 0.88 ± 0.09 nmol/L. However, no statistically significant changes were noticed in the concentrations of plasma total proteins and albumin. Intake of syrup of peaches and pears (peel and pulp) & green tea increased the level of TAS and GSH and decreased the level of LDL. The treatment also decreased significantly (P ≤ 0.05) the levels of plasma cholesterol, TG and heart TG levels. The activities of SOD and GSH-Px were increased following the treatment. It can be concluded that syrup of peaches and pears (peel and pulp) & green tea modulate lipid metabolism and enhance antioxidant status and in this respect green tea produced the best effect followed by peels of pears and peaches. The beneficial effect produced by fruits syrup and green tea may be due to their contents of phytochemicals.
Self monitoring of blood glucose and its association with glycaemic control and lipid levels in type 2 diabetic patients aged 40 - 75 in Trinidad and Tobago  [PDF]
B. Shivananda Nayak, Khateija Gowrie, Renelle Romano, Carl Spencer, Domonique Noel, Hellen Bissoon, Ikageng Dipatene, Nadia Mahabir, Rissa Ragbir, Shalane Xavier
Journal of Diabetes Mellitus (JDM) , 2012, DOI: 10.4236/jdm.2012.23046
Abstract: This study was done to assess whether self monitoring of blood glucose is associated with better glycaemic control in type 2 diabetic Trinidadians. Data was collected from 146 type 2 diabetics via interviews and medical files. Variables extracted included fasting blood glucose, HbA1c and lipid profile. Recent users of the glucometer had better glycemic control compared with longstanding users (HbA1c: 8.4% ± 0.28% vs 9.4% ± 0.62%). Diabetics using a glucometer for >11 years had the highest cholesterol (234 ± 27mg/dL) while those using it 6 months to 5 yrs had the lowest values (206 ± 8 mg/dL). Using the glucometer occasionally or once a week had little impact on these indices. Usage of insulin preparation was positively correlated with HbA1c (r = 0.295; p = 0.001) while those relying on oral hypoglycaemic agents showed a negative correlation (r = -0.265). Further, those who took their medication as prescribed had a lower HbA1c than those who took their medication occasionally. Ironically, HbA1c fell with increasing duration between clinic visits with those visiting annually having the lowest HbA1c (9.0% ± 0.2% vs 7.1% ± 0.7%). Compliance with lifestyle and exercise resulted in lower HbA1c and blood lipids. Poor client education on glucometer usage, administration of insulin and non-compliance with diet and exercise were associated with higher HbA1c.
Effect of Artemether Treatment on Plasma Lipid Profile in Malaria  [PDF]
Nkereuwem Edikpo, Paul Obiekwe Okonkwo, Elias Adikwu
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.57074

This study was undertaken to assess the effect of artemether treatment on plasma lipid profile in malaria infection. While the importance of lipid to plasmodial infective processes and metabolism is being increasingly appreciated, little is known about the attendant effect of chemotherapy on plasma lipid profile. Thirty patients with uncomplicated malaria were chosen from two secondary health-care facilities in Yobe State, Nigeria with informed consents and ethical clearance. Based on predetermined inclusion criteria patients were given 3.2 mg/kg of artemether with 1.6 mg/kg on subsequent days for a total of five days. This was done after the collection of urine and blood samples for urinalysis, malaria parasite density count and serum lipid analysis. A follow-up was planned seven (7) days from first dose during when clinical assessment and repeat malaria parasite density count and serum lipid analysis were done. Data were analyzed with statistical package for social scientist and Microsoft Excel spread sheet while level of significance at p ≤ 0.05 was calculated using paired t-test. Serum HDL cholesterol concentration recorded a significant decline of 0.13 mmol/L from a pre-treatment mean concentration of 1.17 mmol/L (p < 0.04). Triglyceride, total cholesterol, LDL-cholesterol, VLDL-cholesterol showed increment or reductions that were not significant. The clinical cure rate was 50% and mean percentage reduction in parasitaemia was 52%. A possible explanation for this low cure rate could be resistance, unfavorable pharmacokinetic disposition or lack of full adherence. A trial with complete parasite clearance, possibly using artemisinin-based combinational therapy would provide a more compelling result.

