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Search Results: 1 - 10 of 25587 matches for " Linyou Cheng "
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Hepatoprotective Activity of Yigan Mingmu Oral Liquid against Isoniazid/Rifampicin-Induced Liver Injuries in Rats  [PDF]
Yuxin Chen, Qigui Mo, Baibo Xie, Bingxin Ma, Xinyu Zang, Gao Zhou, Linyou Cheng, James Hua Zhou, Youwei Wang
Chinese Medicine (CM) , 2018, DOI: 10.4236/cm.2018.94010
Abstract:

Background: To explore the hepatoprotective effect of Yigan mingmu oral liquid (YGMM) on isoniazid-rifampicin induced liver injury in rats. Methods: Total 38 SD rats were randomly divided into 6 groups including control group, model group, silymarin positive control group, and three YGMM treatment groups. Model group was administered intragastrically with INH (100 mg/kg) and RIF (100 mg/kg) for 14 days. Silymarin group and YGMM treatment groups were administered intragastrically with silymarin (100 mg/kg) and different doses of YGMM (1, 2.5, 5 mg/kg) 2 hours before INH and RIF administration from day 4 to day 14.Results: Rats were sacrificed 16 hours after the last day treatment to determine the activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), as well as total bilirubin (TB) content. Oxidative stress was evaluated by measuring total superoxide dismutase (T-SOD) and malondialdehyde (MDA) levels. Histopathological changes in liver tissues were observed under an optical microscope by using hematoxylin and eosin staining. The mice?in model groups showed significantly (p < 0.05) increased levels in AST, ALT, ALP, TB and MDA compared to their control groups; and showed significantly (p < 0.05) decreased level in T-SOD. These changes were significantly (p < 0.05) reversed by the YGMM treatments in a dose-dependent manner. Hepatic pathological changes were attenuated or even reversed by silymarin or YGMM treatments. Conclusions: YGMM has a good hepatoprotective activity on isoniazid-rifampicin induced liver

CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells
Linyou Cheng,Ming Liu,Cuicui Wang,Haizhou Liu,Yuyan Zhang,Xiukun Lin
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/292873
Abstract: In the present studies, a novel compound with potent anti-tumor activity from Ciona intestinalis L. was purified by acetone fractionation, ultrafiltration, gel chromatography and High Performance Liquid Chromatography. The molecular weight of the highly purified compound, designated CI431, was 431Da as determined by HPLC-MS analysis. CI431 exhibited significant cytotoxicity to several cancer cell types. However, only a slight inhibitory effect was found when treating the benign human liver cell line BEL-7702 with the compound. To explore its mechanism against hepatocellular carcinoma, BEL-7402 cells were treated with CI431 in vitro. We found that CI431 induced apoptotic death in BEL-7402 cells in a dose- and time-dependent manner. Cell cycle analysis demonstrated that CI431 caused cell cycle arrest at the G2/M phase, and a sub-G1 peak appeared after 24?h. The mitochondrial-mediated pathway was implicated in this CI431-induced apoptosis as evidenced by the disruption of mitochondrial membrane potential. The results suggest that the CI431 induces apoptosis in BEL-7402 human hepatoma cells by intrinsic mitochondrial pathway. 1. Introduction It is now clear that the oceans are not only home to a tremendous diversity of species but that their inhabitants produce also a wealth of natural products [1]. Since the 1950s, many structurally diverse natural products with astounding bioactivities have been discovered from marine organisms [2]. These compounds are mainly isolated from sessile animals, such as sponges, tunicates, corals, mollusks, and bryozoans [3, 4]. Among sessile animals, tunicates have received the most attention. More commonly known as Ascidiacea, members of the class Ascidiacea (Ascidians) are the most highly investigated tunicates, since they present a benthonic stage in their life, making their collection easier. The chemistry of ascidians has become one of the most active fields of marine natural products; it has been amply demonstrated that these sea creatures are prolific producers of unusual structures with significant bioactivities. Most of these products fall within the area of cancer therapy [5], and a significant number of ascidian-derived compounds have entered into preclinical and clinical trials as antitumor agents [3, 6]. Didemnin B, is perhaps the most studied marine natural product. This cyclic peptide was isolated from the Caribbean tunicate Trididemnum solidum [7]. Early investigation into the bioactivity of this compound revealed its strong antiproliferative effects in vitro against a variety of human tumor cell lines. It was
