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Search Results: 1 - 10 of 120020 matches for " Lingxia Wang "
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Fossil Orangutan-like hominoid teeth from Late Pleistocene human site of Mulanshan cave in Chongzuo of Guangxi and implications on taxonomy and evolution of orangutan
LingXia Zhao,CuiBin Wang,ChangZhu Jin,DaGong Qin,WenShi Pan
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0653-x
Abstract: Fossil records indicate orangutan-like hominoids have been widely distributed in south China during Pleistocene, although currently only surviving in the tropical forests of Kalimantan and Sumatra in Indonesia. This paper describes the recently discovered hominoid fossil teeth from human site of Mulanshan cave in Chongzuo of Guangxi, whose geological age is the Late Pleistocene, about 11000 yeas age based on associated mammal fauna and U-series dating. Compared with those of modern and subfossil orangutans from Indonesia, other fossil great apes from China, the hominoid teeth from Mulanshan cave are orangutan-like, but show somehow different from Indonesia’s orangutans, the average sizes of cheek teeth larger and occlusal enamel wrinkles less and simpler. They are classified temporarily as the subspecies of Pongo pygmaeus weidenreichi. Concerning the variations of morphological features and dental sizes of orangutan-like teeth from southern China and neighboring northern Vietnam, different subspecies or species or genus possibly, but the key evidence is necessary to be identified.
A physical model for the global mean surface air temperature anomalies over the past century
Guangyu Shi,Jiandong Guo,Xiaobiao Fan,Lingxia Wang
Chinese Science Bulletin , 1997, DOI: 10.1007/BF03182645
Abstract:
Specific Antigens to Distinguish M. tuberculosis from M. avium  [PDF]
Qun Liang, Lingxia Zhang, Zeng Tu, Jingyu Wang, Tao Hu, Pengzhi Wang, Weili Wu, Qi Liu, Yanlin Zhao, Yan Li, Weijun Chen
Advances in Microbiology (AiM) , 2012, DOI: 10.4236/aim.2012.23024
Abstract: To distinguish Mycobacterium tuberculosis from Mycobacterium avium, specific M. tuberculosis antigens had been studied for improving the early differential diagnosis effect of tuberculosis caused by different Mycobacterium. The rabbit anti-M. avium sera and anti-M. tuberculosis sera were analyzed for antibody-based reactivity by matrix-assisted laser desorption-ionization mass spectrometry (MALDI-TOF Mass) against M. tuberculosis proteins. The immunoreactive spots, which were attributed to the proteins HspX, GroES and CFP-10, were mostly located at 10 - 60 kDa and PI 4 - 6, subsequently Western blotting result proved that HspX and CFP-10 were specific to M. tuberculosis and ELISA testing result of 30 M. avium positive sera showed that GroES were cross-reactive to M. avium. Lastly, positive and negative tuberculosis reference sera and based on the mechanism of indirect ELISA, the specificity and the sensitivity of the methods targeting the antibodies HspX, GroES or CFP-10 were evaluated at 37% and 26%, 12% and 97%, 81% and 98%, respectively. The combination of these three antibody detection methods allowed to reached a specificity of 42%, and of 39% without taken into account of the method targeting the GroES antibody. Using proteomics approach, we found three M. tuberculosis specific antigens showed good potential in tuberculosis diagnosis, providing basic study for serodiagnosis of tuberculosis.
Risk Factors for Chronic and Recurrent Otitis Media–A Meta-Analysis
Yan Zhang, Min Xu, Jin Zhang, Lingxia Zeng, Yanfei Wang, Qing Yin Zheng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086397
Abstract: Risk factors associated with chronic otitis media (COM) and recurrent otitis media (ROM) have been investigated in previous studies. The objective of this study was to integrate the findings and determine the possible risk factors for COM/ROM based on our meta-analysis. A comprehensive search of electronic bibliographic databases (PubMed, Embase, CNKI and Wanfang database) from 1964 to Dec 2012, as well as a manual search of references of articles, was performed. A total of 2971 articles were searched, and 198 full-text articles were assessed for eligibility; 24 studies were eligible for this meta-analysis. Regarding risk factors for COM/ROM, there were two to nine different studies from which the odds ratios (ORs) could be pooled. The presence of allergy or atopy increased the risk of COM/ROM (OR, 1.36; 95% CI, 1.13–1.64; P = 0.001). An upper respiratory tract infection (URTI) significantly increased the risk of COM/ROM (OR, 6.59; 95% CI, 3.13–13.89; P<0.00001). Snoring appeared to be a significant risk factor for COM/ROM (OR, 1.96; 95% CI, 1.78–2.16; P<0.00001). A patient history of acute otitis media (AOM)/ROM increased the risk of COM/ROM (OR, 11.13; 95% CI, 1.06–116.44; P = 0.04). Passive smoke significantly increased the risk of COM/ROM (OR, 1.39; 95% CI, 1.02–1.89 P = 0.04). Low social status appeared to be a risk factor for COM/ROM (OR, 3.82; 95% CI, 1.11–13.15; P = 0.03). Our meta-analysis identified reliable conclusions that allergy/atopy, URTI, snoring, previous history of AOM/ROM, Second-hand smoke and low social status are important risk factors for COM/ROM. Other unidentified risk factors need to be identified in further studies with critical criteria.
