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Search Results: 1 - 10 of 18413 matches for " Lingmei Peng "
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Relationship between Interleukin-10 ?1082A/G Polymorphism and Risk of Ischemic Stroke: A Meta-Analysis
Jun Jin, Wuying Li, Lingmei Peng, Jian Chen, Rong Li, Peihua Wu, Sheng Tan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094631
Abstract: Objective To analyze the association between ?1082A/G polymorphism in interleukin-10 (IL-10) gene and ischemic stroke (IS) risk by meta-analysis. Methods We carried out a systematic electronic search in PubMed, BIOSIS Previews, Science Direct, Chinese National Knowledge Infrastructure, Chinese Biomedical Database, Weipu database and WANGFANG Database. Pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to assess the strength of the association. Results 7 studies were included. There was no significant association between IL-10 ?1082A/G polymorphism and IS risk under all genetic models in overall estimates (A vs. G: OR = 1.23,95%CI = 0.85–1.79;AA vs. GG: OR = 1.01,95%CI = 0.47–2.19; AG vs. GG: OR = 0.76, 95%CI = 0.38–1.55; AA+AG vs. GG: OR = 0.89,95%CI = 0.46–1.73; AA vs. AG+GG: OR = 1.39, 95%CI = 0.91–2.13). Similarly, no associations were found in subgroup analysis based on ethnicity and source of controls. However, removing the study deviating from Hardy–Weinberg equilibrium (HWE) produced statistically significant associations for overall estimates under recessive model(AA VS. AG+GG OR 1.58, 95% CI 1.04–2.42) and among Asians in all genetic models (A VS.G OR 1.64, 95% CI 1.07–2.53; AA vs. GG OR1.91, 95% CI 1.31–2.80; AG vs. GG OR1.44, 95% CI 1.09–1.91; AA+AG vs. GG OR 1.54, 95% CI 1.18–2.01;AA VS. AG+GG OR 1.79, 95% CI 1.07–3.00). Even after Bonferroni correction, the associations were observed still significantly in Asians under the two models (AA vs. GG OR1.91, 95% CI 1.31–2.80, P = 0.0008; AA+AG vs. GG OR 1.54, 95% CI 1.18–2.01, P = 0.001). Conclusion This meta-analysis indicates that IL10 ?1082 A/G polymorphism is associated with IS susceptibility in Asians and the ?1082 A allele may increase risk of IS in Asians. Considering the sample size is small and between-study heterogeneity is remarkable, more studies with subtle design are warranted in future.
Association between Transforming Growth Factor-Beta 1 T869C Polymorphism and Ischemic Stroke: A Meta-Analysis
Lingmei Peng, Peng Li, Jian Chen, Ke Yan, Fuyuan Huo, Lina Han, Can Li, Sheng Tan, Xiaodan Jiang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067738
Abstract: Objective To explore the association between transforming growth factor-beta1 (TGF-β1) T869C polymorphism and risk of ischemic stroke (IS) by performing a meta-analysis based on published articles. Methods Systematic electronic searches of PubMed, Science Direct, BIOSIS Previews, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, and WANFANG Database were performed. The strength of the association was calculated by pooled odds ratios (ORs) with 95% confidence intervals (95%CIs). Subgroup analysis was conducted to explore potential sources of heterogeneity. Sensitivity analysis was performed to elucidate the stability of the outcomes. Publication bias was evaluated by Begg’s funnel plot and Egger’s test. Results A total of 6 studies involving 1701 cases were included. The overall estimates did not show any significant association between TGF-β1 T869C polymorphism and risk of IS under all genetic models (C vs. T: OR = 1.08,95%CI = 0.88–1.32; CC vs. TT:OR = 1.17,95%CI = 0.79–1.72; CT vs. TT: OR = 0.91, 95%CI = 0.68–1.22; CC+CT vs. TT: OR = 0.99, 95%CI = 0.73–1.35; CC vs. CT+TT: OR = 1.23, 95%CI = 0.95–1.59). Similar lacking associations were observed in subgroup analysis based on ethnicity and source of controls. When stratified by study design, significant increased association of IS risk was found in