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Search Results: 1 - 10 of 45087 matches for " Lin;Lian-Shun "
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Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
Hsieh, Yao-Yuan;Chang, Chi-Chen;Tsai, Fuu-Jen;Peng, Ching-Tien;Yeh, Lian-Shun;Lin, Cheng-Chieh;
Genetics and Molecular Biology , 2004, DOI: 10.1590/S1415-47572004000200006
Abstract: insulin-like growth factor ii (igf2) has been shown to play a role in abnormal cell growth and carcinogenesis. we investigated if the igf2 gene apa i polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. the genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2%) and control (aa = 20.8 ab = 52.8, bb = 26.4%) groups. the allele frequencies did not differ either: a = 54.1, b = 45.9% among women with endometriosis and a = 47.2, b = 52.8% in the control group. therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility.
Cytochrome P450c17alpha (CYP17) gene polymorphism is not associated with leiomyoma susceptibility
Yao-Yuan, Hsieh;Fuu-Jen, Tsai;Chi-Chen, Chang;Chang-Hai, Tsai;Cheng-Chieh, Lin;Lian-Shun, Yeh;
Genetics and Molecular Biology , 2002, DOI: 10.1590/S1415-47572002000400002
Abstract: estrogen plays a role in the pathogenesis of leiomyoma. the cyp17 gene codes for the cytochrome p450c17a enzyme, which is involved in the biosynthesis of estrogen. our aim was to investigate if cyp17 polymorphism could be a useful marker to predict the susceptibility to leiomyoma. our sample of female subjects was divided into two groups: (1) with leiomyoma (n = 159); (2) without leiomyoma (n = 128). a 169-bp fragment encompassing the a1/a2 polymorphic site of the cyp17 gene was amplified by polymerase chain reaction (pcr), restricted by enzyme mspa1i and electrophored on agarose gel. genotypes and allelic frequencies for this polymorphism in both groups were compared. there was no significant difference between the two groups regarding the distribution of the cyp17 gene polymorphism frequencies. the a1 homozygote/heterozygote/a2 homozygote proportions for cyp17 in both groups were: (1) 17.0/46.5/36.5%, and (2) 17.2/45.3/37.5%. the proportions for alleles a1 and a2 were also comparable in the two groups. a1 and a2 allele frequencies were: 7% (40.3/59) in group 1, and 2% (39.8/60) in group 2. no significant association was observed between the risk of leiomyoma and polymorphisms of the cyp 17 gene. so, cyp17 gene polymorphism does not appear to be a useful marker for the prediction of leiomyoma susceptibility.
Measurements of Absorption and Anisotropy Coefficients of the Fat Emulsion Intralipid-10%
ZHANG Lian-Shun,ZHANG Lin,ZHANG Chun-Ping,QI Sheng-Wen,XU Tang,TIAN Jian-Guo,

中国物理快报 , 2004,
Abstract: We report measurements of absorption and anisotropy coefficients of the fat emulsion Intralipid-10%. An addingabsorber method is used for measurement of absorption and anisotropy coefficients of the Intralipid-10%. Using the diffusion theory which has been extended to include anisotropy scat geometry, we found that the standard deviations of multiple measurements for√μα/D are less than 0.6% and the residuals between the measured data and the fits have rms values of 0.1%, where μα is the absorbing coefficient of the solution in our experiment and D is the diffusion coefficient of the medium. The values of the standard deviations and the residuals demonstrate the high precision of the measurements.
Diffuse Backscattering Mueller Matrices Patterns from Turbid Media

