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Search Results: 1 - 10 of 16170 matches for " Lima JL "
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Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability
Neves AR, Lúcio M, Martins S, Lima JL, Reis S
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S37840
Abstract: vel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability Original Research (1489) Total Article Views Authors: Neves AR, Lúcio M, Martins S, Lima JL, Reis S Video abstract presented by Ana Rute Neves Views: 121 Published Date January 2013 Volume 2013:8 Pages 177 - 187 DOI: http://dx.doi.org/10.2147/IJN.S37840 Received: 07 September 2012 Accepted: 06 November 2012 Published: 07 January 2013 Ana Rute Neves,1 Marlene Lúcio,1 Susana Martins,2,3 José Luís Costa Lima,1 Salette Reis1 1REQUIMTE, Chemistry Department, Faculty of Pharmacy, University of Porto, 2Laboratory for Pharmaceutical Technology/Research Centre in Pharmaceutical Sciences, Faculty of Pharmacy, University of Porto, 3Institute of Biomedical Engineering, University of Porto, Portugal Introduction: Resveratrol is a polyphenol found in grapes and red wines. Interest in this polyphenol has increased due to its pharmacological cardio- and neuroprotective, chemopreventive, and antiaging effects, among others. Nevertheless, its pharmacokinetic properties are less favorable, since the compound has poor bioavailability, low water solubility, and is chemically unstable. To overcome these problems, we developed two novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance resveratrol's oral bioavailability for further use in medicines, supplements, and nutraceuticals. Methods and materials: Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) loaded with resveratrol were successfully produced by a modified hot homogenization technique. These were completely characterized to evaluate the quality of the developed resveratrol-loaded nanoparticles. Results: Cryo-scanning electron microscopy morphology studies showed spherical and uniform nanoparticles with a smooth surface. An average resveratrol entrapment efficiency of ~70% was obtained for both SLNs and NLCs. Dynamic light scattering measurements gave a Z-average of 150–250 nm, polydispersity index of ~0.2, and a highly negative zeta potential of around 30 mV with no statistically significant differences in the presence of resveratrol. These characteristics remained unchanged for at least 2 months, suggesting good stability. Differential scanning calorimetry studies confirmed the solid state of the SLNs and NLCs at both room and body temperatures. The NLCs had a less ordered crystalline structure conferred by the inclusion of the liquid lipid, since they had lower values for phase transition temperature, melting enthalpy, and the recrystallization index. The presence of resveratrol induced a disorder in the crystal structure of the nanoparticles, suggesting a favoring of its entrapment. The in vitro release studies on conditions of storage showed a negligible resveratrol release over several hours for both nanosystems and the in vitro simulation of gastrointestinal transit showed that the resveratrol remained mostly associated with the lipid nanoparticles after
Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability
Neves AR,Lúcio M,Martins S,Lima JL
International Journal of Nanomedicine , 2013,
Abstract: Ana Rute Neves,1 Marlene Lúcio,1 Susana Martins,2,3 José Luís Costa Lima,1 Salette Reis11REQUIMTE, Chemistry Department, Faculty of Pharmacy, University of Porto, 2Laboratory for Pharmaceutical Technology/Research Centre in Pharmaceutical Sciences, Faculty of Pharmacy, University of Porto, 3Institute of Biomedical Engineering, University of Porto, PortugalIntroduction: Resveratrol is a polyphenol found in grapes and red wines. Interest in this polyphenol has increased due to its pharmacological cardio- and neuroprotective, chemopreventive, and antiaging effects, among others. Nevertheless, its pharmacokinetic properties are less favorable, since the compound has poor bioavailability, low water solubility, and is chemically unstable. To overcome these problems, we developed two novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance resveratrol's oral bioavailability for further use in medicines, supplements, and nutraceuticals.Methods and materials: Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) loaded with resveratrol were successfully produced by a modified hot homogenization technique. These were completely characterized to evaluate the quality of the developed resveratrol-loaded nanoparticles.Results: Cryo-scanning electron microscopy morphology studies showed