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Search Results: 1 - 10 of 1471 matches for " Lidia Corraliza "
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The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration
Patricia Bogdanov, Lidia Corraliza, Josep A. Villena, Andrea R. Carvalho, José Garcia-Arumí, David Ramos, Jesús Ruberte, Rafael Simó, Cristina Hernández
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097302
Abstract: Background To characterize the sequential events that are taking place in retinal neurodegeneration in a murine model of spontaneous type 2 diabetes (db/db mouse). Methods C57BLKsJ-db/db mice were used as spontaneous type 2 diabetic animal model, and C57BLKsJ-db/+ mice served as the control group. To assess the chronological sequence of the abnormalities the analysis was performed at different ages (8, 16 and 24 weeks). The retinas were evaluated in terms of morphological and functional abnormalities [electroretinography (ERG)]. Histological markers of neurodegeneration (glial activation and apoptosis) were evaluated by immunohistochemistry. In addition glutamate levels and glutamate/aspartate transporter (GLAST) expression were assessed. Furthermore, to define gene expression changes associated with early diabetic retinopathy a transcriptome analyses was performed at 8 week. Furthermore, an additional interventional study to lower blood glucose levels was performed. Results Glial activation was higher in diabetic than in non diabetic mice in all the stages (p<0.01). In addition, a progressive loss of ganglion cells and a significant reduction of neuroretinal thickness were also observed in diabetic mice. All these histological hallmarks of neurodegeneration were less pronounced at week 8 than at week 16 and 24. Significant ERG abnormalities were present in diabetic mice at weeks 16 and 24 but not at week 8. Moreover, we observed a progressive accumulation of glutamate in diabetic mice associated with an early downregulation of GLAST. Morphological and ERG abnormalities were abrogated by lowering blood glucose levels. Finally, a dysregulation of several genes related to neurotransmission and oxidative stress such as UCP2 were found at week 8. Conclusions Our results suggest that db/db mouse reproduce the features of the neurodegenerative process that occurs in the human diabetic eye. Therefore, it seems an appropriate model for investigating the underlying mechanisms of diabetes-induced retinal neurodegeneration and for testing neuroprotective drugs.
Efectos adversos de los fármacos antirretrovirales: Fisiopatología, manifestaciones clínicas y tratamiento
Santos Corraliza,E.; Fuertes Martín,A.;
Anales de Medicina Interna , 2006, DOI: 10.4321/S0212-71992006000700010
Abstract: the suppression of plasma viral loads in hiv infected patients to less than the limit of quantification of the most sensitive commercially available assays and the coincident improvement in cd4 t cell counts is associated with a decrease in the risk of new opportunistic infections in this patients. the descent at the morbibility and mortality is specialy important since the introduction in 1996 the hard activity antirretroviral therapy (haart). however, prolonged treatment with combination regimens can be difficult to sustain because of problems with adherence and toxic effects. all antiretroviral drugs can have both short-term and long-term adverse events. the risk of specific side effects varies acording to specific drug, drug class and even, individual susceptibility. a better understanding of the adverse effects of antiretroviral agents is of interest to try to optimize therapy in hiv infected patients.
Socioeconomic Indicator of Water Availability in the Lower Guayalejo-Tamesí River Basin  [PDF]
Lidia Rangel-Blanco
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.56007
Abstract: Water is the main element for development since it defines and limits the opportunities for growth and economic development. The lack of water will increase constantly owing to the increase of the economic activities, social requests, environmental damage, and the climate changes. The research has as purpose to build an indicator of water availability, in the lower Basin of Guayalejo-Tamesi River in Tamaulipas, Mexico. Considering a quantitative methodology that provides the application of mathematic models through a hydrologic simulation software and scenarios of climate change (WEAP) (MA-GICC); and the qualitative that represents a major economic engineering challenge to convert complex variables such as the human development, the rise of the economic activity, and the increase of the social-demographic in water requirement. Bearing in mind that the valley is one of the most important hydrological systems of the State of Tamaulipas that provides to productive areas; the chemical industry, petrochemical, energetic, agricultural and livestock such as the domestic. Which makes relevant to apply and analyze the IDA, being a new experience at the regional level that needs to be abroad in a general way by the binding instances to the development of these areas which will allow a better social usage and economic of the hydrological system in a sustainable integral environment.
Applicable Quality Models in Higher Education in Argentina  [PDF]
Lidia Giuffré, Silvia E. Ratto
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.410A005
Abstract: The aim of this paper is the study of quality management systems applied to higher education. The specific objectives are to present different models of approach to the concept of quality education applicable in Argentina: to study the legal framework governing university education, and to introduce considerations about its evaluation. The National Education Law 26026/2006 is clear about State responsibility to ensure quality education for all residents, and implementation of assessment policy to secure it. Accreditation is the process commonly used to give public account of the degree of compliance of higher education institutions. Periodic accreditation of undergraduate careers, whose titles correspond to professions regulated by the State, is performed. External evaluations present evaluation reports that are public.