ZHANG Lian-Shun,ZHU Chen,WANG Zhi-Ping,ZHANG Jing,

中国物理快报 , 2006,
Clinical features and surgical treatment of cauda equina schwannoma
Jun-jun HUANG,Lian-shun JIA,Xiong-sheng CHEN
Medical Journal of Chinese People's Liberation Army , 2011,
Abstract: Objective To investigate the clinical features and surgical treatment method of cauda equina schwannoma.Methods Clinical symptoms,imaging characteristics and functional outcomes after surgical treatment of 32 patients with cauda equina schwannoma from June 2007 to March 2009 were retrospectively reviewed.Results Most patients(30 cases) suffered lower extremity numbness/pain before operations and 18 of them suffered in both lower extremities.Physical examination showed bilateral nerve damage or unilateral multiple nerve damage in 25 cases.The initial symptom of 12 cases was simple lumbago.Ten cases were misdiagnosed as lumbar disc herniation.Six patients were scanned by computed tomography but none of them was diagnosed correctly.All the patients were definitely diagnosed by magnetic resonance imaging(MRI),the typical appearance of the schwannoma was a round or ovoid mass with isointense or slightly hyperintense on T1-weighted images,while on T2-weighted images with heterogeneous hyperintense in 25 cases,slightly hyperintense in 2,and homogeneous hyperintense in 5.Gadolinium-enhanced MRI was performed in 13 patients,of whom 10 cases showed heterogeneous or annular enhancing.In all patients,the tumor was resected completely,the functional outcomes were satisfactory except one with a giant tumor,in whom the neurological symptom was aggravated,and no recurrence was found during a short-term follow-up.Conclusions The characteristic features of cauda equina schwannoma were lower extremities numbness/pain and bi-or unilateral polyradiculopathy in physical examination.MRI is helpful for early diagnosis and recommended as the first choice.Functional outcomes are satisfactory in patients with tumor completely resected.
PDGF Suppresses Oxidative Stress Induced Ca2+ Overload and Calpain Activation in Neurons
Lian-Shun Zheng,Yoko Ishii,Qing-Li Zhao,Takashi Kondo,Masakiyo Sasahara
Oxidative Medicine and Cellular Longevity , 2013, DOI: 10.1155/2013/367206
Abstract: Oxidative stress is crucially involved in the pathogenesis of neurological diseases such as stroke and degenerative diseases. We previously demonstrated that platelet-derived growth factors (PDGFs) protected neurons from H2O2-induced oxidative stress and indicated the involvement of PI3K-Akt and MAP kinases as an underlying mechanism. Ca2+ overload has been shown to mediate the neurotoxic effects of oxidative stress and excitotoxicity. We examined the effects of PDGFs on H2O2-induced Ca2+ overload in primary cultured neurons to further clarify their neuroprotective mechanism. H2O2-induced Ca2+ overload in neurons in a dose-dependent manner, while pretreating neurons with PDGF-BB for 24 hours largely suppressed it. In a comparative study, the suppressive effects of PDGF-BB were more potent than those of PDGF-AA. We then evaluated calpain activation, which was induced by Ca2+ overload and mediated both apoptotic and nonapoptotic cell death. H2O2-induced calpain activation in neurons in a dose-dependent manner. Pretreatment of PDGF-BB completely blocked H2O2-induced calpain activation. To the best of our knowledge, the present study is the first to demonstrate the mechanism underlying the neuroprotective effects of PDGF against oxidative stress via the suppression of Ca2+ overload and inactivation of calpain and suggests that PDGF-BB may be a potential therapeutic target of neurological diseases. 1. Introduction Oxidative stress and excitotoxicity play important roles in the pathogenesis of a number of neurological diseases, including ischemic infarction, multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s, Huntington’s, and Parkinson’s diseases [1–3]. Ca2+ has been shown to mediate the cytotoxicity of oxidative stress and excitotoxicity, and cellular Ca2+ overload or the perturbation of intracellular Ca2+ compartmentalization induced by these noxious stimuli can cause cytotoxicity and trigger cell death including both apoptotic and necrotic cell death [4–6]; however, these mechanisms of cellular injury have yet to be elucidated in adequate detail to prevent and treat neurological diseases [7, 8]. Calpains are calcium-regulated cysteine proteases that have been implicated in the regulation of cell death pathways including apoptosis and necrosis [9, 10]. An elevated intracellular calcium concentration will hyperactivate calpains. The activation of calpains was shown to be involved in various pathological conditions, including ischemic brain injuries and chronic neurodegenerative diseases, for example, Alzheimer’s disease [9, 11]. Previous
A Universal Pedicle Screw and V-Rod System for Lumbar Isthmic Spondylolysis: A Retrospective Analysis of 21 Cases
Xiong-sheng Chen, Sheng-yuan Zhou, Lian-shun Jia, Xiao-min Gu, Lei Fang, Wei Zhu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063713
Abstract: Objective To investigate the surgical outcome of a universal pedicle screw-V rod system and isthmic bone grafting for isthmic spondylolysis. Methods Twenty-four patients with isthmic spondylolysis at L5 and grade 0–I spondylolisthesis (Meyerding classification) received isthmic bone graft and stabilization using the universal pedicle screw-V rod system. Back pain was evaluated using the visual analog scale (VAS) and time to bone healing, improvement in spondylolisthesis and intervertebral space height at L5/S1 and L4/L5 were assessed. Results Twenty-one patients were followed up for 24 months and included in the analysis. Back pain was markedly improved at 3 months postoperatively with a statistical difference in VAS scores compared with preoperative VAS scores (P<0.001). The VAS scores were 0 to 3 at 6 months postoperatively in all patients and no back pain was reported in all patients except 2 patients who complained of back pain after prolonged sitting. X-ray examination showed a bone graft healing time of 3 to 12 months. Grade I spondylolisthesis improved to grade 0 in 4 patients and no noticeable change was observed in the remaining 17 cases. The intervertebral space height at L5/S1 was statistically increased (P<0.05) while no statistically significant change was seen at L4/L5. There was no statistically significant difference in the ROM of the intervertebral disks of L5/S1 and L4/5 before and after surgery. Conclusions The universal pedicle screw-V rod system and isthmic bone grafting directly repairs isthmic spondylolysis and reduces back pain, prevents anterior displacement of the diseased segment and maintains intervertebral space height, thus offering a promising alternative to current approaches for isthmic spondylolysis.
用Monte Carlo方法重建OCT图像

