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Search Results: 1 - 10 of 11116 matches for " Lidia Ruiz-Mayor "
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High Blood Pressure Effects on the Brain Barriers and Choroid Plexus Secretion  [PDF]
Ibrahim González-Marrero, Leandro Casta?eyra-Ruiz, Juan M. González-Toledo, Agustín Casta?eyra-Ruiz, Héctor de Paz-Carmona, Lidia Ruiz-Mayor, Agustín Casta?eyra-Perdomo, Emilia M. Carmona-Calero
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.31009
Abstract: High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebrospinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeability of the brain barriers can be studied by using transthyretin and S-100β. In the present work we study the integrity of the brain barrier and the choroid plexus function variations in arterial hypertension. Control rats and spontaneously hypertensive rats were used and the choroid plexus were processed by immunohistochemistry with anti-transthyretin and anti-vasopressin. Western blot was also performed in cerebrospinal fluid, serum and choroid plexus using anti-S-100β, anti-transthyretin. The accumulation of transthyretin immunoreactive was bigger in spontaneously hypertensive rats with respect to the control. Vasopressin was also higher in spontaneously hypertensive rats with respect to the control. Western blot showed that transthyretin tetramer was higher in the spontaneously hypertensive rats than in the control rats. The expression of transthyretin monomer was lower in hypertensive rats than the control in the cerebrospinal fluid, the transthyretin monomer reaction in the blood was stronger in hypertensive than in control rats. Western blot for the S-100 β showed an increase in blood and cerebrospinal fluid of hypertensive rats. The high blood pressure produces a disruption of the blood brain barrier and blood to cerebrospinal fluid barrier that allows extravasations from the cerebrospinal fluid to the blood and from the blood to the cerebrospinal fluid.
Hypertension effects on p73 expression in the rat circumventricular organs and cerebrospinal fluid  [PDF]
Emilia M. Carmona-Calero, Ibrahim González-Marrero, Manuela Casta?eyra-Martin, Juan M. González-Toledo, Leandro Casta?eyra-Ruiz, Héctor de Paz-Carmona, Agustín Casta?eyra-Ruiz, Lidia Ruiz-Mayor, Agustín Casta?eyra-Perdomo
World Journal of Neuroscience (WJNS) , 2012, DOI: 10.4236/wjns.2012.22010
Abstract: It has been reported that spontaneously hypertensive rats (SHR) show ventricular dilation, changes in CSF proteins and variations in the circumventricular organs (CVO) such as: the subcommissural organ (SCO), the subfornical organ (SFO) and the area postrema (AP) which are located in the walls of the third and fourth ventricles. On the other hand, p73 proteins are present in cells of the central nervous system (CNS) such as circumventricular structures and the neuroepithelium which are altered in ventricular dilation. The purpose of the present work is to study the TAp73 isoform expression in the circumventricular organs (CVO) and their variations in ventricular dilatation and arterial hypertension. Brains and cerebrospinal fluid (CSF) from control Wistar-Kyoto rats (WKY) and SHR were used. The paraffin sections containing the CVO were immunohistochemically proc-essed with anti-TAp73 and by western blot, p73 bands in the CSF and circumventricular organ extract were also identified. The western blot study showed bands marked with p73 in the CSF and CVO, the p73 band expression was bigger in the SHR than in the WKY rats. We also found stronger markings in the SFO, SCO and AP of the hypertensive rats than in the WKY rats. It could be concluded that hypertension in the SHR produces altera-tions in the relationship between the p73 protein, circumventricular structures and CSF.
Approximate Robotic Mapping from sonar data by modeling Perceptions with Antonyms
Sergio Guadarrama,Antonio Ruiz-Mayor
Computer Science , 2010,
Abstract: This work, inspired by the idea of "Computing with Words and Perceptions" proposed by Zadeh in 2001, focuses on how to transform measurements into perceptions for the problem of map building by Autonomous Mobile Robots. We propose to model the perceptions obtained from sonar-sensors as two grid maps: one for obstacles and another for empty spaces. The rules used to build and integrate these maps are expressed by linguistic descriptions and modeled by fuzzy rules. The main difference of this approach from other studies reported in the literature is that the method presented here is based on the hypothesis that the concepts "occupied" and "empty" are antonyms rather than complementary (as it happens in probabilistic approaches), or independent (as it happens in the previous fuzzy models). Controlled experimentation with a real robot in three representative indoor environments has been performed and the results presented. We offer a qualitative and quantitative comparison of the estimated maps obtained by the probabilistic approach, the previous fuzzy method and the new antonyms-based fuzzy approach. It is shown that the maps obtained with the antonyms-based approach are better defined, capture better the shape of the walls and of the empty-spaces, and contain less errors due to rebounds and short-echoes. Furthermore, in spite of noise and low resolution inherent to the sonar-sensors used, the maps obtained are accurate and tolerant to imprecision.
Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder
Angel Aneiros-Guerrero, Ana M Lendinez, Arturo R Palomares, Beatriz Perez-Nevot, Lidia Aguado, Alvaro Mayor-Olea, Maximiliano Ruiz-Galdon, Armando Reyes-Engel
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-75
Abstract: A case-control study was designed to evaluate the impact of genetic polymorphisms above described on TMD. A total of 229 individuals (69% women) were included at the study; 86 were patients with TMD and 143 were healthy control subjects. Subjects underwent to a clinical examination following the guidelines by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Genotyping of 20 Single Nucleotide Polymorphisms (SNPs), divided in two groups, was performed by multiplex minisequencing preceded by multiplex PCR. Other seven genetic polymorphisms different from SNPs (deletions, insertions, tandem repeat, null genotype) were achieved by a multiplex-PCR. A chi-square test was performed to determine the differences in genotype and allelic frequencies between TMD patients and healthy subjects. To estimate TMD risk, in those polymorphisms that shown significant differences, odds ratio (OR) with a 95% of confidence interval were calculated.Six of the polymorphisms showed statistical associations with TMD. Four of them are related to enzymes of folates metabolism: Allele G of Serine Hydoxymethyltransferase 1 (SHMT1) rs1979277 (OR = 3.99; 95%CI 1.72, 9.25; p = 0.002), allele G of SHMT1 rs638416 (OR = 2.80; 95%CI 1.51, 5.21; p = 0.013), allele T of Methylentetrahydrofolate Dehydrogenase (MTHFD) rs2236225 (OR = 3.09; 95%CI 1.27, 7.50; p = 0.016) and allele A of Methionine Synthase Reductase (MTRR) rs1801394 (OR = 2.35; 95CI 1.10, 5.00; p = 0.037). An inflammatory oxidative stress enzyme, Gluthatione S-Tranferase Mu-1(GSTM1), null allele (OR = 2.21; 95%CI 1.24, 4.36; p = 0.030) and a neurotransmission receptor, Dopamine Receptor D4 (DRD4), long allele of 48 bp-repeat (OR = 3.62; 95%CI 0.76, 17.26; p = 0.161).Some genetic polymorphisms related to folates metabolism, inflammatory oxidative stress, and neurotransmission responses to pain, has been significantly associated to TMD syndromeTemporomandibular joint disorder (TMD) is characterized by a set of symptoms
Cristina Mayor Ruiz
Abstract: Los nuevos cambios que se proponen para la Universidad espa ola desde el proceso de convergencia europea propician una amplia reflexión en el ámbito de la formación del profesorado universitario. La adecuación al EEES hace necesario pensar en estrategias institucionales que le faciliten a los docentes dicho período de adaptación. La figura del profesor novel adquiere especial relevancia en este nuevo marco de actuaciones, por sus características y situación institucional. En este trabajo revisamos el papel de la universidad con respecto a sus profesores, sus compromisos y responsabilidades; los obstáculos y oportunidades que desde la propia institución se ofrecen; y las acciones y actuaciones a asumir para afrontar los retos y desafíos que tiene planteados.
Cristina Mayor Ruiz
Revista Electrónica de Investigación y Evaluación Educativa , 1996,
Abstract: The faculty must attend to three representative functions of this profession: the teaching, the research, and the management. The work that we present intends to investigate in these responsibilities, as well as in the limitations and preoccupations in connection with the professional conditions of the faculty of the University of Seville. The questionnaire is used as strategies of withdrawal of information. The belief of teachers with experience and beginning teachers certifies the fundamental shaft of this work. The analysis of data and the results originating from the same are presented in this study. El profesorado universitario debe atender a tres funciones representativas de esta profesión: la docencia, la investigación y la gestión. El trabajo que presentamos pretende indagar en estas responsabilidades, así como en las limitaciones y preocupaciones en torno a las condiciones profesionales del profesorado de la Universidad de Sevilla. El cuestionario es utilizado como técnica de recogida de información. La opinión de profesores con experiencia y profesores principiantes junto al grupo de titulación, llevado a cabo mediante el Análisis de Correspondencias Múltiples conforman el eje fundamental de este trabajo. El análisis de datos y los resultados procedentes del mismo son presentados en este estudio.
