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Search Results: 1 - 10 of 18108 matches for " Lijia Fang "
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Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart
Lianguo Hou, Kaoqi Lian, Min Yao, Yun Shi, Xin Lu, Lijia Fang, Tianbo He, Lingling Jiang
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-126
Abstract: The capillary gas chromatography results showed that all the n-3 (or omega-3) PUFAs, especially DHA (~50%) and EPA (~100%), were significantly decreased, and the n-6/n-3 ratio (~115%) was significantly increased in the hearts of diabetic rats. The activity of peroxisomal beta-oxidation, which is crucial to very-long-chain and unsaturated FA metabolism (including DHA), was significantly elevated in DM hearts. Additionally, the real-time PCR results showed that the mRNA expression of most peroxisomal beta-oxidation key enzymes were up-regulated in T2DM rat hearts, which might contribute to the reduction of n-3 (or omega-3) PUFAs.In conclusion, our results indicate that T2DM hearts consume more n-3 PUFAs, especially DHA and EPA, due to exaggerated peroxisomal beta-oxidation.Type 2 diabetes mellitus (T2DM) is associated with high cardiovascular morbidity and mortality [1]. In patients with diabetes, the fatty acid (FA) supply to the heart increases to compensate for the diminished utilization of glucose as an energy source. Although the dramatic increase in FA influx markedly increases the fatty acid oxidation (FAO) [2], it also leads to elevated FA and subsequent triglyceride (TG) synthesis in the diabetic heart, causing cellular lipotoxicity and the initiation of cardiac dysfunction [3]. Alternatively, the diabetic heart is characterized by significant alterations in the fatty acid composition of heart membranes. It has been shown that the linoleic acid (C18:2n-6) content is increased [4] and the n-3 polyunsaturated fatty acid (PUFA) content is decreased [5] in the cardiac phospholipids of STZ-treated rats and fructose-fed rats.Fatty acids are degraded by both mitochondrial and peroxisomal β-oxidation. The fatty acids that are shorter than C20 are primarily oxidized in the mitochondria, and the fatty acids that are greater than C22 (very-long-chain fatty acids, VLCFA), including polyunsaturated fatty acids (PUFA, Polyenoic acids with 20–22 carbon atoms and 3–6 double
Study on Fault Detection of Rolling Element Bearing Based on Translation-Invariant Denoising and Hilbert-Huang Transform
Lijia Xu
Journal of Computers , 2012, DOI: 10.4304/jcp.7.5.1142-1146
Abstract: In order to detect rolling element bearing faults from strong background noise, a new method based on translation-invariant denoising (TID) and hilbert-huang transform (HHT) is proposed. Firstly, the original vibration signals are preprocessed using TID to suppress abnormal interference of noise to improve the decomposition quality of HHT. Secondly, the denoised signals are decomposed into a set of intrinsic mode functions (IMFs) during empirical mode decomposition (EMD) process of HHT. Hilbert spectral analysis is further played on IMFs to capture the bearing defect frequencies. The performance of the proposed method is tested, and the experiment results show that this method can effectively extract the fault features of bearing and recognize the faults successfully. So the proposed method is a good-suited technique for bearing fault detection.
Learning of Content Knowledge and Development of Scientific Reasoning Ability: A Cross Culture Comparison
Lei Bao,Kai Fang,Tianfang Cai,Jing Wang,Lijia Yang,Lili Cui,Jing Han,Lin Ding,Ying Luo
Physics , 2008, DOI: 10.1119/1.2976334
Abstract: Student content knowledge and general reasoning abilities are two important areas in education practice and research. However, there hasn't been much work in physics education that clearly documents the possible interactions between content learning and the development of general reasoning abilities. In this paper, we report one study of a systematic research to investigate the possible interactions between students' learning of physics content knowledge and the development of general scientific reasoning abilities. Specifically, this study seeks to answer the research question of whether and to what extent content learning may affect the development of general reasoning abilities. College entrance testing data of freshman college students in both USA and China were collected using three standardized tests, FCI, BEMA, and Lawson's Classroom Test of Scientific Reasoning (Lawson Test). The results suggest that years of rigorous training of physics knowledge in middle and high schools have made significant impact on Chinese students' ability in solving physics problems, while such training doesn't seem to have direct effects on their general ability in scientific reasoning, which was measured to be at the same level as that of the students in USA. Details of the curriculum structures in the education systems of USA and China are also compared to provide a basis for interpreting the assessment data.
Catalpol Upregulates Hippocampal GAP-43 Level of Aged Rats with Enhanced Spatial Memory and Behavior Response  [PDF]
Jing Liu, Yang Liu, Wei Zou, Lin Song, Lijia An
Journal of Behavioral and Brain Science (JBBS) , 2012, DOI: 10.4236/jbbs.2012.24058
Abstract: Rehmannia glutinosa is a traditional Chinese medical herb and has a long history in cognitive deficits therapy. Its ther-apeutic efficacy has been confirmed by clinical studies. In this study, we attempted to investigate the effects of catalpol, an iridoid from Rehmannia glutinosa, on cognitive and behavioral function of aged rats with memory loss. 22 - 24 month Sprague-Dawley spontaneous rats of memory loss with aging were selected by step-down type passive avoidance test and randomly allocated to two groups: the aged rats with memory loss (control group) and the catal- pol-treated (5 mg/kg) group. We performed open-field and Y-maze test to evaluate special performance and behavior response before and after catalpol treatment for 5 and 10 days. Growth-associated protein (GAP-43) in hippocampus and frontal cortex was measured using immunohistochemistry and quantitative Western Blotting. The results showed that catalpol could significantly improve not only spatial learning and memory but also locomotor activity and ex-plora- tory behavior of aged rats with memory loss. GAP-43 protein in hippocampal CA3 region and dentate granule of catal- pol-treated rats was significantly enhanced than that of control group. Western blot analysis demonstrated a catal- pol-associated increase of GAP-43 in hippocampus of catalpol-treated rats and correlated with spatial memory, loco- motor activity and exploratory behavior. However, there was no difference in GAP-43 protein in frontal cortex between two groups. These results indicated that catalpol could enhance spatial performance and behavioral responses in aged rats with memory loss, and the mechanism may involve up-regulation of GAP-43 level of hippocampus in the brain. It also suggested that catalpol may be a useful natural drug for Alzheimer’s disease (AD) treatment by modulating hippo- campal neuroplasticity.
Time-Varying Bandpass Filter Based on Assisted Signals for AM-FM Signal Separation: A Revisit  [PDF]
Guanlei Xu, Xiaotong Wang, Xiaogang Xu, Lijia Zhou, Limin Shao
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.43031
Abstract:

