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Search Results: 1 - 10 of 14849 matches for " Liming Shen "
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Three-Dimensional Computerized Tomography-Assisted Identification of Necrotic Volume, Distribution, Shape and Prognosis of Collapse in ONFH  [PDF]
Jianying Shen, Hongyu Wei, Qingsheng Yu, Liming Cheng
Advances in Computed Tomography (ACT) , 2016, DOI: 10.4236/act.2016.51001
Abstract: Objective: We constructed 3D-model of ONFH in computer according to three-dimensional computerized tomography (3D-CT) data. We determined the location and volume of necrosis to investigate its clinical efficacy. Method: Totally 92 hips (59 cases) with ONFH (44 males, 15 females) were included, with mean age of 37.5 years (range from 26 to 58). Totally 20 cases (35 hips) were induced by corticosteroid (CTSs), 31 (49 hips) induced by alcohol, 4 (4 hips) induced by trauma and 4 (4 hips) idiopathic. All the hips were categorized into stage ARCO II. Finally diagnosed by MRI, all hips were scanned by CT to acquire data in DICOM format. The images were imported into software to extract 3D-shape of femoral heads, necrotic foci, their volumes and distribution in each quadrant. Deviation of volumes between digital image and biopsy specimen was analyzed by SAS9.1 package. Correlativity between collapse and volume of necrosis under specific pathogeneses was also analyzed. Among the cases necessitating total hip arthroplasty (THA) due to advancing to ARCO III, we randomly selected 8 of them to perform 3D-CT scanning thrice prior to surgical operation. Total femoral heads harvested were torn asunder. Cubic capacity of femoral heads and necrotic foci were hereby measured and compared with those acquired from digital models. Result: Through the digital model, necrotic foci were found mainly locating within the super lateral portion of femoral head, coinciding with those observed in biopsy specimen. Average volumetric ratio of digitally acquired necrosis focus/femoral head in 58 collapsed hips was 36.8%. The ratio of the 34 hips without collapse was 17.3%. In collapsed femoral heads, the distribution of necrosis focus was 23.4% in quadrant 1 (q1), 23.6% in q2, 12.1% in q3, 14.4% in q4, 9.0% in q5, 11.8% in q6, 1.6% in q7 and 3.9% in q8. In femoral heads without collapse, the distribution was 34.2% in q1, 29.6% in q2, 11.8% in q3, 11.3% in q4, 6.0% in q5, 6.0% in q6, 0.5% in q7 and 0.4% in q8. As for the average cubic capacities of femoral heads and necrotic foci, those acquired from the digital model and biopsy specimen had no significant difference in matched-pairs test (t = -1.49, P = 0.179 for femoral heads and t = -1.52, P = 0.172 for necrotic foci). There was significant difference (F = 2.720, P = 0.035 < 0.05) among volumetric ratios of necrotic focus/total femoral head under different pathogeneses, which were 33.55% in alcohol-induced cases, 26.74% in the CTSs-induced, 40.41% in the trauma-induced, and 18.39% in
Biomedical Applications of Graphene
He Shen, Liming Zhang, Min Liu, Zhijun Zhang
Theranostics , 2012,
Abstract: Graphene exhibits unique 2-D structure and exceptional phyiscal and chemical properties that lead to many potential applications. Among various applications, biomedical applications of graphene have attracted ever-increasing interests over the last three years. In this review, we present an overview of current advances in applications of graphene in biomedicine with focus on drug delivery, cancer therapy and biological imaging, together with a brief discussion on the challenges and perspectives for future research in this field.
Transportation inequalities: From Poisson to Gibbs measures
Yutao Ma,Shi Shen,Xinyu Wang,Liming Wu
Statistics , 2011, DOI: 10.3150/00-BEJ268
Abstract: We establish an optimal transportation inequality for the Poisson measure on the configuration space. Furthermore, under the Dobrushin uniqueness condition, we obtain a sharp transportation inequality for the Gibbs measure on $\mathbb{N}^{\Lambda}$ or the continuum Gibbs measure on the configuration space.
