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Search Results: 1 - 10 of 136109 matches for " Li-Ya Qiao "
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Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons
Sharon J Yu, Chun-mei Xia, Jarren C Kay, Li-Ya Qiao
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-48
Abstract: In a rat cystitis model induced by cyclophosphamide (CYP) for 48?h, the mRNA and protein levels of the excitatory neurotransmitter calcitonin gene-related peptide (CGRP) are increased in the L6 dorsal root ganglia (DRG) in response to bladder inflammation. Cystitis-induced CGRP expression in L6 DRG is triggered by endogenous nerve growth factor (NGF) because neutralization of NGF with a specific NGF antibody reverses CGRP up-regulation during cystitis. CGRP expression in the L6 DRG neurons is also enhanced by retrograde NGF signaling when NGF is applied to the nerve terminals of the ganglion-nerve two-compartmented preparation. Characterization of the signaling pathways in cystitis- or NGF-induced CGRP expression reveals that the activation (phosphorylation) of extracellular signal-regulated protein kinase (ERK)5 but not Akt is involved. In L6 DRG during cystitis, CGRP is co-localized with phospho-ERK5 but not phospho-Akt. NGF-evoked CGRP up-regulation is also blocked by inhibition of the MEK/ERK pathway with specific MEK inhibitors U0126 and PD98059, but not by inhibition of the PI3K/Akt pathway with inhibitor LY294002. Further examination shows that cystitis-induced cAMP-responsive element binding protein (CREB) activity is expressed in CGRP bladder afferent neurons and is co-localized with phospho-ERK5 but not phospho-Akt. Blockade of NGF action in vivo reduces the number of DRG neurons co-expressing CGRP and phospho-CREB, and reverses cystitis-induced increases in micturition frequency.A specific pathway involving NGF-ERK5-CREB axis plays an essential role in cystitis-induced sensory activation.
Advances in spatial scaling effects of soil hydraulic properties

SHU Qiao-sheng,XIE Li-ya,

土壤 , 2010,
Abstract: It is very important to study the spatial scaling effects of soil hydraulic properties in eco-hydrological simulation and agricultural water-fertilizer precision management. Some methods, including statistics, stochastic modeling, pedotransfer function (PTF) and fractal theory, can process the spatial variability research for hydraulic properties. Spatial variability modes may vary with the scale because the scales of physical, chemical and biological processes are different. Geostatistical, spectral, multifractal and wavelet analyses are proper ways to study the scaling effects of hydraulic properties, but some problems still exist, of which the scaling transformation is very important all the along. Moreover, some new techniques such as Geographical Information System (GIS) should be integrated into the research.