spherical and uniform nanoparticles with a smooth surface. An average resveratrol entrapment efficiency of ~70% was obtained for both SLNs and NLCs. Dynamic light scattering measurements gave a Z-average of 150–250 nm, polydispersity index of ~0.2, and a highly negative zeta potential of around 30 mV with no statistically significant differences in the presence of resveratrol. These characteristics remained unchanged for at least 2 months, suggesting good stability. Differential scanning calorimetry studies confirmed the solid state of the SLNs and NLCs at both room and body temperatures. The NLCs had a less ordered crystalline structure conferred by the inclusion of the liquid lipid, since they had lower values for phase transition temperature, melting enthalpy, and the recrystallization index. The presence of resveratrol induced a disorder in the crystal structure of the nanoparticles, suggesting a favoring of its entrapment. The in vitro release studies on conditions of storage showed a negligible resveratrol release over several hours for both nanosystems and the in vitro simulation of gastrointestinal transit showed that the resveratrol remained mostly associated with the lipid nanoparticles after their incubation in digestive fluids.Conc
Some considerations on selection criteria and optimization for terminal sire breeds
JL Foulley
Genetics Selection Evolution , 1976, DOI: 10.1186/1297-9686-8-1-89
Abstract:
ECM approaches to heteroskedastic mixed models with constant variance ratios
JL Foulley
Genetics Selection Evolution , 1997, DOI: 10.1186/1297-9686-29-3-297
Abstract:
Prediction of selection response for Poisson distributed traits
JL Foulley
Genetics Selection Evolution , 1993, DOI: 10.1186/1297-9686-25-3-297
Abstract:
La ense?anza de la Medicina Legal en Sevilla (1824-2006): nómina de catedráticos
Carrillo,JL.;
Cuadernos de Medicina Forense , 2005, DOI: 10.4321/S1135-76062005000400003
Abstract: the present article is a new contribution to the knowledge of the genealogy of professors who have taught forensic medicine in the various schools existing in seville from 1824 up until today.
MB ChB curriculum modernisation in South Africa – growing doctors for Africa
JL Seggie
African Journal of Health Professions Education , 2010,
Abstract:
Madagascar rosewood, illegal logging and the tropical timber trade
JL Innes
Madagascar Conservation & Development , 2010,
Abstract: Although deforestation rates in the tropics are reportedly slowing, the loss of both forest area and forest quality remains a significant issue for many countries. This is particularly true of Madagascar, where recent government instability has enabled a significant increase in the incidence of illegal logging of Dalbergia species from National Parks such as Marojejy and Masoala. The logs are exported with relative ease as export permits are being made available. While attempts have been made to improve the management of tropical forests, in 2005, the International Tropical Timber Organization considered that only 7 % of tropical production forests were being managed sustainably. Given the challenges associated with halting illegal logging at source, emphasis has shifted to the control of the trade in forest products. The Convention on the International Trade in Endangered Species provides a mechanism to restrict such trade, but the Madagascan Dalbergia species are not listed. In the USA, the recent amendments to the ‘Lacey Act’ could provide a significant disincentive to the import of illegally logged wood products, but it remains to be seen whether this Act can be enforced effectively.
Review: "Jacobus" (Willem Krog)
JL Coetser
Tydskrif vir letterkunde , 2012,
Abstract: Jacobus. Willem Krog. Pretoria: Protea Boekhuis, 2011. 164 pp. ISBN: 978-1-86919-440-6.
Die mishandelde vrou in die strafreg: 'n regsvergelykende ondersoek
JL Matthee
Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad , 2009,
Abstract: Male killing is about power and control. Women killing abusers is about avoiding power and control … Women do not often kill from anger, while anger is what fuels many male killings. Oliver Quick en Celia Wells Gesinsgeweld bestaan sedert die man en vrou begin het om saam te leef. Gesinsgeweld is diep gewortel in die Suid-Afrikaanse gemeenskap en het traumatiese newe-effekte op die slagoffers daarvan. Gesinsgeweld is geslag-spesifiek deurdat dit meestal geweld deur mans teenoor vroue behels. Daar word beraam dat 18% tot 25% van Suid-Afrikaanse vroue aan mishandeling binne 'n intieme verhouding onderwerp word. Vir vroue is die risiko om deur 'n lewensmaat gedood te word ook veel ho r as vir mans.
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