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Search Results: 1 - 10 of 603702 matches for " Liliana A. Lucci De Angelo;Derchain "
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Rela??o entre tumores ovarianos epiteliais borderline e francamente invasores: epidemiologia, histologia e prognóstico
Derchain, Sophie F. Mauricette;Torres, José Carlos Campos;Teixeira, Luiz Carlos;Andrade, Liliana A. Lucci de Angelo;Masuko, Frederico Ken Miyahara;Santos, Marcos Ant?nio;
Revista Brasileira de Ginecologia e Obstetrícia , 1999, DOI: 10.1590/S0100-72031999000500005
Abstract: purpose: to determine some epidemiological, diagnostic and prognostic aspects in women with borderline and invasive epithelial ovarian tumors. methods: the charts of 198 women treated at caism/unicamp from 1986 to 1996 were revised. for statistical assessment, c2, fisher's exact and t student's tests were used when appropriate, followed by survival curves by the kaplan-meyer method, compared by the log-rank test. the mean follow-up was 50 months (11 to 168). results: the overall rate of borderline tumors was 12% (24 cases), and for invasive carcinoma, 88% (174 cases). the mean age of the patients with borderline tumors was significantly lower than that of those with invasive carcinoma (43 ± 14.8 years vs. 52 ± 12.6 years, p<0.002). the most frequent histologic types were the serous (81 cases: 41%) and the mucinous (46 cases: 23%) tumor. the women with borderline tumors had their diseases diagnosed in earlier stages when compared with the invasive carcinoma patients (p<0.0001). the frozen biopsy, performed on 77 patients, showed a high agreement with the paraffin fixed tissue in the invasive carcinoma cases. however, in borderline tumors, the rate of failure was higher (13%) and the major rate of failure was in mucinous tumors. regarding prognosis, the survival rate was significantly higher in borderline tumors (p<0.001). conclusions: women with epithelial ovarian tumors were younger, presented the disease at earlier stages, and had a better prognosis when compared with those with invasive carcinoma.
Carcinoma de ovário seroso e n?o seroso: tipo histológico em rela??o ao grau de diferencia??o e prognóstico
Ferreira, Patrícia Andréia Rodrigues;Sallum, Luis Felipe Trincas Assad;Sarian, Luis Otávio;Andrade, Liliana A. Lucci De Angelo;Derchain, Sophie;
Revista Brasileira de Ginecologia e Obstetrícia , 2012, DOI: 10.1590/S0100-72032012000500002
Abstract: purpose: to compare the clinical-pathological features of women with serous and non-serous ovarian tumors and to identify the factors associated with survival. methods: in this reconstructed cohort study, 152 women with ovarian carcinoma, who attended medical consultations between 1993 and 2008 and who were followed-up until 2010 were included. the histological type was clearly established for all women: 81 serous carcinomas and 71 non-serous tumors (17 endometrioid, 44 mucinous and 10 clear cell carcinomas). the crude and adjusted odds ratios (or), with the respective 95% confidence intervals (95%ci), were calculated for the clinical and pathological features, comparing serous and non-serous histological types. the hazard ratios (hr) with 95%ci was calculated for overall survival, considering the clinical and pathological features. results: comparison of serous to non-serous tumor types by univariate analysis revealed that serous tumors were more frequently found in postmenopausal women, and were predominantly high histological grade (g2 and g3), advanced stage, with ca125>250 u/ml, and with positive peritoneal cytology. after multivariate regression, the only association remaining was that of high histological grade with serous tumors (adjusted or 15.1; 95%ci 2.9-77.9). we observed 58 deaths from the disease. there was no difference in overall survival between women with serous carcinoma and women with non-serous carcinoma (hr 0.4; 95%ci 0.1 - 1.1). it was observed that women aged 50 years or less (hr 0.4; 95%ci 0.1-0.9) and those who were in menacne (hr 0.3; 95%ci 0.1-0.9) had a longer survival compared respectively to those above 50 years of age and menopaused. high histological grade (g2 and g3) (p<0.01), stages ii-iv (p<0.008) and positive cytology (p<0.001) were significantly associated with worse prognosis. ca125 and the presence of ascites did not correlate with survival. survival was poor when the disease was diagnosed in stages ii to iv and compared to st