In this paper, a new signal separation method mainly for AM-FM components blended in noises is revisited based on the new derived time-varying bandpass filter (TVBF), which can separate the AM-FM components whose frequencies have overlapped regions in Fourier transform domain and even have crossed points in time-frequency distribution (TFD) so that the proposed TVBF seems like a “soft-cutter” that cuts the frequency domain to snaky slices with rational physical sense. First, the Hilbert transform based decomposition is analyzed for the analysis of nonstationary signals. Based on the above analysis, a hypothesis under a certain condition that AM-FM components can be separated successfully based on Hilbert transform and the assisted signal is developed, which is supported by representative experiments and theoretical performance analyses on a error bound that is shown to be proportional to the product of frequency width and noise variance. The assisted signals are derived from the refined time-frequency distributions via image fusion and least squares optimization. Experiments on man-made and real-life data verify the efficiency of the proposed method and demonstrate the advantages over the other main methods.

Generalized Parseval’s Theorem on Fractional Fourier Transform for Discrete Signals and Filtering of LFM Signals  [PDF]
Xiaotong Wang, Guanlei Xu, Yue Ma, Lijia Zhou, Longtao Wang
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.43035
Abstract:

This paper investigates the generalized Parseval’s theorem of fractional Fourier transform (FRFT) for concentrated data. Also, in the framework of multiple FRFT domains, Parseval’s theorem reduces to an inequality with lower and upper bounds associated with FRFT parameters, named as generalized Parseval’s theorem by us. These results theoretically provide potential valuable applications in filtering, and examples of filtering for LFM signals in FRFT domains are demonstrated to support the derived conclusions.