Induction of Apoptosis, G0/G1 Phase Arrest and Microtubule Disassembly in K562 Leukemia Cells by Mere15, a Novel Polypeptide from Meretrix meretrix Linnaeus
Ming Liu,Xiangzhong Zhao,Jin Zhao,Lin Xiao,Haizhou Liu,Cuicui Wang,Linyou Cheng,Ning Wu,Xiukun Lin
Marine Drugs , 2012, DOI: 10.3390/md10112596
Abstract: Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC 50 values of 38.2 μg/mL. Mere15 also caused concentration dependent induction of apoptosis, with overproduction of reactive oxygen species and loss of mitochondrial membrane potential. Moreover, Mere15 arrested cell cycle progression at G 0/G 1 phase of K562 cells in a concentration dependent manner. In addition, Mere15 caused the disassembly of the microtubule cytoskeleton in K562 cells and inhibited the polymerization of tubulin in a cell free system via interaction with tubulin. We concluded that Mere15 was cytotoxic to K562 leukemia cells and the cytotoxicity was related to the apoptosis induction, cell cycle arrest and microtubule disassembly. These results implied that Merer15 was a broad spectrum anticancer polypeptide, not only cytotoxic to various solid cancer cells but also to the chronic myelogenous leukemia cells. Mere15 may have therapeutic potential for the treatment of leukemia.
Non-equilibrium Thermal Super-radiation of Real Materials
Yiling Yu,Linyou Cao
Physics , 2013,
Abstract: We elucidate the theoretically maximal thermal radiation power from real materials at a given temperature. Our results demonstrate that the thermal radiation from real materials may be larger than the blackbody emission in free space,and indicate that this is rooted in the high refractive index of the materials. The refractive index contrast between the materials and environment dictates the radiation of real materials genetically not under thermodynamic equilibrium, but on the other hand can give rise to a larger density of photonic modes than that of the blackbody. One key to maximize the thermal radiation is to minimize the impedance mismatch of the materials with environment. By following this principle, we present a design of a carbon core coated by a four-layer transparent shell with gradually changed refractive indexes that can emit > 30 times more power than the blackbody, which reasonably approaches the predicted radiation maximum.
Leaky Mode Engineering: A General Design Principle for Dielectric Optical Antenna Solar Absorbers
Yiling Yu,Linyou Cao
Physics , 2013, DOI: 10.1016/j.optcom.2013.10.051
Abstract: We present a general principle for the rational design of dielectric optical antennas with optimal solar absorption enhancement: leaky mode engineering. This builds upon our previous study that demonstrates the solar absorption of a material with a given volume only dependent on the density and the radiative loss of leaky modes of the material. Here we systematically examine the correlation among the modal properties (density and radiative loss) of leaky modes, physical features, and solar absorption of dielectric antenna structures. Our analysis clearly points out the general guidelineS for the design of dielectric optical antennas with optimal solar absorption enhancement: a) using 0D structures; b) the shape does not matter much; c) heterostructuring with non-absorbing materials is a promising strategy; d) the design of a large-scale nanostructure array can use the solar absorption of single nanostructures as a reasonable reference.
Semiconductor solar superabsorber
Yiling Yu,Lujun Huang,Linyou Cao
Physics , 2013,
Abstract: Understanding the maximal enhancement of solar absorption in semiconductor materials by light trapping promises the development of affordable solar cells. However, the conventional Lambertian limit is only valid for idealized material systems with weak absorption, and cannot hold for the typical semiconductor materials used in solar cells due to the substantial absorption of these materials. Herein we theoretically demonstrate the maximal solar absorption enhancement for semiconductor materials and elucidate the general design principle for light trapping structures to approach the theoretical maximum. By following the principles, we design a practical light trapping structure that can enable an ultrathin layer of semiconductor materials,for instance, 10 nm thick a-Si, absorb > 90% sunlight above the bandgap. The design has active materials with one order of magnitude less volume than any of the existing solar light trapping designs in literature. This work points towards the development of ultimate solar light trapping techniques.