Clinicopathological aspects and their relation to prognosis in adult-type granulosa cell tumor of the ovary
Andrade, Maurício De Angelo;Pupo, Joyce de Brito;Derchain, Sophie;Andrade, Liliana Aparecida Lucci De Angelo;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2009, DOI: 10.1590/S1676-24442009000500009
Abstract: introduction and objective: the adult granulosa cell tumors (agct) correspond to less than 5% of ovarian neoplasias. they are considered low malignant potential tumors and may recur after many years. the differential diagnosis must be made with other primary or metastatic ovarian neoplasias. the aim was to analyze clinical and pathological aspects of agct and relate them to its evolution. method: in a 10- year (1995-2004) review of the files from university of campinas clinical hospital, brazil, 20 agct cases were found. the clinical records and slides were reviewed and age, symptoms, macro and microscopic aspects, diagnostic staging and recurrence were considered. when there was intraoperative biopsy, its accuracy was evaluated. results: age ranged from 27 to 79 years (mean: 53) and the follow-up from 12 to 96 months (mean: 42). the main symptoms were post-menopause bleeding (45%), abdominal pain (35%) and palpable mass (25%). most tumors were yellowish (60%) and the solid aspect (40%) was more common than the cystic or solid-cystic. the histological patterns were 40% solid, 15% macrofollicular and 45% combined forms. all of them with low mitotic index. only three out of nine intraoperative frozen sections were accurately diagnosed. the clinical staging was 13 cases in ia (65%), one case ic and 6 iiic. in three out of 14 hysterectomies there was simple endometrial hyperplasia with no atypia. only the disease staging was significantly associated with recurrence (p < 0.0001). conclusion: acgt generally occurs after menopause and intraoperative biopsies are commonly inconclusive. only advanced staging was related to the worst prognosis.
Microglandular hyperplasia of the cervix: frequency in cone specimens, histological patterns, clinical aspects and immunohistochemical markers for differential diagnosis with adenocarcinoma
Padr?o, Inês Liguori;Andrade, Liliana Aparecida Lucci De Angelo;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2006, DOI: 10.1590/S1676-24442006000300012
Abstract: although endocervical microglandular hyperplasia (mgh) is a common diagnosis, it can be confused with adenocarcinoma (aca), mainly of the clear cell type. objectives: evaluate the frequency of mgh diagnosis in conization specimens, their histological patterns and characterize the differential diagnosis between mgh and aca through immunohistochemical markers, as well as some clinical aspects. methods: we reviewed 223 cervical cones and 50 aca in cervical biopsies in order to: 1) assess the frequency of mgh in cones; 2) verify immunohistochemical expression of p53, carcinoembryonic antigen (cea) and ki67 in both lesions; 3) correlate the findings to age, parity and hormonal status. results: we found 35 cases of mgh (15.7%), of the following patterns: 21 glandular (60%); 7 reticular (20%); 6 trabecular (17.1%) and one solid (2.8%). average age was 36 years and mean parity was three children. of the mgh patients, 51.42% were pregnant or made use of some hormonal therapy. aca occurred in older patients (mean: 53 years), multiparous and with no hormonal history. cea was negative in mgh and positive in 62% of aca. ki67 was weakly positive (5%-10% stained nuclei) in 8.6% of mgh and strong (> 40% stained nuclei) in 80% of aca. p53 expression was negative in mgh and only present in 10% of aca. conclusions: mgh was common in cones, mainly in young women. half of the cases were associated with hormonal therapy or pregnancy. cea and ki67 were useful but p53 expression was not important for the differential diagnosis with adenocarcinoma.
