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Search Results: 1 - 10 of 75789 matches for " Lilian Maria;Lucia "
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Survey of aflatoxins in tomato products
Mariutti, Lilian Regina Barros;Soares, Lucia Maria Valente;
Ciência e Tecnologia de Alimentos , 2009, DOI: 10.1590/S0101-20612009000200031
Abstract: tomatoes are highly susceptible to fungi contamination in the field, during transportation, processing, and storage. aspergillus flavus and aspergillus parasiticus have been isolated from tomatoes and tomato products, and both fungi species can produce aflatoxin, mycotoxin with hepatotoxic, carcinogenic, teratogenic, and mutagenic effects on all animal species tested so far. in order to verify a possible aflatoxin contamination of tomato products commercialized in brazil, 63 samples of tomato products (pulp, paste, purée, ketchup, dehydrated tomatoes, and dried tomatoes preserved in oil) produced in 5 brazilian states and 1 imported sample (ketchup), totalizing 29 brands, were analyzed by thin layer chromatography. the analytical method showed an average recovery of 86% for all aflatoxins at two spiking levels. the limits of detection for the aflatoxins b1, b2, g1, and g2 varied with the type of the product ranging from 2 to 7 μg/kg. aflatoxins were not detected in any evaluated sample indicating that they did not pose a risk to human health since there was no invasion of raw materials by toxigenic fungi or no conditions for toxin production.
Friedreich's Ataxia: Cardiac Evaluation of 25 Patients with Clinical Diagnosis and Literature Review
Albano Lilian Maria José,Nishioka Silvana Angelina Dório,Moysés Regina Lucia,Wagenführ Jaqueline
Arquivos Brasileiros de Cardiologia , 2002,
Abstract: OBJECTIVE - Cardiac evaluation (clinical, electrocardiographic and echocardiographic) of 25 Brazilian patients with clinical diagnosis of Friedreich's ataxia (FA) related to the frequency and the size of GAA repeats (unstable expansion of trinucleotide repeats that results in the disease). METHODS - Clinical and cardiac study including electrocardiogram and echocardiogram of all patients and molecular analysis to detect the frequency and the size of GAA expansion, by polymerase chain reaction analysis. RESULTS - Homozygous GAA expansion was detected in 17 patients (68%) -- all typical cases. In 8 (32%) cases (6 atypical and 2 typical), no GAA expansion was observed, therefore it was not considered Friedreich's ataxia. All patients with GAA expansion (100%) had electrocardiographic abnormalities, and only 25% of the cases without GAA expansion had some abnormality on this exam. However, only 6% of all patients revealed some signals/symptoms suggestive of cardiac involvement. CONCLUSION - A molecular analysis is essential to confirm the diagnosis of Friedreich's ataxia; however, an adequate cardiac evaluation, including an electrocardiogram, was extremely useful to better screening the patients which should perform these molecular analysis.
Discrimination of acute lymphoblastic leukemia from systemic-onset juvenile idiopathic arthritis at disease onset
Tamashiro, Mirian S.;Aikawa, Nadia Emi;Campos, Lucia Maria A.;Cristofani, Lilian Maria;Odone-Filho, Vicente;Silva, Clovis A.;
Clinics , 2011, DOI: 10.1590/S1807-59322011001000001
Abstract: objective: to assess clinical and laboratory features that differentiate acute lymphoblastic leukemia from systemic juvenile idiopathic arthritis at disease onset. methods: fifty-seven leukemia patients with musculoskeletal involvement, without blasts on peripheral blood and without glucocorticoid therapy at disease onset and 102 systemic juvenile idiopathic arthritis patients (international league of associations for rheumatology criteria) were retrospectively evaluated. the following features were examined: fever, rheumatoid rash, arthritis, limb pain, hepatomegaly, splenomegaly, pericarditis, myocarditis, pleuritis, weight loss, bleeding, anemia, leukopenia, neutropenia, thrombocytopenia, erythrocyte sedimentation rate, and lactic dehydrogenase levels. results: the median age at disease onset was significantly higher in leukemia patients than in those with systemic-onset juvenile