Some Remarks and Experiences on Higher Education and Sustainable Development  [PDF]
Lidia Giuffré, Silvia E. Ratto
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.43017
Abstract: Education for sustainable development should be based on proper environmental management. The general objective of this study is to highlight key aspects of environmental education, with specific objectives. Inclusive education addresses the learning needs with a focus on those who are vulnerable to marginalization and exclusion. Ethics plays a vital role in environmental management and should be a cornerstone to raise awareness of new forms of relationship with the particular and global environment. The cosmovision of indigenous peoples should be respected, including the indissoluble union of each culture with the environment. The feminization of labor is relevant in horticulture crops, with an active role of women in the organization of work. The connections between education and the world of work are key, with preparation for new and indeterminate forms of employment, paying attention to social skills in the context of increasing globalization. University Social Responsibility (USR) implies that the University must act ethically in knowledge transfer, promoting sustainable development. Sustainable development involves new systems of thought, it requires creativity and critical thinking, and an alternative is the creation of role-playing, to lead people to thinking in different ways. It is essential that the new professionals act without static patterns, integrating interdisciplinary teams, to search for the answer to a problem, offering original and innovative alternatives.
The Retinal Pigment Epithelium: Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy
Rafael Simó,Marta Villarroel,Lídia Corraliza,Cristina Hernández,Marta Garcia-Ramírez
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/190724
Abstract: The retinal pigment epithelium (RPE) is an specialized epithelium lying in the interface between the neural retina and the choriocapillaris where it forms the outer blood-retinal barrier (BRB). The main functions of the RPE are the following: (1) transport of nutrients, ions, and water, (2) absorption of light and protection against photooxidation, (3) reisomerization of all-trans-retinal into 11-cis-retinal, which is crucial for the visual cycle, (4) phagocytosis of shed photoreceptor membranes, and (5) secretion of essential factors for the structural integrity of the retina. An overview of these functions will be given. Most of the research on the physiopathology of diabetic retinopathy has been focused on the impairment of the neuroretina and the breakdown of the inner BRB. By contrast, the effects of diabetes on the RPE and in particular on its secretory activity have received less attention. In this regard, new therapeutic strategies addressed to modulating RPE impairment are warranted.
Forma??o por ciclos
Nedbajluk, Lidia;
Educar em Revista , 2006, DOI: 10.1590/S0104-40602006000200016
Abstract: this article was developed having as source the mastercourse studies at universidade federal do paraná, based on curriculum research, knowledge and acquaintance on school practices, tracing formation by cycles. it analyses the diversity of terms used as complement to the term "cycles" at elementary school. (learning cycles, school by means of cycles, teaching by means of cycles, development cycles, formation cycles; cycles of studies) and explains the inadequacy of its use indistinctly. considering the epistemological basis and supporting axes of school curriculum, it ponders the automatic promotion and continued progression and its links with teaching by means of cycles.
La supremacía de la mujer en la difusión romancística de la Leyenda de los Infantes de Lara
Temas medievales , 2008,
Abstract: this article analyses the legend of the infantes de lara where the female characters play a preeminent role which is especially apparent in the spanish romances. in fact, the romances dealing on this subject evince in their formal construction a specific interpretation according to which lambra and sancha occupy central positions in the family crisis and in the preservation of the family lineage.
Guillermo Cabrera Infante y las variantes del poder en el ámbito religioso de La Habana de los cincuentas
Cuadernos del CILHA , 2010,
Abstract: in a trilogy of short stories titled delito por bailar el chachachá (1995), the cuban writer guillermo cabrera infante evokes once again, from his lengthy exile, la habana de los 50. his narrative intention goes beyond the conflicts between characters, in order to wallow in a splendid description of the cultural and social status of the city in which his stories elapse. la habana is seen through his geography, customs, myths, beliefs and system of rules and prohibitions. the essential point of these narratives is not so much what they intend to convey, but rather what they recall, recover and even reveal of that city that is slowly disappearing. the present article examines only one of the stories that encompasses this trilogy;"el gran ecbo", where the previous aspects are clearly palpable, and where you can delve into the intricate networks that support the syncretic island culture. parallel to the thematic focus of the author, this work highlights the valuable use of contemporary literary techniques with which cabrera infante builds a city undergoing transformation, in which modernity, with all his energy, can not erase the forces of the past.
Cancha de Paleta, un cementerio del periodo formativo en Cachi (Valle Calchaqui, Salta)
Cuadernos de la Facultad de Humanidades y Ciencias Sociales. Universidad Nacional de Jujuy , 2007,
Abstract: se presentan los resultados de un trabajo de rescate efectuado en el área urbanizada de cachi, provincia de salta, argentina. cancha de paleta es uno de los dos cementerios localizados en la zona constituidos por tumbas de adultos con características estructurales peculiares y alfarería de superficie negra pulida, de los que sólo se conocen algunas referencias. los objetos del acompa?amiento mortuorio permiten estimar una cronología temprana, conocer más ajustadamente la alfarería regional, vislumbrar aspectos del los comportamientos mortuorios y trazar vinculaciones con otras sociedades formativas del noroeste argentino y los andes meridionales y circunpu?enos. se ha propuesto la existencia de posibles enclaves atacame?os controlando vías de circulación en los sectores más septentrionales del valle calchaquí, el caso de cancha de paleta podría insertase en este tipo de situación.
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