Effect of the Ethanolic Extract of Khaya senegalensis on Some Biochemical Parameters on Rabbit’s in Glucose Overload Condition  [PDF]
Essé Agossou, Mélanie Ahokpe, Justin Behanzin, Marcellin Takin, Ganiou Yessoufou, Loica Zohoun, Lamine Baba-Moussa, Alphonse Sezan
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.61027
Abstract: The effect of the ethanolic extract Khaya senegalensis on some biochemical parameters was tested in rabbits with normal glucose and glucose overload. Phytochemical screening after three batches of 6 rabbits race (TBD) were treated with the extract in oral doses of respectively 10, 25 and 50 mg/kg body weight for 30 days; three other groups receiving respectively these doses of the extract were placed under a priori temporary overload of glucose; a control group received instead distilled water treatment. Blood glucose, triglycerides and total cholesterol were measured by spectrophotometry and weight gain of the animals was performed at the beginning of the experiment and every 2 weeks during the study period. The phytochemical screening revealed the presence of polyphenolic compounds (majority) of saponins of anthracene derivatives and steroids in the extract. The test results indicate that under the dose of 50 mg/kg body weight (BW) there was a significant decrease (p < 0.05) in blood glucose after 24 hours. The extract had no effect on the lipid profile or body weight of rabbits.
Albumin and Lipid Profiles Following Treadmill Exercise among Student Volunteers of Nnamdi Azikiwe University, Nnewi, Nigeria  [PDF]
P. O. U. Adogu, S. C. Meludu, I. A. Modebe, C. F. Ubajaka
Open Journal of Preventive Medicine (OJPM) , 2015, DOI: 10.4236/ojpm.2015.56026
Abstract: The albumin and lipid profile changes following treadmill exercise were assessed among 160 apparently healthy student volunteers made up of 80 males and 80 females within the age bracket of 18 - 30 years, the physically active age group within the universities. The anthropometric indices (weight, height and BMI) of the subjects were taken using reference/standard methods. The blood pressures and pulse rate, then albumin and lipid profiles were also taken before and after exercise. The participants ran on a treadmill and their physical conditions were assessed using the Bruce protocol. Immediate post-exercise blood samples were again analyzed in the laboratory. There were significant increases (P < 0.05) in the after-exercise systolic BP, pulse rate and serum albumin, while marked decrease in diastolic BP was recorded (P < 0.05). Following exercise, total cholesterol and Low Density Lipoprotein reduced significantly (P < 0.01) in both sexes while High Density Lipoprotein increased markedly in males (P < 0.01) but not significantly increased in females (P > 0.5). There were gender variations in response to the treadmill exercise. Some of these findings indicate the expected functional alterations in the life of the students and there is a need to recommend the adoption of regular moderate exercise pattern to the students. These can bring about positive changes in their serum lipid and albumin profiles for better health in the face of stressful academic life.