idiopathic arthritis (5.8 vs. 3.8 years). in addition, the frequencies of limb pain, hepatomegaly, weight loss and hemorrhagic manifestations were significantly higher in leukemia patients than in systemic-onset juvenile idiopathic arthritis patients (70% vs. 1%, 54% vs. 32%, 30% vs. 8%, and 9% vs. 0%, respectively). likewise, the frequencies of anemia, leukopenia, neutropenia, thrombocytopenia and high lactic dehydrogenase levels were statistically higher in leukemia patients than in patients with systemic-onset juvenile idiopathic arthritis (88% vs. 57%, 39% vs. 1%, 60% vs. 1%, 77% vs. 1%, and 56% vs. 14%, respectively). remarkably, multivariate analysis revealed that limb pain (or = 553; 95% ci =46.48-6580.42) and thrombocytopenia (or = 754.13; 95% ci =64.57-8806.72) were significant independent variables that differentiated leukemia from systemic-onset juvenile idiopathic arthritis. the r2 of the nagelkerke test was 0.91, and the kaplan-meier survival curves were similar for acute lymphoblastic leukemia patients with and without limb pain. conclusion: our study emphasizes the importa
TERMINOLOGY CONCEPTS OF PROBIOTIC AND PREBIOTIC AND THEIR ROLE IN HUMAN AND ANIMAL HEALTH
Ferreira,Célia Lucia; Salminen,S; Lukasz,Grzeskowiak; Brizuela,Maria Antonieta; Sanchez,Lilian; Carneiro,Heloísa; Bonnet,M;
Revista de Salud Animal , 2011,
Abstract: the mode of action of specific probiotic bacteria and specific prebiotic ingredients and their effects on the intestinal microbiota modulation in humans and animals has been demonstrated in many studies. intestine is characterized for harboring a complex and dynamic microbiota which, among others, has a function to protect the host from inflammatory disorders. a mature and balanced endogenous microbiota has also an important role in the maintenance of a desirable activity of the immune system. deviations in gut microbiota composition, due to improper diet, radiotherapy, antibiotic treatment, stress and others, may lead to a variety of gastrointestinal disorders. to overcome an unbalanced microbiota, the consumption of specific probiotics and prebiotics has been proved to be effective. for more than three decades, many probiotic microorganisms have been characterized and evaluated. however, the term prebiotic has only recently been identified, characterized and evaluated in human intervention studies. the list of prebiotic ingredients remains limited, and yacon (smallantus sonchifolia) is an andean root to which prebiotic attributes have been inferred recently. humans and animals could seemingly benefit from the consumption of specific prebiotics and probiotics. in this work, terminology aspects of pre- and probiotics, and their roles in human and animal health are discussed.
Targeting Brazilian Market through Digital Branding Strategies: The Relevance of the Cultural Dimension  [PDF]
Lilian Maria de Souza Almeida
Open Journal of Business and Management (OJBM) , 2015, DOI: 10.4236/ojbm.2015.31004
Abstract: While Internet has been achieving its omnipresence worldwide and offering to companies the opportunity of trading in a “no-borders” market, global brands, and those aspiring to become global, face the challenge of dealing with significant cultural differences. Emergent economies account for one of the greatest opportunities for global brands interested in extending their business overseas through digital channels. Among these economies, Brazil has been receiving special focus lately as a promising consumer market. Working from a theoretical point of view through literature and simultaneously examining companies as potential paradigms, this study aims to provide suggestions for global brands interested in targeting the Brazilian market through effective cross-cultural digital branding strategies. The results are valuable insights about how to establish better communication with Brazilian consumers and also offer some guidance to help marketers to keep brands desired and admired in Brazil. It was mainly concluded that global brands should find out the right balance between a standardized and an adapted cultural approach in order to establish a trust-worthy proximity with Brazilian consumers on the digital environment.