XIAO Li-ya,QIAO Wei-hong,

腐蚀科学与防护技术 , 2009,
Abstract: The corrosion mechanisms of metallic materials different corrosive media,such as natural environments(like wet air,acid rain),acid pickling,oil field acidizing are summarized.Imidazoline derivatives as a new,low toxic and useful aqueous inhibitor,can be applied for effectively inhibiting the corrosion of metallic materials in many industial sectors.The inhibiting effect under different conditions is given,and recent development of imidazoline inhibitor is also summarized.
In Vivo Regulation of Brain-Derived Neurotrophic Factor in Dorsal Root Ganglia Is Mediated by Nerve Growth Factor-Triggered Akt Activation during Cystitis
Li-Ya Qiao, Sharon J. Yu, Jarren C. Kay, Chun-Mei Xia
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081547
Abstract: The role of brain-derived neurotrophic factor (BDNF) in sensory hypersensitivity has been suggested; however the molecular mechanisms and signal transduction that regulate BDNF expression in primary afferent neurons during visceral inflammation are not clear. Here we used a rat model of cystitis and found that the mRNA and protein levels of BDNF were increased in the L6 dorsal root ganglia (DRG) in response to bladder inflammation. BDNF up-regulation in the L6 DRG was triggered by endogenous nerve growth factor (NGF) because neutralization of NGF with a specific NGF antibody reduced BDNF levels during cystitis. The neutralizing NGF antibody also subsequently reduced cystitis-induced up-regulation of the serine/threonine kinase Akt activity in L6 DRG. To examine whether the NGF-induced Akt activation led to BDNF up-regulation in DRG in cystitis, we found that in cystitis the phospho-Akt immunoreactivity was co-localized with BDNF in L6 DRG, and prevention of the endogenous Akt activity in the L6 DRG by inhibition of phosphoinositide 3-kinase (PI3K) with a potent inhibitor LY294002 reversed cystitis-induced BDNF up-regulation. Further study showed that application of NGF to the nerve terminals of the ganglion-nerve two-compartmented preparation enhanced BDNF expression in the DRG neuronal soma; which was reduced by pre-treatment of the ganglia with the PI3K inhibitor LY294002 and wortmannin. These in vivo and in vitro experiments indicated that NGF played an important role in the activation of Akt and subsequent up-regulation of BDNF in the sensory neurons in visceral inflammation such as cystitis.
Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat
Chun-Mei Xia, Melisa A Gulick, Sharon J Yu, John R Grider, Karnam S Murthy, John F Kuemmerle, Hamid I Akbarali, Li-Ya Qiao
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-30
Abstract: Colonic inflammation was induced by a single dose of tri-nitrobenzene sulfonic acid (TNBS) instilled intracolonically. The histology of the colon and the urinary bladder was examined by hematoxylin and eosin (H&E) stain. The protein expression of transient receptor potential (TRP) ion channel of the vanilloid type 1 (TRPV1) and brain-derived neurotrophic factor (BDNF) were examined by immunohistochemistry and/or western blot. The inter-micturition intervals and the quantity of urine voided were obtained from analysis of cystometrograms.At 3 days post TNBS treatment, the protein level of TRPV1 was increased by 2-fold (p < 0.05) in the inflamed distal colon when examined with western blot. TRPV1 was mainly expressed in the axonal terminals in submucosal area of the distal colon, and was co-localized with the neural marker PGP9.5. In sensory neurons in the dorsal root ganglia (DRG), BDNF expression was augmented by colonic inflammation examined in the L1 DRG, and was expressed in TRPV1 positive neurons. The elevated level of BDNF in L1 DRG by colonic inflammation was blunted by prolonged pre-treatment of the animals with the neurotoxin resiniferatoxin (RTX). Colonic inflammation did not alter either the morphology of the urinary bladder or the expression level of TRPV1 in this viscus. However, colonic inflammation decreased the inter-micturition intervals and decreased the quantities of urine voided. The increased bladder activity by colonic inflammation was attenuated by prolonged intraluminal treatment with RTX or treatment with intrathecal BDNF neutralizing antibody.Acute colonic inflammation increases bladder activity without affecting bladder morphology. Primary afferent-mediated BDNF up-regulation in the sensory neurons regulates, at least in part, the bladder activity during colonic inflammation.Clinical evidence has shown sensory cross-sensitization between the urinary bladder and the distal colon [1-5]. Patients with inflammatory bowel disease (IBD) are more l
Prevalence of Hematuria among Emergency Department Healthcare Workers  [PDF]
Ho-Hsing Lin, Chi-Wen Juan, Li-Ya Lin, Chi-Wei Lee, Chien-Jen Huang
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.519154
Abstract: Background: In Taiwan, emergency departments are so busy that it is not uncommon for staffs (doctors and nurses) to be deprived of their lunch breaks or breaks to go to the restroom. As a consequence, during their busy shifts some emergency department healthcare workers choose to limit their water intake and no time to micturate which are both risk factors of urinary tract infection or urolithiasis. Hematuria is a common laboratory finding due to urinary tract infection and urolithiasis. Objective: To assess the prevalence of hematuria among the emergency department healthcare workers, we conducted a retrospective study in a district hospital in Taiwan. Documented data included those of healthcare workers who worked in the emergency department, as well as other departments of the same hospital. Methods: We reviewed the three-year records of general body checkup of hospital staffs who served in the emergency room and other departments of the same hospital between January 1, 2009 and December 31, 2011. Statistical software SPSS statistical analysis of survey data recovery is applied; data and test results by the questionnaire analysis patterns are associated with the urinary system abnormalities to ANOVA analysis to explore the hospital group whether there is a significant sex differences, and the other to analyze and verify the correlation analysis to the Scheffe post-hoc comparison method. Results: A higher prevalence of hematuria was observed among emergency department healthcare workers when compared with their colleagues who work in other departments of the same hospital. Female workers have higher risk of urinary system abnormalities than male workers. Nurses in the urinary system abnormalities are higher than other positions category. Shift work system has a negative effect on the urinary system. Conclusion: In conclusion, hematuria is more prevalent among emergency department healthcare workers than healthcare workers working in the inpatient wards. Hematuria might well be due to urinary tract infection which in turns caused by the overwhelmingly busy nature of the emergency department duty that deprived the emergency department healthcare workers from frequent voiding and sufficient intake of fluid.
