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Search Results: 1 - 10 of 4275 matches for " Linda Vi "
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Molecular mechanisms and treatment strategies for Dupuytren’s disease
David B O’Gorman, Linda Vi, Bing Siang Gan
Therapeutics and Clinical Risk Management , 2010, DOI: http://dx.doi.org/10.2147/TCRM.S9165
Abstract: lecular mechanisms and treatment strategies for Dupuytren’s disease Review (3400) Total Article Views Authors: David B O’Gorman, Linda Vi, Bing Siang Gan Published Date August 2010 Volume 2010:6 Pages 383 - 390 DOI: http://dx.doi.org/10.2147/TCRM.S9165 David B O’Gorman1,2,3,4, Linda Vi1,2,5, Bing Siang Gan1,2,3,5,6 1Cell and Molecular Biology Laboratory, 2The Hand and Upper Limb Centre, St. Joseph’s Health Care London, Schulich School of Medicine and Dentistry, 3Departments of Surgery, 4Biochemistry, 5Physiology and Pharmacology, 6Medical Biophysics, The University of Western Ontario, London, OT, Canada Abstract: Dupuytren’s disease (DD) is a common disease of the hand and is characterized by thickening of the palmar fascia and formation of tight collagenous disease cords. At present, the disease is incurable and the molecular pathophysiology of DD is unknown. Surgery remains the most commonly used treatment for DD, but this requires extensive postoperative therapy and is associated with high rates of recurrence. Over the past decades, more indepth exploration of the molecular basis of DD has raised the hopes of developing new treatment modalities. This paper reviews the clinical presentation and molecular pathophysiology of this disease, as well as current and emerging treatment. It also explores the implications of new findings in the laboratory for future treatment.
Update on the management of Dupuytren’s contracture
Linda Vi, David B O’Gorman, Bing Siang Gan
Orthopedic Research and Reviews , 2010, DOI: http://dx.doi.org/10.2147/ORR.S8592
Abstract: ate on the management of Dupuytren’s contracture Review (4979) Total Article Views Authors: Linda Vi, David B O’Gorman, Bing Siang Gan Published Date August 2010 Volume 2010:2 Pages 35 - 43 DOI: http://dx.doi.org/10.2147/ORR.S8592 Linda Vi1, David B O’Gorman2, Bing Siang Gan3 1Department of Physiology and Pharmacology, 2Hand and Upper Limb Centre, Lawson Health Research Institute, Departments of Surgery and Biochemistry, 3Hand and Upper Limb Centre, Lawson Health Research Institute, Departments of Surgery and Medical Biophysics, University of Western Ontario, London, Ontario, Canada Abstract: Dupuytren’s disease (DD) is a pathological condition of the palmar fascia that is characterized by the formation of tight collagenous disease cords leading to permanent finger contractures. The disease is most prevalent in Caucasian men, and its incidence increases with age advancement. The most common complaint from patients having DD is the impairment of normal hand function. At present, the disease is incurable and the pathophysiology of DD is unknown. The most common treatment for DD is surgery; however, this treatment is associated with a high rate of recurrence. More recently, researchers have begun to explore the molecular basis of DD in the hopes of developing new, more effective treatment for DD. This review will summarize the history and clinical presentation of the disease, highlight current and emerging molecular treatments, and explore the implications of these advancements for future work.
Type-1 Collagen differentially alters β-catenin accumulation in primary Dupuytren's Disease cord and adjacent palmar fascia cells
Linda Vi, Anna Njarlangattil, Yan Wu, Bing Gan, David B O'Gorman
BMC Musculoskeletal Disorders , 2009, DOI: 10.1186/1471-2474-10-72
Abstract: Primary DD and patient matched, phenotypically normal palmar fascia (PF) cells were cultured in the presence or absence of type-1 collagen and Transforming Growth Factor-β1. β-catenin and α-smooth muscle actin levels were assessed by western immunoblotting and immunofluorescence microscopy.DD cells display a rapid depletion of cellular β-catenin not evident in patient-matched PF cells. This effect was not evident in either cell type when cultured in the absence of type-1 collagen. Exogenous addition of Transforming Growth Factor-β1 to DD cells in collagen culture negates the loss of β-catenin accumulation. Transforming Growth Factor-β1-induced α-smooth muscle actin, a marker of myofibroblast differentiation, is attenuated by the inclusion of type-1 collagen in cultures of DD and PF cells.Our findings implicate type-1 collagen as a previously unrecognized regulator of β-catenin accumulation and a modifier of TGF-β1 signaling specifically in primary DD cells. These data have implications for current treatment modalities as well as the design of in vitro models for research into the molecular mechanisms of DD.Dupuytren's contracture, or Dupuytren's Disease, (DD) [1-3] is a common, benign palmar fibromatosis of unknown etiology that results in finger contracture and loss of hand function. The most widely accepted treatment is surgical resection of the disease cord, an approach associated with prolonged post-operative rehabilitation and high recurrence rates [4,5]. Recently, minimally invasive treatment alternatives such as clostridial collagenase injection [6,7] and needle aponeurotomy [8-10] have gained popularity. While these approaches require relatively little post-treatment rehabilitation, their long-term efficacy and disease recurrence rates relative to fasciectomy are yet to be clearly established.We and others have identified dysregulated genes in primary cultures of DD cells [11] or DD cord and nodule tissue [12-14]. Many of these gene transcripts encode extrac