WANG Xin-Yu,ZHANG Chun-Ping,ZHANG Lian-Shun,QI Sheng-Wen,XU Tang,TIAN Jian-Guo,

红外与毫米波学报 , 2003,
Abstract: A method for improving the quality of the picture based on Monte Carlo simulation of imaging was presented. The point-spread-function needed by the simulation was achieved by Monte Carlo simulation of light propagation in bio-tissue. A raw picture by OCT of porcine tissue was reconstructed. The reconstructed picture has a better transversal resolution.
Variance Analysis of Growth Traits of 51 Pinus koraiensis Seedling Families

赵光浩, 冷伟伟, 张腾, 许莲顺, 金星, 冯亮, 李宏斌, 赵曦阳
ZHAO Guang-Hao
, LENG Wei-Wei, ZHANG Teng, XU Lian-Shun, JIN Xing, FENG Liang, LI Hong-Bin, ZHAO Xi-Yang

植物研究 , 2018, DOI: 10.7525/j.issn.1673-5102.2018.04.014
Abstract: 为选育生长快、成活率高的优良红松子代家系,以吉林省龙井市开山屯林场的51个红松初级种子园子代家系为材料,对其苗高、地径、成活率及存活率进行测定分析。结果表明:除4年生地径的区组与家系交互作用外,各性状在家系间均达显著差异水平(P<0.05);各性状表型变异系数变化范围为6.85%~29.89%;各性状的遗传力较高,除4年生地径(0.34)和存活率(0.37)外,遗传力均超过0.50,属于高遗传力;高变异系数,高遗传力,有利于家系的评价选择;相关性分析结果表明,各性状间相关关系均达极显著正相关水平。利用布雷津多性状综合评价法对51个红松子代家系进行评价,以10%的入选率,PK29、PK38、PK21、PK37和PK48五个家系入选。入选家系4年生苗高和地径平均值分别为29.26和0.93 cm,分别比总平均值高3.51和0.06 cm,遗传增益分别为10.08%和2.33%。本研究可以为红松优良家系评价提供理论基础和材料。
SiC based Si/SiC heterojunction and its rectifying characteristics

Zhu Feng,Chen Zhi-Ming,Li Lian-Bi,Zhao Shun-Feng,Lin Tao,

中国物理 B , 2009,
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