cohort studies under genetic models except recessive model(C vs. T: OR = 1.18, 95%CI = 1.05–1.32; CC vs. TT: OR = 1.40, 95%CI = 1.10–1.77; CT vs. TT: OR = 1.23, 95%CI = 1.02–1.49; CC+CT vs. TT: OR = 1.27, 95%CI = 1.03–1.57; CC vs. CT+TT, OR = 1.21, 95%CI = 0.99–1.47), whereas in case-control studies a significant decreased risk was detected under heterozygote comparison(CT vs. CC: OR = 0.72, 95%CI = 0.57–0.92). However, after correction for multiple testing, the associations were observed to be null significant in both cohort and case-control subgroups among all genetic models. Conclusion This meta-analysis suggested that current epidemiological studies of TGF-β1 T869C polymorphism are too inconsistent to draw a conclusion on the association with IS susceptibility. Given the small sample size and remarkable between-study heterogeneity, further well-designed prospective large-scale studies are warranted.
Bone Marrow-Derived Mesenchymal Stem Cells Maintain the Resting Phenotype of Microglia and Inhibit Microglial Activation
Ke Yan, Run Zhang, Chengmei Sun, Lei Chen, Peng Li, Yi Liu, Lingmei Peng, Haitao Sun, Kun Qin, Fanfan Chen, Weiyi Huang, Yuxin Chen, Bingke Lv, Mouxuan Du, Yuxi Zou, Yingqian Cai, Lingsha Qin, Yanping Tang, Xiaodan Jiang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084116
Abstract: Many studies have shown that microglia in the activated state may be neurotoxic. It has been proven that uncontrolled or over-activated microglia play an important role in many neurodegenerative disorders. Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown in many animal models to have a therapeutic effect on neural damage. Such a therapeutic effect is attributed to the fact that BMSCs have the ability to differentiate into neurons and to produce trophic factors, but there is little information available in the literature concerning whether BMSCs play a therapeutic role by affecting microglial activity. In this study, we triggered an inflammatory response situation in vitro by stimulating microglia with the bacterial endotoxin lipopolysaccharide (LPS), and then culturing these microglia with BMSC-conditioned medium (BMSC-CM). We found that BMSC-CM significantly inhibited proliferation and secretion of pro-inflammatory factors by activated microglia. Furthermore, we found that the phagocytic capacity of microglia was also inhibited by BMSC-CM. Finally, we investigated whether the induction of apoptosis and the production of nitric oxide (NO) were involved in the inhibition of microglial activation. We found that BMSC-CM significantly induced apoptosis of microglia, while no apoptosis was apparent in the LPS-stimulated microglia. Our study also provides evidence that NO participates in the inhibitory effect of BMSCs. Our experimental results provide evidence that BMSCs have the ability to maintain the resting phenotype of microglia or to control microglial activation through their production of several factors, indicating that BMSCs could be a promising therapeutic tool for treatment of diseases associated with microglial activation.
Quantitative Estimation of Annual Runoff Variation from the Hotan River, China
Lingmei Huang,Lina Wu,Bing Shen
Journal of Sustainable Development , 2009, DOI: 10.5539/jsd.v2n2p120
Abstract: Starting from the existing analysis of runoff from the Hotan River, the varying cause of runoff in the Hotan River is analyzed using the annual runoff accumulated curves and the orderly cluster method, pointing out that the runoff from the Hotan River coming from the mountains falls into the natural runoff with the fluctuations because of being subject to climate changes. It is worth noticing that the Xiaota annual runoff flowing into Tarim River was reduced by 0.322 billion m3 in comparison of the postior 1989 series with the prior 1989 series and under the join action by both human being activities and climate changes.