Discrete Entropic Uncertainty Relations Associated with FRFT  [PDF]
Guanlei Xu, Xiaotong Wang, Lijia Zhou, Xiaogang Xu, Limin Shao
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.43B021
Abstract:

Based on the definition and properties of discrete fractional Fourier transform (DFRFT), we introduced the discrete Hausdorff-Young inequality. Furthermore, the discrete Shannon entropic uncertainty relation and discrete Rényi entropic uncertainty relation were explored. Also, the condition of equality via Lagrange optimization was developed, as shows that if the two conjugate variables have constant amplitudes that are the inverse of the square root of numbers of non-zero elements, then the uncertainty relations reach their lowest bounds. In addition, the resolution analysis via the uncertainty is discussed as well.

Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease
Lijia Guo, Lijuan Han, Laying Yang, Huicai Zeng, Dingding Fan, Yabin Zhu, Yue Feng, Guofen Wang, Chunfang Peng, Xuanting Jiang, Dajie Zhou, Peixiang Ni, Changcong Liang, Lei Liu, Jun Wang, Chao Mao, Xiaodong Fang, Ming Peng, Junsheng Huang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095543
Abstract: Background The asexual fungus Fusarium oxysporum f. sp. cubense (Foc) causing vascular wilt disease is one of the most devastating pathogens of banana (Musa spp.). To understand the molecular underpinning of pathogenicity in Foc, the genomes and transcriptomes of two Foc isolates were sequenced. Methodology/Principal Findings Genome analysis revealed that the genome structures of race 1 and race 4 isolates were highly syntenic with those of F. oxysporum f. sp. lycopersici strain Fol4287. A large number of putative virulence associated genes were identified in both Foc genomes, including genes putatively involved in root attachment, cell degradation, detoxification of toxin, transport, secondary metabolites biosynthesis and signal transductions. Importantly, relative to the Foc race 1 isolate (Foc1), the Foc race 4 isolate (Foc4) has evolved with some expanded gene families of transporters and transcription factors for transport of toxins and nutrients that may facilitate its ability to adapt to host environments and contribute to pathogenicity to banana. Transcriptome analysis disclosed a significant difference in transcriptional responses between Foc1 and Foc4 at 48 h post inoculation to the banana ‘Brazil’ in comparison with the vegetative growth stage. Of particular note, more virulence-associated genes were up regulated in Foc4 than in Foc1. Several signaling pathways like the mitogen-activated protein kinase Fmk1 mediated invasion growth pathway, the FGA1-mediated G protein signaling pathway and a pathogenicity associated two-component system were activated in Foc4 rather than in Foc1. Together, these differences in gene content and transcription response between Foc1 and Foc4 might account for variation in their virulence during infection of the banana variety ‘Brazil’. Conclusions/Significance Foc genome sequences will facilitate us to identify pathogenicity mechanism involved in the banana vascular wilt disease development. These will thus advance us develop effective methods for managing the banana vascular wilt disease, including improvement of disease resistance in banana.
儿童不明原因心悸与直立倾斜试验的关系
Relationship between unexplained palpitation in children and head-up tilt test

甘拓域, ,吴礼嘉,邹润梅,林萍,李芳,杨红,刘平,龚晓辉, ,王成
GAN Tuoyu
, , WU Lijia, ZOU Runmei, LIN Ping, LI Fang, YANG Hong, LIU Ping