Linfoma de Hodgkin na infancia e adolescência: 15 anos de experiência com o protocolo DH-II-90
Souza, Luciana N. S.;Maluf Junior, Paulo T.;Almeida, Maria Tereza A.;Weltman, Eduardo;Cornacchioni, Ana Lucia;Teixeira, Roberto Augusto P.;Odone Filho, Vicente;Cristofani, Lilian Maria;
Revista Brasileira de Hematologia e Hemoterapia , 2010, DOI: 10.1590/S1516-84842010005000085
Abstract: the challenge of new protocols for hodgkin's lymphoma (hl) treatment is to decrease the toxicity without impairing the results. the dh-ii-90 protocol was designed to treat children and adolescents with hl. the objectives of this work were: 1) to assess the overall and event free survival of patients with newly diagnosed hl treated with the dh-ii-90 protocol, 2) to assess the overall and event free survival by stage, age, presence of bulky disease, mediastinal mass, b symptoms, dose and type of radiotherapy, and 3) to describe late effects, data collected from the patients' charts. sixty-eight patients with hl, from 0 to 21 years of age (median age 9 yr, 20f:48m) were treated with abvd and involved-field radiotherapy for low-risk patients, and abvd plus mop or cop and extended field radiotherapy for high-risk patients. stage distribution was: nine (13.2%) stage i a; 29 (42.6%) ii a; five (7.4%) ii b; nine (13.2%) iii a; ten (14.7%) iii b; two (2.9%) iv a and four (5.9%) iv b. the 10-year overall survival was 96.1% ± 3.8% for the low-risk group and 93.3% ± 4.5% for the high-risk group (p= 0.402). the 10-year event free survival was 88.9% ± 5.2% for high-risk and 86.5% ± 6.3% for low-risk patients (p= 0.969). the presence of mediastinal mass and more than 2100 cgy radiation doses had negative impact on event free survival (p= 0.020 and p= 0.014, respectively).thyroid gland dysfunction was frequently observed and there were two cases of thyroid carcinoma. the dh-ii-90 protocol is effective, but, due to the late effects presented by this group of patients, further modifications of the therapy schedule are required.
Friedreich's Ataxia: Cardiac Evaluation of 25 Patients with Clinical Diagnosis and Literature Review
Albano, Lilian Maria José;Nishioka, Silvana Angelina Dório;Moysés, Regina Lucia;Wagenführ, Jaqueline;Bertola, Débora;Sugayama, Sofia Mizuho Miura;Chong, A. Kim;
Arquivos Brasileiros de Cardiologia , 2002, DOI: 10.1590/S0066-782X2002000500002
Abstract: objective - cardiac evaluation (clinical, electrocardiographic and echocardiographic) of 25 brazilian patients with clinical diagnosis of friedreich's ataxia (fa) related to the frequency and the size of gaa repeats (unstable expansion of trinucleotide repeats that results in the disease). methods - clinical and cardiac study including electrocardiogram and echocardiogram of all patients and molecular analysis to detect the frequency and the size of gaa expansion, by polymerase chain reaction analysis. results - homozygous gaa expansion was detected in 17 patients (68%) ? all typical cases. in 8 (32%) cases (6 atypical and 2 typical), no gaa expansion was observed, therefore it was not considered friedreich's ataxia. all patients with gaa expansion (100%) had electrocardiographic abnormalities, and only 25% of the cases without gaa expansion had some abnormality on this exam. however, only 6% of all patients revealed some signals/symptoms suggestive of cardiac involvement. conclusion - a molecular analysis is essential to confirm the diagnosis of friedreich's ataxia; however, an adequate cardiac evaluation, including an electrocardiogram, was extremely useful to better screening the patients which should perform these molecular analysis.
Utiliza??o de ferramentas de análise espacial na vigilancia epidemiológica de leishmaniose visceral americana - Ara?atuba, S?o Paulo, Brasil, 1998-1999
Camargo-Neves, Vera Lucia Fonseca de;Katz, Gizelda;Rodas, Lilian Aparecida Colebrusco;Poletto, Daniela Witacker;Lage, Lisete Cruz;Spínola, Roberta Maria Fernandes;Cruz, Oswaldo Gon?alves;
Cadernos de Saúde Pública , 2001, DOI: 10.1590/S0102-311X2001000500026
Abstract: the control of american visceral leishmaniasis (avl) is based on combating the vector and eliminating the domestic reservoir of the focus area - defined as 200 meters around human or canine cases. this paper discusses the use of spatial analysis techniques in the epidemiological surveillance of avl in ara?atuba, s?o paulo state, in order to propose a model for territorial epidemiological surveillance, reformulating current control strategies. the results showed that avl transmission was not homogeneous; human cases were more frequent in areas with higher canine prevalence rates. vector dispersion appeared to be restricted to a few houses, although it was not possible to model the vector density. in order to study the vector distribution and correlated covariates, a field study based on house sampling is being conducted. the results will aid the development of new spatial analysis tools and possibly redefine protocols and routines for the control of this endemic disease in urban areas.