CAML Does Not Modulate Tetherin-Mediated Restriction of HIV-1 Particle Release
Mohammed S. Ali,Jason Hammonds,Lingmei Ding,Paul Spearman
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009005
Abstract: Tetherin/BST-2 is a recently-identified potent restriction factor in human cells that restricts HIV particle release following particle formation and budding at the plasma membrane. Vpu counteracts tetherin's restriction of particle release in a manner that has not yet been fully defined. We recently identified calcium-modulating cyclophilin ligand (CAML) as a Vpu-interacting protein that also restricts particle release. We hypothesized that CAML may act to enhance tetherin-mediated restriction of particle release and thereby explain how two distinct factors could be responsible for Vpu-responsive restriction.
Characterization of poly (safranine T)-modified electrode and application for simultaneous determination of epinephrine and uric acid coexisting with ascorbic acid
Niu, Lingmei;Lian, Kaoqi;Kang, Weijun;Li, Shan;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011000200003
Abstract: a poly(safranine t) modified glassy carbon electrode was used for the simultaneous determination of epinephrine (ep) and uric acid (ua) in the presence of ascorbic acid (aa). enhanced electrocatalytic currents and well-separated potentials for ep and ua were observed. the anodic peak currents of ep and ua were linear to the corresponding concentrations in the range of 6.0×10-6-1.0×10-4 mol l-1. in addition, the modified electrode showed good sensitivity and stability. satisfactory results were achieved for the determination of ep and ua in injection solutions of ep and in human urine samples.
Diagnosis and prognosis evaluation of 1,2-dichloroethane encephalopathy - Magnetic resonance imaging combined with diffusion tensor imaging and magnetic resonance spectroscopy study
Zhan Fulan,Zheng Wenbin,Liu Lian,Kong Lingmei
Neurology India , 2011,
Abstract: Neuroimaging findings in 1,2-dichloroethane (1,2-DCE) encephalopathy have seldom been reported. We present the comprehensive neuroimaging findings, conventional magnetic resonance imaging (MRI) combined with diffusion tensor imaging (DTI) and 1 H-magnetic resonance spectroscopy ( 1 H-MRS), in a case of 1,2-DCE encephalopathy. On day-4 the signal intensity of the lesions on diffusion-weighted imaging (DWI) was higher than that with T2-weighted imaging (T2WI); mean apparent diffusion coefficient (ADC) values for lesions were lower than control values. On day-20, the mean ADC value was increased gradually, whereas the mean fractional anisotropy (FA) of the lesions was significantly reduced. 1 H-MRS showed reduced ratios of N-acetyl aspartate to creatinine (NAA/Cr) and NAA to choline (NAA/Cho) on day-20 as compared with the control values. Combining conventional MRI with DTI and MRS is valuable in the early diagnosis and prognosis of 1,2-DCE-induced encephalopathy.
Temporal Dynamics of Standardized Precipitation Evapotranspiration Index and Its Influence to Summer Maize Yield from Kaifeng Region in He’nan Province  [PDF]
Kunyu Peng, Jianfeng Peng
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.512006
Abstract: Many quantitative studies get more and more attention on drought occurrence and monitoring trends of drought change using different methods; however few studies involve correlation between drought and crop yield especially drought index. This study analyzed the climate change about annual mean SPEI-3, SPEI-6 and SPEI-12, of Kaifeng region in the period of 1961-2013. The SPEI-3 and SPEI-6 seasonal short timescales showed a decreasing tendency, especially rapidly a decline since 2004, and high-frequency alternate dry/wet periods occurred during 1961-2013. However, the annual timescale SPEI-12 showed almost no evidently rise/decline tendency but severity events of dry/wet episode aggravated in terms of duration and magnitude and remarkable low-frequency change. Correlation analysis results between maize yield from Kaifeng region and multi-month scale annual SPEI showed a high negative significant correlation with -0.689 (ρ < 0.001) in SPEI-3 and only a negative significant correlation (-0.663, ρ < 0.001) in June SPEI-3. Further analysis between maize yield and temperature, precipitation and light during June-September found that precipitation in June and August was the main limiting factor to maize yield and their correlation values were well below the correlation of SPEI-3 of June. Finally, the reconstruction equation found that there was a better change consistency between the maize yield reconstruction and actual production but more error in extremely high and low annual yield. This study provides a reliable analysis of climate change to corn yield and basic data support for services of grain production and food security in the future.
