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Search Results: 1 - 10 of 73393 matches for " Ling-Yan Zhu "
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MicroRNA-17, 20a Regulates the Proangiogenic Function of Tumor-Associated Macrophages via Targeting Hypoxia-Inducible Factor 2α
Zhenqun Xu, Lan Zhao, Ling-Yan Zhu, Min He, Limin Zheng, Yan Wu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077890
Abstract: Tumor-associated macrophages (TAMs) constitute a major component of the leukocyte infiltrate of most solid tumors, and they usually exhibit a proangiogenic phenotype which facilitates tumor growth in most circumstances. However, the precise mechanisms regulating the proangiogenic properties of TAMs remain largely unclear. In the present study, we found that the expression of hypoxia-inducible factor 2α (HIF-2α) was significantly up-regulated in macrophages from tumor tissues of several solid tumors. Macrophages exposed to tumor cell line derived-culture supernatants (TSN) also expressed high levels of HIF-2α in vitro, without a requirement for hypoxia. We identified miR-17 and miR-20a as the key regulators of HIF-2α expression in TAMs, and autocrine IL-6 played an important role in mediating the expression of miR-17, miR-20a, and thereafter HIF-2α in TAMs. Furthermore, the elevated HIF-2α in TAMs stimulated transcription of a set of proangiogenic genes such as VEGFA and PDGFB, which might in turn contribute to the angiogenic process within tumors. Our data provide evidence in support of the critical role of HIF-2α in the proangiogenic activity of TAMs and also reveal a novel mechanism by which miRNAs regulate TAM functions through modulation of HIF-2α expression under non-hypoxic conditions.
Pollution trend and environmental behavior of perfluorooctanoic acid: A review.

ZHU Ling-yan,LIN Jia-hua,

应用生态学报 , 2008,
Abstract: As a kind of emerging persistent organic pollutant (POPs), perfluorooctanoic acid (PFOA) and its salts have caused global ecosystem pollution, and become a new research topic of POPs. Zoological tests indicated that PFOA can damage animal's liver, reproduction, development, immunity, and gene expression, etc. In a report of U. S. EPA's Science Advisory Board, PFOA is described as a "likely" carcinogen. The EPA has initiated a PFOA Stewardship Program to commit related industries to voluntarily reduce the contents of PFOA and its salts in their products to decrease the discharge of PEOA and its parent substances into the environment. The developed countries including European countries and the United States are also taking action to promote the risk assessment of PFOA and related substances, and to evaluate the availability of more secure alternative substances. In this paper, the research advances on the physicochemical properties, environmental sources, transportation and fate, and pollution trend of PFOA were briefly reviewed, and additional discussion was given to the priorities of future research on PFOA.
Teleporting an Unknown Two-qubit Entangled State via Ion-Trap Systems

AI Ling-Yan,DU Gang,ZHU Shi-Liang,ZHANG Zhi-Ming,

中国物理快报 , 2009,
Abstract: We propose a scheme for teleportation of an unknown two-qubit entangled state via trapped ions. In this scheme, we use the GHZ state as a quantum channel and the success probability can reach 1. The distinct advantage of our scheme is insensitive to the heating of the vibrational mode. In addition, Bell-state measurement is not required.
Environmental pollution by polybrominated diphenyl ethers (PBDEs) and their ecological chemical behaviors: A review

TANG Bao-hua,ZHU Ling-yan,ZHOU Qi-xing,

生态学杂志 , 2008,
Abstract: As a specific group of brominated flame retardants(BFRs),polybrominated diphenyl ethers(PBDEs) are widely used in a variety of household and industrial products,including electronics and household furnishings.It was reported that the concentrations of PBDEs are increasing exponentially in biota and abiota in recent years.Because of their lipophilicity and persistence,PBDEs can be bio-accumulated and bio-magnified in biota.In addition,PBDEs are evaporable to some extent,and thus,they can undergo long-distance transport to remote ecosystems.Many evidences indicated that PBDEs have definite toxic effects and endocrine disruption.From the aspects of ecological chemical behavior and eco-toxicity,this paper summarized the research results about the distribution and occurrence level of PBFRs in the environment as well as their toxic effects and behaviors in endocrine disruption,analyzed the existing problems in related researches,and discussed the research directions on PBDEs.
Research advances in animal toxicology of polybrominated diphenyl ethers and expectations on their ecotoxicology.

XU Zhi-qiang,ZHOU Qi-xing,ZHANG Que,ZHU Ling-yan,

应用生态学报 , 2007,
Abstract: As a kind of flame retardants,polybrominated diphenyl ethers(PBDEs) have been widely applied in industrial products and house wears,and detected in soil,sediments,air,and living organisms.PBDEs are proved to be harmful to mammals,birds,and fish.Great concern has been aroused because of their wide spreading,stable structure,and uncertain risk to human health.Based on the foreign toxicological researches and findings,this paper summarized the accumulation and elimination of PBDEs in organisms,their effects on the hepatic enzyme activities,thyroid gland,nerve and immune system,and reproduction and development of animals,and potential risk to human health.The problems in PBDEs toxicological research were analyzed,and future directions in this field were discussed.
Source profiles of particulate organic matters emitted from cereal straw burnings
ZHANG Yuan-xun,SHAO Min,ZHANG Yuan-hang,ZENG Li-min,HE Ling-yan,ZHU Bin,WEI Yong-jie,ZHU Xian-lei,
ZHANG Yuan-xun
,SHAO Min,ZHANG Yuan-hang,ZENG Li-min,HE Ling-yan,ZHU Bin,WEI Yong-jie,ZHU Xian-lei