Update on the management of Dupuytren’s contracture
Linda Vi,David B O’Gorman,Bing Siang Gan
Orthopedic Research and Reviews , 2010,
Abstract: Linda Vi1, David B O’Gorman2, Bing Siang Gan31Department of Physiology and Pharmacology, 2Hand and Upper Limb Centre, Lawson Health Research Institute, Departments of Surgery and Biochemistry, 3Hand and Upper Limb Centre, Lawson Health Research Institute, Departments of Surgery and Medical Biophysics, University of Western Ontario, London, Ontario, CanadaAbstract: Dupuytren’s disease (DD) is a pathological condition of the palmar fascia that is characterized by the formation of tight collagenous disease cords leading to permanent finger contractures. The disease is most prevalent in Caucasian men, and its incidence increases with age advancement. The most common complaint from patients having DD is the impairment of normal hand function. At present, the disease is incurable and the pathophysiology of DD is unknown. The most common treatment for DD is surgery; however, this treatment is associated with a high rate of recurrence. More recently, researchers have begun to explore the molecular basis of DD in the hopes of developing new, more effective treatment for DD. This review will summarize the history and clinical presentation of the disease, highlight current and emerging molecular treatments, and explore the implications of these advancements for future work.Keywords: Dupuytren’s disease, etiology, clinical presentation, treatment
Molecular mechanisms and treatment strategies for Dupuytren’s disease
David B O’Gorman,Linda Vi,Bing Siang Gan
Therapeutics and Clinical Risk Management , 2010,
Abstract: David B O’Gorman1,2,3,4, Linda Vi1,2,5, Bing Siang Gan1,2,3,5,61Cell and Molecular Biology Laboratory, 2The Hand and Upper Limb Centre, St. Joseph’s Health Care London, Schulich School of Medicine and Dentistry, 3Departments of Surgery, 4Biochemistry, 5Physiology and Pharmacology, 6Medical Biophysics, The University of Western Ontario, London, OT, CanadaAbstract: Dupuytren’s disease (DD) is a common disease of the hand and is characterized by thickening of the palmar fascia and formation of tight collagenous disease cords. At present, the disease is incurable and the molecular pathophysiology of DD is unknown. Surgery remains the most commonly used treatment for DD, but this requires extensive postoperative therapy and is associated with high rates of recurrence. Over the past decades, more indepth exploration of the molecular basis of DD has raised the hopes of developing new treatment modalities. This paper reviews the clinical presentation and molecular pathophysiology of this disease, as well as current and emerging treatment. It also explores the implications of new findings in the laboratory for future treatment.Keywords: Dupuytren’s contracture, Dupuytren’s disease, fibrosis
Creative Expression: Effectiveness of a Weekly Craft Group with Women Who Have Experienced Trauma  [PDF]
Linda Garner
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.52011
Abstract: Creativity interventions have been shown to positively influence psychological and emotional health indicators. Nurses can play an important role in the development and implementation of interventions designed to counter the longer-term emotional and psychological consequences of trauma. The purpose of this study was to explore how participation in a nurse-facilitated weekly craft group may influence anxiety, depression, self-esteem, and self-confidence among women who have emotional and physical experienced trauma. A pre/post visual analog scale was used during a 7-week intervention to measure changes in anxiety, depression, stress, self-esteem and self-confidence among a convenience sample of adult female trauma survivors (n = 33). A paired sample t test was used to evaluate the intervention with significance set at p = 0.05. Participant observation and field notes were used for qualitative data generation. Significant reductions were noted in anxiety, depression, and stress along with significant increases in self-esteem and self-confidence. Cohen’s d statistic indicated a large effect size for anxiety (0.72) and stress (0.69). Moderate effect size was determined for self-confidence (0.36), depression (0.41), and self-esteem (0.52). Emergent qualitative themes included: creative expression improved confidence to sooth the self, safe spaces fostered creativity, a sense of accomplishment was stimulated through creative activities, and creative expression groups provided opportunities for positive affirmation. Offered as a complementary intervention, nurse-facilitated creative expression groups can support continued healing long after traditional support services have been exhausted. It is important for nurses to pursue a greater understanding of the art of nursing and the important contribution of creativity when used as a nursing intervention with trauma survivors.