- , 2018, DOI: 10.11817/j.issn.1672-7347.2018.03.008
Abstract: 目的:探讨儿童不明原因心悸与直立倾斜试验(head-up tilt test,HUTT)的关系。方法:选择2008年9月至 2017年2月在中南大学湘雅二医院儿童心血管专科门诊就诊或住院的不明原因心悸患儿142例,年龄3~18(10.12±2.88) 岁,其中男63例,女79例。经询问详细病史、体格检查、常规心电图、动态心电图、胸部X线片、超声心动图、 心肌酶、甲状腺功能等检查排除心脏疾病、系统性疾病及药物影响等。所有患儿行HUTT检查。结果:142例心 悸患儿中HUTT阳性79例(55.6%),阴性63例(44.4%)。HUTT阳性组年龄为5~16(10.72±2.59)岁,高于HUTT阴性组的 3~18(9.37±3.07)岁(t=2.843,P<0.05)。HUTT阳性组男女人数之比为33:46,HUTT阴性组男女人数之比为30:33,两组 比较差异无统计学意义(χ2=0.485,P>0.05)。HUTT阳性患儿中体位性心动过速综合征38例(48.1%),血管迷走性晕厥血 管抑制型36例(45.6%),血管迷走性晕厥混合型5例(6.3%),未见血管迷走性晕厥心脏抑制型、直立性低血压、直立性 高血压等类型。结论:临床上不明原因心悸儿童,超过半数是由自主神经功能失衡引起,及时进行HUTT能为明确病 因提供帮助
中国人直立性高血压的年龄和性别差异—单中心研究
Differences of age and gender in orthostatic#br# hypertension—a single-center study

康美华,许毅,邹润梅,吴礼嘉,林萍,李芳,王成
KANG Meihua
, XU Yi, ZOU Runmei, WU Lijia, LIN Ping, LI Fang, WANG Cheng

- , 2016, DOI: 10.11817/j.issn.1672-7347.2016.08.002
Abstract: 目的:探讨单中心中国人直立性高血压(orthostatic hypertension,OHT)的年龄和性别差异。方法:选择2000年1月至2012年8月在中南大学湘雅二医院晕厥专科门诊就诊或住院的不明原因头晕、晕厥等患者2 994例进行直立倾斜试验(head-up tilt test,HUTT)检查,年龄2.00~78.00(19.07±14.78)岁,男1 406例,女1 588例。符合OHT者745例,分为成人组(≥18岁,247例)和儿童组(<18岁,498例),分析OHT出现率、OHT类型及HUTT后3 min血压增加量的年龄与性别差异。结果:1)OHT出现率为24.88%(745/2 994),男女比较差异未见统计学意义(25.75% vs 24.12%,χ2=1.058,P>0.05);成人组较儿童组出现率高(27.05% vs 23.83%,χ2=4.125,P<0.05);745例OHT患者中52例(6.98%)表现为直立后收缩压、舒张压均升高(sOHT合并dOHT),16例(2.15%)为单纯直立性高收缩压(sOHT),677例(90.87%)为单纯直立性高舒张压(dOHT)。成人组单纯sOHT出现率、sOHT合并dOHT出现率均明显高于儿童组(分别为1.11% vs 0.29%,χ2=7.965,P<0.01;2.88% vs 1.24%,χ2=9.849,P<0.01);成人组单纯dOHT出现率与儿童组比较差异未见统计学意义(23.56% vs 22.20%,χ2=0.668,P>0.05);sOHT合并dOHT与单纯dOHT在不同性别组中出现率差异未见统计学意义(男:1.71% vs 1.76%,χ2=0.014,P>0.05;女:23.68% vs 21.66%,χ2=1.742,P>0.05);但儿童中dOHT出现率男性高于女性(24.53% vs 19.74%,χ2=6.933,P<0.05)。2)与儿童组比较,成人组sOHT合并dOHT收缩压增加量[(25.62±4.96) mmHg vs (23.54±5.83) mmHg,t=1.385,P>0.05]、dOHT舒张压增加量[(13.46±3.49) mmHg vs (13.23±3.22) mmHg, t=0.840,P>0.05]差异均无统计学意义。与儿童组比较,成人组sOHT收缩压增加量[(25.44±4.96) mmHg vs (23.68±5.35 ) mmHg,t=1.411,P>0.05]及dOHT舒张压增加量[(14.09±4.28) mmHg vs (13.05±3.82) mmHg,t=1.887,P>0.05]差异均未见统计学意义。结论:OHT出现率成人高于儿童,以dOHT多见,儿童以男性多见。在sOHT合并dOHT与单纯dOHT中,直立后3 min血压增加量成人与儿童未见差异
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