环境科学学报(英文版) , 2007,
Abstract: Cereal straw is one of the most abundant biomass burned in China but its contribution to fine particulates is not adequately understood.In this study, three main kinds of cereal straws were collected from five grain producing areas in China. Fine particulate matters (PM2.5) from the cereal straws subjected to control burnings, both under smoldering and flaming status, were sampled by using a custom made dilution chamber and sampling system in the laboratory. Element carbon (EC) and organic carbon (OC) was analyzed.141 compounds of organic matters were measured by gas chromatography-mass spectrum (GC-MS). Source profiles of particulate organic matters emitted from cereal straw burnings were obtained. The results indicated that organic matters contribute a large fraction in fine particulate matters. Levoglucosan had the highest contributions with averagely 4.5% in mass of fine particulates and can be considered as the tracer of biomass burnings. Methyloxylated phenols from lignin degradation also had high concentrations in PM2.5,and contained approximately equal amounts of guaiacyl and syringyl compounds. β-Sitostrol also made up relatively a large fraction of PM2.5 compared with the other sterols (0.18%-0.63% of the total fine particle mass). Normal aikanes, PAHs, fatty acids, as well as normal alkanols had relatively lower concentrations compared with the compounds mentioned above. Carbon preference index (CPI) of normal alkanes and alkanoic acids showed characteristics of biogenic fuel burnings. Burning status significantly influenced the formations of EC and PAHs. The differences between the emission profiles of straw and wood combustions were displayed by the fingerprint compounds, which may be used to identify the contributions between wood and straw burnings in source apportionment researches.
A K matrix Construction of Symmetry Enriched Phases of Matter
Ling-Yan Hung,Yidun Wan
Physics , 2013, DOI: 10.1103/PhysRevB.87.195103
Abstract: We construct in the K matrix formalism concrete examples of symmetry enriched topological phases, namely intrinsically topological phases with global symmetries. We focus on the Abelian and non-chiral topological phases and demonstrate by our examples how the interplay between the global symmetry and the fusion algebra of the anyons of a topologically ordered system determines the existence of gapless edge modes protected by the symmetry and that a (quasi)-group structure can be defined among these phases. Our examples include phases that display charge fractionalization and more exotic non-local anyon exchange under global symmetry that correspond to general group extensions of the global symmetry group.
Revisiting Entanglement Entropy of Lattice Gauge Theories
Ling-Yan Hung,Yidun Wan
Physics , 2015, DOI: 10.1007/JHEP04(2015)122
Abstract: Casini et al raise the issue that the entanglement entropy in gauge theories is ambiguous because its definition depends on the choice of the boundary between two regions.; even a small change in the boundary could annihilate the otherwise finite topological entanglement entropy between two regions. In this article, we first show that the topological entanglement entropy in the Kitaev model which is not a true gauge theory, is free of ambiguity. Then, we give a physical interpretation, from the perspectives of what can be measured in an experiement, to the purported ambiguity of true gauge theories, where the topological entanglement arises as redundancy in counting the degrees of freedom along the boundary separating two regions. We generalize these discussions to non-Abelian gauge theories.
Holographic quantum liquids in 1+1 dimensions
Ling-Yan Hung,Aninda Sinha
Physics , 2009, DOI: 10.1007/JHEP01(2010)114
Abstract: In this paper we initiate the study of holographic quantum liquids in 1+1 dimensions. Since the Landau Fermi liquid theory breaks down in 1+1 dimensions, it is of interest to see what holographic methods have to say about similar models. For theories with a gapless branch, the Luttinger conjecture states that there is an effective description of the physics in terms of a Luttinger liquid which is specified by two parameters. The theory we consider is the defect CFT arising due to a probe D3 brane in the AdS Schwarzschild planar black hole background. We turn on a fundamental string density on the worldvolume. Unlike higher dimensional defects, a persistent dissipationless zero sound mode is found. The thermodynamic aspects of these models are considered carefully and certain subtleties with boundary terms are explained which are unique to 1+1 dimensions. Spectral functions of bosonic and fermionic fluctuations are also considered and quasinormal modes are analysed. A prescription is given to compute spectral functions when there is mixing due to the worldvolume gauge field. We comment on the Luttinger conjecture in the light of our findings.
Generalized ADE Classification of Gapped Domain Walls
Ling-Yan Hung,Yidun Wan
Physics , 2015, DOI: 10.1007/JHEP07(2015)120
Abstract: In this paper we would like to demonstrate how the known rules of anyon condensation motivated physically proposed by Bais \textit{et al} can be recovered by the mathematics of twist-free commutative separable Frobenius algebra (CSFA). In some simple cases, those physical rules are also sufficient conditions defining a twist-free CSFA. This allows us to make use of the generalized $ADE$ classification of CSFA's and modular invariants to classify anyon condensation, and thus characterizing all gapped domain walls and gapped boundaries of a large class of topological orders. In fact, this classification is equivalent to the classification we proposed in Ref.1.
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