p53, estrogen and progesterone receptors in diagnostic curettage for endometrial adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy
Bonfitto, Vera Lúcia Leite;Andrade, Liliana Aparecida Lucci de Angelo;
Sao Paulo Medical Journal , 2003, DOI: 10.1590/S1516-31802003000400005
Abstract: context: diagnostic staging is an important prognostic factor for endometrial adenocarcinoma. apart from the histological type and histological grade, some markers seem to be associated with the stage and biological behavior of the disease. among these are p53, estrogen and progesterone receptors. objective: the objectives of the present study were: to compare histological type and grading of endometrial carcinoma in curettage and hysterectomy samples; to assess expression of p53, estrogen and progesterone receptors in curettage specimens; and to correlate these data with morphology and staging of the disease in hysterectomy specimens. type of study: retrospective. setting: department of pathology, faculdade de ciências médicas, universidade estadual de campinas. sample: histological diagnosis from 51 consecutive files. procedures: immunohistochemical reactions for p53, estrogen and progesterone receptors via the avidin-biotin-peroxidase method in 51 curettage samples endometrial carcinoma were compared with the morphological data and disease stage in hysterectomy. marker expression was correlated with histological type and grade and the final stage of the disease. results: according to the histological type: 44 cases (86%) were of endometrioid and 7 (14%) non-endometrioid carcinoma. p53 expression was observed in 16% of endometrioid and 71% of non-endometrioid cases (p < 0.05). although estrogen expression was more evident in endometrioid (54%) than non-endometrioid cases (29%), this was not statistically significant. progesterone receptor expression was significantly higher in endometrioid than non-endometrioid cases (70% vs. 14%, p < 0.05). according to the histological grade: estrogen and progesterone receptors were expressed more frequently in grade i endometrioid carcinoma, while p53 was mainly reported in tumor grades ii and iii. according to final disease stage: p53 and estrogen expression in curettage specimens was not related to stage; progesterone recepto
Immunohistochemical study of basement membrane collagen IV in uterine cervix carcinoma
Pinto, Glauce Aparecida;Vassallo, José;Andrade, Liliana Aparecida Lucci De Angelo;Magna, Luís Alberto;
Sao Paulo Medical Journal , 1998, DOI: 10.1590/S1516-31801998000600004
Abstract: context: the integrity of basement membrane (bm) is damaged during the evolution of a benign or potentially malignant lesion into a malignant one, in which it may undergo several degrees of discontinuity as a necessary condition for the invasive process. immunostaining for collagen iv, which is exclusively found in bm, has been used to evaluate its formation in neoplastic and benign lesions of several organs. objective: to investigate bm continuity pattern in squamous carcinoma "in situ" (cis), microinvasive (mic) and invasive (ic) squamous cell carcinoma of the uterine cervix, and to find out if bm expression could be useful in the diagnosis of early stromal invasion (mic). design: archival material between 1988 and 1993 was studied at the pathological anatomy department - unicamp. procedures: the selected cases, previously formalin fixed and paraffin embedded, were reviewed retrospectively by submitting them to immunohistochemical study via the avidin-biotin-peroxidase method using a monoclonal antibody anticollagen iv. results: in all, 17 cases of cis, 16 of mic and 21 of ic were evaluated. all ic cases showed evident bm discontinuity, either focal or diffuse. in the cis group, a continuous bm pattern was predominant, being focally disrupted in only 2/17 cases (11.8%). the mic group showed an intermediate pattern, but with a clear tendency to bm discontinuity in 10/16 cases (62.5%). inflammatory infiltrate, a variable also studied, cannot be considered responsible for bm discontinuity, since there was no statistical correlation between them. conclusion: we conclude that immunostaining for collagen iv may contribute to the diagnosis of stromal invasion by bm discontinuity.
Primary melanoma of the uterine cervix figo stage III B
Teixeira, Júlio César;Salina, José Roberto;Teixeira, Luiz Carlos;Andrade, Liliana Aparecida Lucci De Angelo;
Sao Paulo Medical Journal , 1998, DOI: 10.1590/S1516-31801998000400007
Abstract: the primary malignant melanoma of the uterine cervix is rare, usually diagnosed at an advanced stage and with poor prognosis. the diagnosis is made through histological evaluation and confirmed by special staining procedures. radical surgery has been used and advocated. however in its advanced stages chemotherapy, immunotherapy or radiotherapy can be employed. a case of a patient with malignant melanoma of the uterine cervix, stage iiib, is presented in addition to a clinical and pathological discussion.