General modal properties of optical resonances in subwavelength nonspherical dielectric structures
Lujun Huang,Yiling Yu,Linyou Cao
Physics , 2013, DOI: 10.1021/nl401150j
Abstract: Subwavelength dielectric structures offer an attractive low loss alternative to plasmonic structures for the development of resonant optics functionality such as metamaterials. Nonspherical like rectangular structures are of most interest from the standpoint of device development due to fabrication convenience. However, no intuitive fundamental understanding of optical resonance in nonspherical structures is available, which has substantially delayed the device development with dielectric materials. Here we elucidate the general fundamentals of optical resonances in nonspherical subwavelength dielectric structures of different shapes (rectangular or triangular) and dimensionalities (1D nanowires and 0D nanoparticles). We demonstrate that the optical properties (i.e. light absorption) of nonspherical structures are dictated by the eigenvalue of the structure's leaky modes. Leaky modes are defined as natural optical modes with propagating waves outside the structure. We also elucidate the dependence of the eigenvalue on physical features of the structures. The eigenvalue shows scaling invariance with the overall size, weakly relies on the refractive index, but linearly depends on the size ratio of different sizes of the structure. We propose a modified Fabry-Perot model to account for this linear dependence. Knowledge of the dominant role of leaky modes and the dependence of leaky mode on physical features can serve as a powerful guide for the rational design of devices with desired optical resonances. It opens up a pathway to design devices with functionality that has not been explored due to lack of intuitive understanding, for instance, imaging devices able to sense incident angle, or superabsorbing photodetectors.
Solar Superabsorption of Semiconductor Materials
Yiling Yu,Lujun Huang,Linyou Cao
Physics , 2013,
Abstract: We theoretically demonstrate the fundamental limit in volume for given materials (e.g. Si, a-Si, CdTe) to fully absorb the solar radiation above bandgap, which we refer as solar superabsorption limit. We also point out the general principles for experimentally designing light trapping structures to approach the superabsorption. This study builds upon an intuitive model, coupled leaky mode theory (CLMT), for the analysis of light absorption in nanostructures. The CLMT provides a useful variable transformation. Unlike the existing methods that rely on information of physical features (e.g. morphology, dimensionality) to analyze light absorption, the CLMT can evaluate light absorption in given materials with only two variables, the radiative loss and the resonant wavelength, of leaky modes, regardless the physical features of the materials. This transformation allows for surveying the entire variable space to find out the solar superabsorption and provides physical insights to guide the design of solar superabsorbing structures.
Ultrathin Semiconductor Perfect Light Absorbers with High Spectral, Polarization, and Angle Selectivity for Arbitrary Wavelengths
Lujun Huang,Yiling Yu,Linyou Cao
Physics , 2014,
Abstract: Enabling perfect light absorption in ultrathin materials promises the development of exotic photonic devices. Here we demonstrate new strategies that can provide capabilities to rationally design ultrathin (thickness < {\lambda}/10~{\lambda}/5) semiconductor perfect absorbers for arbitrary wavelengths, including those at which the intrinsic absorption of the semiconductor is weak, e.g. Si for near-IR wavelengths. This is in stark contrast with the existing studies on ultrathin perfect absorbers, which have focused on metallic materials or highly-absorptive semiconductors. Our design strategies are built upon an intuitive model, coupled leaky mode theory that we recently developed and can turn the design for perfect absorbers to the design for leaky modes. The designed absorber is featured with extraordinary absorption enhancement, miniaturized dimension, and high selectivity for the wavelength, polarization, and angle of incident light. It can enable the development of flexible, light-weight, high-performance, cost-effective, and multifunctional optoelectronic devices that are difficult with current light absorbers.
Diagnosis and Treatment Strategy of Pulmonary Embolism after Video-assisted Thoracic Lobectomy
Hao XU, Congying GUO, Yu LU, Linyou ZHANG
- , 2018, DOI: : 10.3779/j.issn.1009-3419.2018.10.10
Abstract: Background and objective To summarize the clinical features of patients with pulmonary embolism after lobectomy and to explore the methods of diagnosis and treatment of pulmonary embolism after lobectomy. Methods The clinical data of 6 patients with pulmonary embolism after lobectomy between July 2007 and July 2017 were retrospectively analyzed. Results Of the 6 patients, 3 died within 24 h of onset and 3 patients were cured and discharged. Conclusion Pulmonary embolism after lobectomy is a rare postoperative complication in thoracic surgery. It is difficult to diagnose and has a high mortality rate. Preoperative thromboembolic risk assessment and postoperative prevention are important.?
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