Xylitol gummy bear snacks: a school-based randomized clinical trial
Kiet A Ly, Christine A Riedy, Peter Milgrom, Marilynn Rothen, Marilyn C Roberts, Lingmei Zhou
BMC Oral Health , 2008, DOI: 10.1186/1472-6831-8-20
Abstract: Children, first to fifth grade (n = 154), from two elementary schools in rural Washington State, USA, were randomized to xylitol 15.6 g/day (X16, n = 53) or 11.7 g/day (X12, n = 49), or maltitol 44.7 g/day (M45, n = 52). Gummy bear snacks were pre-packaged in unit-doses, labeled with ID numbers, and distributed three times/day during school hours. No snacks were sent home. Plaque was sampled at baseline and six weeks and cultured on modified Mitis Salivarius agar for S. mutans/sobrinus and Rogosa SL agar for Lactobacillus spp. enumeration.There were no differences in S. mutans/sobrinus and Lactobacillus spp. levels in plaque between the groups at baseline. At six weeks, log10 S. mutans/sobrinus levels showed significant reductions for all groups (p = 0.0001): X16 = 1.13 (SD = 1.65); X12 = 0.89 (SD = 1.11); M45 = 0.91 (SD = 1.46). Reductions were not statistically different between groups. Results for Lactobacillus spp. were mixed. Group X16 and M45 showed 0.31 (SD = 2.35), and 0.52 (SD = 2.41) log10 reductions, respectively, while X12 showed a 0.11 (SD = 2.26) log10 increase. These changes were not significant. Post-study discussions with school staff indicated that it is feasible to implement an in-classroom gummy bear snack program. Parents are accepting and children willing to consume gummy bear snacks daily.Reductions in S. mutans/sobrinus levels were observed after six weeks of gummy bear snack consumption containing xylitol at 11.7 or 15.6 g/day or maltitol at 44.7 g/day divided in three exposures. Lactobacillus spp. levels were essentially unchanged in all groups. These results suggest that a xylitol gummy bear snack may be an alternative to xylitol chewing gum for dental caries prevention. Positive results with high dose maltitol limit the validity of xylitol findings. A larger clinical trial is needed to confirm the xylitol results.[ISRCTN63160504]Mutans streptococci (MS), more specifically S. mutans and S. sobrinus, are implicated in the development of den
Molecular identification of forensically significant beetles (Coleoptera) in China based on COI gene
Revista Colombiana de Entomología , 2011,
Abstract: precise identification of insect species plays an essential role in the accurate estimation of the postmortem interval (pmi), especially when information on the postmortem phenomenon is not available. sarcosaphagous beetles infest and colonize human and animal remains in the late stage of decomposition, and their morphological similarity poses a great challenge for forensic entomologists, as an existing key may be incomplete or difficult for non-specialists to use. a method for easy and accurate species-level identification at any life stage is required. in this study, a 272-base pair region of the mitochondrial cytochrome oxidase i (coi) gene was used to explore its utility in the identification of forensically important beetles. twenty-four specimens were collected from 14 locations in nine provinces of china. phenogram analysis of the sequenced segments by the unweighted pairgroup method analysis (upgma) method showed that all specimens were properly assigned into six species with strong similarity, which indicates the possibility of separating congeneric species with the short coi fragment. these results will be instrumental for implementation of the chinese database of forensically relevant beetles.
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