Residual Effects from Occupational Mercury Exposure Include a Proposed Mercury Tremor Biomarker or “Fingerprint”  [PDF]
Linda Jones
Journal of Environmental Protection (JEP) , 2017, DOI: 10.4236/jep.2017.810068
Abstract: The study investigated residual effects of high levels of occupational mercury exposure, 30 years after a cohort of women worked in public service dentistry. They had all used copper amalgam in a pellet form that required heating and handling, and silver amalgam before the encapsulated form was available. Mercury handling practices changed in the mid-1970 when the workforce was urine tested and mercury poisoning became apparent. The aim was to compare control group and exposed group scores on tasks from a neurobehavioural test battery; plus survey results from a composite health, work history and environmental influences survey. The findings showed that the exposed and control groups were equivalent not only on those variables that one would want to be matched (age, alcohol consumption), but also on many of the cognitive and psychomotor test scores. The present paper focuses on psychomotor skill and tremor patterns. Tremor patterns were seen as generating new evidence of long term effects of the historic mercury insult. Data also suggest that there may be a distinctive mercury “fingerprint”, in samples of sinusoidal waveforms that may have potential as a non-invasive sub-clinical biomarker for adverse effects of mercury exposure, in screening or workplace monitoring.
Total Nitrogen and Available Phosphorus Dynamics in Soils Regenerating from Degraded Abandoned Rubber Plantation in Orogun Area of the Rainforest Zone of Southern Nigeria
VI Ichikogu
Ethiopian Journal of Environmental Studies and Management , 2012,
Abstract: Total nitrogen and available phosphorus concentration of soils in three secondary forest fields aged 1, 5 and 10 years of age regenerating from degraded abandoned rubber plantation (Hevea brasiliensis) and a mature forest in the west African Rainforest belt in southern Nigeria were investigated in order to determine the trend of change in the properties of soil in secondary forest during the course of forest restoration from degraded deserted rubber plantation (Hevea brasiliensis). There was a continuous increase in the concentration of total nitrogen in the soil (both topsoil and subsoil). The concentrations of total nitrogen and available phosphorus in the topsoil are higher than the subsoil. The concentration of available phosphorus during the first five years of secondary forest regeneration increased, after which their values declined by the tenth year in both the topsoil and the subsoil. Should this trend of decline in the concentration of phosphorus continue phosphorus may become a limiting factor to plant growth the older the secondary forests become.
The Dynamics of Soil Physical Properties and Exchangeable Cations in Secondary Forests Regenerating from Degraded Abandoned Rubber Plantation (Hevea brasiliensis) in Orogun Area of Southern Nigeria
VI Ichikogu
Ethiopian Journal of Environmental Studies and Management , 2011,
Abstract: The regeneration of soil physicochemical properties in three secondary forest fields aged 1, 5 and 10 years of age following the abandonment of degraded rubber (Hevea brasiliensis) plantation in Orogun were investigated. In addition a mature forest was selected and investigated as the control. Values of important indices of soil physicochemical parameters were ascertained for the three secondary forests categories and the mature forest. The results obtained revealed that there was no significant improvement or changes in soil particle size composition during the course of secondary forest regeneration. The concentrations of the exchangeable cations were higher in the mature forest than the different secondary forest categories. Soil bulk density decreased while water holding capacity and total porosity of soil increased with increasing age of secondary forest. Exchangeable cations improved in the first five year of secondary forest regeneration, after which their values declined by the tenth year in the topsoil (0-10cm layer). Similarly, exchangeable potassium and sodium improved significantly in the subsoil (10-30cm layer) by the fifth year of secondary forest regeneration from degraded abandoned rubber plantation, after which their values declined by the tenth year. However, exchangeable magnesium and calcium declined in the subsoil throughout the course of forest recovery. Effective cation exchange capacity in the topsoil and the subsoil increased linearly with increasing age of secondary forest, while soil pH decreased with increasing age of secondary forest. These results demonstrate that fallowing exerts beneficial effects on soil fertility (i.e. soil fertility improved as fallow age increased).
Organic Matter Dynamics in Soils Regenerating from Degraded Abandoned Rubber Plantation in Orogun Area of the Rainforest Zone of Southern Nigeria
VI Ichikogu
Ethiopian Journal of Environmental Studies and Management , 2011,
Abstract: The area of secondary forest (SF) regenerating from degraded abandoned rubber (Hevea brasiliensis) plantation is increasing in the rainforest zone of south southern Nigeria; however, the build-up of soil organic matter following abandonment is not well understood. This study examined the build-up of soil organic matter in a mature forest and three secondary forest fields aged 1, 5 and 10 years of age following the abandonment of degraded rubber (Hevea brasiliensis) plantation in Orogun in a part of the rainforest zone of south southern Nigeria. This is in order to ascertain the rate of build-up of organic matter in the soil during the course of forest regeneration from degraded abandoned rubber plantation (Hevea brasiliensis). There was a progressive increase in organic matter content of the soil with increasing age of the secondary forest. Organic matter increase was more rapid in the topsoil (0-10cm) than the subsoil (10-30cm): the level of organic matter in the topsoil reached 92.94% of the level of organic matter in the mature forest topsoil by the tenth year and 84.62% of the level of organic matter in the mature forest subsoil by the tenth year. The concentration of organic matter in the topsoil is higher than the subsoil. Reviews of the reported trends in soil organic matter build up during forest establishment after agricultural use show no common trend. This study showed a great variation in soil organic matter build up even within the same locality.
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