Correla??o entre o Diagnóstico Histológico da Biópsia e o da Coniza??o por Cirurgia de Alta Freqüência por Al?a (CAF) no Tratamento da Neoplasia Intra-epitelial Cervical
Juliato, Cássia Raquel Teatin;Teixeira, Julio Cesar;Derchain, Sophie Fran?oise Mauricette;Barbosa, Sérgio Bruno;Martinez, Edson Zangiacomi;Panetta, Kazue;Angelo-Andrade, Liliana AL de;
Revista Brasileira de Ginecologia e Obstetrícia , 2000, DOI: 10.1590/S0100-72032000000200002
Abstract: purpose: to evaluate conization by the loop electrosurgical excision procedure (leep) for the diagnosis and treatment of cervical intraepithelial neoplasms (cin), the importance of the margins and follow-up of these women. methods: 95 women who underwent conization by leep for cin and microinvasive carcinoma from january 1996 to december 1997 were evaluated. for statistical analysis, we used the kappa agreement coefficient and the tendency test of cochran armitage. results: among 63 cases who underwent colposcopically directed biopsy before the conization, the cone presented the same grade of lesion in 20 and no residual disease in 8. the cone lesion presented a higher grade in 24 cases and one of them was a microinvasive carcinoma. among the 25 women who underwent the cone biopsy with a previous biopsy suggestive of cervicitis or cin 1, 56% had cin 2 or 3 in the cone. among the 32 women without previous biopsy, 15 had cin 2 or 3, and four had microinvasive carcinoma in the cone. regarding the margins of the cone, 25 cases presented some grade of cin in the endocervical margins and 2/10 who underwent a second procedure presented residual disease on histological analysis. among the 70 women with free cone margins, 2/4 who underwent a second procedure had residual disease on histological analysis. conclusion: conization by leep without previous directed biopsy depends on the experience of the colposcopist. the second resection after leep for the diagnosis and treatment of cin depends not only on the presence of disease in the cone margins but also on the follow-up. a second histological analysis is recommended in cases with microinvasive carcinoma and glandular lesion and affected margins.
Atipia de células glandulares em esfrega?os do colo do útero: avalia??o dos métodos propedêuticos
Verdiani, Luiz Antonio;Derchain, Sophie Fran?oise Mauricette;Schweller, Marcelo;Gontijo, Renata Clementino;Andrade, Liliana Aparecida Angelo;Zeferino, Luiz Carlos;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000300008
Abstract: purpose: to evaluate the diagnostic procedures used in women with pap smear result of atypical glandular cells. patients and methods: a prospective study with 159 women with atypical glandular cells was carried out between january and december 2000. all women were submitted to a new colpocytology and to colposcopy. directed biopsy was performed in 50 cases, endocervical curettage in 21 and conization in 75. the performance of the diagnostic procedures was described by estimating the sensitivity, specificity, predictive values and likelihood ratio, considering histological results as gold standard. results: the histological evaluation showed 51 intraepithelial squamous lesions, 29 low grade and 22 high grade. five women presented in situ adenocarcinoma and six patients presented invasive neoplasias. colpocytology alone showed sensitivity and specificity of 88.5 and 39%, respectively, and colposcopy alone, 74 and 42%. the association of colpocytology with colposcopy increased the sensitivity to 98.4%, with a significantly lower specificity of 10%. endocervical curettage showed low sensitivity (25%). conclusion: the presence of atypical glandular cells on colpocytology was associated with preinvasive and invasive cervical lesions in 62.2% of the cases with histological evaluation. repeating colpocytology and performing colposcopy allowed to select the women who needed histological evaluation. conization was an adequate procedure when examination continued to show morphologic alterations.
Detec??o do DNA do papilomavírus humano após excis?o da zona de transforma??o com al?a diatérmica para tratamento de neoplasia intra-epitelial cervical
Figueirêdo, Priscila Garcia;Derchain, Sophie Fran?oise Mauricette;Sarian, Luis Otávio Zanatta;Gontijo, Renata Clementino;Andrade, Liliana Aparecida De ?ngelo;Campos, Elizabete Aparecida;Martinez, Edson Zangiacomi;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000100002
Abstract: purpose: to evaluate the detection of high oncogenic risk human papillomavirus dna (hpv-dna) immediately before and 4±1.25 months after large loop excision of the transformation zone (lletz) in the treatment of cervical intraepithelial neoplasia (cin). methods: in this clinical prospective study, 78 patients submitted to lletz from february to december 2001 were enrolled. all patients were submitted to colposcopic evaluation and had pap smear and hybrid capture ii (hc ii) specimens collected immediately before lletz and four months after the procedure. statistical analysis was made through odds ratio (or) calculations with 95% confidence interval (95% ci). results: before excision, 67 (86%) women had positive hc ii for high oncogenic risk hpv-dna, while four months afterwards only 22 (33%) maintained positive hc ii results. positive results of hpv-dna after treatment were not associated with previous viral load, compromised margins in the surgical specimen or age. four months after the procedure, detection of hpv-dna was significantly associated with cytological abnormalities (or = 4.8; ci 95%: 1.7-13.7) but not with histological residual disease or relapse (or = 6.0; ci 95%: 0.8-52.3). conclusion: hpv-dna detection was significantly reduced after treatment of cin, but was not associated with the presence of histologic residual disease or relapse.
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