The Relationship Between Fat Content and Biological Parameters of Bigeye Tuna(Thunnus obseus) in the Western Central Indian Ocean The Relationship Between Fat Content and Biological Parameters of Bigeye Tuna(Thunnus obseus) in the Western Central Indian Ocean
SONG Liming,SHEN Zhibin,LI Jie,LI Dongjing,LI Yuwei
- , 2016,
Abstract: Comparing fat content with physiological status can throw light on the reproduction and feeding behavior of the fish. The biological data of 586 bigeye tuna were collected from the longline fishery in the waters of Western Central Indian Ocean from November, 2012 to March, 2013. The spatial or temporal distribution of the fat content, and the relationships of fat content with gender, round weight, gonadal maturity and fork length were analyzed. A generalized additive model(GAM) was used to analyze the relationships between fat content and fork length(FL), gonadosomatic index(GSI), condition factor(K), and somatic index(SI). Results showed that: 1) the fat content of bigeye tuna was in the range of 3.1%–27.1% with the average 12.8%; 2) there were no significant geographical differences of average fat content(P > 0.05) among 1? squares in general; 3) there were no significant differences(P > 0.05) of the fat content for different genders, months, or gonad maturity stages; 4) there was an extremely significant correlation(P = 0.000) between fat content and FL and GSI. There was no significant correlation(P = 0.051) between fat content and K. There was a significant correlation(P = 0.003) between fat content and SI. The results of this study suggest that the fat content of the matured fish was relatively stable. The survey area was in a spawning region, and the survey period was the spawning season for bigeye tuna
EGFR and HER2 expression in primary cervical cancers and corresponding lymph node metastases: Implications for targeted radiotherapy
Li Shen, Yongjie Shui, Xiaojia Wang, Liming Sheng, Zhengyan Yang, Danfeng Xue, Qichun Wei
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-232
Abstract: Expression of EGFR and HER2 was investigated immunohistochemically in both lymph node metastases and corresponding primary cervical cancers (n = 53). HER2 and EGFR expression was scored using HercepTest criteria (0, 1+, 2+ or 3+).EGFR overexpression (2+ or 3+) was found in 64% (35/53) of the primary cervical tumors and 60% (32/53) of the corresponding lymph node metastases. There was a good concordance between the primary tumors and the paired metastases regarding EGFR expression. Only four patients who had 2+ or 3+ in the primary tumors changed to 0 or 1+ in lymph node metastases, and another two cases changed the other way around. None of the primary tumors or the lymph node metastases expressed HER2 protein.The EGFR expression seems to be common and stable during cervical cancer metastasis, which is encouraging for testing of EGFR targeted radiotherapy. HER2 appears to be of poor interest as a potential target in the treatment of cervical cancer.Cervical cancer represents the second most frequent malignancy in women worldwide, particularly in developing countries [1]. While curable in early stages, the prognosis for advanced stage disease is poor [2]. Radiation has been the gold standard of therapy for many decades. Nowadays, concurrent cisplatin-based chemoradiotherapy has been considered as the standard therapeutic modality for locally advanced cervical cancer [3-6]. However, such treatment remains suboptimal with histopathological residual tumor observed in 40–50% of patients [7,8]. Those presenting with recurrent or metastatic disease have limited treatment options [2,9], and the 5-year survival is less than 5% [10]. There is a clear need for novel, more effective therapeutical strategies to improve overall survival and the quality of life for advanced, recurrent and disseminated cervical cancer. Thus, the testing of molecular targeted therapies against cervical cancer is a logical step to follow [11]. Another strategy is receptor-mediated tumor targeted radi
The NDT for Defects around the Holes Punched by Laser Beam
激光打孔工艺缺陷的检测

Guan E,He Shiping,Shen Liming,
关锷
,董本涵

实验力学 , 1997,
Abstract: 本文应用扫描电子显微镜与扫描声学显微镜分别对45#钢板和某特种材料板激光打孔孔周材料进行了缺陷检测。在孔周200μm的范围内发现材料发生了明显的相变,并存在大量的微裂纹。文中给出了裂纹的长度和深度信息
SYNERGISTIC EFFECT OF ELECTRIC FIELD AND BACTERICIDE AGAINST SULFATE-REDUCING BACTERIA BIOFILMS
电场和杀菌剂对杀灭生物膜下硫酸盐还原菌的协同作用

LIU Jing,ZHENG Jiashen,XU Liming,
刘靖
,郑家shen,许立铭

腐蚀科学与防护技术 , 2002,
Abstract: This work concerns that the effect of square wave current and also the synergistic effect of bactericide and current on the formation and the growth of sulfate-reducing bacteria (SRB) biofilms respectively.The tests indicate there were no significant differences in the course of forming biofilms,but in the same case,the number of SRB per square centimeter was significantly lower with electrical current than without current.When applied within the same electric field with the same current density,two bactericides exhibited enhanced killing action against SRB biofilms growth on mild steel coupons.The same bactericide concentrations used with electrical current resulted in numbers of SRB cells per square centimeter were significantly lower than those due to bactericide treatment alone without curred.And this paper discussed the mechanism of the synergistic effect of bactericide and electrical current in SRB biofilms in terms of mass transfer of bactericide and desorption of calcium ion and magnesium ion from SRB biofilms.