Quantifica??o de anticorpos antitireoperoxidase e antitireoglobulina, tireotrofina e tiroxina livre em gestantes normais
Rodrigues, Lilian de Paiva;Jorge, Silvia Regina Piza Ferreira;Roveran, Valquiria;Yamano, Lucia Mitsuko;Vásquez, M?nica López;Aoki, Tsutomu;Lima, Sonia Maria Rolim Rosa;
Revista Brasileira de Ginecologia e Obstetrícia , 2007, DOI: 10.1590/S0100-72032007000900007
Abstract: purpose: to quantify the presence of antithyroperoxidase (anti-tpo) and antithyroglobulin (anti-tg) antibodies, and the plasmatic concentrations of thyrotropin (tsh) and free thyroxine (ft4) in normal pregnant women. methods: a hundred twenty-seven pregnant women, residing in s?o paulo, aged from 14 to 44 years old and gestational age > 16 weeks, determined by ultrasound performed before the 20th week of pregnancy were included in a transversal study performed in the prenatal clinic of santa casa de misericórdia de s?o paulo, from january 2003 to september 2004. pregnant women using medicines or with thyroidopathy history were excluded. antithyroperoxidase and antithyroglobulin antibodies were quantified by chemiluminescence immunoassay. the immunofluorimetry technique by time-resolved was used for determining the thyrotrophin and free thyroxine. the student's t test, with significance of 5%, was used for analyzing the results. results: the frequency of antithyroid antibodies was 12.6% (8.6% of anti-tpo antibodies, and 4.6% of anti-tg antibodies). the average of tsh concentrations was 2.13±1.0 μu/ml, and the average of t4l was 0.9±0.5 ng/dl. it was observed alteration of the thyroid function in ten pregnant women (8%). three of them had diagnosis of hypothyroidism: one in the clinical form of the disease, with increased tsh and decreased ft4; two in the subclinical form with increased tsh and normal ft4. five presented decreased tsh and increased ft4, consistent with clinical hyperthyroidism and two were diagnosed with subclinical hyperthyroidism, with decreased tsh concentrations only. conclusions: the frequency of antithyroid antibodies was 12.6% in pregnant women, the antithyroperoxidase antibodies being predominant over the antithyroglobulin antibodies. it was observed some thyroid dysfunction in 8% of the cases with alterations of tsh and/or t4l.
Cardiopatia fetal e estratégias de enfrentamento
Benute, Gláucia Rosana Guerra;Nonnenmacher, Daniele;Evangelista, Luiz Flávio Mendes;Lopes, Lilian Maria;Lucia, Mara Cristina Souza;Zugaib, Marcelo;
Revista Brasileira de Ginecologia e Obstetrícia , 2011, DOI: 10.1590/S0100-72032011000900002
Abstract: purpose: to evaluate the coping strategies of women facing a diagnosis of fetal heart disease. methods: we interviewed 50 women who had received a diagnosis of fetal heart disease. for data collection we used a semi-directed and coping strategy inventory. the interview was conducted, on average, 22 days after the diagnosis. results: when asked how they felt about the baby, 56.0% reported concern and fragility, while the remaining 44.0% said they were happy and well. the strategies most used by women were problem solving (73.0%), social support (69.1%) and escape/avoidance (62.7%), and the least used strategy was removal (17.3%). it was found that women with partners, as well as those with 1 or 2 children, used more the problem-solving strategy (p<0.05). conclusions: the active coping strategies, focused on problem solving and seeking social support, coupled with the responsibility and the need for specific care for the survival and welfare of the baby, brought about a closer relationship with the pregnancy, strengthening the maternal-fetal bond.
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