La docencia universitaria y las prácticas evaluativas
Ruiz,Lidia F; Pachano,Lizabeth;
Educere , 2005,
Abstract: evaluating learning is one of the aspects that require deeper modifications within the changes and transformations universities should be aware of in order to improve their educational process. since it is practiced by teachers through tests as the only information measuring element the student receives. a diagnose to determine current evaluative practices used by teachers to establish student performance was performed. the sample was made up out of 211 professors from different faculties at the university of los andes. a questionnaire was used for collecting information. from the diagnose, some considerations were generated supporting the final reflections in order to contribute to the student’s integral education; with the purpose of facing the challenges forced by the new millennium before globalization and the knowledge society.
Carmen Yot Domínguez,Cristina Mayor Ruiz
Olhar de Professor , 2012, DOI: 10.5212/olharprofr.v.15i2.0007
Abstract: This article describes the training program for beginning teachers at the University of Seville which considers future teachers′ own experience, and proposes the improvement of each of its phases, among others: the creation and strengthening of a social network where beginning teachers, and expert teachers can interact and communicate, incorporate the blog as a useful tool for the development of a portfolio that helps them refl ect on their teaching practice, as well as use games and simulations as a strategy or a tool for learning.Resumen: En el presente artículo se describe el programa de iniciación a la docencia de la Universidad de Sevilla a partir de la propia vivencia y se proponen líneas de mejora a cada una de sus fases, entre otras: crear y dinamizar una red social donde profesores principiantes y expertos puedan interactuar y comunicarse, incorporar el blog como herramienta útil para el desarrollo de un portfolio que ayude a la refl exión sobre la práctica pedagógica y utilizar los juegos y simulaciones como una estrategia o herramienta de aprendizaje más.
Forma??o pedagógica na pós-gradua??o em saúde no ambiente Moodle: um compromisso social
Moreno, Lidia Ruiz;Sonzogno, Maria Cecília;
Pro-Posi??es , 2011, DOI: 10.1590/S0103-73072011000300011
Abstract: the objectives of our study are to reflect on the academic education process and analyze the concepts and practices regarding didactic-pedagogical aspects of post-graduate students attending the 'bimodal didactic-pedagogical education in health' discipline. questionnaires and messages posted on discussion forums in the moodle platform were used for data collection. the data analysis was based on the following areas: curriculum conceptions and practices, biopsychosocial model, teachers' education, teaching-learning and evaluation. our results revealed that there is a predominance of reports concerning the traditional curriculum model in undergraduate courses experienced by the post-graduate students, although it was possible to identify some progress related to the diversity of practices and learning settings. the concepts and practices reflect the transition faced by the brazilian higher education nowadays, where approaches based on the biomedical model coexist with very subtle changes, on which we must reflect critically during teaching education in health.
La narrativa biográfica: Opción metodológica para investigar la relación enfermera-personas viviendo con VIH/SIDA Biographical narrative: A methodological alternative to know more about the relation nurse-patient, living with HIV/AIDS
Yurian Lidia Rubiano Mesa,Alexander Ruiz Silva
Index de Enfermería , 2012,
Abstract: Ante la importancia de avanzar en el conocimiento de la relación de cuidado enfermera-paciente, y, en particular, sobre los elementos de carácter moral que la orientan y regulan, este artículo analiza, a partir de algunos referentes teóricos, la pertinencia del paradigma cualitativo -con enfoque narrativo biográfico- para estudiar los valores, los sentimientos y las acciones morales que articulan la relación entre enfermeras y personas que viven con Virus de Inmunodeficiencia Adquirido-Síndrome de Inmunodeficiencia Adquirida. Being so fundamental to advance in the knowledge of the relation of care nurse-patient, and, particularly, on the moral aspects that guide and regulate such a relation, this article analyzes, based on some theoretical models, the relevance of the qualitative paradigm -with a narrative biographical approach- to study the values, feelings and moral actions that constitute the relation between nurses and persons who live with Human Immunodeficiency Virus or Acquired Immunodeficiency Syndrome.
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