The Effects of Periconceptional Risk Factor Exposure and Micronutrient Supplementation on Birth Defects in Shaanxi Province in Western China
Wenfang Yang, Lingxia Zeng, Yue Cheng, Zhijun Chen, Xiang Wang, Xu Li, Hong Yan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0053429
Abstract: Objectives 1) To understand the current prevalence and main types of birth defects, 2) assess the periconceptional exposure of factors associated with birth defects in Shaanxi Province, and 3) provide scientific evidence for local governments to formulate services for the primary prevention of birth defects. Methods We sampled 16,541 households from 128 townships in 16 counties/districts in Shaanxi province using a multi-stage random sampling method. Among them, 10,544 women who had live born or stillborn infants with gestational age ≥28 weeks between 2008 and 2009 were interviewed using a structured questionnaire designed to collect information about periconceptional risk factor exposure, health care service utilization, and micronutrient supplements. Logistic regression was performed to assess the risk factors associated with birth defects and adjustments were made for imbalanced social-demographic characteristics between case and control groups. Results The prevalence of congenital birth defect in Shaanxi province was 14.3/1000 births. The environment risk factors associated with birth defects include unhealthy lifestyle (Alcohol, odds ratio (OR): 3.60, 95% confidence interval (CI) 1.64?7.91; Smoking, OR: 1.32, 95% CI: 0.99?1.75; Drink strong tea, OR: 1.81, 95% CI: 1.27?2.59), exposure to heavy pollution (OR: 1.53, 95% CI: 1.01?2.30), maternal diseases (OR: 1.77, 95% CI: 1.35?2.33), drug use (OR: 2.11, 95% CI: 1.51?2.95), maternal chemical pesticide exposure (OR: 2.30, 95% CI: 1.16?4.57), and adverse pregnancy history (OR: 10.10, 95% CI: 7.55?13.53). Periconceptional folic acid or multiple micronutrients including folic acid supplementation, was associated with a reduced rate of birth defects (OR: 0.54, 95% CI: 0.29?0.998). Conclusions Health care service utilization, unhealthy lifestyle factors, and environment risk factors seem to be associated with birth defects in Shaanxi province. Governmental agencies should focus on effective primary preventative methods, such as the delivery of periconceptional health education for minimizing potential risk factor exposures, periconceptional folic acid or micronutrient supplementation, environment monitoring, and assessment of factories with high levels of pollution.
Navigation Mechanism in Virtual Scene and Its Three Model Avatar Application
Duan Xinyu,Liu Lingxia
Research Journal of Applied Sciences, Engineering and Technology , 2013,
Abstract: In this study, we have a research of the navigation mechanism in virtual scene and its three model avatar application. Scene navigation is a very important aspect in virtual environment construct. When running VRML, we assume existence of an invisible viewer avatar in the scene. We can take this advantage for conducting collision detection. Paper first studied scene navigation mechanism in VRML, mainly about Navigation Info node and its field’s value significance. Aiming at WALK, FLY, EXAMINE, ANY and NONE navigation type, we discussed theirs concrete application method and effect. Finally, incorporation with a 3D virtual scene example, study gives some research report about avatar Size space cylinder application.
Immunogenicity and Protective Efficacy against Murine Tuberculosis of a Prime-Boost Regimen with BCG and a DNA Vaccine Expressing ESAT-6 and Ag85A Fusion Protein
Jia Lu,Chun Wang,Zhiguang Zhou,Ying Zhang,Tingting Cao,Chunwei Shi,Zhenhua Chen,Lingxia Chen,Changxue Cai,Xionglin Fan
Clinical and Developmental Immunology , 2011, DOI: 10.1155/2011/617892
Abstract: Heterologous prime-boost regimens utilizing BCG as a prime vaccine probably represent the best hope for the development of novel tuberculosis (TB) vaccines. In this study, we examined the immunogenicity and protective efficacy of DNA vaccine (pcD685A) expressing the fusion protein of Ag85A and ESAT-6 (r685A) and its booster effects in BCG-immunized mice. The recombinant r685A fusion protein stimulated higher level of antigen-specific IFN-γ release in tuberculin skin test- (TST-) positive healthy household contacts of active pulmonary TB patients than that in TST-negative population. Vaccination of C57BL/6 mice with pcD685A resulted in significant protection against challenge with virulent Mycobacterium tuberculosis H37Rv when compared with the control group. Most importantly, pcD685A could act as a BCG booster and amplify Th1-type cell-mediated immunity in the lung of BCG-vaccinated mice as shown the increased expression of IFN-γ. The most significant reduction in bacterial load of both spleen and lung was obtained in mice vaccinated with BCG prime and pcD685A DNA booster when compared with BCG or pcD685A alone. Thus, our study indicates that pcD685A may be an efficient booster vaccine against TB with a strong ability to enhance prior BCG immunity.