Assessment of Dental Age of Children Aged 3.5 to 16.9 Years Using Demirjian’s Method: A Meta-Analysis Based on 26 Studies
Jin Yan, Xintian Lou, Liming Xie, Dedong Yu, Guofang Shen, Yilin Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084672
Abstract: Background A method for assessing dental maturity in different populations was first developed in 1973 by Demirjian and has been widely used and accepted since then. While the accuracy for evaluating dental age using Demirjian’s method compared to children’s chronological age has been extensively studied in recent years, the results currently available remain controversial and ambiguous. Methods A literature search of PubMed, Embase, Web of Science, CNKI and CBM databases was conducted to identify all eligible studies published before July 12th, 2013. Weighted mean difference (WMD) with corresponding 95% confidence interval (95% CI) was used to evaluate the applicability of Demirjian’s method for estimating chronological age in children. Results: A meta-analysis was conducted on 26 studies with a total of 11,499 children (5,301 boys and 6,198 girls) aged 3.5 to 16.9 years. Overall, we found that Demirjian’s method overestimated dental age by 0.35 (4.2 months) and 0.39 (4.68 months) years in males and females, respectively. A subgroup analysis by age revealed that boys and girls between the ages of 5 to 14 were given a dental age estimate that was significantly more advanced than their chronological age. Differences between underestimated dental ages and actual chronological ages were lower for male and female 15- and 16-year-old subgroups, though a significant difference was found in the 16-year-old subgroup. Conclusions Demirjian’s method’s overestimation of actual chronological tooth age reveals the need for population-specific standards to better estimate the rate of human dental maturation.
Epitaxial Growth of Spinel Cobalt Ferrite Films on MgAl$_2$O$_4$ Substrates by Direct Liquid Injection Chemical Vapor Deposition
Liming Shen,Matthias Althammer,Neha Pachauri,B. Loukya,Ranjan Datta,Milko Iliev,Ningzhong Bao,Arunava Gupta
Physics , 2013, DOI: 10.1016/j.jcrysgro.2013.12.012
Abstract: The direct liquid injection chemical vapor deposition (DLI-CVD) technique has been used for the growth of cobalt ferrite (CFO) films on (100)-oriented MgAl$_2$O$_4$ (MAO) substrates. Smooth and highly epitaxial cobalt ferrite thin films, with the epitaxial relationship $\mathrm{MAO} (100)\:[001] \parallel \mathrm{CFO} (100)\:[001]$, are obtained under optimized deposition conditions. The films exhibit bulk-like structural and magnetic properties with an out-of-plane lattice constant of $8.370\;\mathrm{\AA}$ and a saturation magnetization of $420\;\mathrm{kA/m}$ at room temperature. The Raman spectra of films on MgAl$_2$O$_4$ support the fact that the Fe$^{3+}$- and the Co$^{2+}$-ions are distributed in an ordered fashion on the B-site of the inverse spinel structure. The DLI-CVD technique has been extended for the growth of smooth and highly oriented cobalt ferrite thin films on a variety of other substrates, including MgO, and piezoelectric lead magnesium niobate-lead titanate and lead zinc niobate-lead titanate substrates.
PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation
Yan Yang?,Wencheng Li?,Mainul Hoque?,Liming Hou?,Steven Shen,Bin Tian?,Brian D. Dynlacht
PLOS Genetics , 2016, DOI: 10.1371/journal.pgen.1005794
Abstract: The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and RNA polymerase II (PolII) elongation. Here, we provide the first genome-wide profiles for the distribution of the entire complex in mammalian cells using chromatin immunoprecipitation and high throughput sequencing. We show that Paf1C is recruited not only to promoters and gene bodies, but also to regions downstream of cleavage/polyadenylation (pA) sites at 3’ ends, a profile that sharply contrasted with the yeast complex. Remarkably, we identified novel, subunit-specific links between Paf1C and regulation of alternative cleavage and polyadenylation (APA) and upstream antisense transcription using RNAi coupled with deep sequencing of the 3’ ends of transcripts. Moreover, we found that depletion of Paf1C subunits resulted in the accumulation of PolII over gene bodies, which coincided with APA. Depletion of specific Paf1C subunits led to global loss of histone H2B ubiquitylation, although there was little impact of Paf1C depletion on other histone modifications, including tri-methylation of histone H3 on lysines 4 and 36 (H3K4me3 and H3K36me3), previously associated with this complex. Our results provide surprising differences with yeast, while unifying observations that link Paf1C with PolII elongation and RNA processing, and indicate that Paf1C subunits could play roles in controlling transcript length through suppression of PolII accumulation at transcription start site (TSS)-proximal pA sites and regulating pA site choice in 3’UTRs.
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