Alteration of fatty acid metabolism in the liver, adipose tissue, and testis of male mice conceived through assisted reproductive technologies: fatty acid metabolism in ART mice
Wang Li-Ya,Le Fang,Wang Ning,Li Lei
Lipids in Health and Disease , 2013, DOI: 10.1186/1476-511x-12-5
Abstract: Background Lipid metabolism plays important roles in the whole process of pregnancy. Previous studies have demonstrated abnormalities of lipid metabolism in the placentas of pregnancies obtained by assisted reproductive technology (ART). Therefore, we hypothesized that ART micromanipulation may affect lipid metabolism in offspring, and focused on the fatty acid metabolism in ART male offspring in this study. Methods The fatty acid metabolism in the liver, adipose tissue and testis was detected. The comparison between naturally conceived (NC), controlled ovarian hyperstimulation (COH), in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) mice was made to analyze the effect of ART on offspring. The mice models in this study included two age groups: adult group and old group. The fatty acid composition and the expression of lipid metabolism-related genes were analyzed by GC-MS and qRT-PCR. Results The fatty acid composition in the liver and adipose tissue were significantly altered in ART mice, but no significant difference was found in the testis. In adipose tissue, ART mice showed decreased monounsaturated fatty acids (MUFAs) and increased polyunsaturated fatty acids (PUFAs) in both adult and old mice, while the alteration of saturated fatty acids (SFAs) in the adult disappeared in the old. In liver, the changes were much complex in adult mice, while increased MUFAs and decreased PUFAs were found in ART old mice. The activities of fatty acid metabolism-related enzymes and the expression of lipogenic and lipolytic proteins changed in ART groups, with the adult mice and old mice showing inconsistent alterations. Further analysis indicated that SFAs was closely associated with the alterations of fatty acid metabolism-related enzyme activities and the expression of lipogenic and lipolytic proteins. Furthermore, we also found that the effect of separated ART treatments on fatty acid metabolism varied with different ages and tissues. Conclusions ART treatments had effect on the fatty acid composition in adipose tissue and liver of male mice. The alteration of SFAs content was crucial for the regulation of fatty acid composition. These changes might have potential effects on the health of ART male offspring which need further investigation.
Concept Layout Model of Transportation Terminals
Li-ya Yao,Li-shan Sun,Wu-hong Wang,Hui Xiong
Discrete Dynamics in Nature and Society , 2012, DOI: 10.1155/2012/148216
Concept Layout Model of Transportation Terminals
Li-ya Yao,Li-shan Sun,Wu-hong Wang,Hui Xiong
Discrete Dynamics in Nature and Society , 2012, DOI: 10.1155/2012/148216
Abstract: Transportation terminal is the key node in transport systems. Efficient terminals can improve operation of passenger transportation networks, adjust the layout of public transportation networks, provide a passenger guidance system, and regulate the development of commercial forms, as well as optimize the assembly and distribution of modern logistic modes, among others. This study aims to clarify the relationship between the function and the structure of transportation terminals and establish the function layout design. The mapping mechanism of demand, function, and structure was analyzed, and a quantitative relationship between function and structure was obtained from a design perspective. Passenger demand and terminal structure were decomposed into several demand units and structural elements following the principle of reverse engineering. The relationship maps between these two kinds of elements were then analyzed. Function-oriented concept layout model of transportation terminals was established using the previous method. Thus, a technique in planning and design of transportation structures was proposed. Meaningful results were obtained from the optimization of transportation terminal facilities, which guide the design of the functional layout of transportation terminals and improve the development of urban passenger transportation systems. 1. Introduction With the accelerated urbanization and motorization, construction of transportation terminals in major cities in China is gradually approaching the ideal. The operating efficiency of terminals, which are key nodes in the transportation network, directly influences the efficiency of transportation networks. However, the occurrence of passenger interleaving and long-distance walking due to deficiencies in the layout of transportation terminals result in a low operating efficiency. This problem is aggravated with the increase in transportation demand. In many advanced cities, planning, design, and management of transportation terminals adaptive to their cities have been investigated since the 1950s to alleviate traffic congestion [1–3]. Batarliene and Jara?uniene [4] studied the interaction between different transport modes in transport terminals. Piccioni et al. [5] gave an application for facility location and optimal location models. Some scholars succeeded in the study of traffic characteristics of pedestrian. Lam et al. [6, 7] and Young Seth [8] obtained pedestrian walking speed at different facilities. Cheung and Lam [9, 10], Lee and Lam [11] and Delft [12] explained the pedestrian flow
Existence of Feasible Solutions of Bilevel Programming

FAN Li-Ya,LIU San-Yang,

数学物理学报(A辑) , 2003,
Abstract: Bilevel programming is usually formulated with two optimization problems where the constraint set of the first one (upper level problem) is partially determined by the optimal reactions of the second one (lower level problem). The paper is devoted to study the existence of feasible solutions, which plays a fundamental and important role in bilevel programming, by means of the w pseudo monotonicity of the Clarke's subdifferential mapping of the lower level objective function.
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