Immunogenicity and Protective Efficacy of a Novel Recombinant BCG Strain Overexpressing Antigens Ag85A and Ag85B
Chun Wang,Ruiling Fu,Zhenhua Chen,Kun Tan,Lingxia Chen,Xindong Teng,Jia Lu,Chunwei Shi,Xionglin Fan
Clinical and Developmental Immunology , 2012, DOI: 10.1155/2012/563838
Abstract: Recombinant Bacillus Calmette-Guérin (rBCG) strain is the promising vaccine candidate for tuberculosis (TB) prevention, which aims at providing more enduring and enhanced protection than the parental BCG vaccine. In this study, three rBCG strains overexpressing immunodominant antigens Ag85B (rBCG::85B), Ag85A (rBCG::85A), or both (rBCG::AB) of Mycobacterium tuberculosis were constructed, respectively. rBCG strains showed higher level of overexpression of Ag85A and/or Ag85B proteins than BCG containing empty vector pMV261(rBCG::261), which had low levels of endogenous expression of both proteins as expected. rBCG::AB strain could provide the strongest short-term and long-term protection in the lung against intravenous infection with virulent M. tuberculosis than rBCG::261 control and other two rBCG strains overexpressing single antigen. The stronger and longer-lasting protection provided by rBCG::AB than rBCG::261 was correlated with systemic in vitro antigen-specific IFN-γ responses. Therefore, our results indicate that rBCG::AB could be a very promising TB vaccine candidate and should be further evaluated for the preclinical test.
Proteomic Analysis of Salt-Responsive Proteins in the Leaves of Mangrove Kandelia candel during Short-Term Stress
Lingxia Wang, Xiao Liu, Meng Liang, Fanglin Tan, Wenyu Liang, Yiyong Chen, Yongxiang Lin, Li Huang, Jianhong Xing, Wei Chen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0083141
Abstract: Salt stress is a major abiotic stress that limits crop productivity in many regions of the world. A comparative proteomic approach to identify salt stress-responsive proteins and to understand the molecular mechanisms was carried out in the woody halophyte Kandelia candel. Four-leaf-old K. candel seedlings were exposed to 150 (control), 300, 450, and 600 mM NaCl for 3 days. Proteins extracted from the leaves of K. candel seedlings were separated by two-dimensional gel electrophoresis (2-DE). More than 900 protein spots were detected on each gel, and 53 differentially expressed protein spots were located with at least two-fold differences in abundance on 2-DE maps, of which 48 were identified by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass spectrometry (MALDI-TOF-TOF/MS). The results showed that K. candel could withstand up to 450 mM NaCl stress by up-regulating proteins that are mainly involved in photosynthesis, respiration and energy metabolism, Na+ compartmentalization, protein folding and assembly, and signal transduction. Physiological data, including superoxide dismutase (SOD) and dehydroascorbate reductase (DHAR) activities, hydrogen peroxide (H2O2) and superoxide anion radicals (O2?) contents, as well as Na+ content and K+/Na+ ratios all correlated well with our proteomic results. This study provides new global insights into woody halophyte salt stress responses. Identification of differentially expressed proteins promotes better understanding of the molecular basis for salt stress reduction in K. candel.
Immunogenicity and Protective Efficacy against Murine Tuberculosis of a Prime-Boost Regimen with BCG and a DNA Vaccine Expressing ESAT-6 and Ag85A Fusion Protein
Jia Lu,Chun Wang,Zhiguang Zhou,Ying Zhang,Tingting Cao,Chunwei Shi,Zhenhua Chen,Lingxia Chen,Changxue Cai,Xionglin Fan
Journal of Immunology Research , 2011, DOI: 10.1155/2011/617892
Abstract: Heterologous prime-boost regimens utilizing BCG as a prime vaccine probably represent the best hope for the development of novel tuberculosis (TB) vaccines. In this study, we examined the immunogenicity and protective efficacy of DNA vaccine (pcD685A) expressing the fusion protein of Ag85A and ESAT-6 (r685A) and its booster effects in BCG-immunized mice. The recombinant r685A fusion protein stimulated higher level of antigen-specific IFN-γ release in tuberculin skin test- (TST-) positive healthy household contacts of active pulmonary TB patients than that in TST-negative population. Vaccination of C57BL/6 mice with pcD685A resulted in significant protection against challenge with virulent Mycobacterium tuberculosis H37Rv when compared with the control group. Most importantly, pcD685A could act as a BCG booster and amplify Th1-type cell-mediated immunity in the lung of BCG-vaccinated mice as shown the increased expression of IFN-γ. The most significant reduction in bacterial load of both spleen and lung was obtained in mice vaccinated with BCG prime and pcD685A DNA booster when compared with BCG or pcD685A alone. Thus, our study indicates that pcD685A may be an efficient booster vaccine against TB with a strong ability to enhance prior BCG immunity.
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