Daily Hazelnut Intake Exerts Multiple Reversible Effects on Plasma Profile of Healthy Subjects  [PDF]
Chiara Santi, Antonio Giorni, Caterina Toriani Terenzi, Pierluigi Altavista, Loretta Bacchetta
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.86045
Abstract: Life sciences such as medical, nutritional, and those related to agrarian biotechnologies are experiencing a constant increase. Therefore, food consumption is today related to health state. Aiming to create an innovative spinneret system that defines the tight correlation between high nutritional and nutraceutical value of foods and their beneficial effects on consumer’s health state, we tested the effects related to the administration of 40 g of the Tonda Gentile Romana Italian hazelnut cultivar (Viterbo, Italy). To this end, we enrolled 24 subjects for a period of 14 weeks, based on a crossover design. Although several papers and reviews on hazelnut intake benefits are available, few studies have investigated the effects of hazelnut-enriched diet on plasma key parameters commonly used to ascertain the individuals well-being status. The primary endpoint of the trial was to assess LDL change related to hazelnut administration, which resulted in significant beneficial effects on cholesterol parameters (LDL dropped from 133.09 mg/dl to 119.18 mg/dl). Interestingly, despite within the normal ranges, uric acid and serum creatinine mean values significantly decreased after hazelnut intake. A significant increment was also observed for ALT (from 30.9 U/L to 35.22 U/L, P = 0.01), while GGT significantly decreased from 38.04 mg/dl at T0 to 35
Effect of Various Doses of Cinnamon on Lipid Profile in Diabetic Individuals
Alam Khan,Mahpara Safdar,Mohammad Muzaffar Ali Khan
Pakistan Journal of Nutrition , 2003,
Abstract: The effect of cinnamon doses on blood serum triglyceride (TGL), total cholesterol, high-density lipoproteins (HDL) and low-density lipoproteins (LDL) was studied in type 2 diabetic individuals for 60 days. Sixty type 2 diabetic individuals of both sexes and of age 48 6.5 years were divided into 6 groups; each group was having 10 individuals. Groups 1, 2 and 3 were assigned for 1g, 3g and 6g cinnamon doses/day respectively. Groups 4, 5 and 6 were assigned for 1g, 3g and 6g placebo doses/day respectively. The doses were equally distributed over the day. Cinnamon and placebo were given in the form of capsules with breakfast, lunch and dinner. The doses were taken for 40 days and after 40 days; there was a 20 days blank period. Fasting blood samples were taken on days 0 (starting day of the experiment) 20, 40 and 60 and blood serums were separated. The TGL, cholesterol, HDL and LDL of blood serum of both the cinnamon and placebo groups were determined. Cinnamon doses significantly (P<0.05) reduced the mean fasting serum TGL and cholesterol levels while the placebo doses did not change the serum TGL and cholesterol levels. Cinnamon doses reduced the mean fasting serum HDL levels but the reduction was non significant at P<0.05, while placebo doses did not affect the serum HDL levels. Cinnamon doses significantly (P<0.05) reduced the mean fasting serum LDL levels while the placebo doses did not affect the serum LDL levels. The data demonstrated that cinnamon intake reduced blood serum TGL, cholesterol and LDL significantly (P<0.05) in type 2 diabetic individuals. In the light of this research, it is recommended that individuals who have high TGL, cholesterol and LDL levels, they should use cinnamon in their food preparations on regular basis. This will keep their TGL, cholesterol and LDL levels low.
The Professional Medical Journal , 2004,
Abstract: Introduction: Now a days Calcium channel blockers and Betablockers are widely used for the treatment of essential hypertension. Beta blockers have been observedto increase the serum cholesterol, serum triglycerides and serum LDL cholesterol levels, calcium channelblockers have been noted to have a beneficial effect on lipid profile. Setting: In outpatient clinic ofBahawal Victoria Hospital, Bahawalpur Period: From 1st Sep 2003 to 31 Mar 2004 (three months).Material & Methods: Blood pressure, systolic and diastolic, and lipid profile (Serum cholesterol, LDLcholesterol, HDL cholesterol and serum triglycerides) were investigated in patients receiving Amlodipinetherapy. This was a 3 months follow-up study, which was carried on 90 patients. The effects of drugswere assessed at various time intervals. Second generation Calcium channel blocker, Amlodipine, whichis widely used for treatment of Hypertension was selected to observe its effect on serum lipid profile invarious patients. Results: The mean systolic and diastolic blood pressure decreased from 158 mm Hg and104.4 mm Hg to 122.26 mm Hg and 38.56 mm Hg respectively after 90 days of treatment withAmlodipine. The fall in serum cholesterol level (mg/dl) and LDL-cholesterol (mg/dl) was from 188.13and 125.40 to 170.76 and 105.7 after respectively after 90 days. Conclusion: Amlodipine significantlyreduced blood pressure, decreased the level of serum cholesterol and LDL cholesterol but did not affectsignificantly the HDL cholesterol and serum triglycerides.
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